Abstract:
:It has been found that exposure to manganese (Mn) could induce reproductive dysfunction, but its occupational risk in male workers is unclear. This study aims to assess the association of occupational Mn exposure with reproductive hormones and semen quality in a cross-sectional study. Urinary Mn, semen quality, and reproductive hormones were explored in 84 male workers occupationally exposed to Mn and 92 referents. Multiple linear regression analyses were used to assess the relationship. Urinary Mn levels in Mn-exposed workers ranged from 0.56 to 34.25 µg/L, and the average level was 15.92 ± 8.49 µg/L. Compared with the control group, gonadotropin-releasing hormone (GnRH) levels and luteinizing hormone (LH) levels increased significantly and the levels of testosterone (TSTO) decreased significantly in the Mn-exposed group. There was a significant positive linear association between urinary Mn and GnRH and LH, while the linear association between urinary Mn and TSTO was negative. Sperm progressive motility and total motility decreased significantly in the Mn-exposed group. There was a significantly negative linear association between urinary Mn and sperm progressive motility and total motility. In conclusion, occupational Mn exposure was inversely associated with reproductive health of male workers, resulting in the abnormality of hormones secretion and decrease of sperm motility.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Yang H,Wang J,Yang X,Wu F,Qi Z,Xu B,Liu W,Deng Ydoi
10.1177/0748233718810109subject
Has Abstractpub_date
2019-01-01 00:00:00pages
53-62issue
1eissn
0748-2337issn
1477-0393journal_volume
35pub_type
杂志文章abstract::The developmental toxicity of 2,4-Pentanedione (2,4-PD; CAS No. 123-54-6), a widely used industrial chemical, was investigated by vapour exposure, because of its widespread use, and potential for human exposure. Timed-pregnant Fischer 344 rats were exposed on gestational days (gd) 6 to 15 inclusive to analytically mea...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379000600308
更新日期:1990-05-01 00:00:00
abstract::Electrical and electronic waste (E-waste) has now become the fastest growing solid waste around the world. Primitive recycling operations for E-waste have resulted in severe contamination of toxic metals and organic chemicals in the related areas. In this study, six dust and soil samples collected from E-waste recycli...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711399313
更新日期:2011-10-01 00:00:00
abstract::Atrazine is a commonly used herbicide that has previously been implicated as an endocrine-disrupting compound. Previous studies have shown that estrogenic endocrine-disrupting compounds affect the development of the heart, cartilage, and bone in zebrafish ( Danio rerio). To determine whether atrazine has effects simil...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718760419
更新日期:2018-05-01 00:00:00
abstract::Previous cross-sectional studies have shown that exposure to cleaning chemicals among health-care workers (HCWs) is associated with respiratory disorders and ventilatory function changes. This study aimed to further explore this association using a longitudinal approach. A prospective 2-year follow-up study was carrie...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715610043
更新日期:2016-12-01 00:00:00
abstract::As one of the main components of risk assessment, exposure assessment plays a key role in evaluating risk. Many different scenarios can be developed to estimate the risk from exposure to chemicals such as persistent organic pollutants (POPs). The US Food and Drug Administration (FDA)'s Center for Food Safety and Appli...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233701th104oa
更新日期:2001-06-01 00:00:00
abstract::Nanomaterials are widely used nowadays in a range of technological and biomedical fields. Graphene as a nanomaterial used in the health-care sector and in workplaces has raised some concerns about its toxicity. This study aimed to evaluate the cytotoxicity of graphene nanoparticles (GNPs) on the A549 epithelial cells ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718817180
更新日期:2019-01-01 00:00:00
abstract::The negative health effects caused by lead (Pb) exposure are widely recognized; however, the molecular mechanisms remain unknown. The aim of this study was to assess the effect of occupational Pb exposure on telomere length and to investigate the potential mechanisms leading to telomere shortening. A cohort of 334 mal...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715601758
更新日期:2016-12-01 00:00:00
abstract::The following is a review of some of the work we have done since 2004 regarding the importance of molds and their mycotoxins in the phenomenon of sick building syndrome (SBS). In these studies we showed that the macrocyclic trichothecene mycotoxins (MTM) of Stachybotrys chartarum (SC) are easily dissociated from the s...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233709348287
更新日期:2009-10-01 00:00:00
abstract::Trivalent chromium (Cr) is an environmental contaminant, which is extensively used in tanning industries throughout the world and causes various forms of health hazards in tannery workers. Therefore, a cross-sectional study design was used to evaluate the DNA damage and oxidative stress condition in tannery workers ex...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712457447
更新日期:2014-06-01 00:00:00
abstract::Orange B, a pyrazolone dye used to color frankfurter and sausage casings, was given in distilled drinking water to pregnant Osborne-Mendel rats throughout gestation. Assessed on the basis of fluid consumption, the dose levels of 0, 0.05, 0.1, 0.2, and 0.4% corresponded to daily Orange B consumption of 0, 67.5, 129.6, ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379501100402
更新日期:1995-07-01 00:00:00
abstract::In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DN...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1191/0748233705th224oa
更新日期:2005-09-01 00:00:00
abstract::Chloropentafluorobenzene (CPFB) has been identified as a candidate simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse effects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/liter resulted in reduced weight...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700406
更新日期:1991-07-01 00:00:00
abstract::Cutting fluids can become contaminated with metals (e.g., nickel, Ni) and nitrosamines (e.g., N-nitrosodiethanolamine, NDELA) and there is concern that these classes of contaminants can modulate dermal disposition and ultimately the toxicity of cutting fluid additives, such as irritant biocides (e.g., triazine). Bioci...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233705th229oa
更新日期:2005-10-01 00:00:00
abstract::Within hours after the terrorist attack on the Pentagon on September 11, 2001, an extensive sampling effort was initiated within the building to include surface wipe sampling for select coplanar polychlorinated biphenyls (PCBs), congeners of polychlorinated dibenzo(p)dioxins and dibenzofurans (dioxins/furans) and lead...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233701th106oa
更新日期:2001-06-01 00:00:00
abstract::The objective of this study was to examine the potential of arsenate to induce cardiomyocyte cell death and to explore the cellular mechanisms of arsenate toxicity. Isolated cardiomyocytes in culture from embryonic chick hearts were treated with a pentavalent arsenic species (H3AsO4) or arsenate. Arsenate produced a s...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709105593
更新日期:2009-04-01 00:00:00
abstract::In response to reported increased cancer risks among farmers, the Agricultural Health Study (AHS) was designed to examine health outcomes and environmental exposures among farm families in the United States. In the pilot phase of the AHS, food, beverage, air, dermal, dust, surface wipe, and biological specimens (blood...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379801400117
更新日期:1998-01-01 00:00:00
abstract::Occupational exposure in a copper smelting industry may produce various adverse health effects including cancer. Despite a number of well-documented studies reporting an increased risk of cancer among copper smelter workers, the data on genotoxic effects in this industry are scarce. In view of the above, an assessment...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711422735
更新日期:2012-10-01 00:00:00
abstract::Zinc oxide nanoparticles (ZnO NPs) are produced in high tonnage each year; they are widely used in consumer and industrial products, also now finding applications in bioimaging and drug delivery. In the present study, comparison between ZnO NPs (39 nm) and its bulk/micron form (particle size = 5 µm) on liver function ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719878970
更新日期:2019-10-01 00:00:00
abstract::In this study, the cytotoxic potential of fluoride and endosulfan in combination was investigated in Swiss albino mice bone marrow cells using the chromosomal aberration (CA) and micronucleus (MN) test systems. Fluoride (25.1 mg kg-1 body weight [bw] in water) and endosulfan (1.8 mg kg-1 bw by oral intubation) were ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720979423
更新日期:2020-12-16 00:00:00
abstract::Yoghurt is a popular dairy product in Iran because of its beneficial influence on human health and nutritional value. Aflatoxin M1 (AFM1) is the metabolite of potential carcinogen aflatoxin B1, which can contaminate milk through the feed and is not eliminated by common processing heat treatment. An analytical method u...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710394236
更新日期:2011-08-01 00:00:00
abstract::Pesticides are registered in Canada under the authority of the Pest Control Products Act (PCP), administered by the Department of Agriculture. The Department of Agriculture calls upon various federal departments, including Health & Welfare Canada, to provide expert advice on hazards which may be associated with the us...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378800400305
更新日期:1988-09-01 00:00:00
abstract::Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233704th207oa
更新日期:2004-09-01 00:00:00
abstract::This study reports on airborne exposure levels and soil concentrations of lead in regard to abatement of a steel structure (water tank). The tank was de-leaded by abrasive sand blasting. The ball of the tank had a lead surface level that exceeded the Environmental Protection Agency (EPA) definition of lead-based paint...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233702th127oa
更新日期:2002-02-01 00:00:00
abstract::Cyclophosphamide (CP) is an alkylating agent that has been considered effective for cancer treatment. Lycopene, the pigment in tomato fruits, has beneficial effect in the treatment of some diseases. The goal of this study is to evaluate the protective effect of lycopene alone or combined with melatonin (Mel) in inhibi...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712459916
更新日期:2014-07-01 00:00:00
abstract::The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disrupti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719851702
更新日期:2019-06-01 00:00:00
abstract::Exposure estimates produced using predictive exposure assessment methods are associated with a number of uncertainties that relate to the inherent variability of the values for a given input parameter (e.g., body weight, ingestion rate, inhalation rate) and to unknowns concerning the representativeness of the assumpti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::People live in the mountains distributed across the world and are exposed to reduced inspired oxygen and lower barometric pressure along with other factors that lead to high-altitude diseases. The present study was conducted to examine what extent of marketed medicines used in the management of high-altitude sickness ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710369125
更新日期:2010-08-01 00:00:00
abstract::The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. In the present study, the effects of in-utero JP-8 jet fuel exposure ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708089045
更新日期:2007-10-01 00:00:00
abstract::The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708090908
更新日期:2007-11-01 00:00:00
abstract::Tris(2-chloroethyl)phosphate (TRCP), a flame-retardant plasticizer used in plastics, polymeric foams and synthetic fibers, was studied as part of the National Toxicology Program's class study of phosphate flame-retardants. TRCP was administered at 0, 22, 44, 88, 175 and 350 mg/kg to both sexes of rats and 0, 44, 88, 1...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379000600101
更新日期:1990-01-01 00:00:00