Association study of copy number variation in BMP8A gene with the risk of ankylosing spondylitis in Iranian population.

abstract：:The bone morphogenetic proteins were originally identified based on their ability to induce ectopic bone formation in vivo and have since been identified as members of the transforming growth factor-beta gene superfamily. It has been well established that the bone morphogenetic cytokines enhance osteogenic activity in...

journal_title：Journal of cellular biochemistry

authors： Gimble JM,Morgan C,Kelly K,Wu X,Dandapani V,Wang CS,Rosen V

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:MIAT may be implicated in the pathogenesis of age-related hearing loss (AHL). This study aimed to clarify the effect of a MIAT signaling pathway on the risk of AHL. METHODS:Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, auditory brainstem response (ABR) and quantitative hair cell counts...

journal_title：Journal of cellular biochemistry

authors： Hao S,Wang L,Zhao K,Zhu X,Ye F

更新日期：2019-04-01 00:00:00

abstract：:This study aimed at elucidating the molecular mechanism of miR-381-3p in cervical cancer progression, which may provide a novel therapeutic target for patients with cervical cancer. The expression of miR-381-3p was confirmed by quantitative reverse transcription polymerase chain reaction. Microarray analysis was condu...

journal_title：Journal of cellular biochemistry

authors： Shang A,Zhou C,Bian G,Chen W,Lu W,Wang W,Li D

更新日期：2019-01-01 00:00:00

abstract：:The cardiomyocyte differentiation from mouse embryonic stem cells (mESCs) is a dynamic and complex process that involved in the precision regulation of histone acetylation. The formation of action potential (AP) in mature cardiomyocytes is based on the expression pattern of Na+ , Ca2+ , and K+ ion channels, in which t...

journal_title：Journal of cellular biochemistry

authors： Wang D,Liu C,Li Z,Wang Y,Wang W,Wu X,Wang K,Miao W,Li L,Peng L

更新日期：2017-12-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common cancers worldwide and has especially high morbidity and mortality in China. LEM domain containing 1 (LEMD1), an important cancer-testis antigen, has been reported to be overexpressed in various cancers and promotes the progression of cancers. However, the biological charac...

journal_title：Journal of cellular biochemistry

authors： Li Q,Ge Y,Chen X,Wang L,Xia Y,Xu Z,Li Z,Wang W,Yang L,Zhang D,Xu Z

更新日期：2019-09-01 00:00:00

abstract：:Breast cancer, the most common cancer in women worldwide, is associated with high mortality. The long non-coding RNAs (lncRNAs) with a little capacity of coding proteins is playing an increasingly important role in the cancer paradigm. Accumulating evidences demonstrate that lncRNAs have crucial connections with breas...

journal_title：Journal of cellular biochemistry

authors： He Y,Li X,Meng Y,Fu S,Cui Y,Shi Y,Du H

更新日期：2019-10-01 00:00:00

abstract：:Platelet-derived growth factor-D (PDGF-D) can enhance invasion and metastasis in several human malignancies. Although several studies have been performed to investigate the association between clinicopathological characteristics and prognosis in epithelial ovarian cancer (EOC), the mediation effect of PDGF-D on above-...

journal_title：Journal of cellular biochemistry

authors： Yang C,Zhang M,Cai Y,Rong Z,Wang C,Xu Z,Xu H,Song W,Hou Y,Lou G

更新日期：2019-01-16 00:00:00

abstract：:Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP14) is an efficient extracellular matrix (ECM) degrading enzyme that plays important roles in tissue homeostasis and cell invasion. Like a number of type I membrane proteins, MT1-MMP can be internalized from the cell surface through early and recycling endosomes to...

journal_title：Journal of cellular biochemistry

authors： Hakulinen J,Sankkila L,Sugiyama N,Lehti K,Keski-Oja J

更新日期：2008-12-01 00:00:00

abstract：:Enhanced phosphorylation of the ribosomal protein s6 kinase, p70(s6k), and the translational repressor, 4E-BP1, are associated with either insulin-induced or amino acid-induced protein synthesis. Hyperphosphorylation of p70(s6k) and 4E-BP1 in response to insulin or amino acids is mediated through the mammalian target ...

journal_title：Journal of cellular biochemistry

authors： Pham PT,Heydrick SJ,Fox HL,Kimball SR,Jefferson LS Jr,Lynch CJ

更新日期：2000-09-07 00:00:00

abstract：:This study aimed to address the insufficiency of traditional meta-analysis and provide improved guidelines for the clinical practice of osteosarcoma treatment. The heterogeneity of the fixed-effect model was calculated, and when necessary, a random-effect model was adopted. Furthermore, the direct and indirect evidenc...

journal_title：Journal of cellular biochemistry

authors： Zhang T,Zhang S,Yang F,Wang L,Zhu S,Qiu B,Li S,Deng Z

更新日期：2018-01-01 00:00:00

abstract：:This laboratory recently reported the development of a biotin-cellulose/streptavidin affinity chromatography method based on the DNase I sensitivity of active chromatin to isolate a DNA fraction from murine erythroleukemia (MEL) cells that is more than 15-fold enriched in active genes (Dawson et al.: Journal of Biolog...

journal_title：Journal of cellular biochemistry

authors： Dawson BA,Herman T,Haas AL,Lough J

更新日期：1991-06-01 00:00:00

abstract：:We report here that the antiestrogen tamoxifen (TAM) induces cell death in human breast cancer cell line MCF-7. We assessed the type of cell death induced by TAM in this breast cancer cell line on the basis of morphological and biochemical characteristics. Dying cells showed morphological characteristics of apoptosis,...

journal_title：Journal of cellular biochemistry

authors： Chen H,Tritton TR,Kenny N,Absher M,Chiu JF

更新日期：1996-04-01 00:00:00

abstract：:During embryonic development, the hematopoietic system is the first to generate terminally differentiated, functional cell types. The urgent necessity for the early formation of blood and blood vessels during embryogenesis means that the induction, expansion, and maturation of these systems must be rapidly and precise...

journal_title：Journal of cellular biochemistry

authors： Snyder A,Fraser ST,Baron MH

更新日期：2004-10-01 00:00:00

abstract：:Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

journal_title：Journal of cellular biochemistry

authors： Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

更新日期：2018-12-01 00:00:00

abstract：:Little is known about how adhesion molecules on APCs accumulate at immunological synapses. We show here that ICAM-1 on APCs is continuously internalized and rapidly recycled back to the interface after antigen-priming T-cell contact. The internalization rate is high in APCs, including Raji B cells and dendritic cells,...

journal_title：Journal of cellular biochemistry

authors： Jo JH,Kwon MS,Choi HO,Oh HM,Kim HJ,Jun CD

更新日期：2010-12-01 00:00:00

abstract：:Osteoclasts are highly differentiated terminal cells formed by fusion of hematopoietic stem cells. Previously, osteoprotegerin (OPG) inhibit osteoclast differentiation and bone resorption by blocking receptor activator of nuclear factor-κB ligand (RANKL) binding to RANK indirect mechanism. Furthermore, autophagy plays...

journal_title：Journal of cellular biochemistry

authors： Tong X,Gu J,Song R,Wang D,Sun Z,Sui C,Zhang C,Liu X,Bian J,Liu Z

更新日期：2018-09-06 00:00:00

abstract：:Roscovitine (ROSC), a selective cyclin-dependent kinase (CDK) inhibitor, arrests human estrogen receptor-α (ER-α) positive MCF-7 breast cancer cells in the G(2) phase of the cell cycle and concomitantly induces apoptosis via a p53-dependent pathway. The effect of ROSC is markedly diminished in MCF-7 cells maintained i...

journal_title：Journal of cellular biochemistry

authors： Węsierska-Gądek J,Gritsch D,Zulehner N,Komina O,Maurer M

更新日期：2011-03-01 00:00:00

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:Prolongation of cell survival through prevention of apoptosis is considered to be a significant factor leading to anabolic responses in bone. The current studies were carried out to determine the role of the small GTPase, RhoA, in osteoblast apoptosis, since RhoA has been found to be critical for cell survival in othe...

journal_title：Journal of cellular biochemistry

authors： Yoshida T,Clark MF,Stern PH

更新日期：2009-04-01 00:00:00

abstract：:Interferon-τ (IFNT) is a major cytokine produced by the ruminant trophoectoderm during the peri-implantation period exerting immunomodulatory actions on various cells including neutrophils. The current in vitro study was undertaken to analyze the concentration-dependent effects of IFNT on neutrophil gene dynamics to u...

journal_title：Journal of cellular biochemistry

authors： Manjari P,Hyder I,Kapoor S,Senthilnathan M,Dang AK

更新日期：2018-12-01 00:00:00

abstract：:Although effective for the treatment of hematological malignancies, the FDA approved proteasome inhibitors bortezomib and carfilzomib have limited efficacy in solid tumors including triple negative breast cancer (TNBC). Chemotherapy is the only option for treating TNBC due to the absence of specific therapeutic target...

journal_title：Journal of cellular biochemistry

authors： Deshmukh RR,Kim S,Elghoul Y,Dou QP

更新日期：2017-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is an incidence rate nearly equal to its mortality rate. The poor prognosis of the disease can be explained by the absence of effective biomarkers for screening and early detection, together with the aggressive behavior and resistance to the currently available chemotherapy. The...

journal_title：Journal of cellular biochemistry

authors： Barati Bagherabad M,Afzaljavan F,ShahidSales S,Hassanian SM,Avan A

更新日期：2019-03-01 00:00:00

abstract：:Histamine, a major mediator present in mast cells that is released into the extracellular milieu upon degranulation, is well known to possess a wide range of biological activities in several classic physiological and pathological processes. However, whether and how it participates in angiogenesis remains obscure. In t...

journal_title：Journal of cellular biochemistry

authors： Lu Q,Wang C,Pan R,Gao X,Wei Z,Xia Y,Dai Y

更新日期：2013-05-01 00:00:00

abstract：:Stathmin/oncoprotein18 regulates microtubule dynamics and participates in mitotic entry and exit. We isolated stathmin as a physically interacting partner of KIFC1, a minus-end-directed kinesin functioning in bipolar spindle formation and maintenance. We found that stathmin depletion leads to multipolar spindle format...

journal_title：Journal of cellular biochemistry

authors： Shrestha D,Kim N,Song K

更新日期：2018-02-01 00:00:00

abstract：:The P-glycoprotein (p170, P-gp) encoded by human MDR1 gene functions as a pump to extrude anticancer drugs from cancer cells. Over-expression of p170 is closely related to primary and induced drug resistance phenotype of tumor cells. Recent studies have demonstrated that expression of cyclooxygenase-2 (COX-2) is posit...

journal_title：Journal of cellular biochemistry

authors： Xia W,Zhao T,Lv J,Xu S,Shi J,Wang S,Han X,Sun Y

更新日期：2009-09-01 00:00:00

abstract：:Garlic is known as a potent spice and a medicine with broad therapeutic properties ranging from antibacterial to anticancer, antidiabetic, and anticoagulant. Two major proteins of 40 KD and 14 KD constituting approximately 96% of total garlic proteins have been recently purified at our Institute. This immunocytochemic...

journal_title：Journal of cellular biochemistry

authors： Wen GY,Mato A,Wisniewski HM,Malik MN,Jenkins EC,Sheikh AM,Kim KS

更新日期：1995-08-01 00:00:00

abstract：:Efficient catabolism of host-derived compounds is essential for bacterial survival and virulence. While these links in intracellular bacteria are well studied, such studies in extracellular bacteria lag behind, mostly for technical reasons. The field has identified important metabolic pathways, but the mechanisms by w...

journal_title：Journal of cellular biochemistry

authors： Meadows JA,Wargo MJ

更新日期：2014-02-01 00:00:00

abstract：:p38 mitogen-activated protein kinase (MAPK) is of fundamental importance in a cell's response to environmental stresses, cytokines and DNA damage. p38 resides in the cytoplasm of resting cells, and translocates into the nucleus upon activation, yet the exact mechanisms remain largely unclear. We show here that the pho...

journal_title：Journal of cellular biochemistry

authors： Gong X,Ming X,Deng P,Jiang Y

更新日期：2010-08-15 00:00:00

abstract：:The microtubule binding protein, nucleolar spindle-associated protein 1 (NUSAP1), has a crucial function in mitosis and its expression is closely associated with carcinogenesis. Herein, we aimed to determine the function of NUSAP1 in the development of human esophageal squamous cell carcinoma (ESCC), and the associati...

journal_title：Journal of cellular biochemistry

authors： Guan C,Liu Z,Lu C,Xiao M,Shi H,Ni R,Bian Z

更新日期：2019-02-21 00:00:00

abstract：:In addition to cholesterol-lowering effect, HMG-CoA reductase inhibition by statins has been shown to have protective effect in many cells type. The loss of vision in retinal degeneration disease associates with oxidative stress and apoptosis in retinal pigment epithelium (RPE) cell. This study was designed to examine...

journal_title：Journal of cellular biochemistry

authors： Qian J,Keyes KT,Long B,Chen G,Ye Y

更新日期：2011-09-01 00:00:00