Catering to chondrocytes.

Abstract:

:An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al, this issue).

journal_name

Sci Transl Med

authors

Evans CH

doi

10.1126/scitranslmed.aav7043

subject

Has Abstract

pub_date

2018-11-28 00:00:00

issue

469

eissn

1946-6234

issn

1946-6242

pii

10/469/eaav7043

journal_volume

10

pub_type

评论,杂志文章,评审
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  • siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice.

    abstract::Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target these molecules represents a major gap in translational cardiovascular research. Here, we tested the efficacy of a small interfering RNA (siRNA) nanoparticle (NP) platform targeting ...

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    更新日期:2020-07-22 00:00:00

  • Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.

    abstract::SORLA/SORL1 is a unique neuronal sorting receptor for the amyloid precursor protein that has been causally implicated in both sporadic and autosomal dominant familial forms of Alzheimer's disease (AD). Brain concentrations of SORLA are inversely correlated with amyloid-β (Aβ) in mouse models and AD patients, suggestin...

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    authors: Caglayan S,Takagi-Niidome S,Liao F,Carlo AS,Schmidt V,Burgert T,Kitago Y,Füchtbauer EM,Füchtbauer A,Holtzman DM,Takagi J,Willnow TE

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  • A "datathon" model to support cross-disciplinary collaboration.

    abstract::In recent years, there has been a growing focus on the unreliability of published biomedical and clinical research. To introduce effective new scientific contributors to the culture of health care, we propose a "datathon" or "hackathon" model in which participants with disparate, but potentially synergistic and comple...

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  • One integrin to rule them all?

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    更新日期:2015-05-20 00:00:00

  • A noncoding RNA antisense to moesin at 5p14.1 in autism.

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  • Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

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  • Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.

    abstract::Asthma is a clinically heterogeneous genetic disease, and its pathogenesis is incompletely understood. Genome-wide association studies link ORM (yeast)-Like protein isoform 3 [corrected] (ORMDL3), a member of the ORM gene family, to nonallergic childhood-onset asthma. Orm proteins negatively regulate sphingolipid (SL)...

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  • Prevention of cystic fibrosis: The beginning of the end?

    abstract::Prenatal and postnatal treatment with a CFTR modifier attenuates pathological changes in a ferret model of cystic fibrosis (Sun et al., this issue). ...

    journal_title:Science translational medicine

    pub_type: 评论,杂志文章,评审

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  • Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration.

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    doi:10.1126/scitranslmed.aav7756

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    更新日期:2019-06-05 00:00:00

  • Parallel discovery of Alzheimer's therapeutics.

    abstract::As the prevalence of Alzheimer's disease (AD) grows, so do the costs it imposes on society. Scientific, clinical, and financial interests have focused current drug discovery efforts largely on the single biological pathway that leads to amyloid deposition. This effort has resulted in slow progress and disappointing ou...

    journal_title:Science translational medicine

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    doi:10.1126/scitranslmed.3008228

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  • Immune-mediated pathology in Duchenne muscular dystrophy.

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    journal_title:Science translational medicine

    pub_type: 杂志文章,评审

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    更新日期:2019-02-13 00:00:00

  • Tuberculosis following PD-1 blockade for cancer immunotherapy.

    abstract::Because of the well-established therapeutic benefit of boosting antitumor responses through blockade of the T cell inhibitory receptor PD-1, it has been proposed that PD-1 blockade could also be useful in infectious disease settings, including Mycobacterium tuberculosis (Mtb) infection. However, in preclinical models,...

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  • Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration.

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    journal_title:Science translational medicine

    pub_type: 杂志文章

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  • Epidermal electronics for noninvasive, wireless, quantitative assessment of ventricular shunt function in patients with hydrocephalus.

    abstract::Hydrocephalus is a common and costly neurological condition caused by the overproduction and/or impaired resorption of cerebrospinal fluid (CSF). The current standard of care, ventricular catheters (shunts), is prone to failure, which can result in nonspecific symptoms such as headaches, dizziness, and nausea. Current...

    journal_title:Science translational medicine

    pub_type: 临床试验,杂志文章

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    更新日期:2018-10-31 00:00:00

  • Long noncoding RNA Chast promotes cardiac remodeling.

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    journal_title:Science translational medicine

    pub_type: 杂志文章

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  • Molecular profiling: moving away from tumor philately.

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    journal_title:Science translational medicine

    pub_type: 杂志文章

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  • Production and transplantation of bioengineered lung into a large-animal model.

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    journal_title:Science translational medicine

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  • Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States.

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  • PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia.

    abstract::Overcoming drug resistance and targeting leukemic stem cells (LSCs) remain major challenges in curing BCR-ABL+ human leukemia. Using an advanced drug/proliferation screen, we have uncovered a prosurvival role for protein phosphatase 2A (PP2A) in tyrosine kinase inhibitor (TKI)-insensitive leukemic cells, regulated by ...

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    pub_type: 杂志文章

    doi:10.1126/scitranslmed.aan8735

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  • Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus.

    abstract::Vaccines against influenza viruses with pandemic potential, including H5N1, are under development. Because of a lack of preexisting immunity to these viruses, adjuvants (immune potentiators or enhancers) are needed to improve immune responses, to conserve scarce vaccine, and for cross-protection against strains that h...

    journal_title:Science translational medicine

    pub_type: 杂志文章

    doi:10.1126/scitranslmed.3000624

    authors: Khurana S,Chearwae W,Castellino F,Manischewitz J,King LR,Honorkiewicz A,Rock MT,Edwards KM,Del Giudice G,Rappuoli R,Golding H

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  • Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.

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    journal_title:Science translational medicine

    pub_type: 杂志文章

    doi:10.1126/scitranslmed.aas9164

    authors: Reyes NJ,Yu C,Mathew R,Kunnen CM,Kalnitsky J,Redfern RL,Leonardi A,Perez VL,MacLeod AS,Gupta PK,Saban DR

    更新日期:2018-07-25 00:00:00

  • Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection.

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    journal_title:Science translational medicine

    pub_type: 杂志文章

    doi:10.1126/scitranslmed.3002099

    authors: Feng G,Nadig SN,Bäckdahl L,Beck S,Francis RS,Schiopu A,Whatcott A,Wood KJ,Bushell A

    更新日期:2011-05-18 00:00:00

  • Rapid emergence of protease inhibitor resistance in hepatitis C virus.

    abstract::About 170 million people worldwide are infected with hepatitis C virus (HCV). The current standard therapy leads to sustained viral elimination in only approximately 50% of the treated patients. Telaprevir, an HCV protease inhibitor, has substantial antiviral activity in patients with chronic HCV infection. However, i...

    journal_title:Science translational medicine

    pub_type: 杂志文章

    doi:10.1126/scitranslmed.3000544

    authors: Rong L,Dahari H,Ribeiro RM,Perelson AS

    更新日期:2010-05-05 00:00:00

  • Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.

    abstract::Hepatitis B virus (HBV)-induced hepatitis and carcinogen-induced hepatocellular carcinoma (HCC) are associated with serum androgen concentration. However, how androgen or the androgen receptor (AR) contributes to HBV-induced hepatocarcinogenesis remains unclear. We found that hepatic AR promotes HBV-induced hepatocarc...

    journal_title:Science translational medicine

    pub_type: 杂志文章

    doi:10.1126/scitranslmed.3001143

    authors: Wu MH,Ma WL,Hsu CL,Chen YL,Ou JH,Ryan CK,Hung YC,Yeh S,Chang C

    更新日期:2010-05-19 00:00:00

  • Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.

    abstract::Gene therapy is emerging as a therapeutic modality for treating disorders of the retina. Photoreceptor cells are the primary cell type affected in many inherited diseases of retinal degeneration. Successfully treating these diseases with gene therapy requires the identification of efficient and safe targeting vectors ...

    journal_title:Science translational medicine

    pub_type: 杂志文章

    doi:10.1126/scitranslmed.3002103

    authors: Vandenberghe LH,Bell P,Maguire AM,Cearley CN,Xiao R,Calcedo R,Wang L,Castle MJ,Maguire AC,Grant R,Wolfe JH,Wilson JM,Bennett J

    更新日期:2011-06-22 00:00:00

  • Surf's up for ER stress.

    abstract::A new type of biological clock regulates the unfolded protein response. ...

    journal_title:Science translational medicine

    pub_type: 评论,杂志文章

    doi:10.1126/scitranslmed.aan6728

    authors: Haspel J

    更新日期:2017-06-28 00:00:00

  • Aptamers against mouse and human tumor-infiltrating myeloid cells as reagents for targeted chemotherapy.

    abstract::Local delivery of anticancer agents has the potential to maximize treatment efficacy and minimize the acute and long-term systemic toxicities. Here, we used unsupervised systematic evolution of ligands by exponential enrichment to identify four RNA aptamers that specifically recognized mouse and human myeloid cells in...

    journal_title:Science translational medicine

    pub_type: 杂志文章

    doi:10.1126/scitranslmed.aav9760

    authors: De La Fuente A,Zilio S,Caroli J,Van Simaeys D,Mazza EMC,Ince TA,Bronte V,Bicciato S,Weed DT,Serafini P

    更新日期:2020-06-17 00:00:00