Modulation of neural oscillations by vagus nerve stimulation in posttraumatic multifocal epilepsy: case report.


:The putative mechanism of vagus nerve stimulation (VNS) for medically refractory epilepsy is desynchronization of hippocampal and thalamocortical circuitry; however, the nature of the dose-response relationship and temporal dynamics is poorly understood. For greater elucidation, a study in a nonepileptic rat model was previously conducted and showed that rapid-cycle (RC) VNS achieved superior desynchrony compared to standard-cycle (SC) VNS. Here, the authors report on the first in-human analysis of the neuromodulatory dose-response effects of VNS in a patient with posttraumatic, independent, bilateral mesial temporal lobe epilepsy refractory to medications and SC-VNS who was referred as a potential candidate for a responsive neurostimulation device. During stereotactic electroencephalography (SEEG) recordings, the VNS device was initially turned off, then changed to SC-VNS and then RC-VNS settings. Spectral analysis revealed a global reduction of power in the theta (4-8 Hz) and alpha (8-15 Hz) bands with both SC- and RC-VNS compared to the stimulation off setting (p < 0.001). Furthermore, in the alpha band, both SC- and RC-VNS were associated with greater global desynchrony compared to the off setting (p < 0.001); and, specifically, in the bilateral epileptogenic hippocampi, RC-VNS further reduced spectral power compared to SC-VNS (p < 0.001). The dose-response and temporal effects suggest that VNS modulates regional and global dynamics differently.


J Neurosurg


Journal of neurosurgery


Ilyas A,Toth E,Pizarro D,Riley KO,Pati S




Has Abstract


2018-11-01 00:00:00










  • Correlation of thin fibrous cap possessing adipophilin-positive macrophages and intraplaque hemorrhage with high clinical risk for carotid endarterectomy.

    abstract:OBJECT:Preoperative clinical risk classification of carotid artery (CA) stenosis anticipates the outcome of CA intervention. A higher incidence of neurological morbidity was noted after CA stenting (CAS) in patients with medical risks than in those without risks. However, little is known about the correlation between c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hao H,Iihara K,Ishibashi-Ueda H,Saito F,Hirota S

    更新日期:2011-04-01 00:00:00

  • Magnetic resonance imaging-documented extravasation as an indicator of acute hypertensive intracerebral hemorrhage.

    abstract:OBJECT:The aim of this study was to determine the usefulness of magnetic resonance (MR) imaging-documented extravasation as an indicator of continued hemorrhage in patients with acute hypertensive intracerebral hemorrhage (ICH). METHODS:The authors studied 108 patients with acute hyperintensive ICH. Imaging modalities...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Murai Y,Ikeda Y,Teramoto A,Tsuji Y

    更新日期:1998-04-01 00:00:00

  • Early detection of delayed traumatic intracranial hematomas using near-infrared spectroscopy.

    abstract::Delayed intracranial hematomas are an important treatable cause of secondary brain injury in patients with head trauma. Early identification and treatment of these lesions, which appear or enlarge after the initial computerized tomography (CT) scan, may improve neurological outcome. Serial examinations using near-infr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Gopinath SP,Robertson CS,Contant CF,Narayan RK,Grossman RG,Chance B

    更新日期:1995-09-01 00:00:00

  • Awake surgery for WHO Grade II gliomas within "noneloquent" areas in the left dominant hemisphere: toward a "supratotal" resection. Clinical article.

    abstract:OBJECT:It has been demonstrated that an extensive resection (total or subtotal) may significantly increase the overall survival in patients with WHO Grade II gliomas (low-grade gliomas [LGGs]). Yet, recent data have shown that conventional MR imaging underestimates the spatial extent of LGG, since tumor cells were foun...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yordanova YN,Moritz-Gasser S,Duffau H

    更新日期:2011-08-01 00:00:00

  • Prognostic value of diffusion tensor imaging parameters for Gamma Knife radiosurgery in meningiomas.

    abstract::OBJECTIVE Diffusion tensor imaging (DTI) parameters are able to differentiate between meningioma subtypes. The hypothesis that there is a correlation between DTI parameters and the change in tumor size after Gamma Knife radiosurgery (GKRS) was analyzed. METHODS DTI parameters were measured using MRI before GKRS in 26 ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Speckter H,Bido J,Hernandez G,Mejía DR,Suazo L,Valenzuela S,Perez-Then E,Stoeter P

    更新日期:2016-12-01 00:00:00

  • Surgical implications of the thickened pituitary stalk accompanied by central diabetes insipidus.

    abstract:OBJECT:The authors discuss the indications for and timing of a diagnostic neurosurgical procedure in children with diabetes insipidus (DI) and a thickened pituitary stalk (TPS) on magnetic resonance (MR) imaging. METHODS:Seven children with a TPS who presented with DI eventually underwent surgery for diagnostic purpos...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Beni-Adani L,Sainte-Rose C,Zerah M,Brunelle F,Constantini S,Renier D,Lellouch-Tubiana A,Leger J,Pierre-Kahn A

    更新日期:2005-08-01 00:00:00

  • Placental alkaline phosphatase as a tumor marker for primary intracranial germinoma.

    abstract::A sensitive enzyme-linked immunosorbent assay (ELISA) was used in a retrospective study of placental alkaline phosphatase (PLAP) levels in serum, cerebrospinal fluid (CSF), and intratumoral cyst fluid in primary intracranial germinoma. The ELISA showed no cross-reactivity with intestinal alkaline phosphatase except in...

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    pub_type: 杂志文章


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    更新日期:1988-05-01 00:00:00

  • Reduction of cellular energy requirements. Screening for agents that may protect against CNS ischemia.

    abstract::Protection of the brain and spinal cord against ischemia is a goal of vast clinical importance. One approach to this objective is to reduce the tissue's functional activity in order to preserve energy for the metabolic processes that are essential to viability. Experiments to explore ways of reducing function-related ...

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  • Ultrasound diagnosis of an intraneural ganglion cyst of the peroneal nerve. Case report.

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    pub_type: 杂志文章


    authors: Leijten FS,Arts WF,Puylaert JB

    更新日期:1992-03-01 00:00:00

  • Effect of intrathecal fibrinolysis on cerebrospinal fluid absorption after experimental subarachnoid hemorrhage.

    abstract::The effect of intrathecal fibrinolysis on cerebrospinal fluid (CSF) absorption was investigated after experimental subarachnoid hemorrhage (SAH). In 11 cats, SAH was induced by intracisternal application of 1 to 4 ml of fresh autologous blood. Thirty minutes after the experimental SAH, the CSF outflow resistance was f...

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    pub_type: 杂志文章


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  • Venous sinus stenting for reduction of intracranial pressure in IIH: a prospective pilot study.

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    pub_type: 杂志文章


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    更新日期:2017-11-01 00:00:00

  • Dorsal root entry zone lesions for the treatment of post-herpetic neuralgia.

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    pub_type: 杂志文章


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    更新日期:1984-06-01 00:00:00

  • Magnetic resonance imaging for the evaluation of patients with occult cervical spine injury.

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  • Measurement of flow of cerebrospinal fluid in shunts by transcutaneous thermal convection. Technical note.

    abstract::With the goal of developing a practical method of performing noninvasive measurements of flow in cerebrospinal fluid (CSF) shunts, transcutaneous thermal convection CSF shunt flow measurement was investigated using dimensional analysis, numerical modeling, and bench testing. Using appropriate manufacturing practices a...

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    pub_type: 杂志文章


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  • Spontaneous regression of a herniated cervical disc in a patient with myelopathy. Case report.

    abstract::The authors present a case of spontaneous regression of a herniated cervical nucleus pulposus in a patient with myelopathy. This 37-year-old woman developed sudden quadriparesis; she had reported no history of trauma. Magnetic resonance (MR) imaging revealed a large disc herniation and increased signal intensity of th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Song JH,Park HK,Shin KM

    更新日期:1999-01-01 00:00:00

  • Temporal bone neoplasms: a report on 20 surgically treated cases.

    abstract::The surgical resection of neoplasms involving the petrous bone and surrounding areas in 20 patients is reported. Technical advances described include the total resection of several tumors previously considered inoperable due to involvement of dura and brain, petrous internal carotid artery (ICA), the vein of Labbé, an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sekhar LN,Pomeranz S,Janecka IP,Hirsch B,Ramasastry S

    更新日期:1992-04-01 00:00:00

  • Subtemporal decompression for slit-ventricle syndrome: successful outcome after dramatic change in intracranial pressure wave morphology. Report of two cases.

    abstract::Subtemporal decompression is recognized as an effective treatment for slit-ventricle syndrome; however, the effects of this procedure have not been demonstrated using both pre- and postsurgical intracranial pressure (ICP) monitoring. The authors report two cases in which slit-ventricle syndrome and elevated ICP had be...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Allan R,Chaseling R

    更新日期:2004-11-01 00:00:00

  • Resolution of brain edema in severe brain injury at controlled high and low intracranial pressures.

    abstract::A series of 87 patients with severe brain injury were studied. Intracranial pressure (ICP) monitoring and external ventricular drainage were used to control ICP at high and low levels. Clearance of ytterbium-169-labeled diethylenetriaminepentaacetic acid (169Yb-DTPA), Evans blue dye, and ventricular cerebrospinal flui...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


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    更新日期:1984-10-01 00:00:00

  • An investigation into quality of life improvement in patients undergoing microvascular decompression for hemifacial spasm.

    abstract::OBJECTIVE Hemifacial spasm (HFS) is a movement disorder characterized by involuntary spasms of the facial muscles, and it can negatively impact quality of life (QOL). This retrospective study and systematic review with meta-analysis was conducted to investigate the QOL in patients with HFS following intervention with ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,meta分析


    authors: Lawrence JD,Frederickson AM,Chang YF,Weiss PM,Gerszten PC,Sekula RF

    更新日期:2018-01-01 00:00:00

  • Desmoid-type fibromatoses involving the brachial plexus: treatment options and assessment of c-KIT mutational status.

    abstract:OBJECT:Desmoid-type fibromatoses are a locally invasive soft-tissue lesion that is most commonly encountered in abdominal sites. The tumor also affects head and neck areas, particularly the supraclavicular region, where it may encase and distort the brachial plexus and compromise neurovascular structures. Neurosurgeons...

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    pub_type: 杂志文章


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    更新日期:2006-05-01 00:00:00

  • Enhancing nerve regeneration across a silicone tube conduit by using interposed short-segment nerve grafts.

    abstract::Isolated nerve segments may inherently contain all of the necessary factors required to support regeneration within a silicone tube conduit placed across a nerve gap. Thirty-six adult Lewis rats each weighing approximately 250 g were randomized into three groups. A sciatic nerve gap (13-15 mm in length) was bridged by...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


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    更新日期:1997-12-01 00:00:00

  • Intracranial extension of inflammatory pseudotumor of the orbit. Case report.

    abstract::Orbital pseudotumors are inflammatory lesions of the orbit of unknown etiology, which initially mimic an orbital neoplasm. Involvement of the other orbit is uncommon, and extension into the paranasal sinus rare. Intracranial extension of pseudotumor of the orbit is previously unreported. This is a case report of a pat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kaye AH,Hahn JF,Craciun A,Hanson M,Berlin AJ,Tubbs RR

    更新日期:1984-03-01 00:00:00

  • Neurosurgical decision making: personal and professional preferences.

    abstract:OBJECT:Physicians are often solicited by patients or colleagues for clinical recommendations they would make for themselves if faced by a clinical situation. The act of making a recommendation can alter the clinical course being taken. The authors sought to understand this dynamic across different neurosurgical scenari...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tanweer O,Wilson TA,Kalhorn SP,Golfinos JG,Huang PP,Kondziolka D

    更新日期:2015-03-01 00:00:00

  • Symptomatic contralateral subdural hygromas after decompressive craniectomy: plausible causes and management protocols.

    abstract:OBJECT:Contralateral subdural hygromas are occasionally observed after decompressive craniectomies (DCs). Some of these hygromas are symptomatic, and the etiology and management of these symptomatic contralateral subdural collections (CLDCs) present surgical challenges. The authors share their experience with managing ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Salunke P,Garg R,Kapoor A,Chhabra R,Mukherjee KK

    更新日期:2015-03-01 00:00:00

  • Postendarterectomy heparin-induced thrombocytopenia. Case report.

    abstract::Two episodes of massive bleeding from a sutured arteriotomy were observed within 30 hours after carotid endarterectomy. The patient had received anticoagulation therapy with heparin for 72 hours prior to surgery. A platelet count of 93,000/cu mm was demonstrated following the second hemorrhage. The potential problem o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Rogers LA

    更新日期:1988-10-01 00:00:00

  • Long-term results in direct carotid-cavernous fistulas after treatment with detachable balloons.

    abstract::Transarterial embolization of direct carotid-cavernous fistulas (CCFs) using detachable balloons is the best initial option for occlusion of the fistula and preservation of the internal carotid artery. However, the long-term safety and efficacy of this treatment is unknown. The authors reviewed the long-term outcome o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Lewis AI,Tomsick TA,Tew JM Jr,Lawless MA

    更新日期:1996-03-01 00:00:00

  • Complement fixation by IgM and IgG autoantibodies on cultured human glial cells.

    abstract::The humoral immune response to autologous gliomas has been investigated in 16 patients using immune adherence and anti-C3 immunofluorescence assays of serum samples. Significant antiglioma antibody activity was detected in 56% of these sera. Fractionation experiments demonstrated that IgM class antibodies were more ef...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Garson JA,Quindlen EA,Kornblith PL

    更新日期:1981-07-01 00:00:00

  • Transparaspinal exposure of dumbbell tumors of the spine. Report of two cases.

    abstract::The authors present a surgical technique for resection of dumbbell tumors of the spine. The transparaspinal exposure combines laminectomy and sectioning of the paraspinal muscles through a transverse incision. The procedure allows total tumor resection by means of a single posterior approach in selected patients, thus...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Onesti ST,Ashkenazi E,Michelsen WJ

    更新日期:1998-01-01 00:00:00

  • The metabolic response to severe head injury.

    abstract::Caloric expenditure and nitrogen balance were measured in 14 steroid-treated comatose head-injured patients acutely and up to 28 days after injury. During this period patients were fed with a continuous enteral infusion of a formula containing 2 Kcal/cc and 10 gm nitrogen/liter. Indirect calorimetry was carried out fo...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Clifton GL,Robertson CS,Grossman RG,Hodge S,Foltz R,Garza C

    更新日期:1984-04-01 00:00:00

  • New approach to cervical flexion deformity in ankylosing spondylitis. Case report.

    abstract::The treatment of cervical fixed flexion deformity in ankylosing spondylitis presents a challenging problem that is traditionally managed by a corrective cervicothoracic osteotomy. The authors report a new approach to this problem that involves performing a two-level osteotomy at the level of maximum spinal curvature, ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Duff SE,Grundy PL,Gill SS

    更新日期:2000-10-01 00:00:00