Pediatric risk of mortality (PRISM) score.


:The Pediatric Risk of Mortality (PRISM) score was developed from the Physiologic Stability Index (PSI) to reduce the number of physiologic variables required for pediatric ICU (PICU) mortality risk assessment and to obtain an objective weighting of the remaining variables. Univariate and multivariate statistical techniques were applied to admission day PSI data (1,415 patients, 116 deaths) from four PICUs. The resulting PRISM score consists of 14 routinely measured, physiologic variables, and 23 variable ranges. The performance of a logistic function estimating PICU mortality risk from the PRISM score, age, and operative status was tested in a different sample from six PICUs (1,227 patients, 105 deaths), each PICU separately, and in diagnostic groups using chi-square goodness-of-fit tests and receiver operating characteristic (ROC) analysis. In all groups, the number and distribution of survivors and nonsurvivors in adjacent mortality risk intervals were accurately predicted: total validation group (chi 2(5) = 0.80; p greater than .95), each PICU separately (chi 2(5) range 0.83 to 7.38; all p greater than .10), operative patients (chi 2(5) = 2.03; p greater than .75), nonoperative patients (chi 2(5) = 2.80, p greater than .50), cardiovascular disease patients (chi 2(5) = 4.72; p greater than .25), respiratory disease patients (chi 2(5) = 5.82; p greater than .25), and neurologic disease patients (chi 2(5) = 7.15; p greater than .10). ROC analysis also demonstrated excellent predictor performance (area index = 0.92 +/- 0.02).


Crit Care Med


Critical care medicine


Pollack MM,Ruttimann UE,Getson PR




Has Abstract


1988-11-01 00:00:00












  • Hypophosphatemia and Reye's syndrome.

    abstract::Hypophosphatemia may occur in Reye's syndrome. We retrospectively studied 42 patients with Reye's syndrome to determine the frequency and degree of hypophosphatemia, to identify possible causes, and to determine whether hypophosphatemia was related to the severity of disease or mortality. Nineteen (46%) patients were ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Carroll JL,Kanter RK

    更新日期:1985-06-01 00:00:00

  • Sodium bicarbonate infusion to reduce cardiac surgery-associated acute kidney injury: a phase II multicenter double-blind randomized controlled trial.

    abstract:OBJECTIVES:Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute kidney inju...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: McGuinness SP,Parke RL,Bellomo R,Van Haren FM,Bailey M

    更新日期:2013-07-01 00:00:00

  • Improving code team performance and survival outcomes: implementation of pediatric resuscitation team training.

    abstract:OBJECTIVE:To determine whether implementation of Composite Resuscitation Team Training is associated with improvement in survival to discharge and code team performance after pediatric in-hospital cardiopulmonary arrest. DESIGN, SETTING, AND SUBJECTS:We conducted a prospective observational study with historical contr...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Knight LJ,Gabhart JM,Earnest KS,Leong KM,Anglemyer A,Franzon D

    更新日期:2014-02-01 00:00:00

  • Admission of incompetent patients to intensive care: doctors' responsiveness to family wishes.

    abstract:OBJECTIVE:When a patient is incompetent, the family is often considered to be a natural surrogate. The doctors' responsiveness to family wishes may vary. We explored if doctors' personal characteristics were associated with responsiveness to the relatives' wishes when admission to the intensive care unit (ICU) is consi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Escher M,Perneger TV,Heidegger CP,Chevrolet JC

    更新日期:2009-02-01 00:00:00

  • Clinician Perception of a Machine Learning-Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock.

    abstract:OBJECTIVE:To assess clinician perceptions of a machine learning-based early warning system to predict severe sepsis and septic shock (Early Warning System 2.0). DESIGN:Prospective observational study. SETTING:Tertiary teaching hospital in Philadelphia, PA. PATIENTS:Non-ICU admissions November-December 2016. INTERVE...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ginestra JC,Giannini HM,Schweickert WD,Meadows L,Lynch MJ,Pavan K,Chivers CJ,Draugelis M,Donnelly PJ,Fuchs BD,Umscheid CA

    更新日期:2019-11-01 00:00:00

  • Optimal release time during airway pressure release ventilation in neonatal sheep.

    abstract:OBJECTIVE:To systematically investigate the effect of altering release time during airway pressure release ventilation in a neonatal animal model before and after oleic acid-induced acute lung injury. DESIGN:Prospective, nonrandomized, controlled study with repeated measures. SETTING:University research laboratory. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Martin LD,Wetzel RC

    更新日期:1994-03-01 00:00:00

  • Clinician Perspectives Regarding In-Hospital Cardiac Arrest Resuscitation: A Multicenter Survey.

    abstract:OBJECTIVES:Evaluate clinicians' sentiments about participating in cardiac arrest resuscitations and identify factors associated with confidence in resuscitation of cardiac arrest. DESIGN:Electronic survey. SETTING:Twenty-one hospitals in Utah and Idaho. SUBJECTS:All attending physicians, residents, and nurses in a m...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Peltan ID,Poll J,Sorensen J,Guidry D,Chandler M,Beninati W,Brown SM

    更新日期:2019-03-01 00:00:00

  • Prevention of ventilator-associated pneumonia and ventilator-associated conditions: a randomized controlled trial with subglottic secretion suctioning.

    abstract:OBJECTIVES:Ventilator-associated pneumonia diagnosis remains a debatable topic. New definitions of ventilator-associated conditions involving worsening oxygenation have been recently proposed to make surveillance of events possibly linked to ventilator-associated pneumonia as objective as possible. The objective of the...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验


    authors: Damas P,Frippiat F,Ancion A,Canivet JL,Lambermont B,Layios N,Massion P,Morimont P,Nys M,Piret S,Lancellotti P,Wiesen P,D'orio V,Samalea N,Ledoux D

    更新日期:2015-01-01 00:00:00

  • Thromboembolic disease: prophylaxis and treatment.

    abstract::Thromboembolic disease ranks among the most dangerous and common complication in the postoperative or post-traumatic patient. As previously mentioned, the incidence is increasing and fatalities from this complication have also risen substantially. The pathogenesis of thromboembolic disease and the predictability of it...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Evarts CM

    更新日期:1976-03-01 00:00:00

  • Transfusion-Associated Circulatory Overload in ICUs: A Scoping Review of Incidence, Risk Factors, and Outcomes.

    abstract::Transfusion-associated circulatory overload is the most frequent serious adverse transfusion reaction, with an incidence close to 1% of transfused patients in the general adult population. Patients in ICUs are probably more at risk of transfusion-associated circulatory overload as they are more frequently transfused a...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: De Cloedt L,Savy N,Gauvin F,Taylor S,Lacroix J,Emeriaud G

    更新日期:2019-06-01 00:00:00

  • Oliguria, volume overload, and loop diuretics.

    abstract::Acute kidney injury (AKI) is commonly and increasingly encountered in patients with critical illness. In the past, epidemiologic studies have consistently found that oliguria further increases the risk of death from AKI. Compared with patients outside the intensive care unit (ICU), critically ill patients are more lik...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Bagshaw SM,Bellomo R,Kellum JA

    更新日期:2008-04-01 00:00:00

  • Pentoxifylline improves tissue oxygenation following anesthesia and operation.

    abstract::Pentoxifylline has been shown to increase red blood cell malleability, thus increasing capillary blood flow in a number of disease states. The present study was undertaken to determine whether pentoxifylline might improve tissue oxygenation after anesthesia and during an operation in rats. Rats were anesthetized and d...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Soliman MH,O'Neal K,Waxman K

    更新日期:1987-02-01 00:00:00

  • Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation.

    abstract:OBJECTIVE:To study the effects of high-dose epinephrine, compared with standard-dose epinephrine, on the dynamics of superficial cortical cerebral blood flow as well as global cerebral oxygenation during experimental cardiopulmonary resuscitation. We hypothesized that high-dose epinephrine might be unable to improve ce...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Gedeborg R,Silander HC,Ronne-Engström E,Rubertsson S,Wiklund L

    更新日期:2000-05-01 00:00:00

  • Adrenal insufficiency during the late stage of polymicrobial sepsis.

    abstract:OBJECTIVES:Although studies have indicated that adrenal insufficiency occurs after severe trauma and hemorrhagic shock, it remains controversial whether adrenal function is depressed during the late stage of polymicrobial sepsis. DESIGN:Prospective, controlled animal study. SETTING:A university research laboratory. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Koo DJ,Jackman D,Chaudry IH,Wang P

    更新日期:2001-03-01 00:00:00

  • Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome.

    abstract:OBJECTIVE:To determine prevalence, risk factors, and outcome of thrombocytopenia in medical intensive care patients. DESIGN:Prospective observational study. SETTING:The 12-bed medical intensive care unit of a university hospital. PATIENTS:All consecutively admitted patients with normal platelet count at admission an...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Strauss R,Wehler M,Mehler K,Kreutzer D,Koebnick C,Hahn EG

    更新日期:2002-08-01 00:00:00

  • Diagnosis and follow-up of infections in intensive care patients: value of C-reactive protein compared with other clinical and biological variables.

    abstract:OBJECTIVE:To evaluate diagnostic and prognostic values of C-reactive protein (CRP) dosage in critically ill patients. DESIGN:Prospective, observational study. SETTING:Medical intensive care unit (ICU) in a university hospital. PATIENTS:A consecutive series of 74 patients admitted to the ICU. INTERVENTION:CRP measur...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Reny JL,Vuagnat A,Ract C,Benoit MO,Safar M,Fagon JY

    更新日期:2002-03-01 00:00:00

  • Atrial fibrillation with high degree atrioventricular block masquerading as ventricular fibrillation masquerading as asystole during cardiac arrest.

    abstract::Ventricular fibrillation (VF) can masquerade as asystole. We report a 54-yr-old male in cardiac arrest who, on surface ECG, appeared to be in VF or asystole. A bedside intracardiac recording using a transmyocardial pacing wire showed the true rhythm to be atrial fibrillation (AF) with high grade atrioventricular block...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ornato JP,Gonzales ER,Garnett R

    更新日期:1987-04-01 00:00:00

  • Principles of antibacterial dosing in continuous renal replacement therapy.

    abstract:OBJECTIVES:To outline the concepts involved in optimizing antibacterial dosing in critically ill patients with acute renal failure undergoing continuous renal replacement therapy (CRRT), provide a strategy for optimizing dosing, and summarize the data required to implement the strategy. DATA SOURCES:MEDLINE search fro...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Choi G,Gomersall CD,Tian Q,Joynt GM,Freebairn R,Lipman J

    更新日期:2009-07-01 00:00:00

  • Proteomics and systems biology approaches to signal transduction in sepsis.

    abstract::Sepsis and resulting multiple system organ failure are the leading causes of mortality in intensive care units. Although it is generally appreciated that rampant, deregulated inflammatory pathways play a major role in sepsis, a comprehensive understanding based on the integrated response of multiple signal transductio...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Nguyen A,Yaffe MB

    更新日期:2003-01-01 00:00:00

  • Effect of insulin therapy on coagulation and fibrinolysis in medical intensive care patients.

    abstract:OBJECTIVE:Most intensive care deaths beyond the first few days of critical illness are attributable to nonresolving organ failure, either due to or coinciding with sepsis. One of the mechanisms that is thought to contribute to the pathogenesis of organ failure is microvascular thrombosis. Recently, we reported signific...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验


    authors: Langouche L,Meersseman W,Vander Perre S,Milants I,Wouters PJ,Hermans G,Gjedsted J,Hansen TK,Arnout J,Wilmer A,Schetz M,Van den Berghe G

    更新日期:2008-05-01 00:00:00

  • Energy expenditure in critically ill children.

    abstract:OBJECTIVES:To measure energy expenditure in critically ill children and compare it with the energy expenditure predicted by recommended formulas, and relate the measured energy expenditure to nutritional and clinical indices. DESIGN:A prospective, clinical study. SETTING:Tertiary care pediatric intensive care unit in...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Briassoulis G,Venkataraman S,Thompson AE

    更新日期:2000-04-01 00:00:00

  • Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.

    abstract:OBJECTIVES:Our goal was to "reverse translate" the human response to surgical sepsis into the mouse by modifying a widely adopted murine intra-abdominal sepsis model to engender a phenotype that conforms to current sepsis definitions and follows the most recent expert recommendations for animal preclinical sepsis resea...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Stortz JA,Hollen MK,Nacionales DC,Horiguchi H,Ungaro R,Dirain ML,Wang Z,Wu Q,Wu KK,Kumar A,Foster TC,Stewart BD,Ross JA,Segal M,Bihorac A,Brakenridge S,Moore FA,Wohlgemuth SE,Leeuwenburgh C,Mohr AM,Moldawer LL,E

    更新日期:2019-11-01 00:00:00

  • Antifibrillatory and electrophysiologic actions of moricizine alone and in combination with lidocaine: a prospective, randomized trial.

    abstract:OBJECTIVE:The Cardiac Arrhythmia Suppression Trial II showed that moricizine acutely increases the occurrence of sudden cardiac death. Thus the objective of this investigation was to evaluate the antifibrillatory properties of moricizine (a new antiarrhythmic agent) alone and in combination with lidocaine (an establish...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ujhelyi MR,O'Rangers EA,Fan C,Kluger J,Chow MS

    更新日期:1993-10-01 00:00:00

  • Total liquid ventilation with perfluorocarbons increases pulmonary end-expiratory volume and compliance in the setting of lung atelectasis.

    abstract:OBJECTIVE:To compare compliance and end-expiratory lung volume during reexpansion of normal and surfactant-deficient ex vivo atelectatic lungs with either gas or total liquid ventilation. DESIGN:Controlled, animal study using an ex vivo lung preparation. SETTING:A research laboratory at a university medical center. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Tooley R,Hirschl RB,Parent A,Bartlett RH

    更新日期:1996-02-01 00:00:00

  • Plasma aluminum concentrations in long-term mechanically ventilated patients receiving stress ulcer prophylaxis with sucralfate.

    abstract:OBJECTIVES:To determine plasma aluminum concentrations and 24-hr urine aluminum excretion rate in long-term mechanically ventilated patients treated with 6 g of sucralfate daily for stress ulcer prophylaxis. DESIGN:Prospective study in long-term mechanically ventilated critically ill patients. SETTING:A surgical inte...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章


    authors: Tryba M,Kurz-Müller K,Donner B

    更新日期:1994-11-01 00:00:00

  • The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation.

    abstract:OBJECTIVE:To test the hypothesis that the lectin-like domain of tumor necrosis factor, mimicked by the TIP peptide, can improve lung function after unilateral orthotopic lung isotransplantation. Because of a lack of a specific treatment for ischemia reperfusion-mediated lung injury, accompanied by a disrupted barrier i...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Hamacher J,Stammberger U,Roux J,Kumar S,Yang G,Xiong C,Schmid RA,Fakin RM,Chakraborty T,Hossain HM,Pittet JF,Wendel A,Black SM,Lucas R

    更新日期:2010-03-01 00:00:00

  • Nitrogen balance, protein loss, and the open abdomen.

    abstract:OBJECTIVE:Goal-directed nutritional support is essential to improving morbidity and mortality. Open abdominal decompression is similarly crucial to the successful treatment of intra-abdominal hypertension and abdominal compartment syndrome. The open abdomen, however, places the patient at risk for potentially significa...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Cheatham ML,Safcsak K,Brzezinski SJ,Lube MW

    更新日期:2007-01-01 00:00:00

  • Suspended animation for delayed resuscitation from prolonged cardiac arrest that is unresuscitable by standard cardiopulmonary-cerebral resuscitation.

    abstract::Standard cardiopulmonary-cerebral resuscitation fails to achieve restoration of spontaneous circulation in approximately 50% of normovolemic sudden cardiac arrests outside hospitals and in essentially all victims of penetrating truncal trauma who exsanguinate rapidly to cardiac arrest. Among cardiopulmonary-cerebral r...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Safar P,Tisherman SA,Behringer W,Capone A,Prueckner S,Radovsky A,Stezoski WS,Woods RJ

    更新日期:2000-11-01 00:00:00

  • Complications of the flow-directed pulmonary artery catheter: A prospective analysis in 219 patients.

    abstract::In order to determine and analyze the complication rate of the insertion and maintenance of the balloon-tipped, flow-directed pulmonary artery catheter (PAC), the authors prospectively studied the use of 320 catheters in 219 critically ill patients. Mean patient age was 53 +/- 1 years, and 36% had a history of cardiov...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Sise MJ,Hollingsworth P,Brimm JE,Peters RM,Virgilio RW,Shackford SR

    更新日期:1981-04-01 00:00:00

  • Human Albumin Improves Long-Term Behavioral Sequelae After Subarachnoid Hemorrhage Through Neurovascular Remodeling.

    abstract:OBJECTIVE:Subarachnoid hemorrhage results in significant long-lasting neurologic sequelae. Here, we investigated whether human albumin improves long-term outcomes in experimental subarachnoid hemorrhage and whether neurovascular remodeling is involved in the protection of albumin. DESIGN:Laboratory investigation. SET...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Xie Y,Liu W,Zhang X,Wang L,Xu L,Xiong Y,Yang L,Sang H,Ye R,Liu X

    更新日期:2015-10-01 00:00:00