Iron supplementation in female blood donors deferred by copper sulfate screening.


:Female blood donors with low hematocrit levels detected by copper sulfate screening were selected randomly to receive either 75 mg of iron per day, as ferrous gluconate, or a calcium phosphate placebo. Their ferritin, serum iron, total iron-binding capacity, zinc protoporphyrin, and hemoglobin values, as well as their suitability to donate blood, were determined initially (Visit 1) and at four follow-up visits (Visits 2-5). By the second visit, the serum ferritin and iron values of donors receiving iron supplementation differed significantly from those of donors receiving placebo. By the fifth visit, a less marked but significant increase in hemoglobin had occurred in the iron group, but not in the placebo group. At no time was there a significant difference between the groups' suitability to donate blood, with each group donating at almost half of their visits. The authors conclude that iron supplementation at this dose level in deferred female blood donors improves their iron status and hemoglobin levels, but does not significantly increase their suitability to donate blood as compared with the suitability of placebo-treated donors.






Cable RG,Morse EE,Keltonic J,Kakaiya R,Kiraly T




Has Abstract


1988-09-01 00:00:00












  • Liquid storage at 4 degrees C of previously frozen red cells.

    abstract::Fresh human blood was collected in citrate-phosphate-dextrose, frozen by a high-glycerol technique, and stored at -80 degrees C. The red cells were thawed, deglycerolized, and resuspended in a final wash solution, ADSOL (Fenwal Laboratories), or an additive solution (AS) containing glucose, adenine, mannitol, and phos...


    pub_type: 杂志文章


    authors: Moore GL,Ledford ME,Mathewson PJ,Hankins DJ

    更新日期:1987-11-01 00:00:00

  • Functional antibodies to Haemophilus influenzae type B, Neisseria meningitidis, and Streptococcus pneumoniae contained in intravenous immunoglobulin products.

    abstract:BACKGROUND:Intravenous immunoglobulin G (IVIG) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (PAD). However, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause invasive infection in patients with PAD. In this stu...


    pub_type: 杂志文章


    authors: Lee S,Kim HW,Kim KH

    更新日期:2017-01-01 00:00:00

  • Analysis of exome sequencing data sets reveals structural variation in the coding region of ABO in individuals of African ancestry.

    abstract:BACKGROUND:ABO is a blood group system of high clinical significance due to the prevalence of ABO variation that can cause major, potentially life-threatening, transfusion reactions. STUDY DESIGN AND METHODS:Using multiple large-scale next-generation sequence data sets, we demonstrate the application of read-depth app...


    pub_type: 杂志文章


    authors: Fox K,Johnsen JM,Coe BP,Frazar CD,Reiner AP,NHLBI Exome Sequencing Project, Minority Health-GRID Network.,Eichler EE,Nickerson DA

    更新日期:2016-11-01 00:00:00

  • Characteristics of thawed autologous umbilical cord blood.

    abstract:BACKGROUND:Autologous umbilical cord blood (AutoUCB) has historically been cryopreserved for potential use in hematopoietic transplantation. Increasingly, private AutoUCB banking is performed for therapies unavailable today. A Phase I trial using AutoUCB treatment for early pediatric Type 1 diabetes afforded us an oppo...


    pub_type: 杂志文章


    authors: Rosenau EH,Sugrue MW,Haller M,Fisk D,Kelly SS,Chang M,Hou W,Eldjerou L,Slayton W,Cogle CR,Wingard JR

    更新日期:2012-10-01 00:00:00

  • A comparative study of reducing the extracellular potassium concentration in red blood cells by washing and by reduction of additive solution.

    abstract:BACKGROUND:Extracellular potassium concentration (K(+)) increases in the supernatant of whole and packed red blood cell units (pRBCs) with duration of refrigerated storage in citrate-phosphate-dextrose-adenine (CPDA-1) and additive solution (AS). Studies have shown that to avoid hyperkalemia, washed pRBCs are preferred...


    pub_type: 杂志文章


    authors: Bansal I,Calhoun BW,Joseph C,Pothiawala M,Baron BW

    更新日期:2007-02-01 00:00:00

  • Red cell alloantibodies in thalassemia major. Results of an Italian cooperative study.

    abstract::Clinical and serological data on 1435 Italian thalassemia major patients were collected during a cooperative study involving 19 centers in 10 regions. The main findings were as follows: 18 percent of the patients were under 6 years of age, 63 percent between 6 and 15, and 19 percent over 15. Forty-one percent had unde...


    pub_type: 杂志文章


    authors: Sirchia G,Zanella A,Parravicini A,Morelati F,Rebulla P,Masera G

    更新日期:1985-03-01 00:00:00

  • Comparison of a manual hexadimethrine bromide-antiglobulin test with saline- and albumin-antiglobulin tests for pretransfusion testing.

    abstract::A prospective double-blind study compared a manual hexadimethrine bromide (Polybrene) antiglobulin antibody detection test (P-AHG) and crossmatch with the albumin-antiglobulin antibody detection test and saline-antiglobulin crossmatch routinely used in our laboratory. A total of 10,084 pretransfusion blood samples fro...


    pub_type: 杂志文章


    authors: Mintz PD,Anderson G

    更新日期:1987-03-01 00:00:00

  • Evaluation of the National Healthcare Safety Network Hemovigilance Module for transfusion-related adverse reactions in the United States.

    abstract:INTRODUCTION:The National Healthcare Safety Network (NHSN) Hemovigilance Module (HM) collects data on the frequency, severity, and imputability of transfusion-associated adverse events. These events contribute to significant morbidity and mortality among transfusion patients. We report results from the first systematic...


    pub_type: 杂志文章


    authors: Edens C,Haass KA,Cumming M,Osinski A,O'Hearn L,Passanisi K,Eaton L,Visintainer P,Savinkina A,Kuehnert MJ,Basavaraju SV,Andrzejewski C

    更新日期:2019-02-01 00:00:00

  • Can the interval between antibody identifications be increased for alloimmunized patients?

    abstract:BACKGROUND:New alloantibody formation is unpredictable in patients who have been previously alloimmunized. Pretransfusion testing is designed to detect these antibodies while antibody identification (ABI) techniques are designed to identify the specificity of the antibody. Pretransfusion testing intervals are prescribe...


    pub_type: 杂志文章


    authors: Goss C,Avecilla ST,Garbaini J,Degtyaryova D,Lo D,Chang DY,Cushing M

    更新日期:2016-02-01 00:00:00

  • Is placental blood a reliable source for the evaluation of neonatal hemostasis at birth?

    abstract:BACKGROUND:Phlebotomy is among the main determinants of anemia of prematurity. Blood sparing policies endorsed umbilical cord blood (here called placental) as an alternative source for laboratory testing. Little is known on the suitability of placental blood to evaluate neonatal hemostasis of newborn infants. We aimed ...


    pub_type: 杂志文章


    authors: Raffaeli G,Tripodi A,Manzoni F,Scalambrino E,Pesenti N,Amodeo I,Cavallaro G,Villamor E,Peyvandi F,Mosca F,Ghirardello S

    更新日期:2020-05-01 00:00:00

  • Bacterial screening of apheresis platelets with a rapid test: a 113-month single center experience.

    abstract:BACKGROUND:The 2016 Food and Drug Administration draft guidance describes the use of a rapid test (RT) to enhance platelet transfusion safety and availability. This study reports a 113-month experience of screening of apheresis platelets (APs) by RT. STUDY DESIGN AND METHODS:From July 2008 to October 2015, all APs und...


    pub_type: 杂志文章


    authors: Ruby KN,Thomasson RR,Szczepiorkowski ZM,Dunbar NM

    更新日期:2018-07-01 00:00:00

  • A comparison of human immunodeficiency virus, hepatitis C virus, hepatitis B virus, and human T-lymphotropic virus marker rates for directed versus volunteer blood donations to the American Red Cross during 2005 to 2010.

    abstract:BACKGROUND:At most US blood centers, patients may still opt to choose specific donors to give blood for their anticipated transfusion needs. However, there is little evidence of improved safety with directed donation when compared to volunteer donation. STUDY DESIGN AND METHODS:The percentage of directed donations mad...


    pub_type: 杂志文章


    authors: Dorsey KA,Moritz ED,Steele WR,Eder AF,Stramer SL

    更新日期:2013-06-01 00:00:00

  • Dimethyl sulfoxide: effects on function of fresh platelets and on the viability of platelets in storage.

    abstract::Dimethyl sulfoxide (DMSO) is used as a cryoprotective agent when platelets are frozen. We examined the effect of DMSO (0.1 to 10%) on platelet aggregation, release, and prostaglandin synthesis (as indicated by malondialdehyde formation) in response to thrombin, collagen, arachidonic acid and calcium ionophore. Inhibit...


    pub_type: 杂志文章


    authors: Fratantoni JC,Poindexter BJ

    更新日期:1983-03-01 00:00:00

  • Down regulation of human natural killer cell-mediated cytolysis induced by blood transfusion: role of transforming growth factor-β(1), soluble Fas ligand, and soluble Class I human leukocyte antigen.

    abstract:BACKGROUND:Human natural killer (NK) cells are thought to play a role in antiviral response and tumor immune surveillance. The molecular mechanisms of down regulation of NK-cell activity observed after red blood cell (RBC) transfusion is still undefined. STUDY DESIGN AND METHODS:Both effects of blood transfusion (ex v...


    pub_type: 杂志文章


    authors: Ghio M,Contini P,Negrini S,Mazzei C,Zocchi MR,Poggi A

    更新日期:2011-07-01 00:00:00

  • Does therapeutic plasma exchange have a role in the treatment of prosthetic hip-associated cobalt toxicity? A case report and literature review.

    abstract:BACKGROUND:Prosthetic hip-associated cobalt toxicity (PHACT) is an uncommon, but potentially devastating, complication for patients with metal-on-metal hip implants (MoMs). Clinical management of PHACT is poorly defined, with primary intervention being MoM explant followed by chelation therapy. Therapeutic plasma excha...


    pub_type: 杂志文章,评审


    authors: Grant ML,Karp JK,Palladino M,Le N,Hall N,Herman JH

    更新日期:2016-09-01 00:00:00

  • Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.

    abstract:BACKGROUND:Viral contamination of platelet (PLT) concentrates can result in transfusion-transmitted diseases. A photochemical treatment (PCT) process with amotosalen-HCl and long-wavelength ultraviolet light (UVA), which cross-links nucleic acids, was developed to inactivate viruses and other pathogens in PLT concentra...


    pub_type: 杂志文章


    authors: Lin L,Hanson CV,Alter HJ,Jauvin V,Bernard KA,Murthy KK,Metzel P,Corash L

    更新日期:2005-04-01 00:00:00

  • Incidence of breakage of human RBCs frozen with 40-percent wt/vol glycerol using two different methods for storage at -80 degrees C.

    abstract:BACKGROUND:We reported previously that the incidence of breakage was 34.2 percent when human RBCs were frozen with 40-percent wt/vol glycerol in polyolefin plastic bags stored in aluminum containers at -80 degrees C and subjected to transportation. When human RBCs were frozen with 40-percent wt/vol glycerol at -80 degr...


    pub_type: 杂志文章


    authors: Valeri CR,Lane JP,Srey R,Ragno G

    更新日期:2003-03-01 00:00:00

  • Monitoring for underutilization of RBC components and platelets.

    abstract:BACKGROUND:Monitoring blood transfusion for overutilization is standard practice at most institutions. STUDY DESIGN AND METHODS:This study monitored for underutilization of blood transfusion over a 14-month period, by evaluating patients who had Hb levels that were reported to be <5 g per dL or platelet counts <10 x 1...


    pub_type: 杂志文章


    authors: Saxena S,Wehrli G,Makarewicz K,Sartorelli J,Shulman IA

    更新日期:2001-05-01 00:00:00

  • A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells.

    abstract:BACKGROUND:Studies have demonstrated that immunity against platelet (PLT) transfusions is dependent on recipient antigen-presenting cells (APCs) and their ability to produce nitric oxide (NO). To further analyze this, we focused on NO's major metabolite peroxynitrite (ONOO(-)) and its ability to affect PLT immunity. S...


    pub_type: 杂志文章


    authors: Semple JW,Speck ER,Fabron A Jr,Kim RA,Freedman J

    更新日期:2008-09-01 00:00:00

  • A Bombay individual lacking H and Le antigens but expressing normal levels of alpha-2- and alpha-4-fucosyltransferases.

    abstract:BACKGROUND:The rare Bombay phenotype is usually due to a primary genetic defect in an alpha-2- or alpha-4-fucosyltransferase. The present study was done to investigate a patient with normal transferases, who exhibits the Bombay phenotype. CASE REPORT:Red cells of the patient, his parents, and siblings were phenotyped ...


    pub_type: 杂志文章


    authors: Shechter Y,Etzioni A,Levene C,Greenwell P

    更新日期:1995-09-01 00:00:00

  • Field-expedient thawing of fresh-frozen plasma.

    abstract:INTRODUCTION:Frozen plasma is superior to crystalloids for hemorrhage resuscitation but remains logistically challenging in austere environments because of specialized clinical equipment for on-demand thawing. This research examines some ad hoc thawing techniques that have been implemented by military medical personnel...


    pub_type: 杂志文章


    authors: Meledeo MA,Peltier GC,McIntosh CS,Corley JB,Bynum JA,Cap AP

    更新日期:2020-06-01 00:00:00

  • Platelet glycolytic flux increases stimulated by ultraviolet-induced stress is not the direct cause of platelet morphology and activation changes: possible implications for the role of glucose in platelet storage.

    abstract:BACKGROUND:Stress-enhanced platelet (PLT) storage lesions include increased glycolysis, discoid-to-sphere morphology change, and spontaneous PLT activation. It is not clear if reduction in glycolysis can alleviate storage lesion development. STUDY DESIGN AND METHODS:Apheresis PLT concentrates were exposed to 17.2 J/mL...


    pub_type: 杂志文章


    authors: Li J,Goodrich L,Hansen E,Edrich R,Gampp D,Goodrich RP

    更新日期:2005-11-01 00:00:00

  • Delayed hemolytic transfusion reaction caused by anti-P1 antibody.

    abstract::A 67-year-old white woman received transfusions of a total of 87 units of whole blood and red blood cells during and within 48 hours following a pneumonectomy. Although she had previously received blood transfusions, unexpected antibodies were not detectable by routine screening. On the second postoperative day, she d...


    pub_type: 杂志文章


    authors: Chandeysson PL,Flye MW,Simpkins SM,Holland PV

    更新日期:1981-01-01 00:00:00

  • Identification and quantitation of the protein content of blood group antibody eluates prepared by the rapid acid-stromal method. Use in committed erythroid progenitor cell assays.

    abstract::Anti-D sensitized red cells were converted to stroma, either by digitonin or hypotonic lysis, and eluates prepared by the modified rapid acid-stromal method. SDS-PAGE and both rocket- and crossed-immunoelectrophoresis showed that, of the total protein content of the eluates, 11 to 25 percent was IgG, 18 to 45 percent ...


    pub_type: 杂志文章


    authors: Rearden A,Chiu P,Elmajian D

    更新日期:1983-05-01 00:00:00

  • How do we perform and bill for blood bank physician consultative services?

    abstract::Transfusion medicine (TM) physicians provide medical services that benefit all patients such as providing 24-hour laboratory coverage, advising health care providers on test interpretation and selection, validating new methods, and supervising technical personnel. These services ensure delivery of accurate, reliable, ...


    pub_type: 杂志文章


    authors: Jhang JS,Francis RO,Winkler A,Tormey C

    更新日期:2017-10-01 00:00:00

  • Estimating the risk of blood donation fainting for self versus others: the moderating effect of fear.

    abstract:BACKGROUND:People overestimate the likelihood that blood donors will experience faint and prefaint reactions, particularly if they are themselves fearful of having blood drawn. This study investigated the influence of making a risk assessment for oneself versus others, and examined whether providing information about t...


    pub_type: 杂志文章


    authors: France CR,France JL

    更新日期:2019-06-01 00:00:00

  • Benefits to blood banks of a sales and operations planning process.

    abstract::A formal sales and operations planning (S&OP) process is a decision making and communication process that balances supply and demand while integrating all business operational components with customer-focused business plans that links high level strategic plans to day-to-day operations. Furthermore, S&OP can assist in...


    pub_type: 杂志文章


    authors: Keal DA,Hebert P

    更新日期:2010-12-01 00:00:00

  • The in vitro evaluation of modifications in CPD-adenine anticoagulated-preserved blood at various hematocrits.

    abstract::Erythrocytes stored in the new CPD-adenine anticoagulant (CPDA-1) barely met the 70 per cent 24-hour postinfusion 51Cr recoveries on day 35 when stored at hematocrit greater than or equal to 75 per cent. CPDA-1 differs from CPD in that it has 1.25 times the glucose concentration plus 17.3 mg adenine/63 ml. In an effor...


    pub_type: 杂志文章


    authors: Moore GL,Ledford ME,Peck CC

    更新日期:1980-07-01 00:00:00

  • Sterility and quality of blood dispensed in syringes for infants.

    abstract::A unit-dose system was designed to dispense precise quantities of blood in a form ready for immediate transfusion into neonatal patients. The principles were similar to those used by pharmacies to dispense individual doses of drugs. In the blood center, the precise volume of blood ordered for a neonatal patient was as...


    pub_type: 杂志文章


    authors: Strauss RG,Crawford GF,Elbert C,Floss AM,Liesch M

    更新日期:1986-03-01 00:00:00

  • Continuous- and semicontinuous-flow blood centrifugation systems: therapeutic applications, with plasma-, platelet, lympha-, and eosinapheresis.

    abstract::Blood centrifugation, with a continuous-flow or semicontinuous-flow system, was used in the treatment of 17 patients with various hematologic disorders. Total plasma exchange (TPE) controlled symptoms of hyperviscosity and arrested bleeding in three patients. In two patients, TPE made is possible to perform urgent sur...


    pub_type: 杂志文章


    authors: Pineda AA,Brzica SM Jr,Taswell HF

    更新日期:1977-09-01 00:00:00