[Intravitreal Therapy Combining Dexamethasone and Bevacizumab in Treating Radiation Retinopathy and Opticopathy].

Abstract:

:Radiation Retinopathy is a progressive chronic disease triggered by ionising radiation and is characterised by vascular endothelial damage that can lead to macular edema, optic disc edema and proliferative retinopathy. We discuss a case of a patient with radiation retinopathy and optic disc edema who we treated with a combination of intravitreal bevacizumab and dexamethasone. After 3 injections of bevacizumab, and one of dexamethasone, the patient experienced a resolution of optic disc edema and a marked increase of his visual acuity and remained stable throughout the follow-up period. EINLEITUNG:Die Strahlenretinopathie ist eine chronische, fortschreitende Erkrankung, die durch die Wirkung ionisierender Strahlung verursacht wird. Häufig ist die Ursache einer Strahlenretinopathie die Behandlung eines intra- oder periokulären Tumors. FALLVORSTELLUNG:Ein pseudophaker Patient stellte sich im August 2016 mit einer seit ca. 1 Woche bestehenden Visusverschlechterung des linken Auges in unserer Klinik vor. In der Patientengeschichte war eine Protonenbestrahlung des linken Auges vor 3 Jahren bei Aderhautmelanom bekannt. Es zeigte sich ein Makulaödem mit Exsudatbildung und Papillenödem. Wir stellten die Diagnose einer Strahlenoptiko- und -retinopathie. Es erfolgten intravitreale Injektionen mit Dexamethason (Ozurdex®) und am Folgetag mit 1,25 mg Bevacizumab. Im Abstand von jeweils 4 Wochen injizierten wir erneut 2-mal Bevacizumab. Das Makulaödem und das Papillenödem zeigten sich deutlich rückläufig. Der Patient erfuhr einen Anstieg des bestkorrigierten Visus von 0,4 auf 0,8. In den monatlichen Kontrollen zeigte sich ein stabiler Befund, sodass wir zunächst auf weitere Bevacizumab-Injektionen verzichteten. Es traten keine Komplikationen auf. SCHLUSSFOLGERUNG:Die Kombination aus intravitrealer Gabe von Steroiden und Anti-VEGF erwies sich in diesem Fall als effektive Behandlungsmodalität bei iatrogen induzierter Strahlenoptikopathie und -retinopathie. Weitere Studien sind zur Ermittlung des Stellenwerts der kombinierten Therapie notwendig.

journal_name

Klin Monbl Augenheilkd

authors

Filev FS,Mirshahi A

doi

10.1055/a-0735-9865

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

319-322

issue

3

eissn

0023-2165

issn

1439-3999

journal_volume

237

pub_type

杂志文章
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    doi:

    authors: Grupp A

    更新日期:1975-07-01 00:00:00

  • [Long-term observation of ablatio-prophylaxis with kryopexy (author's transl)].

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    doi:

    authors: Kreissig I,Ruge I

    更新日期:1976-06-01 00:00:00

  • [Millenniums update on posterior capsule opacification (PCO) scores, centration, biocompatibility and fixation of foldable intraocular lenses (IOL) - an analysis of 1,221 pseudophakic post mortem globes].

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  • [Better prognosis for amblyopics by means of full prismatic correction after monocular treatment (author's transl)].

    abstract::Binocular training with full prismatic correction after the monocular therapy by occlusion brings a further improvement of the visual acuity as well as shown in a study of 29% (138 cases) of 469 selected cases with binocular problems and 43% (260 cases) of about 600 unselected cases of squint actually in treatment in ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Pestalozzi D,Schwarzenbach A

    更新日期:1979-09-01 00:00:00

  • [Ophthalmic-pharmacological complications (author's transl)].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

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    doi:

    authors: Lisch K

    更新日期:1976-07-01 00:00:00

  • [New trends in tonometry].

    abstract:BACKGROUND:Though the knowledge about the risk of elevated intraocular pressure for pathogenesis for development and progress of glaucoma is more than 400 years old. It took another 300 years before by means of tonometry this elevation could be quantified. After discussion of the key words it is our aim to demonstrate ...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-927161

    authors: Draeger JA,Schwenteck T,Ruokonen PC

    更新日期:2006-10-01 00:00:00

  • [Therapy of parapapillary subretinal neovascularization].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050277

    authors: Stur M

    更新日期:1988-10-01 00:00:00

  • [Use of an automatic laboratory rinsing machine for cleaning and disinfection of ophthalmosurgical instruments (author's transl)].

    abstract::A report is given on the use of an automatic rinsing machine for the cleaning of surgical eye instruments combining the processes of disinfection, cleaning and drying in one operation and thus providing good protection against corrosion and optimal protective treatment of the cutting blades. To allow use in ophthalmol...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Dausch D,Brewitt H

    更新日期:1977-11-01 00:00:00

  • Contact Lenses in the Management of Corneal Dystrophies.

    abstract::Among the group of diseases comprising corneal dystrophies, there are a number for which contact lenses may be considered. For example, soft contact lenses may be beneficial in the management of recurrent corneal erosions and advanced bullous keratopathy and may lead to disease attenuation in some conditions. They als...

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    pub_type: 杂志文章,评审

    doi:10.1055/a-0735-9801

    authors: Farooq AV,Colby K

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  • [Indications for Retinal Laser Therapy Revisited].

    abstract:BACKGROUND:Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0042-123831

    authors: Enders P,Schaub F,Fauser S

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  • [Experimental studies of the significance of the renin-angiotensin system in the retina. A review].

    abstract::BACKGROUND Many peptides now identified in the brain were previously thought of as exclusively peripheral hormones. Among those, the renin-angiotensin system (RAS) is not only found to be of great importance in peripheral vasomotor and electrolyte homeostasis but also acts as neurotransmitter or modulator in the centr...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1045478

    authors: Jacobi PC,Jurklies B,Kohler K,Zrenner E

    更新日期:1994-06-01 00:00:00

  • [An in-vivo evaluation of Brilliant Blue G in macular surgery].

    abstract:OBJECTIVE:The aim of this study was to evaluate the functional outcome of Brilliant Blue G (BBG) and the staining properties in macular surgery. METHODS:BBG was applied during vitrectomy for macular holes (n = 21) or epiretinal membranes (n = 18) in a prospective, non-comparative consecutive series of patients (Brilli...

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    doi:10.1055/s-0031-1273351

    authors: Höing A,Remy M,Dirisamer M,Priglinger S,Schönfeld CL,Kampik A,Haritoglou C

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  • [Circulating immune complexes in uveitis].

    abstract::The serum of 63 patients suffering from various clinical types of endogenous uveitis with unknown etiology was investigated for the presence of circulating immune complexes (CIC). None of the patients was suffering from a systemic disease usually associated with CIC. Significantly elevated CIC levels were detected in ...

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    pub_type: 杂志文章

    doi:10.1055/s-2008-1054906

    authors: Radda TM,Menzel EJ,Gnad HD

    更新日期:1983-09-01 00:00:00

  • [Electroophthalmological characteristics in ischemic retinopathy (author's transl)].

    abstract::In the ERG the b-wave and the oscillatory potentials are reduced or nonrecordable in ischemic retinopathy. The photopic b-wave appeared to be more sensitive than the scotopic b-wave. In the EOG the slow oscillation is reduced. These clinical observations are in accordance with the results of experimental studies in rh...

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    doi:

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    更新日期:1979-03-01 00:00:00

  • [Choroidal Neovascularisation Other than Typical Neovascular Age-Related Macular Degeneration].

    abstract::Choroidal neovascularisation (CNV) in the context of exsudative age-related macular degeneration (nAMD) can be divided into type 1 (occult) and type 2 (classical) membranes. Retinal angiomatous proliferation (RAP) or polypoidal choroidal vasculopathy (PCV) are "rare subtypes" of chorioretinal neovascularisation and ar...

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  • [Anti-inflammatory treatment in dry eye disease].

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    pub_type: 临床试验,杂志文章

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  • [Catalase activity in argon-laser irradiation].

    abstract::Catalase may provide protection against photochemical action of superoxide radicals and hydrogen peroxide. The authors tried to measure its activity in freshly enucleated calf eyes before and after argon laser irradiation. It was established by iodometric titration that catalase activity was reduced after irradiation ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

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    doi:10.1055/s-2008-1050720

    authors: Wolf S,Mayer UM

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  • [Paediatric retinal detachment and hereditary vitreoretinal disorders].

    abstract::The number of retinal detachments in children is very low in comparison to the number in adults. One predisposing factor for development of paediatric retinal detachment is suffering from hereditary vitreoretinal degeneration (e.g., Stickler syndrome, Wagner syndrome, Kniest dysplasia, familial exudative vitreoretinop...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

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    doi:10.1055/s-2008-1046058

    authors: Lang GE,Rott HD,Naumann GO

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  • [Ab externo sclerostomy with the Er:YAG laser: report of outcome after 2 years].

    abstract:OBJECT:Results over a period of 24 months of performing the Er:YAG laser ab externo sclerostomy. MATERIAL AND METHODS:The procedure was performed 81 times (chronic glaucoma with open angle (n = 55) and narrow angle (n = 15), 6 secondary glaucoma, 4 pigment glaucoma, 1 normal pressure glaucoma) in 74 eyes of 64 patient...

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    doi:10.1055/s-2008-1035199

    authors: Kampmeier J,Klafke M,Hibst R,Wierschin S,Schütte E,Steiner R

    更新日期:1996-04-01 00:00:00

  • [Anti VEGF Therapy Under Real-Life Conditions: Adherance Determines Long Term Outcome in Neovascular AMD].

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  • [Anti-VEGF inhibitors and their role in the treatment of diabetic macular oedema].

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  • [Keratoplasty in private practice].

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    doi:10.1055/s-2008-1046177

    authors: Witmer R

    更新日期:1990-05-01 00:00:00

  • [Management of periorbital and orbital infections].

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    pub_type: 杂志文章,评审

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    authors: Knipping S,Bloching M

    更新日期:2004-11-01 00:00:00

  • [Influence of corneal transparency on the quality of topographies].

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  • [A family with blepharophimosis, ptosis, epicanthus inversus and telecanthus. Occurrence of the hereditary marker in five generations].

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    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045911

    authors: Kuckelkorn R,Reim M

    更新日期:1992-11-01 00:00:00

  • [Results of combined cataract/glaucoma operations (author's transl)].

    abstract::In general the combined cataract/glaucoma operation is a good procedure for treating cataract and glaucoma simultaneously. The operation was performed in 157 eyes between 1976 and 1980. The mean IOP remained constant after surgery for a follow-up period of over three years on average. The review covered 136 eyes, of w...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1055119

    authors: Robert Y,Gloor B

    更新日期:1982-05-01 00:00:00

  • [Surgical transvenous embolization of spontaneous carotid cavernous sinus fistulas in two patients].

    abstract:BACKGROUND:Arteriovenous communications in which blood flows from meningeal branches of the internal and external carotid arteries into the venous circulation around and in the cavernous sinus are termed spontaneous (dural) carotid sinus cavernous fistulas. Due to their mostly low shunt volume they are rarely life thre...

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    pub_type: 杂志文章

    doi:10.1055/s-2000-10356

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  • [Automatic measurement of dye filling of simultaneous digital ICG- and fluorescein angiography sequences].

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    pub_type: 杂志文章

    doi:10.1055/s-2000-10558

    authors: Török B,Hirschi R,Székely G,Brechbühler C,Blass L,Barabás K,Bischoff P

    更新日期:2000-05-01 00:00:00