Association study of copy number variation in BMP8A gene with the risk of ankylosing spondylitis in Iranian population.


BACKGROUND:Copy number variation (CNV) of DNA segments has been considered as an important component of genetic variation, affecting the quality and quantity of gene expression. Bone morphogenic protein 8A (BMP8A) has been reported to function in bone formation. With respect to the bone and joint complications in ankylosing spondylitis (AS), this investigation aimed to study the role of BMP8A gene CNV in impressing the gene expression as well as the disease risk. METHODS:A total of 900 individuals, including 450 patients with AS and 450 healthy controls were enrolled. The copy numbers of BMP8A gene were detected by TaqMan real-time polymerase chain reaction (PCR) method. BMP8A messenger RNA (mRNA) transcript level in peripheral blood mononuclear cells (PBMCs) was also measured by SYBR Green real-time gene expression PCR method. RESULTS:No significant association of BMP8A copy number was detected with the risk of AS. BMP8A mRNA expression level was significantly downregulated in patients compared with controls. mRNA expression level of BMP8A in both AS patients with and without syndesmophyte was significantly lower than the healthy control group. There was no correlation between the mRNA expression level of BMP8A and both demographic and clinical data of the patients. CONCLUSIONS:Although BMP8A gene expression was downregulated in patients with AS, its copy number could not affect the transcript level of BMP8A gene in PBMCs and was not associated with susceptibility to AS in Iranian population. BMP8a may take into account as an indicator of bone formation process in AS, but it seems that mechanisms other than CNV may regulate this protein.


J Cell Biochem


Shahba S,Jafari Shakib R,Jamshidi A,Vojdanian M,Akhtari M,Aslani S,Poursani S,Nikokar I,Mahmoudi M




Has Abstract


2018-11-28 00:00:00






  • Cultured AIDS-related Kaposi's sarcoma (AIDS-KS) cells demonstrate impaired bioenergetic adaptation to oxidant challenge: implication for oxidant stress in AIDS-KS pathogenesis.

    abstract::Despite its recognition as the most prevalent HIV associated cancer, speculation still abounds regarding the pathogenesis of AIDS-related Kaposi's sarcoma (AIDS-KS). However, it has been established that both cytokines, e.g. IL-6, and HIV-associated products, e.g., Tat, are integral in AIDS-KS cellular proliferation. ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Mallery SR,Bailer RT,Hohl CM,Ng-Bautista CL,Ness GM,Livingston BE,Hout BL,Stephens RE,Brierley GP

    更新日期:1995-11-01 00:00:00

  • ANRIL and ANRASSF1 long noncoding RNAs are upregulated in gastric cancer.

    abstract::Gastric cancer (GC) is the fifth most frequent cancer and the third-leading cause of cancer-related death worldwide. It is a highly heterogeneous disease regarding the morphological and molecular viewpoints. Since it is curable in primary stages, early detection could improve the survival rate. Long noncoding RNAs con...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Kangarlouei R,Irani S,Noormohammadi Z,Memari F,Mirfakhraie R

    更新日期:2019-08-01 00:00:00

  • Hypoxia-inducible factor 1alpha modulates adhesion, migration, and FAK phosphorylation in vascular smooth muscle cells.

    abstract::Hypoxia promotes angiogenesis by modulating the transcriptional regulator hypoxia-inducible factor 1alpha (HIF-1alpha). HIF-1alpha is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF). The remodeling of ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Corley KM,Taylor CJ,Lilly B

    更新日期:2005-12-01 00:00:00

  • Transcriptional regulation of basic fibroblast growth factor gene expression in capillary endothelial cells.

    abstract::The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Weich HA,Iberg N,Klagsbrun M,Folkman J

    更新日期:1991-10-01 00:00:00

  • Extrachromosomal human immunodeficiency virus type-1 DNA can initiate a spreading infection of HL-60 cells.

    abstract::In this report, we describe a human immunodeficiency virus type-1 (HIV-1)-infected promyelocytic cell line, OM, derived from HL-60 cells. Although the OM cell line was biologically cloned twice, the pattern of HIV-1 expression during culture appeared analogous to a classical acute spreading infection and was inhibited...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Butera ST,Perez VL,Besansky NJ,Chan WC,Wu BY,Nabel GJ,Folks TM

    更新日期:1991-04-01 00:00:00

  • Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G2 /M Arrest.

    abstract::Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. While Gemcitabine-based chemotherapy is the first-line treatment for locally advanced pancreatic cancer, its resistance is a large obstacle in the field. Understanding the molecular basis of gemcitabine resistance is therefore ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Peng T,Dou QP

    更新日期:2017-09-01 00:00:00

  • LncRNA PTCSC3 inhibits triple-negative breast cancer cell proliferation by downregulating lncRNA H19.

    abstract::Long noncoding RNA (lncRNA) PTCSC3 (hereafter PTCSC3 is used to represent lncRNA PTCSC3) inhibits glioma and thyroid cancer, indicating its potential tumor suppression function in other types of cancers. We explored the potential involvement of PTCSC3 in triple-negative breast cancer (TNBC). In the current study, we f...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang N,Hou M,Zhan Y,Sheng X

    更新日期:2019-09-01 00:00:00

  • Comparison of the mechanism of induction of apoptosis in ovarian carcinoma cells by the conformationally restricted synthetic retinoids CD437 and 4-HPR.

    abstract::All-trans-retinoic acid (ATRA) has been shown to inhibit the growth of a number of ovarian tumor cell lines while others have been found to be resistant to retinoid suppression of growth. Interestingly, two synthetic retinoids, CD437 and 4-HPR, inhibit the growth of both ATRA-sensitive (CA-OV-3) and ATRA-resistant (SK...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Holmes WF,Soprano DR,Soprano KJ

    更新日期:2003-05-15 00:00:00

  • Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells.

    abstract::Forkhead box class O6 (FOXO6) is an important member of FOXO family, which has been demonstrated to be implicated in tumor development. However, the role of FOXO6 in colorectal cancer (CRC) is still unclear. The study aimed to investigate the potential roles of FOXO6 in the development of CRC. Our results showed that ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Li Q,Tang H,Hu F,Qin C

    更新日期:2019-03-01 00:00:00

  • Leptin Induces Oxidative Stress Through Activation of NADPH Oxidase in Renal Tubular Cells: Antioxidant Effect of L-Carnitine.

    abstract::Leptin is a protein involved in the regulation of food intake and in the immune and inflammatory responses, among other functions. Evidences demonstrate that obesity is directly associated with high levels of leptin, suggesting that leptin may directly link obesity with the elevated cardiovascular and renal risk assoc...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Blanca AJ,Ruiz-Armenta MV,Zambrano S,Salsoso R,Miguel-Carrasco JL,Fortuño A,Revilla E,Mate A,Vázquez CM

    更新日期:2016-10-01 00:00:00

  • LncRNA Erbb4-IR promotes esophageal squamous cell carcinoma (ESCC) by downregulating miR-145.

    abstract::Erbb4-IR is a recently identified lncRNA with pivotal functions in renal injury. The present study investigated the roles of Erbb4-IR in esophageal squamous cell carcinoma (ESCC). It was observed that Erbb4-IR was upregulated in tumor tissues of patients with ESCC. Plasma levels of Erbb4-IR in patients with ESCC were ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhang Y,Zhang L,Wang R,Wang B,Hua P,Li J

    更新日期:2019-10-01 00:00:00

  • Inhibitory effect of paeoniflorin on the inflammatory vicious cycle between adipocytes and macrophages.

    abstract::Obesity is associated with a state of chronic, low-grade inflammation. It is considered that the paracrine loop involving free fatty acid (FFA) and tumor necrosis factor (TNF)α between adipocytes and macrophages establishes an inflammatory vicious cycle that augments the inflammatory changes and insulin resistance in ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jiang B,Qiao J,Yang Y,Lu Y

    更新日期:2012-08-01 00:00:00

  • Twist-ing cell fate: mechanistic insights into the role of twist in lineage specification/differentiation and tumorigenesis.

    abstract::Bone marrow-derived mesenchymal stem cells (MSC), are multipotent cells that give rise to multiple lineages including osteoblasts, adipocytes, muscle, and fibroblasts. MSCs are useful for clinical applications such as cell therapy because they can be isolated from an individual and expanded for use in tissue repair, a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Cakouros D,Raices RM,Gronthos S,Glackin CA

    更新日期:2010-08-15 00:00:00

  • microRNA-542-5p protects against acute lung injury in mice with severe acute pancreatitis by suppressing the mitogen-activated protein kinase signaling pathway through the negative regulation of P21-activated kinase 1.

    abstract::Severe acute pancreatitis (SAP) is a condition associated with high rates of mortality and lengthy hospital stays. In the current study, SAP mouse models were established in BALB/c wild-type and P21-activated kinase 1 (PAK1) knockdown mice with the objective of determining the expression of microRNA-542-5p (miR-542-5p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wu XM,Ji KQ,Wang HY,Zhao Y,Jia J,Gao XP,Zang B

    更新日期:2019-01-01 00:00:00

  • Impact of IL-22 and IL-22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women.

    abstract::Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)-22 can trigger inflammation and hyperproliferation, leading to increased production of several pro-inflammatory cytokines such as IL-1, IL-6, and IL-8. We aimed to...

    journal_title:Journal of cellular biochemistry

    pub_type: 临床试验,杂志文章


    authors: Niu Z,Zhao X,Liu H,Quan J,Lin Y,Li J,Wang J,Liu M,Song W,Chen A,Liu S

    更新日期:2018-06-01 00:00:00

  • In Vivo Characterization of I91T Sod2 Polymorphism of Saccharomyces cerevisiae.

    abstract::The mitochondrial antioxidant enzyme Mn-Superoxide Dismutase (Sod2) is essential for mammalian survival. I82T mutation in human Sod2 has been linked to a wide variety of diseases, including Alzheimer's and Parkinson's diseases as well as some types of cancers. Yeast wild-type (WT) Sod2 and the mutant Sod2 I91T, which ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: de Carvalho MD,De Mesquita JF,Eleutherio EC

    更新日期:2017-05-01 00:00:00

  • Passage-dependent expression of STRO-1 in human gingival mesenchymal stem cells.

    abstract::The expression of STRO-1, the essential mesenchymal stem cell marker, was found to decrease with advancing passages in few tissues. Because STRO-1 was identified and isolated from human gingiva, we were interested to know its status after a few passages. Human gingival mesenchymal stem cells (HGMSCs) were isolated fro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ranga Rao S,Subbarayan R

    更新日期:2019-03-01 00:00:00

  • Biological evidence of the relationship between Helicobacter pylori and associated extragastric diseases.

    abstract:BACKGROUND:Gram-negative bacterium, Helicobacter pylori is notorious for various pathologies like peptic ulcers, gastritis, functional dyspepsia, and various cancers. METHODS:Systemic effects of its toxins have led scientists' attention toward the extragastric pathologies associated with it. To date, it has been shown...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Zendehdel A,Roham M

    更新日期:2019-08-01 00:00:00

  • Cellular responses elicited by insulin mimickers in cells lacking detectable plasma membrane insulin receptors.

    abstract::Madin-Darby canine kidney (MDCK) cells were previously shown to have few or no plasma membrane insulin binding sites (Hofmann et al: J Biol Chem 258:11774, 1983]. Accordingly, neither insulin-stimulated incorporation of [14C]glucose into glycogen, nor insulin-induced uptake of radiolabeled alpha-aminoisobutyrate ([3H]...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hofmann C,Crettaz M,Bruns P,Hessel P,Hadawi G

    更新日期:1985-01-01 00:00:00

  • The diagnosis and prognosis values of WNT mRNA expression in colon adenocarcinoma.

    abstract::WNT family genes have participated in the progression and development of many cancers, however, the association between colon adenocarcinoma (COAD) and WNTs have been rarely reported. This study investigated the significance of WNT genes expression in COAD from the standpoint of diagnosis and prognosis. The RNA-sequen...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ruan GT,Zhu LC,Gong YZ,Liao XW,Wang XK,Liao C,Wang S,Yan L,Xie HL,Zhou X,Li YZ,Gao F

    更新日期:2020-06-01 00:00:00

  • Melatonin reduces protein and lipid oxidative damage induced by homocysteine in rat brain homogenates.

    abstract::Numerous data indicate that hyperhomocysteinemia is a risk factor for cardio- and cerebrovascular diseases. At least in part, homocysteine (HCY) impairs cerebrovascular function because it generates large numbers of free radicals. Since melatonin is a well-known antioxidant, which reduces oxidative stress and decrease...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ortega-Gutiérrez S,Fuentes-Broto L,García JJ,López-Vicente M,Martínez-Ballarín E,Miana-Mena FJ,Millán-Plano S,Reiter RJ

    更新日期:2007-10-15 00:00:00

  • Circular RNA circ-PRKCI functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-3680-3p in esophageal squamous cell carcinoma.

    abstract::Circular RNA (circRNA) is a new noncoding RNAs and plays an important role in many pathological processes. Recently, studies have shown that circular RNA_PRKCI (circ-PRKCI) regulates cell proliferation and cell migration of tumor cells. Esophageal carcinoma is a highly malignant digestive tract tumor, which is divided...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Shi N,Shan B,Gu B,Song Y,Chu H,Qian L

    更新日期:2019-06-01 00:00:00

  • Novel identification of peripheral dopaminergic D2 receptor in male germ cells.

    abstract::Dopamine is a recognized modulator in the central nervous system (CNS) and peripheral organ functions. The presence of peripheral dopamine receptors outside the CNS has suggested an intriguing interaction between the nervous system and other functional systems, such as the reproductive system. In the present study we ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Otth C,Torres M,Ramírez A,Fernandez JC,Castro M,Rauch MC,Brito M,Yañez AJ,Rodríguez-Gil JE,Slebe JC,Concha II

    更新日期:2007-01-01 00:00:00

  • Gastrokine 1 regulates NF-κB signaling pathway and cytokine expression in gastric cancers.

    abstract::Gastrokine 1 (GKN1) plays an important role in the gastric mucosal defense mechanism and also acts as a functional gastric tumor suppressor. In this study, we examined the effect of GKN1 on the expression of inflammatory mediators, including NF-κB, COX-2, and cytokines in GKN1-transfected AGS cells and shGKN1-transfec...

    journal_title:Journal of cellular biochemistry

    pub_type: 临床试验,杂志文章


    authors: Yoon JH,Cho ML,Choi YJ,Back JY,Park MK,Lee SW,Choi BJ,Ashktorab H,Smoot DT,Nam SW,Lee JY,Park WS

    更新日期:2013-08-01 00:00:00

  • Isolation and characterization of the chicken vitamin D receptor gene and its promoter.

    abstract::The sequences from several independent cDNA clones encoding the chicken vitamin D receptor as well as primer extension assay have clearly delineated the 5' terminus and the transcriptional start site. Screening a chicken genomic library produced genomic clones containing vitamin D receptor (VDR) gene fragments. Restri...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lu Z,Jehan F,Zierold C,DeLuca HF

    更新日期:2000-02-01 00:00:00

  • Inhibition of mammalian collagenases by thiol-containing peptides.

    abstract::The following thiol-containing peptide analogues of the carboxyl side of the collagenase-sensitive bond of collagen were synthesized and tested as inhibitors of collagenases partially purified from homogenates of rabbit V-2 tumor and culture medium of pig synovium: HSCH2CH(CH3)CO-Ala-OEt (I), HSCH2CH(CH2Ph)CO-Ala-OEt ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Gray RD,Miller RB,Spatola AF

    更新日期:1986-01-01 00:00:00

  • Binding motifs of CBP2 a potential cell surface target for carcinoma cells.

    abstract::Previously we have shown (Hebert et al. [1999] J. Cell Biochem. 73:248-258) that among many cell lines the CBP2 gene product, Hsp47, eludes its retention receptor, erd2P, resulting in the appearance of Hsp47 on the cell surface associated with the tetraspanin protein CD9. Since Hsp47 possesses a highly restricted bind...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sauk JJ,Coletta RD,Norris K,Hebert C

    更新日期:2000-05-01 00:00:00

  • Current progress in CRISPR-based diagnostic platforms.

    abstract::The CRISPR-Cas system is a key technology for genome editing and regulation in a wide range of organisms and cell types. Recently, CRISPR-Cas-based diagnostic platform has shown idealistic properties for pathogen detection. Integrating the CRISPR-Cas platform along with lateral flow system allows rapid, sensitive, spe...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Khambhati K,Bhattacharjee G,Singh V

    更新日期:2019-03-01 00:00:00

  • Effects of resveratrol on H(2)O(2)-induced apoptosis and expression of SIRTs in H9c2 cells.

    abstract::Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though many studies have demonstrated that resveratrol can activate SIRT1, whether it has effect on other sirtuins (SIRT2-7) are unknown. The present study shows that exposure of H9c2 cells to 50 microM H(2)O(2) for 6 h caused a signifi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yu W,Fu YC,Zhou XH,Chen CJ,Wang X,Lin RB,Wang W

    更新日期:2009-07-01 00:00:00

  • Nuclear localization and Overexpression of Smoothened in Pancreatic and Colorectal Cancers.

    abstract::Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

    更新日期:2019-02-19 00:00:00