[Intravitreal Therapy Combining Dexamethasone and Bevacizumab in Treating Radiation Retinopathy and Opticopathy].

Abstract:

:Radiation Retinopathy is a progressive chronic disease triggered by ionising radiation and is characterised by vascular endothelial damage that can lead to macular edema, optic disc edema and proliferative retinopathy. We discuss a case of a patient with radiation retinopathy and optic disc edema who we treated with a combination of intravitreal bevacizumab and dexamethasone. After 3 injections of bevacizumab, and one of dexamethasone, the patient experienced a resolution of optic disc edema and a marked increase of his visual acuity and remained stable throughout the follow-up period. EINLEITUNG:Die Strahlenretinopathie ist eine chronische, fortschreitende Erkrankung, die durch die Wirkung ionisierender Strahlung verursacht wird. Häufig ist die Ursache einer Strahlenretinopathie die Behandlung eines intra- oder periokulären Tumors. FALLVORSTELLUNG:Ein pseudophaker Patient stellte sich im August 2016 mit einer seit ca. 1 Woche bestehenden Visusverschlechterung des linken Auges in unserer Klinik vor. In der Patientengeschichte war eine Protonenbestrahlung des linken Auges vor 3 Jahren bei Aderhautmelanom bekannt. Es zeigte sich ein Makulaödem mit Exsudatbildung und Papillenödem. Wir stellten die Diagnose einer Strahlenoptiko- und -retinopathie. Es erfolgten intravitreale Injektionen mit Dexamethason (Ozurdex®) und am Folgetag mit 1,25 mg Bevacizumab. Im Abstand von jeweils 4 Wochen injizierten wir erneut 2-mal Bevacizumab. Das Makulaödem und das Papillenödem zeigten sich deutlich rückläufig. Der Patient erfuhr einen Anstieg des bestkorrigierten Visus von 0,4 auf 0,8. In den monatlichen Kontrollen zeigte sich ein stabiler Befund, sodass wir zunächst auf weitere Bevacizumab-Injektionen verzichteten. Es traten keine Komplikationen auf. SCHLUSSFOLGERUNG:Die Kombination aus intravitrealer Gabe von Steroiden und Anti-VEGF erwies sich in diesem Fall als effektive Behandlungsmodalität bei iatrogen induzierter Strahlenoptikopathie und -retinopathie. Weitere Studien sind zur Ermittlung des Stellenwerts der kombinierten Therapie notwendig.

journal_name

Klin Monbl Augenheilkd

authors

Filev FS,Mirshahi A

doi

10.1055/a-0735-9865

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

319-322

issue

3

eissn

0023-2165

issn

1439-3999

journal_volume

237

pub_type

杂志文章
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    doi:

    authors: Denden A

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  • [Enhancements after Refractive Corneal Surgery].

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    更新日期:1994-02-01 00:00:00

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    doi:

    authors: Lommatzsch P,Vorpahl K,Bauke G,Klug H

    更新日期:1979-01-01 00:00:00

  • [Therapy of parapapillary subretinal neovascularization].

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    doi:10.1055/s-2008-1050277

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    更新日期:1988-10-01 00:00:00

  • [Indications, technique and results of anterior vitrectomy (author's transl)].

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    doi:

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  • Latanoprost is a vasoconstrictor in isolated porcine ciliary arteries.

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    doi:10.1055/s-2001-15904

    authors: Brogiolo G,Flammer J,Haefliger IO

    更新日期:2001-05-01 00:00:00

  • [Eye involvement in cancer].

    abstract::Intraocular metastatic tumors are rare. They are seen in 10% of patients having died of a malignant tumor. Frequently metastatic tumors of the eye are not observed clinically because the may develop in the terminal stage of the disease. The most frequent primary tumor is carcinoma of the breast with 60% of all intraoc...

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    pub_type: 杂志文章

    doi:

    authors: Vogel M

    更新日期:1997-04-01 00:00:00

  • [Peripapillary melanoma; 10-year follow-up].

    abstract:UNLABELLED:In early stages choroidal peripapillary choroidal melanoma may be confused with a choroidal nevus or melanocytoma. CASE REPORT:A 41-year old female was diagnosed having a choroidal nevus in close proximity to the optic nerve head. Unfortunately the patient did not show up for annual review of this lesion. T...

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    authors: Fischer P,Müller-Jensen K,Frenzel H

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  • [Approaches in medical treatment in glaucoma (author's transl)].

    abstract::The developments concern methods of application and therapeutic agents. Regarding drug aplication Ocusert has to be mentioned: inserted in the cul de sac of the eye once a week it releases a low concentration of a substance continuously and with a constant rate. For acetazolamid (Diamox) it has been shown, that in lon...

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    doi:

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    更新日期:1977-02-01 00:00:00

  • [Better prognosis for amblyopics by means of full prismatic correction after monocular treatment (author's transl)].

    abstract::Binocular training with full prismatic correction after the monocular therapy by occlusion brings a further improvement of the visual acuity as well as shown in a study of 29% (138 cases) of 469 selected cases with binocular problems and 43% (260 cases) of about 600 unselected cases of squint actually in treatment in ...

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    authors: Pestalozzi D,Schwarzenbach A

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  • [Visual acuity following Descemet-membrane endothelial keratoplasty (DMEK): first 100 cases operated on for Fuchs endothelial dystrophy].

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  • [Can fixation disparity be detected reliably by measurement and correctional techniques according H.J. Haase (MKH)?].

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  • [Ocular involvement in MuSK antibody-positive myasthenia gravis].

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    更新日期:2006-01-01 00:00:00

  • [Reis-Bücklers corneal dystrophy].

    abstract::In the literature two types of anterior corneal dystrophy are referred to as Reis-Bücklers' dystrophy. These are the one originally described by Bücklers in 1949 and known by us as the geographical form, and a honeycomb form. On the basis of electron-microscopic findings the geographical form is considered by some aut...

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    authors: Winkelman JE,Wittebol-Post D,Delleman JW

    更新日期:1986-02-01 00:00:00

  • [Can the cutting performance of trephines still be improved?].

    abstract:PURPOSE:Today, for the preparation of donor and recipient cornea during keratoplasty either single-use or reusable metal trephines are commonly used although excimer and femtosecond laser systems are available. Due to the surgical techniques as well as the configuration of metal trephine's cutting edge irregular cornea...

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    更新日期:2005-09-01 00:00:00

  • [Meningioma of the optic nerve sheath. Diagnostic problems despite use of modern imaging procedures].

    abstract::In spite of modern optical examination techniques such as sonography, nuclear magnetic resonance tomography (NMR) and x-ray computer tomography up to now the meningioma of the optic nerve sheath still poses a problem in respect of differential diagnosis. This problem is illustrated by two case reports. In both patient...

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    更新日期:1992-01-01 00:00:00

  • [Carcinoma in situ of the conjunctiva bulbi. Clinical and histopathologic findings].

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  • [Surgical technical principles of trans-scleral suture of posterior chamber lenses].

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    authors: Sundmacher R,Althaus C

    更新日期:1993-04-01 00:00:00

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  • ["Blow-out" orbital trauma and diplopia. Conservative or surgical approach?].

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  • [Boldness and caution: Jacques Daviel's approach to cataract extraction (1745-1752)].

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  • [Cost Comparison of Licensed Intravitreal Therapies for Insufficiently Anti-VEGF Responding Fovea Involving Diabetic Macular Edema in Germany].

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    doi:

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    更新日期:1978-04-01 00:00:00

  • [46-year follow up of malignant transformation of choroid nevus with vascularized surface drusen].

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    pub_type: 杂志文章

    doi:10.1055/s-2008-1046005

    authors: Daicker B

    更新日期:1991-05-01 00:00:00

  • [Retinopathy of prematurity].

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    doi:

    authors: Völcker HE,Naumann G

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