Developmental venous anomaly in adult patients with diffuse glioma: A clinically relevant coexistence?


OBJECTIVE:To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma. METHODS:We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié-Salpêtrière Hospital (external validation set). We included 219 patients with diffuse glioma (experimental set), 252 patients with brain metastasis (control set), and 200 patients with diffuse glioma (validation set). The inclusion criteria were age ≥18 years at diagnosis, histopathologic diagnosis of diffuse glioma according to the 2016 World Health Organization classification of tumors of the CNS, surgery as first-line treatment without previous oncologic treatment, available presurgical MRI performed with similar acquisition protocol, and absence of a nodular-like or a ring-like pattern of contrast enhancement on MRI that may preclude the identification of a possible developmental venous anomaly within the glioma. RESULTS:We found more developmental venous anomaly in the experimental set (21.5%) than in the control set (5.2%, p < 0.001). Similarly, we found more developmental venous anomaly in the validation set (23.5%) than in the control set (5.2%, p < 0.001). There was no difference in the developmental venous anomaly prevalence between the experimental and validation sets. The developmental venous anomaly distribution was not significantly associated with histopathologic, molecular, or imaging findings of the diffuse gliomas. CONCLUSIONS:We report and replicate in an external cohort a high prevalence of developmental venous anomaly in adult patients with diffuse glioma, which suggests a potential underlying common predisposition or a causal relationship that requires deeper investigations.






Roux A,Edjlali M,Porelli S,Tauziede-Espariat A,Zanello M,Dezamis E,Zah-Bi G,Sanson M,Puget S,Capelle L,Varlet P,Oppenheim C,Pallud J




Has Abstract


2019-01-01 00:00:00














  • Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers.

    abstract:OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...


    pub_type: 杂志文章


    authors: Anheim M,Elbaz A,Lesage S,Durr A,Condroyer C,Viallet F,Pollak P,Bonaïti B,Bonaïti-Pellié C,Brice A,French Parkinson Disease Genetic Group.

    更新日期:2012-02-07 00:00:00

  • Physical activity, but not body mass index, predicts less disability before and after stroke.

    abstract:OBJECTIVE:To determine whether physical activity and body mass index (BMI) predict instrumental or basic activities of daily living (I/ADL) trajectories before or after stroke compared to individuals who remained stroke-free. METHODS:Using a prospective cohort, the Health and Retirement Study, we followed adults witho...


    pub_type: 杂志文章


    authors: Rist PM,Capistrant BD,Mayeda ER,Liu SY,Glymour MM

    更新日期:2017-05-02 00:00:00

  • Vimentin and desmin in maturing skeletal muscle and developmental myopathies.

    abstract::I studied vimentin and desmin immunoreactivities in the skeletal muscle of 30 human fetuses and children ranging from 8 weeks' gestation to 2 years of age, and in 45 infants and children and five adults with developmental neuromuscular diseases. Acridine orange-RNA fluorescence also identified regenerating myofibers i...


    pub_type: 杂志文章


    authors: Sarnat HB

    更新日期:1992-08-01 00:00:00

  • Double-blind comparison of cabergoline and bromocriptine in Parkinson's disease patients with motor fluctuations.

    abstract::In the present study we compared the efficacy and safety of the new dopamine agonist cabergoline (CBG) with bromocriptine (BCR) in Parkinson's disease (PD). CBG has a very long half-life and can be administered as a single daily dose. Forty-four PD patients with uncontrolled motor fluctuations participated in the stud...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Inzelberg R,Nisipeanu P,Rabey JM,Orlov E,Catz T,Kippervasser S,Schechtman E,Korczyn AD

    更新日期:1996-09-01 00:00:00

  • A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS.

    abstract:OBJECTIVE:To compare the efficacy, tolerability, and safety of IV methylprednisolone (IV MP) vs oral methylprednisolone (oMP) at equivalent high doses in patients with multiple sclerosis (MS) experiencing a recent relapse. METHODS:Patients with a clinical relapse within the previous 2 weeks and at least 1 gadolinium (...


    pub_type: 杂志文章,随机对照试验


    authors: Martinelli V,Rocca MA,Annovazzi P,Pulizzi A,Rodegher M,Martinelli Boneschi F,Scotti R,Falini A,Sormani MP,Comi G,Filippi M

    更新日期:2009-12-01 00:00:00

  • Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity.

    abstract:OBJECTIVE:To evaluate differences in cerebrovascular reactivity (CVR) to mild hypercapnia in obese/overweight individuals with and without insulin resistance (IR) compared to comparable lean controls. METHODS:A total of 60 cognitively normal participants (20 lean controls and 24 obese/overweight individuals with and 1...


    pub_type: 杂志文章


    authors: Frosch OH,Yau PL,Osorio RS,Rusinek H,Storey P,Convit A

    更新日期:2017-07-18 00:00:00

  • Erythrocyte thiolmethyltransferase: another failed marker for Alzheimer's and Parkinson's diseases.

    abstract::There are reports that patients with Parkinson's disease (PD) and Alzheimer's disease (AD) have reduced levels of thiolmethyltransferase (TMT) in erythrocyte membranes. TMT methylates thiols and thiocarbamates, thereby reducing their toxicity. We examined TMT levels in erythrocytes from patients with PD and AD and fro...


    pub_type: 杂志文章


    authors: Hurwitz A,Hubble JP,Glatt SL,Koller WC,Pollack J

    更新日期:1995-10-01 00:00:00

  • Inflammatory markers and cognition in well-functioning African-American and white elders.

    abstract:BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...


    pub_type: 杂志文章


    authors: Yaffe K,Lindquist K,Penninx BW,Simonsick EM,Pahor M,Kritchevsky S,Launer L,Kuller L,Rubin S,Harris T

    更新日期:2003-07-08 00:00:00

  • PM2.5 associated with gray matter atrophy reflecting increased Alzheimers risk in older women.

    abstract:OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...


    pub_type: 杂志文章


    authors: Younan D,Wang X,Casanova R,Barnard R,Gaussoin SA,Saldana S,Petkus AJ,Beavers DP,Resnick SM,Manson JE,Serre ML,Vizuete W,Henderson VW,Sachs BC,Salinas JA,Gatz M,Espeland MA,Chui HC,Shumaker SA,Rapp SR,Chen JC,Wom

    更新日期:2020-11-18 00:00:00

  • Levodopa, melanoma, and Parkinson's disease.

    abstract::Previous reports and the Physicians' Desk Reference caution against the use of levodopa in Parkinson's disease (PD) patients with melanoma. A critical review of the literature reveals only anecdotal evidence to support a link between levodopa and melanoma. In fact, levodopa has an antitumor effect on melanoma. We repo...


    pub_type: 杂志文章,评审


    authors: Weiner WJ,Singer C,Sanchez-Ramos JR,Goldenberg JN

    更新日期:1993-04-01 00:00:00

  • Undetermined stroke genesis and hidden cardiomyopathies determined by cardiac magnetic resonance.

    abstract:OBJECTIVE:To determine whether cardiac magnetic resonance imaging (CMR) could be useful in identifying previously undiagnosed cardiomyopathies in a cohort of patients with ischemic stroke who underwent standard etiologic investigation and to describe the type and frequency of these cardiomyopathies. METHODS:We perform...


    pub_type: 杂志文章


    authors: Fonseca AC,Marto JP,Pimenta D,Guimarães T,Alves PN,Inácio N,Viana-Baptista M,Pinho E Melo T,Pinto FJ,Ferro JM,Almeida AG

    更新日期:2020-01-07 00:00:00

  • Hemifacial spasm due to contralateral acoustic neuroma: case report.

    abstract::A patient with a large acoustic neuroma had contralateral hemifacial spasm. On CT, the brainstem was markedly displaced and distorted by the tumor. After total removal of the tumor the hemifacial spasm was temporarily worse, but disappeared 14 days after the operation. ...


    pub_type: 杂志文章


    authors: Nishi T,Matsukado Y,Nagahiro S,Fukushima M,Koga K

    更新日期:1987-02-01 00:00:00

  • Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis.

    abstract::Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (s...


    pub_type: 临床试验,杂志文章


    authors: Rinker JR 2nd,Trinkaus K,Cross AH

    更新日期:2006-10-10 00:00:00

  • Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis.

    abstract:BACKGROUND:The antivirally active MxA protein is induced by interferon (IFN) alpha/beta and inhibits the replication of single-stranded RNA viruses including measles virus (MV). The authors investigated whether the MxA gene contributed to the development of subacute sclerosing panencephalitis (SSPE) in Japanese individ...


    pub_type: 杂志文章


    authors: Torisu H,Kusuhara K,Kira R,Bassuny WM,Sakai Y,Sanefuji M,Takemoto M,Hara T

    更新日期:2004-02-10 00:00:00

  • Neurophysiologic study of central pain in patients with Parkinson disease.

    abstract:BACKGROUND:Patients with Parkinson disease (PD) may present with various types of pain. In some instances, no cause can be identified and pain is considered a primary disorder (primary central pain [PCP]). We hypothesized that PCP in patients with PD (PD-PCP) may be due to a dysfunction of pain pathways or the processi...


    pub_type: 杂志文章


    authors: Schestatsky P,Kumru H,Valls-Solé J,Valldeoriola F,Marti MJ,Tolosa E,Chaves ML

    更新日期:2007-12-04 00:00:00

  • Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.

    abstract:OBJECTIVES:We aimed to determine the incidence of electrographic seizures in children in the pediatric intensive care unit who underwent EEG monitoring, risk factors for electrographic seizures, and whether electrographic seizures were associated with increased odds of mortality. METHODS:Eleven sites in North America ...


    pub_type: 杂志文章,多中心研究


    authors: Abend NS,Arndt DH,Carpenter JL,Chapman KE,Cornett KM,Gallentine WB,Giza CC,Goldstein JL,Hahn CD,Lerner JT,Loddenkemper T,Matsumoto JH,McBain K,Nash KB,Payne E,Sánchez SM,Fernández IS,Shults J,Williams K,Yang A,Dlu

    更新日期:2013-07-23 00:00:00

  • The anatomic basis of delusions after right cerebral infarction.

    abstract::We studied the nature and causes of delusions after infarction of the right cerebral hemisphere. Delusions involved orientation in time and place, events in the recent past, and the identities of familiar individuals. Some were transient and disorganized, and others were more fixed. No particular site in the right hem...


    pub_type: 杂志文章


    authors: Levine DN,Grek A

    更新日期:1984-05-01 00:00:00

  • Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus.

    abstract:OBJECTIVE:Compare the cost and effectiveness of nonbenzodiazepine antiepileptic drugs (non-BZD AEDs) for treatment of BZD-resistant convulsive status epilepticus (SE). METHODS:Decision analysis model populated with effectiveness data from a systematic review and meta-analysis of the literature, and cost data from publ...


    pub_type: 杂志文章,meta分析


    authors: Sánchez Fernández I,Gaínza-Lein M,Lamb N,Loddenkemper T

    更新日期:2019-05-14 00:00:00

  • Orthostatic tremor: Clinical, electrophysiologic, and treatment findings in 184 patients.

    abstract:OBJECTIVE:To evaluate the clinical, electrophysiologic, and treatment outcome features of orthostatic tremor (OT) in a large case series. METHODS:We performed medical record review of 184 patients who met clinical and electrodiagnostic criteria for OT from 1976 to 2013 at the Mayo Clinic. Demographic, clinical, electr...


    pub_type: 杂志文章


    authors: Hassan A,Ahlskog JE,Matsumoto JY,Milber JM,Bower JH,Wilkinson JR

    更新日期:2016-02-02 00:00:00

  • Efficacy of subcutaneous sumatriptan in repeated episodes of migraine.

    abstract::This double-blind, placebo-controlled, multicenter, crossover study investigated the efficacy and tolerability of sumatriptan administered for up to three separate migraine attacks. One hundred twenty adults received sumatriptan (SC, 6 mg; three attacks) and placebo (one attack). Patients completed questionnaires asse...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Cady RK,Dexter J,Sargent JD,Markley H,Osterhaus JT,Webster CJ

    更新日期:1993-07-01 00:00:00

  • Longitudinal diffusion changes following postoperative delirium in older people without dementia.

    abstract:OBJECTIVE:To investigate the effect of postoperative delirium on longitudinal brain microstructural changes, as measured by diffusion tensor imaging. METHODS:We studied a subset of the larger Successful Aging after Elective Surgery (SAGES) study cohort of older adults (≥70 years) without dementia undergoing elective s...


    pub_type: 杂志文章


    authors: Cavallari M,Dai W,Guttmann CRG,Meier DS,Ngo LH,Hshieh TT,Fong TG,Schmitt E,Press DZ,Travison TG,Marcantonio ER,Jones RN,Inouye SK,Alsop DC,SAGES Study Group.

    更新日期:2017-09-05 00:00:00

  • Melioidosis and bilateral third-nerve palsies.

    abstract::Central nervous system involvement in melioidosis is unusual. We describe a 34-year-old man who developed a Pseudomonas pseudomallei meningitis, manifested as bilateral third-nerve palsies, 13 years after having been in southeast Asia. Diagnosis was established by a fourfold rise in the serum antibody titer for the ba...


    pub_type: 杂志文章


    authors: Beck RW,Janssen RS,Smiley ML,Schatz NJ,Savino PJ,Rubin DH

    更新日期:1984-01-01 00:00:00

  • 3-O-methyldopa and motor fluctuations in Parkinson's disease.

    abstract::High plasma levels of 3-O-methyldopa (OMD) were found in parkinsonian patients chronically treated with levodopa, particularly in those with on-off phenomenon. However, no relation could be established between circulating levels of the levodopa metabolite and the presence of motor response fluctuations at any stage of...


    pub_type: 杂志文章


    authors: Fabbrini G,Juncos JL,Mouradian MM,Serrati C,Chase TN

    更新日期:1987-05-01 00:00:00

  • Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD.

    abstract:BACKGROUND:Both AD and normal aging cause brain atrophy, limiting the ability of MRI to distinguish between AD and age-related brain tissue loss. MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging. OBJECTIVES:To determine the effects of AD on c...


    pub_type: 杂志文章,多中心研究


    authors: Schuff N,Capizzano AA,Du AT,Amend DL,O'Neill J,Norman D,Kramer J,Jagust W,Miller B,Wolkowitz OM,Yaffe K,Weiner MW

    更新日期:2002-03-26 00:00:00

  • Can allodynic migraine patients be identified interictally using a questionnaire?

    abstract:OBJECTIVE:The gradual development of cutaneous allodynia during the course of a migraine attack is commonly detected by quantitative sensory testing (QST) in migraineurs seeking secondary and tertiary medical help. In this study, the authors developed a questionnaire that tested the recollection of the patients on thei...


    pub_type: 杂志文章


    authors: Jakubowski M,Silberstein S,Ashkenazi A,Burstein R

    更新日期:2005-11-08 00:00:00

  • Effects of 3-OM-dopa on monoamine metabolism in rat brain.

    abstract::We studied the effects of 3-methoxy, 4-hydroxy-phenylalanine (3-OM-dopa) on monoamine turnover, L-3-4-dihydroxy-phenylalanine (L-dopa) reversal of catecholamine depletion induced by alpha-methyl-paratyrosine (alpha-MT), and the passage of L-dopa across the blood-brain barrier of the rat brain. 3-OM-dopa did not affect...


    pub_type: 杂志文章


    authors: Gervas JJ,Muradás V,Bazán E,Aguado EG,de Yébenes JG

    更新日期:1983-03-01 00:00:00

  • Domain-dependent clustering and genotype-phenotype analysis of LGI1 mutations in ADPEAF.

    abstract:OBJECTIVE:In families with autosomal dominant partial epilepsy with auditory features (ADPEAF) with mutations in the LGI1 gene, we evaluated clustering of mutations within the gene and associations of penetrance and phenotypic features with mutation location and predicted effect (truncation or missense). METHODS:We ab...


    pub_type: 杂志文章


    authors: Ho YY,Ionita-Laza I,Ottman R

    更新日期:2012-02-21 00:00:00

  • Relapse occurrence in women with multiple sclerosis during pregnancy in the new treatment era.

    abstract:OBJECTIVE:To determine the rate of relapse occurrence during pregnancy and postpartum. METHODS:In a cross-sectional study using the national multiple sclerosis (MS) registry, pregnant women with relapsing MS were identified. Data on demographics, clinical characteristics, and disease-modifying therapies (DMTs), includ...


    pub_type: 杂志文章


    authors: Alroughani R,Alowayesh MS,Ahmed SF,Behbehani R,Al-Hashel J

    更新日期:2018-03-06 00:00:00

  • Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

    abstract:OBJECTIVE:To examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS). METHODS:We measured Nf light chain (NfL) and phosphorylated Nf heavy chain (pNfH) CSF and NfL serum levels in patients with ALS with first symptom onset...


    pub_type: 杂志文章,多中心研究


    authors: Feneberg E,Oeckl P,Steinacker P,Verde F,Barro C,Van Damme P,Gray E,Grosskreutz J,Jardel C,Kuhle J,Koerner S,Lamari F,Amador MDM,Mayer B,Morelli C,Muckova P,Petri S,Poesen K,Raaphorst J,Salachas F,Silani V,Stuben

    更新日期:2018-01-02 00:00:00

  • A presenilin 1 R278I mutation presenting with language impairment.

    abstract::Presenilin (PSEN)1 mutations are responsible for many cases of autosomal dominant Alzheimer disease (AD), although the clinical spectrum has not been fully defined. The authors describe two members of a kindred with a novel PSEN1 mutation (R278I) presenting with language impairment and relative preservation of memory....


    pub_type: 杂志文章


    authors: Godbolt AK,Beck JA,Collinge J,Garrard P,Warren JD,Fox NC,Rossor MN

    更新日期:2004-11-09 00:00:00