Abstract:
BACKGROUND:Sepsis is more common in the elderly. TNF⍺ is recognized as an important mediator in sepsis and Toll-like receptors (TLRs) play an important role in initiating signaling cascades to produce TNF⍺. Little is known about how innate immunity is altered in healthy human aging that predisposes to sepsis. AIMS AND METHODS:We tested the hypothesis that aging dysregulates the innate immune response to TLR 2 and 4 ligands. We performed whole blood assays on 554 healthy subjects aged 40-80 years. TNFα production was measured at baseline and after stimulation with the TLR2 agonists: peptidoglycan, lipoteichoic acid, Pam3CysK, Zymosan A and the TLR4 agonist lipopolysaccharide (LPS). In a subset of subjects (n = 250), we measured Toll-like receptor (TLR) 2, 4 and MyD88 expression using real-time PCR. RESULTS AND DISCUSSION:We measured a 2.5% increase per year in basal secretion of TNFα with aging (n = 554 p = 0.02). Likewise, TNFα secretion was increased with aging after stimulation with peptidoglycan (1.3% increase/year; p = 0.0005) and zymosan A (1.1% increase/year p = 0.03). We also examined the difference between baseline and stimulated TNFα for each individual. We found that the increase was driven by the elevated baseline levels. In fact, there was a diminished stimulated response to LPS (1.9% decrease/year; p = 0.05), lipoteichoic acid (2.1% decrease/year p = 0.03), and Pam3CysK (2.6% decrease/year p = 0.0007). There were no differences in TLR or MyD88 mRNA expression with aging, however, there was an inverse relationship between TLR expression and stimulated TNFα production. CONCLUSIONS:With aging, circulating leukocytes produce high levels of TNFα at baseline and have inadequate responses to TLR2 and TLR4 agonists. These defects likely contribute to the increased susceptibility to sepsis in older adults.
journal_name
Aging Clin Exp Resjournal_title
Aging clinical and experimental researchauthors
Bailey KL,Smith LM,Heires AJ,Katafiasz DM,Romberger DJ,LeVan TDdoi
10.1007/s40520-018-1064-0subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1185-1193issue
9eissn
1594-0667issn
1720-8319pii
10.1007/s40520-018-1064-0journal_volume
31pub_type
杂志文章abstract:BACKGROUND:The Short Physical Performance Battery (SPPB) and the De Morton Mobility Index (DEMMI) are two commonly used instruments to assess mobility in older patients. AIMS:To compare the two assessments in acute senior trauma patients with regard to sensitivity to change during an acute care, and prediction of disc...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01249-9
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The relative weight of various etiologies of dementia and mild cognitive impairment (MCI) as predictors of intra-hospital, short- and long-term mortality in very old acutely ill patients suffering from multiple comorbid conditions remains unclear. We investigated intra-hospital, 1- and 5-year mortal...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324953
更新日期:2011-02-01 00:00:00
abstract::Senescence of the brain seems to be related to increased levels of free oxygen radical (FOR). FOR may damage macromolecular compounds such as: proteins, lipids, and DNA. In the aging brain, increased FOR levels damage DNA, mitochondrial DNA (mtDNA), and nuclear DNA (nDNA). In DNA they damage single and double strands,...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-013-0004-2
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abstract:AIMS:This study aimed at examining whether ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) were independently associated with carotid Intima-media thickness (CIMT) or carotid artery plaque (CAP) in elderly people. METHODS:A cross-sectional analysis was performed in 155 individuals aged over 7...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01415-z
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIMS:The relationships between blood pressure (BP) and cognition are complex and are still partly unclear. The impact of history of hypertension, present BP levels, and left ventricular hypertrophy (LVH) on cognition was investigated in a 10-year follow-up study of an aged population. METHODS:The popula...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324544
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Accumulation of aggregated α-synuclein from the enteric nervous system is believed to be involved in the pathogenesis of Parkinson's disease (PD). The appendix contains abundant α-synuclein and lacks a blood-tissue barrier, suggesting that appendectomy might reduce α-synuclein aggregation, and therefore the ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40520-019-01354-9
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Despite the increase in research on delirium, it remains underdiagnosed and difficult to manage, and the outcome is poor especially in older people. AIMS:To identify the clinically diagnosed rates of delirium, the possible aetiologies, to describe treatment, number and type of psychotropic medication used a...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0227-x
更新日期:2014-12-01 00:00:00
abstract::Most visual and cognitive functions are affected by aging over the lifespan. In this study, our aim was to investigate the loss in sensitivity to different classes of second-order stimuli-a class of stimuli supposed to be mainly processed in extrastriate cortex-in the aging population. These stimuli will then allow on...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-018-1018-6
更新日期:2019-05-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::New onset epilepsy and seizures are common neurological disorders in aged people, second only to stroke and dementia. They are frequently related to other pathological conditions including stroke, trauma, tumors and neurological diseases whereas in about one-third of cases the origin is unknown. Besides the origin, th...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01396-z
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:Advances such as passive monitoring technology (PMT), which provides holistic supervision of chronically ill and elderly patients, enable and support improved monitoring and observation, thus empowering the growing population of older adults to live more independently while lowering health care expenses. AI...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01323-2
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades. AIMS:To clarify the relationship between cumulative MS factors and symptomatic KOA. METHODS:A cross-sectional survey involving 119 women aged 45-88 years who were...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0808-6
更新日期:2018-05-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03327392
更新日期:2004-06-01 00:00:00
abstract::Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01156-z
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson's disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a p...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01353-w
更新日期:2020-09-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0786-8
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Given the impact of recurrent falls in older people, risk evaluation for falling is an important part of geriatric assessment. Available clinical tools usually do not include patients' self-perceived risk of falling. The objective of this study was to evaluate association with and predictive capacity of self-...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-013-0130-x
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Diagnosis of dementia is often difficult in subjects with low educational level. Our aim was to evaluate the role of functional performance and the possibility of preferring scores of activities of daily living (ADL) and instrumental activities of daily living (IADL) in screening elderly people for ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324675
更新日期:2007-04-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/s40520-019-01170-1
更新日期:2019-06-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01746-2
更新日期:2021-01-11 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/BF03324776
更新日期:2008-06-01 00:00:00
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journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-014-0278-z
更新日期:2015-06-01 00:00:00
abstract::Vascular dementia (VaD) is a general term describing problems with reasoning, planning, judgment, memory, and other thought processes caused by brain damage from impaired blood flow to the brain. Cognitive rehabilitation and physical therapy are the mainstays of dementia treatment, although often ineffective because o...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-015-0343-2
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Walking is the core physical activity of older persons. The assessment of walking capacity is increasingly important for clinical purposes and clinical research. Differences between assessment tools and protocols for short walks to obtain gait characteristics can be responsible for changes, e.g., in...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-020-01703-z
更新日期:2020-09-15 00:00:00
abstract:OBJECTIVES:Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. METHODS:We studied AF patients ≥ 45 years in Sweden 1998-2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Regis...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01449-3
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Nursing home institutionalization tends to exacerbate loss of functioning. AIMS:Examine the feasibility and the effect of a psychomotor intervention-a multimodal exercise program promoting simultaneous cognitive and motor stimulation-on the executive (planning ability and selective attention) and physical f...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0803-y
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The majority of older adults do not reach the physical activity guidelines. One possible explanation for this may be that older adults overestimate their physical activity levels, because they are unable to identify exercise intensity. METHODS:Forty-four older adults were recruited and randomly assigned int...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-017-0746-3
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cognitive and physical deficits independently raise the risk for negative events in older adults. Less is known about whether their co-occurrence constitutes a distinct risk profile. This study quantifies the association between cognitive impairment, no dementia (CIND), slow walking speed (WS) and their comb...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章
doi:10.1007/s40520-019-01297-1
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Asymmetric vestibular function, decreased plantar sensation, postural control and functional ability have been associated with fall-related wrist fractures. OBJECTIVE:To investigate whether multi-sensory training (MST) improves postural control, vestibular function, foot sensation and functional ability amo...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40520-019-01143-4
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Lumbar spinal stenosis (LSS), osteoarthritis (OA) of the knee, and osteoporosis are major locomotive diseases in the elderly population. The aim of this study was to examine the effectiveness of exercise in these three diseases. METHODS:We reviewed the relevant literature, i.e., systematic reviews ...
journal_title:Aging clinical and experimental research
pub_type: 杂志文章,评审
doi:10.1007/BF03324783
更新日期:2010-04-01 00:00:00