Growth and migration of gingival epithelial cells on mineralized and partially demineralized root surfaces in an in vitro system.


:The capacity of epithelial cells to migrate and grow from gingival explants cultured on mineralized and partially demineralized root surfaces in an in vitro system was assessed. Explants of attached gingiva were obtained from mongrel dogs, cut into rectangular pieces (1 x 2 mm) and cultured either on mineralized or partially demineralized cementum in a defined culture medium containing transferrin, insulin, epidermal growth factor, cortisone, high density lipoprotein and selenium. After seven days of culture, the specimens were prepared for scanning electron microscopic examination. The amount of epithelial outgrowth from each explant was assessed by measuring the distances between the four aspects of the rectangular explant and the furthest epithelial cell located opposite to each of these aspects. The mean value obtained for epithelial outgrowth of explants grown on mineralized cementum was six times higher than that for explants cultured on partially demineralized cementum. These results indicate that partially demineralized cementum does not support epithelial growth and migration in vitro.


J Periodontol


Pitaru S,Hekmati M,Soldinger M,Savion N




Has Abstract


1988-08-01 00:00:00












  • Attachment of Porphyromonas gingivalis to corroded commercially pure titanium and titanium-aluminum-vanadium alloy.

    abstract:BACKGROUND:Titanium dental material can become corroded because of electrochemical interaction in the oral environment. The corrosion process may result in surface modification. It was hypothesized that a titanium surface modified by corrosion may enhance the attachment of periodontal pathogens. This study evaluates th...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Barão VA,Yoon CJ,Mathew MT,Yuan JC,Wu CD,Sukotjo C

    更新日期:2014-09-01 00:00:00

  • Immediate implant placement: a procedure without incisions.

    abstract::Primary socket closure in immediate implantation may be difficult, due to the opening left by the extracted tooth. The absolute need for bone augmentation and primary flap closure for implants placed into fresh extraction sites has never been proven. The hypothesis of the present study was that immediate implants can ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Schwartz-Arad D,Chaushu G

    更新日期:1998-07-01 00:00:00

  • A Novel Rat Model of Polymicrobial Peri-Implantitis: A Preliminary Study.

    abstract:BACKGROUND:Peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. To the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known micr...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Koutouzis T,Eastman C,Chukkapalli S,Larjava H,Kesavalu L

    更新日期:2017-02-01 00:00:00

  • Tuning cytokines enriches dendritic cells and regulatory T cells in the periodontium.

    abstract:BACKGROUND:Periodontal disease results from the pathogenic interactions between the tissue, immune system, and microbiota; however, standard therapy fails to address the cellular mechanism underlying the chronic inflammation. Dendritic cells (DC) are key regulators of T cell fate, and biomaterials that recruit and prog...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Sands RW,Verbeke CS,Ouhara K,Silva EA,Hsiong S,Kawai T,Mooney D

    更新日期:2020-11-01 00:00:00

  • EDTA gel root conditioning: lack of effect on clinical and radiographic outcomes of intrabony defect treatment with enamel matrix derivative.

    abstract:BACKGROUND:The adjunctive use of enamel matrix derivative (EMD) in the surgical therapy of intrabony defects results in improved outcomes compared to surgical debridement alone. However, the role of EDTA root conditioning in EMD therapy has not been investigated. The purpose of this study was to compare the 12-month ou...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Parashis AO,Tsiklakis K,Tatakis DN

    更新日期:2006-01-01 00:00:00

  • Salivary-soluble CD44 levels in smokers and non-smokers with chronic periodontitis: a pilot study.

    abstract:BACKGROUND:Smoking is the most important environmental risk factor for periodontal disease. Elevated levels of serum-soluble CD44 (sCD44) have been detected in smokers and also have been recognized as a diagnostic marker in some smoking-induced diseases. The present study investigates the salivary sCD44 profiles of smo...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Ghallab N,Shaker O

    更新日期:2010-05-01 00:00:00

  • The impact of periodontal therapy and the adjunctive effect of antiseptics on breath odor-related outcome variables: a double-blind randomized study.

    abstract:BACKGROUND:Bad breath is often caused by periodontitis and/or tongue coating. This study followed the impact of initial periodontal therapy on several halitosis-related outcome variables over a 6-month period. Organoleptic ratings are often uncomfortable for the patient and have several disadvantages. They are, for ins...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Quirynen M,Zhao H,Soers C,Dekeyser C,Pauwels M,Coucke W,Steenberghe Dv

    更新日期:2005-05-01 00:00:00

  • Oral manifestations of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease). Review and case reports.

    abstract::A review of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Disease) is presented. Special emphasis is placed on the oral manifestations which include hemorrhagic vesicles, nodules, papules and ulcers that involve the gingiva and other areas of the mucosa. Two cases are included which were seen in a periodont...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Bartolucci EG,Swan RH,Hurt WC

    更新日期:1982-03-01 00:00:00

  • Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: A 6-month randomized controlled clinical trial.

    abstract:BACKGROUND:Sodium alendronate (ALN) is an aminobisphosphonate and potent inhibitor of bone resorption. It has been suggested that ALN might be a promising carrier of biomolecules for periodontal bone repair. The aim of this randomized split-mouth clinical trial was to evaluate the effects of the topical application of ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Carvalho Dutra B,Oliveira AMSD,Oliveira PAD,Miranda Cota LO,Silveira JO,Costa FO

    更新日期:2019-10-01 00:00:00

  • Oral hygiene and compliance as risk factors in periodontitis.

    abstract::Periodontitis is an inflammatory disease caused by microbial infection in the subgingival region. Risk factors associated with the development and progression of this disease are numerous, multifactorial, complex, and often not well defined across individuals and population groups. The focus of this paper is to provid...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审


    authors: Bakdash B

    更新日期:1994-05-01 00:00:00

  • Relationship between intake of green tea and periodontal disease.

    abstract:BACKGROUND:Green tea is a very popular beverage, and in vitro studies have shown that green tea polyphenols inhibit the growth and cellular adherence of periodontal pathogens and their production of virulence factors. We investigated the epidemiologic relationship between the intake of green tea and periodontal disease...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Kushiyama M,Shimazaki Y,Murakami M,Yamashita Y

    更新日期:2009-03-01 00:00:00

  • Localization of fibronectin in gingival connective tissue of the beagle dog. Ultrastructural detection with ferritin and peroxidase-conjugated antibodies.

    abstract::Ferritin and peroxidase-conjugated antibodies were used in an indirect antibody method to localize fibronectin in gingival connective tissues. Fibronectin was found in the basal lamina beneath the epithelium and endothelium. Collagen fibrils associated with the basement membranes were also heavily coated by fibronecti...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Cho MI,Lee YL,Garant PR

    更新日期:1986-07-01 00:00:00

  • Bacterial Concentration Fluorescence Immunoassay (BCFIA) for the Detection of Periodontopathogens in Plaque.

    abstract::A bacterial concentration fluorescence immunoassay (BCFIA) was developed to rapidly detect periodontopathic bacteria in human plaque samples. The BCFIA utilized fluorescent-tagged monoclonal antibodies (MAbs) directed against the lipopolysaccharide of selected Gram-negative bacteria. Microorganisms identified in plaqu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Wolff LF,Anderson L,Sandberg GP,Reither L,Binsfeld CA,Corinaldesi G,Shelburne CE

    更新日期:1992-12-01 00:00:00

  • The association between smoking cessation and periodontal status and salivary proteinase levels.

    abstract:BACKGROUND:Little information is available about the effects of the cessation of cigarette smoking on oral health, although cigarette smoking has been shown to be associated with a variety of oral diseases. The aim of this study was to compare periodontal status, salivary proteolytic activity, especially collagenase-2 ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Liede KE,Haukka JK,Hietanen JH,Mattila MH,Rönkä H,Sorsa T

    更新日期:1999-11-01 00:00:00

  • Update on the changing numbers and distribution of periodontists.

    abstract::A review of the 2006 and past American Dental Association (ADA) studies on the distribution of dentists provides information on the evolving number of periodontists. Despite an overall increase in the number of periodontists, major differences continue in practitioner/population ratios in different geographic areas. A...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Waldman HB,Chaudhry RA

    更新日期:2009-05-01 00:00:00

  • Using the Theory of Planned Behavior to Identify Predictors of Oral Hygiene: A Collection of Unique Behaviors.

    abstract:BACKGROUND:This study aims to identify predictors of performed oral hygiene behaviors (OHBs) based on the Theory of Planned Behavior (TPB), oral health knowledge, and demographic factors. METHODS:Using a questionnaire, 381 participants in three general dental offices and one hospital dental department in York, Pennsyl...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Brein DJ,Fleenor TJ Jr,Kim SW,Krupat E

    更新日期:2016-03-01 00:00:00

  • 1-Tetradecanol complex: therapeutic actions in experimental periodontitis.

    abstract:BACKGROUND:The present study was planned to investigate the therapeutic actions of 1-tetradecanol complex (1-TDC), a novel monounsaturated fatty acid mixture, in established periodontitis in rabbits. METHODS:Periodontitis was initiated in 18 New Zealand White rabbits using ligatures around mandibular second premolars,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Hasturk H,Goguet-Surmenian E,Blackwood A,Andry C,Kantarci A

    更新日期:2009-07-01 00:00:00

  • The true gingival fibroma. An analysis of 129 fibrous gingival lesions.

    abstract::A histologic review of 129 circumscribed mesenchymal lesions of the gingivae was performed. Two cases were peripheral reparative giant cell granulomas; eight were peripheral odontogenic fibromas; 41 were inflammatory hyperplasias; 68 were pyogenic granulomas; 11 were "hard fibromas"; one lesion exhibited the histologi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Schneider LC,Weisinger E

    更新日期:1978-08-01 00:00:00

  • Factitious gingival ulceration: as presenting sign of Munchausen's syndrome?

    abstract::This report describes the case of a 21-year-old female who presented with localized gingival ulceration that over a period of 4 weeks became generalized, affecting all the buccal gingiva as well as the lower lip. A detailed medical history suggested that the patient was generating the lesions herself. She was monitore...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Heasman PA,MacLeod I,Smith DG

    更新日期:1994-05-01 00:00:00

  • The relationship of 17-hydroxycorticosteroid to acute necrotizing ulcerative gingivitis.

    abstract::Eleven patients presenting with acute necrotizing ulcerative gingivitis (ANUG) collected 24-hour urine samples during and after the course of their ANUG. The Porter-Silber technique was used to determine the 17-hydroxycorticosteroid concent of the urine, a physiological measure of stress. All of the patients had signi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Maupin CC,Bell WB

    更新日期:1975-12-01 00:00:00

  • Surgical crown lengthening: a 12-month clinical wound healing study.

    abstract:BACKGROUND:Surgical crown lengthening has been proposed as a means of facilitating restorative procedures and preventing periodontal injuries in teeth with structurally inadequate clinical crowns or exposing tooth structure in the presence of deep, subgingival pathologies which may hamper the access for proper restorat...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Pontoriero R,Carnevale G

    更新日期:2001-07-01 00:00:00

  • Effect of periodontal treatment on the protein composition of whole and parotid saliva.

    abstract::Cystatins are physiological inhibitors of cysteine proteinases and widely distributed in human tissues and fluids including saliva. Cystatins S, SA, SN, and D are only found in glandular saliva and tear fluid whereas cystatin C has been detected in all tested biological fluids. Previous studies demonstrated that total...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Henskens YM,van der Weijden FA,van den Keijbus PA,Veerman EC,Timmerman MF,van der Velden U,Amerongen AV

    更新日期:1996-03-01 00:00:00

  • Platelet-Rich Fibrin With 1.2% Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.

    abstract:BACKGROUND:Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal i...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Pradeep AR,Garg V,Kanoriya D,Singhal S

    更新日期:2016-12-01 00:00:00

  • Parameter on chronic periodontitis with slight to moderate loss of periodontal support. American Academy of Periodontology.

    abstract::The American Academy of Periodontology has developed the following parameter on the treatment of chronic periodontitis with slight to moderate loss of periodontal supporting tissues. Patients should be informed of the disease process, therapeutic alternatives, potential complications, expected results, and their respo...

    journal_title:Journal of periodontology

    pub_type: 指南,杂志文章,实务指引



    更新日期:2000-05-01 00:00:00

  • Clinical evaluation of gingival recession treated by coronally repositioned flap technique.

    abstract::Thirty-four areas of gingival recession in ten patients were treated by a coronally repositioned flap procedure. All but four of these areas had received a free gingiva graft previously. The postoperative evaluations of the wound healing were made at 2 weeks and at 1, 2, 4, 6 and 12 months after the final surgery. In ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Tenenbaum H,Klewansky P,Roth JJ

    更新日期:1980-12-01 00:00:00

  • Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study.

    abstract:BACKGROUND:This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previo...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Vieira CL,Cury PR,Miname MH,Martinez LR,Bortolotto LA,Giuliano IB,Santos RD,Caramelli B

    更新日期:2011-05-01 00:00:00

  • A bone regenerative approach to alveolar ridge maintenance following tooth extraction. Report of 10 cases.

    abstract::TEN PATIENTS WHO REQUIRED two or more anterior teeth extractions were utilized in this study. Extraction procedures were carried out with a full thickness surgical flap approach. After flap reflection, teeth were removed with a minimum of trauma to the surrounding bone. Following extraction silicone-based impression t...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章


    authors: Lekovic V,Kenney EB,Weinlaender M,Han T,Klokkevold P,Nedic M,Orsini M

    更新日期:1997-06-01 00:00:00

  • The acro-osteolysis (Hadju-Cheney) syndrome. Review of the literature and report of a case.

    abstract::Acro-osteolysis ( Hadju - Cheney ) Syndrome is a rare disorder of bone metabolism characterized by progressive destruction of the distal phalangeal bone, curvature of the spine, aplasia of the facial sinuses, and persistence of the cranial sutures. The purpose of this manuscript is to focus on the description of the o...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Allen CM,Claman L,Feldman R

    更新日期:1984-04-01 00:00:00

  • Histologic evaluation of the effects of intrasulcular toothbrushing on human sulcular epithelium.

    abstract::Nineteen young adult Caucasian males had an average Gingival Index Score of 0.47. Each was asked to demonstrate his present method of toothbrushing: thirteen used the scrub method, and six combined the scrub and roll methods. Control gingival tissue specimens were taken from the mandibular left first bicuspid or first...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Fry HR,App GR

    更新日期:1978-04-01 00:00:00

  • Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: radiographic observations.

    abstract:BACKGROUND:Platelet-rich plasma (PRP) harbors growth factors identified in bone. It has been suggested that these factors enhance osteogenesis. The objective of this study was to conduct a radiographic evaluation on local bone formation following surgical implantation of a PRP preparation using a critical-size rat calv...

    journal_title:Journal of periodontology

    pub_type: 杂志文章


    authors: Pryor ME,Yang J,Polimeni G,Koo KT,Hartman MJ,Gross H,Agelan A,Manns JM,Wikesjö UM

    更新日期:2005-08-01 00:00:00