Oxidative stress in cervical cancer pathogenesis and resistance to therapy.

abstract：:WNT signaling pathways play an important role in both development and disease. By analyzing the signaling capabilities of commercially available WNT3a preparations towards the PI3K/AKT/GSK3 signaling pathway, we discovered unexpected inconsistencies from lot to lot of recombinant WNT3a. We provide evidence that: (1) T...

journal_title：Journal of cellular biochemistry

authors： Cajanek L,Adlerz L,Bryja V,Arenas E

更新日期：2010-12-01 00:00:00

abstract：:E-peptide of the pro-Insulin-like growth factor-I (pro-IGF-I) is produced from pre-pro-IGF-I by proteolytic cleavage in the post-translational processing. Previous in vitro studies conducted in our laboratory showed that Ea4-peptide of rainbow trout (rt) pro-IGF-I or Eb-peptide of human (h) pro-IGF-I exhibited activit...

journal_title：Journal of cellular biochemistry

authors： Chen MJ,Chiou PP,Lin P,Lin CM,Siri S,Peck K,Chen TT

更新日期：2007-08-01 00:00:00

abstract：:Annexin II is a multifunctional calcium-dependent phospholipid binding protein whose presence in epidermis has previously been reported. However, like other members of annexin family, annexin II has been regarded as either an intracellular protein or associated with the cellular membrane. Here, we report the presence ...

journal_title：Journal of cellular biochemistry

authors： Karimi-Busheri F,Marcoux Y,Tredget EE,Li L,Zheng J,Ghoreishi M,Weinfeld M,Ghahary A

更新日期：2002-01-01 00:00:00

abstract：:Epidemiological studies have shown that chronic exposure to arsenic can result in liver injury, peripheral neuropathy, arteriosclerosis, and an increased incidence of cancer of the lung, skin, bladder, and liver. The overexpression of inducible cyclooxygenase-2 (Cox-2) has been associated with vascular inflammation an...

journal_title：Journal of cellular biochemistry

authors： Tsai SH,Liang YC,Chen L,Ho FM,Hsieh MS,Lin JK

更新日期：2002-01-01 00:00:00

abstract：:Angiogenesis, the formation of new capillary blood vessels, occurs almost exclusively in the microcirculation. This process is controlled by the interaction between factors with positive and negative regulatory activity. In this study, we have compared the effect of two well described positive regulators, vascular end...

journal_title：Journal of cellular biochemistry

authors： Cavallaro U,Tenan M,Castelli V,Perilli A,Maggiano N,Van Meir EG,Montesano R,Soria MR,Pepper MS

更新日期：2001-01-01 00:00:00

abstract：:In order to assess, in a controlled in vitro model, the differentiation potential of adult bone marrow derived stem cells we have developed a coculture procedure using adult rat cardiomyocytes and mesenchymal stem cells (MSCs) from transgenic GFP positive rats. We investigated in the cocultured MSCs the time course of...

journal_title：Journal of cellular biochemistry

authors： Gallo MP,Ramella R,Alloatti G,Penna C,Pagliaro P,Marcantoni A,Bonafé F,Losano G,Levi R

更新日期：2007-01-01 00:00:00

abstract：:Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Here we report th...

journal_title：Journal of cellular biochemistry

authors： Zhang L,Deng X,Shi X,Dong X

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In this study, we aimed to study the molecular mechanisms underlying the symptoms of hyperresponsiveness during intubation. METHOD:The value of circulating long noncoding RNA (lncRNA)-prognosis-associated gallbladder cancer (PAGBC) in the prediction of hyperresponsiveness upon intubation duri...

journal_title：Journal of cellular biochemistry

authors： Li LX,Li YJ,He JX

更新日期：2018-09-23 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a progressive and disabling disorder, characterized by synovial inflammation and joint effusion. This study aimed to explore the role of stanniocalcin-1 (STC1) in the development of OA by regulating the survival and inflammation of fibroblast-like synovial (FLS) cells. METHODS:Microarr...

journal_title：Journal of cellular biochemistry

authors： Wu Y,Li Z,Jia W,Li M,Tang M

更新日期：2019-06-01 00:00:00

abstract：:A large number of natural compounds, such as phenolic compounds, have been scientifically evaluated in the search for enzyme inhibitors. The interactions between the phenolic compound p-coumaric acid and the enzymes present in snake venoms (used as research tools) were evaluated in vitro and in silico. The p-coumaric ...

journal_title：Journal of cellular biochemistry

authors： Cesar PHS,Cardoso Trento MV,Sales TA,Marques TR,Braga MA,Ramalho TC,Marcussi S

更新日期：2019-09-01 00:00:00

abstract：:Although effective for the treatment of hematological malignancies, the FDA approved proteasome inhibitors bortezomib and carfilzomib have limited efficacy in solid tumors including triple negative breast cancer (TNBC). Chemotherapy is the only option for treating TNBC due to the absence of specific therapeutic target...

journal_title：Journal of cellular biochemistry

authors： Deshmukh RR,Kim S,Elghoul Y,Dou QP

更新日期：2017-05-01 00:00:00

abstract：:Plasminogen activator inhibitor type-1 (PAI-1) is the major negative regulator of the plasmin-dependent pericellular proteolytic cascade. PAI-1 gene expression is normally growth state regulated but frequently elevated in chronic fibroproliferative and neoplastic diseases affecting both stromal restructuring and cellu...

journal_title：Journal of cellular biochemistry

authors： Qi L,Allen RR,Lu Q,Higgins CE,Garone R,Staiano-Coico L,Higgins PJ

更新日期：2006-10-01 00:00:00

abstract：:Hantavirus infections are now recognized to be a global problem. The hantaviruses include several genotypic variants of the virus with different distributions in varying geographical regions. The virus genotypes seem to segregate in association with certain manifestations specific for each syndrome. They primarily inc...

journal_title：Journal of cellular biochemistry

authors： Kalaiselvan S,Sankar S,Ramamurthy M,Ghosh AR,Nandagopal B,Sridharan G

更新日期：2017-05-01 00:00:00

abstract：:As a microaerobe, Helicobacter pylori employs the global regulator SpoT for defending against oxidative stress in vitro. However, the mechanisms how SpoT affects bacterial gene expression is still unknown. Moreover, the function of SpoT in H. pylori colonization in the host is remaining undetermined. To explore the fu...

journal_title：Journal of cellular biochemistry

authors： Sun Y,Li X,Li W,Zhao M,Wang L,Liu S,Zeng J,Liu Z,Jia J

更新日期：2012-11-01 00:00:00

abstract：:The deficiency of the enzyme glutaryl-CoA dehydrogenase, known as glutaric acidemia type I (GA-I), leads to the accumulation of glutaric acid (GA) and glutarilcarnitine (C5DC) in the tissues and body fluids, unleashing important neurotoxic effects. l-carnitine (l-car) is recommended for the treatment of GA-I, aiming t...

journal_title：Journal of cellular biochemistry

authors： Guerreiro G,Faverzani J,Jacques CED,Marchetti DP,Sitta A,de Moura Coelho D,Kayser A,Kok F,Athayde L,Manfredini V,Wajner M,Vargas CR

更新日期：2018-12-01 00:00:00

abstract：:Anoikis is a form of programmed cell death induced by loss of contact from neighboring cells or from their extracellular matrix (ECM). Many tumorigenic cells are anoikis resistant, facilitating cancer progression and metastasis. Trastuzumab is a monoclonal antibody used for the treatment of breast and gastric cell can...

journal_title：Journal of cellular biochemistry

authors： Onyeisi JOS,Castanho de Almeida Pernambuco Filho P,de Araujo Lopes S,Nader HB,Lopes CC

更新日期：2019-08-01 00:00:00

abstract：:Circular RNA (circRNA) is a new noncoding RNAs and plays an important role in many pathological processes. Recently, studies have shown that circular RNA_PRKCI (circ-PRKCI) regulates cell proliferation and cell migration of tumor cells. Esophageal carcinoma is a highly malignant digestive tract tumor, which is divided...

journal_title：Journal of cellular biochemistry

authors： Shi N,Shan B,Gu B,Song Y,Chu H,Qian L

更新日期：2019-06-01 00:00:00

abstract：:The mitogen regulated protein/proliferin (MRP/PLF) gene is transcribed in primary mouse embryo fibroblasts (MEFs), but the pre-mRNA is not properly converted into a stable cytoplasmic mRNA and instead is rapidly degraded, apparently in the nucleus [Malyankar et al. (1994): Proc Natl Acad Sci USA 91:335-359]. In 3T3 ce...

journal_title：Journal of cellular biochemistry

authors： Malyankar UM,Rittling SR,Denhardt DT

更新日期：1996-02-01 00:00:00

abstract：:Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial-mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in an inflammatory microenvironment. B...

journal_title：Journal of cellular biochemistry

authors： Ye K,Chen QW,Sun YF,Lin JA,Xu JH

更新日期：2018-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) produced by endothelial cells and macrophages play important roles in atherogenesis because they promote the formation of oxidized low-density lipoproteins (oxLDL). Extracellular-superoxide dismutase (EC-SOD) is mainly produced by vascular smooth muscle cells (VSMCs), is secreted into the...

journal_title：Journal of cellular biochemistry

authors： Makino J,Asai R,Hashimoto M,Kamiya T,Hara H,Ninomiya M,Koketsu M,Adachi T

更新日期：2016-11-01 00:00:00

abstract：:Long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been implicated as a tumor suppressor gene in several human cancer types. However, little is known regarding its involvement and potential mechanism in human breast cancer. In this study, we explored the effect of MEG3 on the growth of human breast cancer c...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Wu J,Jing H,Huang G,Sun Z,Xu S

更新日期：2019-04-01 00:00:00

abstract：:Membrane receptors for steroid hormones affect signaling pathways that modulate nuclear function, influence neuronal activity, ion flow, and the circulatory system. Indeed, 'new' steroid hormones have been identified by their interaction with membrane-initiated signaling systems. A brief summary of the FASEB Summer Re...

journal_title：Journal of cellular biochemistry

authors： Nemere I,Pietras RJ,Blackmore PF

更新日期：2003-02-15 00:00:00

abstract：:We have previously demonstrated the direct involvement of a type 1 Ser/Thr phosphatase (PPase 1) in endothelial cell (EC) barrier regulation [Am. J. Physiol. 269:L99-L108, 1995]. To further extend this observation, we microinjected either the Ser/Thr PPase inhibitor, calyculin, or the PPase 1 inhibitory protein, I-2 i...

journal_title：Journal of cellular biochemistry

authors： Verin AD,Csortos C,Durbin SD,Aydanyan A,Wang P,Patterson CE,Garcia JG

更新日期：2000-07-19 00:00:00

abstract：:Cutaneous melanoma (CM) has become a major public health concern. Studies illustrate that minichromosome maintenance protein 7 (MCM7) participate in various diseases including skin disease. Our study aimed to study the effects of MCM7 silencing on CM cell autophagy and apoptosis by modulating the AKT threonine kinase ...

journal_title：Journal of cellular biochemistry

authors： Yang Y,Ma S,Ye Z,Zhou X

更新日期：2020-02-01 00:00:00

abstract：:Madin-Darby canine kidney (MDCK) cells were previously shown to have few or no plasma membrane insulin binding sites (Hofmann et al: J Biol Chem 258:11774, 1983]. Accordingly, neither insulin-stimulated incorporation of [14C]glucose into glycogen, nor insulin-induced uptake of radiolabeled alpha-aminoisobutyrate ([3H]...

journal_title：Journal of cellular biochemistry

authors： Hofmann C,Crettaz M,Bruns P,Hessel P,Hadawi G

更新日期：1985-01-01 00:00:00

abstract：:Autophosphorylation is an important mechanism by which protein kinases regulate their own biological activities. Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features autophosphorylation activity. We provide evidence that Ser186 i...

journal_title：Journal of cellular biochemistry

authors： Hashimoto YK,Satoh T,Okamoto M,Takemori H

更新日期：2008-08-01 00:00:00

abstract：:The human myeloid nuclear differentiation antigen (MNDA) is expressed specifically in maturing cells of the myelomonocytic lineage and in monocytes and granulocytes. Epitope enhancement was used to confirm the strict lineage- and stage-specific expression of MNDA in bone marrow as well as in other paraffin-embedded fi...

journal_title：Journal of cellular biochemistry

authors： Kao WY,Briggs JA,Kinney MC,Jensen RA,Briggs RC

更新日期：1997-05-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) was reported to be involved in adipogenesis. However, the regulating mechanism of STAT3 remains unclear. The present results showed that STAT3 was activated within 2-h adipogenic induction, in which the phosphorylated STAT3 translocated from cytoplasm to the n...

journal_title：Journal of cellular biochemistry

authors： Zhang K,Guo W,Yang Y,Wu J

更新日期：2011-02-01 00:00:00

abstract：:Labeled oligonucleotide analogues for antisense imaging of messenger RNA (mRNA) have great potential for detection of endogenous gene expression in vivo. Successful antisense imaging may be useful for detecting cellular gene expression patterns and early molecular changes in disease. Conclusive demonstration of this t...

journal_title：Journal of cellular biochemistry

authors： Lewis MR,Jia F

更新日期：2003-10-15 00:00:00

abstract：:Resistance to therapies, recurrence, and metastasis remain challenging issues for breast cancer patients, particularly for triple-negative and breast cancer stem cells. The activation of the epithelial-to-mesenchymal transition (EMT) plays an indispensable role in the poor prognosis of those types. The accumulating pr...

journal_title：Journal of cellular biochemistry

authors： Koohestanimobarhan S,Salami S,Imeni V,Mohammadi Z,Bayat O

更新日期：2018-09-06 00:00:00