Catering to chondrocytes.


:An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al, this issue).


Sci Transl Med


Evans CH




Has Abstract


2018-11-28 00:00:00












  • Integration of early physiological responses predicts later illness severity in preterm infants.

    abstract::Physiological data are routinely recorded in intensive care, but their use for rapid assessment of illness severity or long-term morbidity prediction has been limited. We developed a physiological assessment score for preterm newborns, akin to an electronic Apgar score, based on standard signals recorded noninvasively...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Saria S,Rajani AK,Gould J,Koller D,Penn AA

    更新日期:2010-09-08 00:00:00

  • siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice.

    abstract::Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target these molecules represents a major gap in translational cardiovascular research. Here, we tested the efficacy of a small interfering RNA (siRNA) nanoparticle (NP) platform targeting ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Tao W,Yurdagul A Jr,Kong N,Li W,Wang X,Doran AC,Feng C,Wang J,Islam MA,Farokhzad OC,Tabas I,Shi J

    更新日期:2020-07-22 00:00:00

  • Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.

    abstract::SORLA/SORL1 is a unique neuronal sorting receptor for the amyloid precursor protein that has been causally implicated in both sporadic and autosomal dominant familial forms of Alzheimer's disease (AD). Brain concentrations of SORLA are inversely correlated with amyloid-β (Aβ) in mouse models and AD patients, suggestin...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Caglayan S,Takagi-Niidome S,Liao F,Carlo AS,Schmidt V,Burgert T,Kitago Y,Füchtbauer EM,Füchtbauer A,Holtzman DM,Takagi J,Willnow TE

    更新日期:2014-02-12 00:00:00

  • A "datathon" model to support cross-disciplinary collaboration.

    abstract::In recent years, there has been a growing focus on the unreliability of published biomedical and clinical research. To introduce effective new scientific contributors to the culture of health care, we propose a "datathon" or "hackathon" model in which participants with disparate, but potentially synergistic and comple...

    journal_title:Science translational medicine

    pub_type: 杂志文章,评审


    authors: Aboab J,Celi LA,Charlton P,Feng M,Ghassemi M,Marshall DC,Mayaud L,Naumann T,McCague N,Paik KE,Pollard TJ,Resche-Rigon M,Salciccioli JD,Stone DJ

    更新日期:2016-04-06 00:00:00

  • One integrin to rule them all?

    abstract::Myofibroblast-derived αvβ1 integrin has emerged as a critical mediator of transforming growth factor-β activation in experimental models of tissue fibrosis (Reed et al., this issue). ...

    journal_title:Science translational medicine

    pub_type: 评论,杂志文章


    authors: Dietz HC

    更新日期:2015-05-20 00:00:00

  • A noncoding RNA antisense to moesin at 5p14.1 in autism.

    abstract::People with autism spectrum disorder (ASD) are characterized by deficits in social interaction, language, and behavioral flexibility. Rare mutations and copy number variations have been identified in individuals with ASD, but in most patients, the causal variants remain unknown. A genome-wide association study (GWAS),...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Kerin T,Ramanathan A,Rivas K,Grepo N,Coetzee GA,Campbell DB

    更新日期:2012-04-04 00:00:00

  • Emerging therapies for inherited retinal degeneration.

    abstract::Inherited retinal degenerative diseases, a genetically and phenotypically heterogeneous group of disorders, affect the function of photoreceptor cells and are among the leading causes of blindness. Recent advances in molecular genetics and cell biology are elucidating the pathophysiological mechanisms underlying these...

    journal_title:Science translational medicine

    pub_type: 杂志文章,评审


    authors: Scholl HP,Strauss RW,Singh MS,Dalkara D,Roska B,Picaud S,Sahel JA

    更新日期:2016-12-07 00:00:00

  • Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

    abstract::The amyloid-forming proteins tau, αB crystallin, and amyloid P protein are all found in lesions of multiple sclerosis (MS). Our previous work established that amyloidogenic peptides from the small heat shock protein αB crystallin (HspB5) and from amyloid β fibrils, characteristic of Alzheimer's disease, were therapeut...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Kurnellas MP,Adams CM,Sobel RA,Steinman L,Rothbard JB

    更新日期:2013-04-03 00:00:00

  • Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.

    abstract::Asthma is a clinically heterogeneous genetic disease, and its pathogenesis is incompletely understood. Genome-wide association studies link ORM (yeast)-Like protein isoform 3 [corrected] (ORMDL3), a member of the ORM gene family, to nonallergic childhood-onset asthma. Orm proteins negatively regulate sphingolipid (SL)...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Worgall TS,Veerappan A,Sung B,Kim BI,Weiner E,Bholah R,Silver RB,Jiang XC,Worgall S

    更新日期:2013-05-22 00:00:00

  • Prevention of cystic fibrosis: The beginning of the end?

    abstract::Prenatal and postnatal treatment with a CFTR modifier attenuates pathological changes in a ferret model of cystic fibrosis (Sun et al., this issue). ...

    journal_title:Science translational medicine

    pub_type: 评论,杂志文章,评审


    authors: Ferkol TW

    更新日期:2019-03-27 00:00:00

  • Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration.

    abstract::Large bone defects cannot form a callus and exhibit high complication rates even with the best treatment strategies available. Tissue engineering approaches often use scaffolds designed to match the properties of mature bone. However, natural fracture healing is most efficient when it recapitulates development, formin...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: McDermott AM,Herberg S,Mason DE,Collins JM,Pearson HB,Dawahare JH,Tang R,Patwa AN,Grinstaff MW,Kelly DJ,Alsberg E,Boerckel JD

    更新日期:2019-06-05 00:00:00

  • Parallel discovery of Alzheimer's therapeutics.

    abstract::As the prevalence of Alzheimer's disease (AD) grows, so do the costs it imposes on society. Scientific, clinical, and financial interests have focused current drug discovery efforts largely on the single biological pathway that leads to amyloid deposition. This effort has resulted in slow progress and disappointing ou...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Lo AW,Ho C,Cummings J,Kosik KS

    更新日期:2014-06-18 00:00:00

  • Immune-mediated pathology in Duchenne muscular dystrophy.

    abstract::Immunological and inflammatory processes downstream of dystrophin deficiency as well as metabolic abnormalities, defective autophagy, and loss of regenerative capacity all contribute to muscle pathology in Duchenne muscular dystrophy (DMD). These downstream cascades offer potential avenues for pharmacological interven...

    journal_title:Science translational medicine

    pub_type: 杂志文章,评审


    authors: Rosenberg AS,Puig M,Nagaraju K,Hoffman EP,Villalta SA,Rao VA,Wakefield LM,Woodcock J

    更新日期:2015-08-05 00:00:00

  • Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

    abstract::Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation and activation capacity could act as reversible inhibitors of platel...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Papa AL,Jiang A,Korin N,Chen MB,Langan ET,Waterhouse A,Nash E,Caroff J,Graveline A,Vernet A,Mammoto A,Mammoto T,Jain A,Kamm RD,Gounis MJ,Ingber DE

    更新日期:2019-02-13 00:00:00

  • Tuberculosis following PD-1 blockade for cancer immunotherapy.

    abstract::Because of the well-established therapeutic benefit of boosting antitumor responses through blockade of the T cell inhibitory receptor PD-1, it has been proposed that PD-1 blockade could also be useful in infectious disease settings, including Mycobacterium tuberculosis (Mtb) infection. However, in preclinical models,...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Barber DL,Sakai S,Kudchadkar RR,Fling SP,Day TA,Vergara JA,Ashkin D,Cheng JH,Lundgren LM,Raabe VN,Kraft CS,Nieva JJ,Cheever MA,Nghiem PT,Sharon E

    更新日期:2019-01-16 00:00:00

  • Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration.

    abstract::Retinal prosthetic implants are the only approved treatment for retinitis pigmentosa, a disease of the eye that causes blindness through gradual degeneration of photoreceptors. An array of microelectrodes triggered by input from a camera stimulates surviving retinal neurons, with each electrode acting as a pixel. Unin...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Weitz AC,Nanduri D,Behrend MR,Gonzalez-Calle A,Greenberg RJ,Humayun MS,Chow RH,Weiland JD

    更新日期:2015-12-16 00:00:00

  • Epidermal electronics for noninvasive, wireless, quantitative assessment of ventricular shunt function in patients with hydrocephalus.

    abstract::Hydrocephalus is a common and costly neurological condition caused by the overproduction and/or impaired resorption of cerebrospinal fluid (CSF). The current standard of care, ventricular catheters (shunts), is prone to failure, which can result in nonspecific symptoms such as headaches, dizziness, and nausea. Current...

    journal_title:Science translational medicine

    pub_type: 临床试验,杂志文章


    authors: Krishnan SR,Ray TR,Ayer AB,Ma Y,Gutruf P,Lee K,Lee JY,Wei C,Feng X,Ng B,Abecassis ZA,Murthy N,Stankiewicz I,Freudman J,Stillman J,Kim N,Young G,Goudeseune C,Ciraldo J,Tate M,Huang Y,Potts M,Rogers JA

    更新日期:2018-10-31 00:00:00

  • Long noncoding RNA Chast promotes cardiac remodeling.

    abstract::Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in cardiac development. However, understanding of lncRNAs in cardiac diseases is still limited. Global lncRNA expression profiling indicated that several lncRNA transcripts are deregulated during pressure overload-induced cardiac hypert...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Viereck J,Kumarswamy R,Foinquinos A,Xiao K,Avramopoulos P,Kunz M,Dittrich M,Maetzig T,Zimmer K,Remke J,Just A,Fendrich J,Scherf K,Bolesani E,Schambach A,Weidemann F,Zweigerdt R,de Windt LJ,Engelhardt S,Dandekar T,

    更新日期:2016-02-17 00:00:00

  • Molecular profiling: moving away from tumor philately.

    abstract::Despite the remarkable enhancements in breast cancer classification and characterization, an exhaustive comprehension of the underlying carcinogenic processes and an accurate prediction of its clinical behavior are yet to be achieved. On the wave of recent scientific advances and clinical findings, new cutting-edge te...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Reis-Filho JS,Weigelt B,Fumagalli D,Sotiriou C

    更新日期:2010-09-01 00:00:00

  • Production and transplantation of bioengineered lung into a large-animal model.

    abstract::The inability to produce perfusable microvasculature networks capable of supporting tissue survival and of withstanding physiological pressures without leakage is a fundamental problem facing the field of tissue engineering. Microvasculature is critically important for production of bioengineered lung (BEL), which req...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Nichols JE,La Francesca S,Niles JA,Vega SP,Argueta LB,Frank L,Christiani DC,Pyles RB,Himes BE,Zhang R,Li S,Sakamoto J,Rhudy J,Hendricks G,Begarani F,Liu X,Patrikeev I,Pal R,Usheva E,Vargas G,Miller A,Woodson L,

    更新日期:2018-08-01 00:00:00

  • Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States.

    abstract::Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections to date has relied heavily on reverse transcription polymerase chain reaction testing. However, limited test availability, high false-negative rates, and the existence of asymptomatic or subclinical infections have resulted in an unde...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Silverman JD,Hupert N,Washburne AD

    更新日期:2020-07-29 00:00:00

  • PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia.

    abstract::Overcoming drug resistance and targeting leukemic stem cells (LSCs) remain major challenges in curing BCR-ABL+ human leukemia. Using an advanced drug/proliferation screen, we have uncovered a prosurvival role for protein phosphatase 2A (PP2A) in tyrosine kinase inhibitor (TKI)-insensitive leukemic cells, regulated by ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Lai D,Chen M,Su J,Liu X,Rothe K,Hu K,Forrest DL,Eaves CJ,Morin GB,Jiang X

    更新日期:2018-02-07 00:00:00

  • Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus.

    abstract::Vaccines against influenza viruses with pandemic potential, including H5N1, are under development. Because of a lack of preexisting immunity to these viruses, adjuvants (immune potentiators or enhancers) are needed to improve immune responses, to conserve scarce vaccine, and for cross-protection against strains that h...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Khurana S,Chearwae W,Castellino F,Manischewitz J,King LR,Honorkiewicz A,Rock MT,Edwards KM,Del Giudice G,Rappuoli R,Golding H

    更新日期:2010-01-20 00:00:00

  • Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.

    abstract::Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids needed to avert tear evaporation and to help maintain ocular surface homeostasis. Obstruction of MGs or other forms of MG dysfunction can promote chronic diseases of the ocular surface. Although chronic eyelid inflammation, such as al...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Reyes NJ,Yu C,Mathew R,Kunnen CM,Kalnitsky J,Redfern RL,Leonardi A,Perez VL,MacLeod AS,Gupta PK,Saban DR

    更新日期:2018-07-25 00:00:00

  • Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection.

    abstract::Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of t...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Feng G,Nadig SN,Bäckdahl L,Beck S,Francis RS,Schiopu A,Whatcott A,Wood KJ,Bushell A

    更新日期:2011-05-18 00:00:00

  • Rapid emergence of protease inhibitor resistance in hepatitis C virus.

    abstract::About 170 million people worldwide are infected with hepatitis C virus (HCV). The current standard therapy leads to sustained viral elimination in only approximately 50% of the treated patients. Telaprevir, an HCV protease inhibitor, has substantial antiviral activity in patients with chronic HCV infection. However, i...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Rong L,Dahari H,Ribeiro RM,Perelson AS

    更新日期:2010-05-05 00:00:00

  • Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.

    abstract::Hepatitis B virus (HBV)-induced hepatitis and carcinogen-induced hepatocellular carcinoma (HCC) are associated with serum androgen concentration. However, how androgen or the androgen receptor (AR) contributes to HBV-induced hepatocarcinogenesis remains unclear. We found that hepatic AR promotes HBV-induced hepatocarc...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Wu MH,Ma WL,Hsu CL,Chen YL,Ou JH,Ryan CK,Hung YC,Yeh S,Chang C

    更新日期:2010-05-19 00:00:00

  • Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.

    abstract::Gene therapy is emerging as a therapeutic modality for treating disorders of the retina. Photoreceptor cells are the primary cell type affected in many inherited diseases of retinal degeneration. Successfully treating these diseases with gene therapy requires the identification of efficient and safe targeting vectors ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Vandenberghe LH,Bell P,Maguire AM,Cearley CN,Xiao R,Calcedo R,Wang L,Castle MJ,Maguire AC,Grant R,Wolfe JH,Wilson JM,Bennett J

    更新日期:2011-06-22 00:00:00

  • Surf's up for ER stress.

    abstract::A new type of biological clock regulates the unfolded protein response. ...

    journal_title:Science translational medicine

    pub_type: 评论,杂志文章


    authors: Haspel J

    更新日期:2017-06-28 00:00:00

  • Aptamers against mouse and human tumor-infiltrating myeloid cells as reagents for targeted chemotherapy.

    abstract::Local delivery of anticancer agents has the potential to maximize treatment efficacy and minimize the acute and long-term systemic toxicities. Here, we used unsupervised systematic evolution of ligands by exponential enrichment to identify four RNA aptamers that specifically recognized mouse and human myeloid cells in...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: De La Fuente A,Zilio S,Caroli J,Van Simaeys D,Mazza EMC,Ince TA,Bronte V,Bicciato S,Weed DT,Serafini P

    更新日期:2020-06-17 00:00:00