SLiM 3: Forward Genetic Simulations Beyond the Wright-Fisher Model.


:With the desire to model population genetic processes under increasingly realistic scenarios, forward genetic simulations have become a critical part of the toolbox of modern evolutionary biology. The SLiM forward genetic simulation framework is one of the most powerful and widely used tools in this area. However, its foundation in the Wright-Fisher model has been found to pose an obstacle to implementing many types of models; it is difficult to adapt the Wright-Fisher model, with its many assumptions, to modeling ecologically realistic scenarios such as explicit space, overlapping generations, individual variation in reproduction, density-dependent population regulation, individual variation in dispersal or migration, local extinction and recolonization, mating between subpopulations, age structure, fitness-based survival and hard selection, emergent sex ratios, and so forth. In response to this need, we here introduce SLiM 3, which contains two key advancements aimed at abolishing these limitations. First, the new non-Wright-Fisher or "nonWF" model type provides a much more flexible foundation that allows the easy implementation of all of the above scenarios and many more. Second, SLiM 3 adds support for continuous space, including spatial interactions and spatial maps of environmental variables. We provide a conceptual overview of these new features, and present several example models to illustrate their use.


Mol Biol Evol


Haller BC,Messer PW




Has Abstract


2019-03-01 00:00:00














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    pub_type: 杂志文章


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    journal_title:Molecular biology and evolution

    pub_type: 杂志文章


    authors: Leblois R,Estoup A,Rousset F

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    journal_title:Molecular biology and evolution

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    authors: Schaeffer SW,Aquadro CF,Anderson WW

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    journal_title:Molecular biology and evolution

    pub_type: 杂志文章


    authors: Lucas-Lledó JI,Maddamsetti R,Lynch M

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    authors: Silberman JD,Simpson AG,Kulda J,Cepicka I,Hampl V,Johnson PJ,Roger AJ

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    journal_title:Molecular biology and evolution

    pub_type: 信件


    authors: Marco A,Marín I

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    journal_title:Molecular biology and evolution

    pub_type: 杂志文章


    authors: Turbeville JM,Field KG,Raff RA

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    journal_title:Molecular biology and evolution

    pub_type: 杂志文章


    authors: Wu J,Susko E

    更新日期:2011-05-01 00:00:00