[Intravitreal Therapy Combining Dexamethasone and Bevacizumab in Treating Radiation Retinopathy and Opticopathy].


:Radiation Retinopathy is a progressive chronic disease triggered by ionising radiation and is characterised by vascular endothelial damage that can lead to macular edema, optic disc edema and proliferative retinopathy. We discuss a case of a patient with radiation retinopathy and optic disc edema who we treated with a combination of intravitreal bevacizumab and dexamethasone. After 3 injections of bevacizumab, and one of dexamethasone, the patient experienced a resolution of optic disc edema and a marked increase of his visual acuity and remained stable throughout the follow-up period. EINLEITUNG:Die Strahlenretinopathie ist eine chronische, fortschreitende Erkrankung, die durch die Wirkung ionisierender Strahlung verursacht wird. Häufig ist die Ursache einer Strahlenretinopathie die Behandlung eines intra- oder periokulären Tumors. FALLVORSTELLUNG:Ein pseudophaker Patient stellte sich im August 2016 mit einer seit ca. 1 Woche bestehenden Visusverschlechterung des linken Auges in unserer Klinik vor. In der Patientengeschichte war eine Protonenbestrahlung des linken Auges vor 3 Jahren bei Aderhautmelanom bekannt. Es zeigte sich ein Makulaödem mit Exsudatbildung und Papillenödem. Wir stellten die Diagnose einer Strahlenoptiko- und -retinopathie. Es erfolgten intravitreale Injektionen mit Dexamethason (Ozurdex®) und am Folgetag mit 1,25 mg Bevacizumab. Im Abstand von jeweils 4 Wochen injizierten wir erneut 2-mal Bevacizumab. Das Makulaödem und das Papillenödem zeigten sich deutlich rückläufig. Der Patient erfuhr einen Anstieg des bestkorrigierten Visus von 0,4 auf 0,8. In den monatlichen Kontrollen zeigte sich ein stabiler Befund, sodass wir zunächst auf weitere Bevacizumab-Injektionen verzichteten. Es traten keine Komplikationen auf. SCHLUSSFOLGERUNG:Die Kombination aus intravitrealer Gabe von Steroiden und Anti-VEGF erwies sich in diesem Fall als effektive Behandlungsmodalität bei iatrogen induzierter Strahlenoptikopathie und -retinopathie. Weitere Studien sind zur Ermittlung des Stellenwerts der kombinierten Therapie notwendig.


Klin Monbl Augenheilkd


Filev FS,Mirshahi A




Has Abstract


2020-03-01 00:00:00












  • [An objective rapid testing method for viability of corneal endothelium after conservations (author's transl)].

    abstract::An objective procedure for assessing damage to corneal endothelium is described; it is based on photometrical determination of the dye toluidine blue absorbed by damaged cells. This inexpensive quick test is suitable both for preoperative assessment of grafts and for checking procedures for cornea conversation. The us...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Schrapel A,Letko G,Giessmann HG

    更新日期:1982-01-01 00:00:00

  • [ERG and EOG results in X-chromosomal vitreo-retinal degeneration (author transl)].

    abstract::ERG and EOG were performed in three male patients deriving from two no related families and who had vitreo-retinal degeneration including macula area. The EOG was below normal and ERG-potentials particularly b-waves reduced. The finding although of interest are not pathognomically significant. Therefore the diagnosis ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Denden A

    更新日期:1975-01-01 00:00:00

  • [Enhancements after Refractive Corneal Surgery].

    abstract::This review article focusses on the management of enhancements after corneal refractive laser surgery. Fundamental issues regarding enhancement embrace identification of the underlying reason for postoperative ametropia, assurance of stability of refraction, type of primary refractive laser treatment and thorough eval...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审


    authors: Kook D,Mayer WJ,Shajari M,Steinwender G,Kohnen T

    更新日期:2020-07-01 00:00:00

  • [Objective vernier acuity testing in adults, children and infants. Possibilities and limits of a new method].

    abstract:BACKGROUND:Recently, a method of objective Vernier acuity testing using a modified Catford drum was presented. A tight correlation between the objective Vernier acuity and the Snellen acuity was reported (Hopkisson et al. 1991). PATIENTS AND METHODS:In 41 cooperative patients with strabismic amblyopia and 20 normal su...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Gräf M,Dietrich H

    更新日期:1994-02-01 00:00:00

  • [Experimental studies of the tensile strength of laser adhesions].

    abstract::This paper presents results of measurements of laser adhesions in rabbit eyes. A circular area of the retina 2.5 mm in diameter was covered with laser burns (diameter of laser beam 200 microns). The strength of the adhesion was measured on the 8th and 22nd days after coagulation. The adhesive area consisted of 60-65 l...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Misita V

    更新日期:1984-07-01 00:00:00

  • [Contribution to the epithelial tumors of the ciliary body (clinical, histopathological and electronmicroscopical observation) (author's transl)].

    abstract::An adenoma of the non pigmented epithelium of the ciliary body was supposed to be an irisciliary body melanoma (32P-test positive) and was treated by irido-cyclectomy. Vision acuity remained 0,4 one year after operation. The tumor formed adenoid tubes lined with a cubical or cylindrical epithelium. The cytoplasm of al...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Lommatzsch P,Vorpahl K,Bauke G,Klug H

    更新日期:1979-01-01 00:00:00

  • [Therapy of parapapillary subretinal neovascularization].

    abstract::A large variety of diseases may cause a subretinal neovascularization originating from choroidal vessels. Four cases of parapillary choroidal neovascularisation are described, including neovascularization caused by senile and myopic degeneration, by drusen of the optic nerve head, and by angioid streaks. Obliteration ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Stur M

    更新日期:1988-10-01 00:00:00

  • [Indications, technique and results of anterior vitrectomy (author's transl)].

    abstract::The indications for anterior vitrectomy are presented and the surgical technique is described. An analysis is made of the results of anterior vitrectomy in 93 eyes followed for 4 years and compared with the results of a previous study in which vitreous loss was treated more conservatively. The results of anterior vitr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Luntz MH

    更新日期:1977-06-01 00:00:00

  • Latanoprost is a vasoconstrictor in isolated porcine ciliary arteries.

    abstract:PURPOSE:The purpose of this study was to assess the vasoconstrictor effect of the prostaglandin F2 alpha analog latanoprost in isolated porcine ciliary arteries. MATERIAL AND METHODS:With a myograph system to measure isometric forces, porcine ciliary arteries were exposed, in a cumulative manner, to increasing concent...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Brogiolo G,Flammer J,Haefliger IO

    更新日期:2001-05-01 00:00:00

  • [Eye involvement in cancer].

    abstract::Intraocular metastatic tumors are rare. They are seen in 10% of patients having died of a malignant tumor. Frequently metastatic tumors of the eye are not observed clinically because the may develop in the terminal stage of the disease. The most frequent primary tumor is carcinoma of the breast with 60% of all intraoc...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Vogel M

    更新日期:1997-04-01 00:00:00

  • [Peripapillary melanoma; 10-year follow-up].

    abstract:UNLABELLED:In early stages choroidal peripapillary choroidal melanoma may be confused with a choroidal nevus or melanocytoma. CASE REPORT:A 41-year old female was diagnosed having a choroidal nevus in close proximity to the optic nerve head. Unfortunately the patient did not show up for annual review of this lesion. T...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Fischer P,Müller-Jensen K,Frenzel H

    更新日期:2000-12-01 00:00:00

  • [Approaches in medical treatment in glaucoma (author's transl)].

    abstract::The developments concern methods of application and therapeutic agents. Regarding drug aplication Ocusert has to be mentioned: inserted in the cul de sac of the eye once a week it releases a low concentration of a substance continuously and with a constant rate. For acetazolamid (Diamox) it has been shown, that in lon...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Merté HJ

    更新日期:1977-02-01 00:00:00

  • [Better prognosis for amblyopics by means of full prismatic correction after monocular treatment (author's transl)].

    abstract::Binocular training with full prismatic correction after the monocular therapy by occlusion brings a further improvement of the visual acuity as well as shown in a study of 29% (138 cases) of 469 selected cases with binocular problems and 43% (260 cases) of about 600 unselected cases of squint actually in treatment in ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Pestalozzi D,Schwarzenbach A

    更新日期:1979-09-01 00:00:00

  • [Visual acuity following Descemet-membrane endothelial keratoplasty (DMEK): first 100 cases operated on for Fuchs endothelial dystrophy].

    abstract:PURPOSE:The aim of this study was to evaluate the visual outcome and endothelial cell density in the first series of 100 eyes after Descemet membrane endothelial keratoplasty (DMEK) for the treatment of Fuchs endothelial dystrophy. DESIGN:This was a non-randomised prospective clinical trial. METHODS:The first 100 con...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章


    authors: Droutsas K,Ham L,Dapena I,Geerling G,Oellerich S,Melles G

    更新日期:2010-06-01 00:00:00

  • [Can fixation disparity be detected reliably by measurement and correctional techniques according H.J. Haase (MKH)?].

    abstract:BACKGROUND:The theory of the "Measuring and Correction Methods of H.-J. Haase" (MCH) states that a small misalignment of one eye, called fixation disparity, indicates a difficulty in overcoming a "vergence position of rest" that is different from ortho position. This difficulty, so the theory, can cause asthenopic comp...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章


    authors: Gerling J,de Paz H,Schroth V,Bach M,Kommerell G

    更新日期:2000-06-01 00:00:00

  • [Ocular involvement in MuSK antibody-positive myasthenia gravis].

    abstract:BACKGROUND:Antibodies (Ab) against the acetylcholine receptor (AChR) are found in 80 - 90 % of generalized myasthenia gravis (MG), but only in 50 % of pure ocular MG. Furthermore, Ab against the muscle-specific receptor tyrosine kinase (MuSK) were detected in 38 - 54 % of patients with AChR-Ab-negative ("seronegative")...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Bau V,Hanisch F,Hain B,Zierz S

    更新日期:2006-01-01 00:00:00

  • [Reis-Bücklers corneal dystrophy].

    abstract::In the literature two types of anterior corneal dystrophy are referred to as Reis-Bücklers' dystrophy. These are the one originally described by Bücklers in 1949 and known by us as the geographical form, and a honeycomb form. On the basis of electron-microscopic findings the geographical form is considered by some aut...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Winkelman JE,Wittebol-Post D,Delleman JW

    更新日期:1986-02-01 00:00:00

  • [Can the cutting performance of trephines still be improved?].

    abstract:PURPOSE:Today, for the preparation of donor and recipient cornea during keratoplasty either single-use or reusable metal trephines are commonly used although excimer and femtosecond laser systems are available. Due to the surgical techniques as well as the configuration of metal trephine's cutting edge irregular cornea...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Lingenfelder C,Kupferschmid S,Grabowy U,Kleinen L,Spraul CW

    更新日期:2005-09-01 00:00:00

  • [Meningioma of the optic nerve sheath. Diagnostic problems despite use of modern imaging procedures].

    abstract::In spite of modern optical examination techniques such as sonography, nuclear magnetic resonance tomography (NMR) and x-ray computer tomography up to now the meningioma of the optic nerve sheath still poses a problem in respect of differential diagnosis. This problem is illustrated by two case reports. In both patient...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Klemm M,Guthoff R,Zanella F

    更新日期:1992-01-01 00:00:00

  • [Carcinoma in situ of the conjunctiva bulbi. Clinical and histopathologic findings].

    abstract::The present paper communicates clinical and pathohistologic findings in a case of carcinoma in situ of the conjunctiva (Bowen's disease) with a five-year course. Initially, there are clinical similarities between Bowen's disease and Mooren's ulcer; the diagnosis can be established on the basis of the histologic findin...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Pham Duy T,Scholman HJ,Mercks C

    更新日期:1987-10-01 00:00:00

  • [Surgical technical principles of trans-scleral suture of posterior chamber lenses].

    abstract:BACKGROUND:Most reports on transscleral suture fixation of posterior chamber lenses (PCL) do not mention the principal difficulty that the surgeon has no valid information which structures were perforated by the needle and where he happened to fix the PCL loops. To know this exactly is a "conditio sine qua non". Withou...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Sundmacher R,Althaus C

    更新日期:1993-04-01 00:00:00

  • [Experimental findings with a fibrin tissue adhesive in conjunctival and skleral surgery in a rabbit model (author's transl)].

    abstract::The authors investigated the wound closure of conjunctival wounds with fibrin adhesive as compared to a suture technique in rabbits. Similarly, the fixation of a transplant of lyophilized dura mater on the sclera by fibrin adhesive was also compared with a suture technique. Both clinically and histologically, there we...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Härting F,Mellin KB

    更新日期:1981-07-01 00:00:00

  • ["Blow-out" orbital trauma and diplopia. Conservative or surgical approach?].

    abstract::The treatment of orbital fractures, type blow-out, has always been discussed about. One hundred-twenty patients, subdivided in four groups were examined. Incarceration of the peri-muscular structures or not. Surgical or conservative treatment. These four groups have been studied with the purpose of establishing a trea...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Magnocavallo M,Klainguti G

    更新日期:1992-05-01 00:00:00

  • [Boldness and caution: Jacques Daviel's approach to cataract extraction (1745-1752)].

    abstract::The introduction of cataract extraction by Jacques Daviel, in 1752/53, appears to us as a revolutionary step in eye surgery. It should be realized, however, that this achievement was not only the result of intuition and bold decision in critical situations, but also of careful evaluation, over seven years, of extracti...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 传,历史文章,杂志文章


    authors: Koelbing HM

    更新日期:1985-03-01 00:00:00

  • [Cost Comparison of Licensed Intravitreal Therapies for Insufficiently Anti-VEGF Responding Fovea Involving Diabetic Macular Edema in Germany].

    abstract:BACKGROUND:In the treatment of center-involving diabetic macular edema, despite initial therapy with an anti-VEGF compound, an insufficient response may occur. Further therapy options include a switch of anti-VEGF products or to corticosteroid implants, such as Fluocinolone acetonide or Dexamethasone. OBJECTIVES:First...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Neubauer AS,Haritoglou C,Ulbig MW

    更新日期:2019-02-01 00:00:00

  • [Retinal dysplasia with hydrocephalus (author's transl)].

    abstract::A Study is described of a family in which four children of the same generation died during early childhood; three of them had an obvious hydrocephalus. Two of the latter could be examined clinically, and their eyes removed for pathology. One of them presented clinically bilateral leucocoria; histology showed a total d...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Gerhard JP,Brini A,Willard D,Rohmer A,Messer J

    更新日期:1978-04-01 00:00:00

  • [46-year follow up of malignant transformation of choroid nevus with vascularized surface drusen].

    abstract::The unusual long and atypical clinical course of a prominent black choroidal tumor is presented. It was stationary for decades and became symptomatic for many years. The histologic findings post mortem showed a choroidal nervus with focal malignant change. Its symptoms were obviously caused by subretinal vascularized ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Daicker B

    更新日期:1991-05-01 00:00:00

  • [Retinopathy of prematurity].

    abstract::This review summarizes the knowledge and highlights recent advances in clinical research of retinopathy of prematurity (ROP). This disease is still important, because improvements in neonatal intensive care during the last years have increased the survival of the most immature newborns, but did not diminish the ROP fr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审


    authors: Jandeck C,Kellner U,Foerster MH

    更新日期:2004-03-01 00:00:00

  • [Clinical findings in phakolytic glaucoma (author's transl)].

    abstract::1300 enucleated globes were examined from 1966-1974: Among these 20 eyes (1.5%) revealed a "phacolytic glaucoma" histologically. The clinical diagnosis before enucleation were "secondary glaucoma" or "absolute glaucoma" (19) and once "uveitis dolorosa". "Phakolysis" was considered in only 3 eyes. 15 cases revealed sur...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Völcker HE,Naumann G

    更新日期:1975-05-01 00:00:00

  • [Rehabilitation of patients with retinal disease (author's transl)].

    abstract::Report on a catamnestic study which attempted to follow up patients who had undergone successful surgery for retinal detachment. A striking finding was that, even today, the vast majority of doctors discourage strenuous physical activity and sport. One of the reasons for this seems to be the discussion concerning the ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章


    authors: Mewe L

    更新日期:1981-12-01 00:00:00