The efficacy and safety of ciclesonide for the treatment of perennial allergic rhinitis: a systematic review and meta-analysis.

Abstract:

INTRODUCTION:Allergic rhinitis is a chronic inflammatory disease which affects 1 out of 6 individuals. Perennial allergic rhinitis accounts for 40% of AR cases. Ciclesonide is one of the relatively new intranasal steroid for allergic rhinitis. OBJECTIVE:The purpose of this study was to evaluate the efficacy and safety of ciclesonide in the treatment of perennial allergic rhinitis. METHODS:We searched Pubmed, Scientific Citation Index, Embase, Clinical Trial Registries for randomized controlled trials and Cochrane Central Register of Controlled Trials to find out the randomized controlled Trial comparing ciclesonide with placebo for PAR. RESULTS:Eight studies were included. In comparison with placebo groups, ciclesonide groups significantly decreased Reflective Total Nasal Symptom Score (MD=-0.56; 95% CI -0.72 to 0.39, p<0.00001) with heterogeneity (p=0.19, I2=24%), Instantaneous Total Nasal Symptom Score (MD=-0.57; 95% CI -0.75 to -0.39, p<0.00001) with heterogeneity (p=0.34, I2=11%). A significant effect for Reflective Nasal Symptom Score Subtotal (MD=-0.15; 95% CI -0.18 to -0.13, p<0.00001) with heterogeneity (p=0.12, I2=24%) was also demonstrated. Rhinoconjunctivitis quality of life questionnaire score (RQLQs) (MD=-0.27; 95% CI -0.39 to -0.15, p<0.00001) with heterogeneity (p=0.58, I2=0%) in the treatment of ciclesonide was also significantly reduced. In addition, the difference in Treatment-Emergent Adverse Events between the two groups was not significant. CONCLUSION:Ciclesonide can improve perennial allergic rhinitis without increasing adverse events. Ciclesonide may be another valuable choice for perennial allergic rhinitis in the future.

authors

Yang Q,Wang F,Li B,Wu W,Xie D,He L,Xiang N,Dong Y

doi

10.1016/j.bjorl.2018.10.008

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

371-378

issue

3

eissn

1808-8694

issn

1808-8686

pii

S1808-8694(18)30576-7

journal_volume

85

pub_type

杂志文章,meta分析
  • Bioethics and medical/legal considerations on cochlear implants in children.

    abstract:UNLABELLED:Cochlear implants are the best treatment for congenital profound deafness. Pediatric candidates to implantation are seen as vulnerable citizens, and the decision of implanting cochlear devices is ultimately in the hands of their parents/guardians. The Brazilian Penal Code dictates that deaf people may enjoy ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:

    authors: Miziara ID,Miziara CS,Tsuji RK,Bento RF

    更新日期:2012-06-01 00:00:00

  • Gender differences in binaural speech-evoked auditory brainstem response: are they clinically significant?

    abstract:INTRODUCTION:Binaurally evoked auditory evoked potentials have good diagnostic values when testing subjects with central auditory deficits. The literature on speech-evoked auditory brainstem response evoked by binaural stimulation is in fact limited. Gender disparities in speech-evoked auditory brainstem response resul...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2018.04.005

    authors: Jalaei B,Azmi MHAM,Zakaria MN

    更新日期:2019-01-01 00:00:00

  • Prevalence of depressive symptoms in patients with cleft lip and palate.

    abstract:INTRODUCTION:Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face. OBJECTIVE:To evaluate the prevalence of depressive symptoms in children and adolescents with nonsyndromic cleft lip and/or palate (nsCL/P). METHODS:We conducted an observational, case-control study, with a case stu...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.01.004

    authors: Lima LS,Ribeiro GS,Aquino SN,Volpe FM,Martelli DR,Swerts MS,Paranaíba LM,Martelli Júnior H

    更新日期:2015-03-01 00:00:00

  • [Review of experimental models: sinusitis in rabbits].

    abstract:INTRODUCTION:In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invas...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.1016/j.bjorl.2014.07.011

    authors: Perez AC,Buzatto GP,Dantas Ide P,Dorgam JV,Valera FC,Tamashiro E,Lima WT

    更新日期:2014-09-01 00:00:00

  • A study on the relationship between mouth breathing and facial morphological pattern.

    abstract:UNLABELLED:Breathing is responsible for facial and cranial morphology development. AIM:investigate in order to see if there is any relationship between oral breathing and facial type. MATERIAL AND METHODS:119 male and female teenagers, with ages ranging between 15 and 18 years. The sample was separated in two groups:...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/s1808-8694(15)30101-4

    authors: Bianchini AP,Guedes ZC,Vieira MM

    更新日期:2007-07-01 00:00:00

  • A critical analysis of 33 patients with substernal goiter surgically treated by neck incision.

    abstract:UNLABELLED:The possibility of needing a combined access, with neck and chest incisions makes the treatment of substernal goiter a challenge both in the pre-op and the intraoperative. We hereby, discuss a standardization of the surgical technique to minimize the need for a chest approach, making the substernal goiter a ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/s1808-8694(15)30774-6

    authors: Neves MC,Rosano M,Hojaij FC,Abrahão M,Cervantes O,Andreoni DM

    更新日期:2009-03-01 00:00:00

  • Nasal cavity changes and the respiratory standard after maxillary expansion.

    abstract:UNLABELLED:Mandibular cross-sectional deficiency is a dentofacial defect in connection with the narrowing of the mandibular arch width. This abnormality is a significant etiopathogenic factor and it is often associated with nasal breathing difficulties. This atresia may be treated through Rapid Maxillary Expansion or S...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.1016/S1808-8694(15)31388-4

    authors: Ramires T,Maia RA,Barone JR

    更新日期:2008-09-01 00:00:00

  • Stromal and epithelial syndecan-1 expression in benign and malignant salivary gland tumors: which is more reflective of behavior?

    abstract:INTRODUCTION:Salivary gland tumors are a diverse group of lesions, with various origins and extremely different behaviors, leading to a variety of outcomes for patients. Therefore, the need to discover novel markers with the ability to predict the behavior of benign and malignant salivary gland neoplasms is crucial. Sy...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2019.07.006

    authors: Alaeddini M,Yazdani F,Etemad-Moghadam S

    更新日期:2019-09-04 00:00:00

  • Endoscopic endonasal technique: treatment of paranasal and anterior skull base malignancies.

    abstract:UNLABELLED:Technical and technological innovations have spearheaded the expansion of the indications for the use of endoscopic endonasal approaches to extirpate malignancies of the sinonasal tract and adjacent skull base. OBJECTIVE:Critical review of the available literature regarding the use of endoscopic endonasal a...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.5935/1808-8694.20130138

    authors: Kasemsiri P,Prevedello DM,Otto BA,Old M,Ditzel Filho L,Kassam AB,Carrau RL

    更新日期:2013-11-01 00:00:00

  • Pediatric phoniatry outpatient ward: clinical and epidemiological characteristics.

    abstract:UNLABELLED:Children with language or learning impairment and normal hearing need phoniatric assessment to analyse various communication and development aspects targeting the differential diagnosis and therapeutic indications. OBJECTIVE:Characterize clinical and epidemiological features of a pediatric population treate...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.5935/1808-8694.20130029

    authors: Fávero ML,Higino TC,Pires AP,Burke PR,Silva FL,Tabith Júnior A

    更新日期:2013-03-01 00:00:00

  • Etiology of hearing impairment in children and adolescents of a reference center APADA in the city of Salvador, state of Bahia.

    abstract:UNLABELLED:Hearing represents the main source for acquisition of language and speaking skills in childhood. In the first months of life, the hearing impaired child is deprived of sound stimulation in the most important period of development, and consequently, might present emotional, social and linguistic disorders. Th...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/s1808-8694(15)30031-8

    authors: da Silva LP,Queiros F,Lima I

    更新日期:2006-01-01 00:00:00

  • Otologic and audiologic characteristics of type 2 diabetics in a tertiary health institution in Nigeria.

    abstract:INTRODUCTION:This cross-sectional comparative study was carried out at the Diabetes outpatient clinic of LAUTECH Teaching Hospital (LTH) Ogbomoso, Nigeria. OBJECTIVE:This study assessed patterns of otologic diseases and auditory acuity among type 2 diabetics and determinants of these findings among diabetics. METHODS...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.10.016

    authors: Adebola SO,Olamoyegun MA,Sogebi OA,Iwuala SO,Babarinde JA,Oyelakin AO

    更新日期:2016-09-01 00:00:00

  • Nasal lavage cytology and mucosal histopathological alterations in patients with rhinitis.

    abstract:INTRODUCTION:The extent of epithelial lesion in allergic and non-allergic rhinitis and its association with inflammatory changes in nasal lavage has not been clarified. OBJECTIVE:To verify the association between the inflammatory cells in the nasal lavage, epithelial lesion extent and basement membrane thickness, in t...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2019.01.005

    authors: Kovalhuk LCS,Telles EQ,Lima MN,Rosario Filho NA

    更新日期:2020-01-01 00:00:00

  • Software for subjective visual vertical assessment: an observational cross-sectional study.

    abstract:UNLABELLED:Spatial orientation in relation to the gravitational axis is significantly important for the maintenance of the posture, gait and for most of the human's motor activities. The subjective visual vertical exam evaluates the individual's perception of vertical orientation. OBJECTIVES:The aims of this study wer...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.5935/1808-8694.20120008

    authors: Pavan TZ,Funabashi M,Carneiro JA,Pontelli TE,Tedeschi W,Colafêmina JF,Carneiro AA

    更新日期:2012-10-01 00:00:00

  • Frequency of GJB2 mutations in patients with nonsyndromic hearing loss from an ethnically characterized Brazilian population.

    abstract:INTRODUCTION:In different parts of the world, mutations in the GJB2 gene are associated with nonsyndromic hearing loss, and the homozygous 35delG mutation (p.Gly12Valfs*2) is a major cause of hereditary hearing loss. However, the 35delG mutation is not equally prevalent across ethnicities, making it important to study ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2017.10.013

    authors: Felix F,Ribeiro MG,Tomita S,Zalis MG

    更新日期:2019-01-01 00:00:00

  • Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods.

    abstract:INTRODUCTION:In many regions, laryngeal carcinoma is a common upper respiratory tract cancer, most commonly involving the glottic region. The treatment of early glottic cancer includes radiotherapy, open surgery and laryngeal laser microsurgery. However, the preferred treatment for early glottic cancer is still controv...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2020.06.013

    authors: Wang G,Li G,Wu J,Song P

    更新日期:2020-08-06 00:00:00

  • The effect of Foreign Body Aspiration training on the knowledge level of pupils.

    abstract:INTRODUCTION:Educators dealing with 0-6 years old children must be individuals who are willing to take all kind of measures in order to ensure the safety of children in educational institutions and playgrounds, providing protection from diseases, and who are able to apply first aid measures in case of an accident. OBJ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.06.005

    authors: Akca SO

    更新日期:2016-07-01 00:00:00

  • Auditory-perceptual analysis of voice in abused children and adolescents.

    abstract:INTRODUCTION:Abused children and adolescents are exposed to factors that can trigger vocal changes. OBJECTIVE:This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communicati...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2014.11.006

    authors: Stivanin L,Santos FP,Oliveira CC,Santos Bd,Ribeiro ST,Scivoletto S

    更新日期:2015-01-01 00:00:00

  • Tympanic paragangliomas: case reports.

    abstract::Glomus tumors, also called paragangliomas, originate from nonchromaffin cells. The tumor is typically vascular and grows from capillary and pre-capillary vessels in-between epithelial cells. It is worth mentioning that the most common symptoms are pulsating tinnitus and hearing loss. Imaging studies (CT and MRI) are n...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/s1808-8694(15)31293-3

    authors: Neto ME,Vuono IM,Souza LR,Testa JR,Pizarro GU,Barros F

    更新日期:2005-01-01 00:00:00

  • Frontonasal dysplasia: clinical evaluation on audiological and brainstem electrophysiological profiles.

    abstract:UNLABELLED:Frontonasal dysplasia (FND) is a rare malformative complex affecting the frontal portion of the face, the eyes and the nose; it may occur singly or associated with other clinical signs. No systematic studies describing hearing in this condition were found. AIM:To evaluate hearing sensitivity and sound stimu...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1590/s1808-86942011000500013

    authors: Antoneli MZ,Giacheti CM,Genaro KF,Zorzetto NL,Richieri-Costa A

    更新日期:2011-09-01 00:00:00

  • The role of tumor necrosis factor-alpha (TNF-alpha) in bone resorption present in middle ear cholesteatoma.

    abstract:UNLABELLED:Cholesteatoma may cause bone erosion, with high morbidity and mortality rates. Tumor necrosis factor-alpha (TNF-a) is one of the main cytokines involved in this process. Our goal was to evaluate the role of TNF-a in Bone Resorption and its effect on cholesteatoma. MATERIAL AND METHODS:analysis and critical ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.1016/s1808-8694(15)31133-2

    authors: Vitale RF,Ribeiro Fde A

    更新日期:2007-01-01 00:00:00

  • The impact of sentinel lymph node biopsy on the quality of life in patients with oral cavity squamous cell carcinoma.

    abstract:INTRODUCTION:Sentinel lymph node biopsy is a proven method for staging the neck in patients with early oral cavity squamous cell carcinoma because it results in less comorbidity than the traditional method of selective neck dissection, with the same oncological results. However, the real effect of that method on the qu...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2020.11.015

    authors: Seferin MR,Pinto FR,Leite AKN,Dedivitis RA,Kulcsar MAV,Cernea CR,Matos LL

    更新日期:2020-12-27 00:00:00

  • Otomicroscopic and histologic findings of induced myringosclerosis in rats: a critical study of an experimental model.

    abstract:UNLABELLED:Myringosclerosis is characterized by hyaline changes of the lamina propria of the tympanic membrane. Experimental studies have used otomicroscopy or histology to evaluate myringosclerosis in animals, but they do not correlate precisely these two methods. AIM:The present study evaluates the accuracy of otomi...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/s1808-8694(15)31272-6

    authors: Santos PF,Leal MC,Peixoto C,Caldas Neto S,Rosas ST

    更新日期:2005-09-01 00:00:00

  • Orofacial-cervical alterations in individuals with upper airway resistance syndrome.

    abstract:INTRODUCTION:Studies that assess the upper airways in sleep-related breathing disorders have been performed only in patients with obstructive sleep apnea syndrome who seek medical attention. Therefore, in addition to the need for population studies, there are no data on the orofacial-cervical physical examination in su...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.05.015

    authors: de Oliveira PW,Gregorio LL,Silva RS,Bittencourt LR,Tufik S,Gregório LC

    更新日期:2016-07-01 00:00:00

  • Effect of mitomycin C on the secretion of granulocyte macrophages colonies stimulating factor and interleukin-5 in eosinophilic nasal polyps stromal culture.

    abstract:UNLABELLED:The research involving tissue factors, such as granulocyte macrophage colonies stimulating factor (GM-CSF) and interleukin 5 (IL-5), leads to the mechanisms involved in the maintenance of eosinophilia, which is essential for the pathogenesis on eosinophilic nasal polyps. Mitomycin C has been successfully use...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/s1808-8694(15)31199-x

    authors: Crosara PF,Vasconcelos AC,Guimarães RE,Becker HM,Becker CG,Crosara SL,Nascimento E

    更新日期:2005-07-01 00:00:00

  • Efficacy and safety of Sultamicillin (Ampicillin/Sulbactan) and Amoxicillin/Clavulanic acid in the treatment of upper respiratory tract infections in adults--an open-label, multicentric, randomized trial.

    abstract:UNLABELLED:Upper respiratory tract infections are the most common causes of medical visits in children and adults, demanding massive use of antibiotics. Bacterial resistance caused by beta-lactamase is one of the most serious problems in this matter. Sultamicillin, a double pro-drug of Ampicillin/Sulbactan, is a potent...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/s1808-8694(15)30041-0

    authors: Ferreira JB,Rapoport PB,Sakano E,Kós AO,Piltcher OB,Pignatari SS,Pinheiro SD,Mocellin M

    更新日期:2006-01-01 00:00:00

  • Mismatch negativity in children with specific language impairment and auditory processing disorder.

    abstract:INTRODUCTION:Mismatch negativity, an electrophysiological measure, evaluates the brain's capacity to discriminate sounds, regardless of attentional and behavioral capacity. Thus, this auditory event-related potential is promising in the study of the neurophysiological basis underlying auditory processing. OBJECTIVE:To...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2014.08.022

    authors: Rocha-Muniz CN,Befi-Lopes DM,Schochat E

    更新日期:2015-07-01 00:00:00

  • Study of otoacoustic emissions during the female hormonal cycle.

    abstract:UNLABELLED:The hormonal changes that occur in a short time span promote modifications all over the woman's body, with physical and emotional manifestations which are frequently observed. AIM:to evaluate the activity of the external ciliated cells in women during their menstrual cycle, observing the effect of hormonal ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/s1808-8694(15)30759-x

    authors: Arruda PO,Silva IM

    更新日期:2008-01-01 00:00:00

  • Epidemiology of communication disorders in childhood phoniatric clinical practice.

    abstract:INTRODUCTION:Language acquisition and development require an understanding of physical and psychosocial aspects during diagnosis and treatment. At this point, a partnership between phoniatric physicians and other health professionals is often a determinant for favorable prognosis. OBJECTIVE:To identify the clinical an...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.01.006

    authors: Baptista MG,Novaes BC,Favero ML

    更新日期:2015-07-01 00:00:00

  • Antioxidant therapy in the elderly with tinnitus.

    abstract:INTRODUCTION:Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is poorly...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bjorl.2015.04.016

    authors: Polanski JF,Soares AD,de Mendonça Cruz OL

    更新日期:2016-05-01 00:00:00