The efficacy and safety of ciclesonide for the treatment of perennial allergic rhinitis: a systematic review and meta-analysis.

Abstract:

INTRODUCTION:Allergic rhinitis is a chronic inflammatory disease which affects 1 out of 6 individuals. Perennial allergic rhinitis accounts for 40% of AR cases. Ciclesonide is one of the relatively new intranasal steroid for allergic rhinitis. OBJECTIVE:The purpose of this study was to evaluate the efficacy and safety of ciclesonide in the treatment of perennial allergic rhinitis. METHODS:We searched Pubmed, Scientific Citation Index, Embase, Clinical Trial Registries for randomized controlled trials and Cochrane Central Register of Controlled Trials to find out the randomized controlled Trial comparing ciclesonide with placebo for PAR. RESULTS:Eight studies were included. In comparison with placebo groups, ciclesonide groups significantly decreased Reflective Total Nasal Symptom Score (MD=-0.56; 95% CI -0.72 to 0.39, p<0.00001) with heterogeneity (p=0.19, I2=24%), Instantaneous Total Nasal Symptom Score (MD=-0.57; 95% CI -0.75 to -0.39, p<0.00001) with heterogeneity (p=0.34, I2=11%). A significant effect for Reflective Nasal Symptom Score Subtotal (MD=-0.15; 95% CI -0.18 to -0.13, p<0.00001) with heterogeneity (p=0.12, I2=24%) was also demonstrated. Rhinoconjunctivitis quality of life questionnaire score (RQLQs) (MD=-0.27; 95% CI -0.39 to -0.15, p<0.00001) with heterogeneity (p=0.58, I2=0%) in the treatment of ciclesonide was also significantly reduced. In addition, the difference in Treatment-Emergent Adverse Events between the two groups was not significant. CONCLUSION:Ciclesonide can improve perennial allergic rhinitis without increasing adverse events. Ciclesonide may be another valuable choice for perennial allergic rhinitis in the future.

authors

Yang Q,Wang F,Li B,Wu W,Xie D,He L,Xiang N,Dong Y

doi

10.1016/j.bjorl.2018.10.008

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

371-378

issue

3

eissn

1808-8694

issn

1808-8686

pii

S1808-8694(18)30576-7

journal_volume

85

pub_type

杂志文章,meta分析
  • Better outcome for parotid versus neck metastasis of head and neck cutaneous squamous cell carcinoma: a new report on reemerging data.

    abstract:INTRODUCTION:Regional metastases of cutaneous head and neck squamous cell carcinoma occur in approximately 5 % of cases, being the most important prognostic factor in survival, currently with no distinction between parotid and neck metastasis. OBJECTIVE:The purpose of this study was to evaluate the prognostic features...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2019.10.007

    authors: Girardi FM,Wagner VP,Martins MD,Abentroth AL,Hauth LA

    更新日期:2019-11-15 00:00:00

  • Auditory-perceptual analysis of voice in abused children and adolescents.

    abstract:INTRODUCTION:Abused children and adolescents are exposed to factors that can trigger vocal changes. OBJECTIVE:This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communicati...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2014.11.006

    authors: Stivanin L,Santos FP,Oliveira CC,Santos Bd,Ribeiro ST,Scivoletto S

    更新日期:2015-01-01 00:00:00

  • Acupuncture for tinnitus immediate relief.

    abstract::The treatment of tinnitus, which is defined as conscientious perception of a sound originated in the ears or nervous system, represents until the current days a great challenge. The use of Acupuncture (ACP) is based on the stimulation with needles of specific points on the human anatomy. A prospective, randomized and ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/s1808-8694(15)30053-7

    authors: Okada DM,Onishi ET,Chami FI,Borin A,Cassola N,Guerreiro VM

    更新日期:2006-03-01 00:00:00

  • Effect of hearing aids use on speech stimulus decoding through speech-evoked ABR.

    abstract:INTRODUCTION:The electrophysiological responses obtained with the complex auditory brainstem response (cABR) provide objective measures of subcortical processing of speech and other complex stimuli. The cABR has also been used to verify the plasticity in the auditory pathway in the subcortical regions. OBJECTIVE:To co...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2016.11.002

    authors: Leite RA,Magliaro FCL,Raimundo JC,Gândara M,Garbi S,Bento RF,Matas CG

    更新日期:2016-12-08 00:00:00

  • Use of Muller's maneuver in the evaluation of patients with sleep apnea--literature review.

    abstract:UNLABELLED:Sleep apnea-hypopnea syndrome was described twenty years ago, and since then there have been doubts and controversies regarding it. Fiberoptic nasopharyngoscopy with Muller's maneuver, first described by Borowieck and Sassin (1983), is among them. AIM:Careful literature review on Muller's maneuver, regardin...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:

    authors: Soares MC,Sallum AC,Gonçalves MT,Haddad FL,Gregório LC

    更新日期:2009-05-01 00:00:00

  • Temporal processing and long-latency auditory evoked potential in stutterers.

    abstract:INTRODUCTION:Stuttering is a speech fluency disorder, and may be associated with neuroaudiological factors linked to central auditory processing, including changes in auditory processing skills and temporal resolution. OBJECTIVE:To characterize the temporal processing and long-latency auditory evoked potential in stut...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2016.02.015

    authors: Prestes R,de Andrade AN,Santos RB,Marangoni AT,Schiefer AM,Gil D

    更新日期:2017-01-01 00:00:00

  • Anthropometric study of the caucasian nose in the city of Curitiba: relevance of population evaluation.

    abstract:INTRODUCTION:Norms and patterns of nasal esthetics are essential for an adequate preoperative evaluation and surgical programming. The esthetic nasal patterns used are a blend of artistic beauty ideals and tracings in models and celebrities. Because they do not consider population measures, they vary according to the p...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2017.06.004

    authors: Ballin AC,Carvalho B,Dolci JEL,Becker R,Berger C,Mocellin M

    更新日期:2018-01-01 00:00:00

  • Assessment of the auditory handicap in adults with unilateral hearing loss.

    abstract:UNLABELLED:Hearing impairment (HI) is characterized by unilateral hearing loss in one ear and can result in learning difficulties, language impairment and socio-emotional difficulties. To assess the perception of hearing handicap in adult subjects, patients with unilateral sensorineural HI, non-users of individual hear...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:

    authors: Araújo PG,Mondelli MF,Lauris JR,Richiéri-Costa A,Feniman MR

    更新日期:2010-05-01 00:00:00

  • Comparative study between pure tone audiometry and auditory steady-state responses in normal hearing subjects.

    abstract:INTRODUCTION:Auditory steady-state responses (ASSR) are an important tool to detect objectively frequency-specific hearing thresholds. Pure-tone audiometry is the gold-standard for hearing evaluation, although sometimes it may be inconclusive, especially in children and uncooperative adults. AIM:Compare pure tone thre...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.5935/1808-8694.20140009

    authors: Beck RM,Ramos BF,Grasel SS,Ramos HF,Moraes MF,Almeida ER,Bento RF

    更新日期:2014-01-01 00:00:00

  • Is there any association between Helicobacter pylori and otitis media with effusion?

    abstract:INTRODUCTION:It is proposed that Helicobacter pylori can be responsible for the development of otitis media with effusion. OBJECTIVE:The aim of this study is to investigate the prevalence of H. pylori in the adenoid tissue and fluid of the middle ear in patients who suffer from adenoid hyperplasia and otitis media wit...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2018.11.002

    authors: Damghani MA,Dehghan E

    更新日期:2020-01-01 00:00:00

  • Adherence of obstructive sleep apnea syndrome patients to continuous positive airway pressure in a public service.

    abstract:INTRODUCTION:The standard therapy for obstructive sleep apnea syndrome (OSAS) is continuous positive airway pressure (CPAP), but its correct and frequent use is essential to control the disease. PURPOSE:To analyze adherence to CPAP among patients with OSAS treated in a multidisciplinary outpatient clinic of a public t...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.5935/1808-8694.20140027

    authors: Queiroz DL,Yui MS,Braga AA,Coelho ML,Küpper DS,Sander HH,Almeida LA,Fernandes RM,Eckeli AL,Valera FC

    更新日期:2014-04-01 00:00:00

  • Evaluation of selective attention in patients with misophonia.

    abstract:INTRODUCTION:Misophonia is characterized by the aversion to very selective sounds, which evoke a strong emotional reaction. It has been inferred that misophonia, as well as tinnitus, is associated with hyperconnectivity between auditory and limbic systems. Individuals with bothersome tinnitus may have selective attenti...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2018.02.005

    authors: Silva FED,Sanchez TG

    更新日期:2019-01-01 00:00:00

  • A retrospective analysis of revision framework surgeries for unilateral vocal fold paralysis.

    abstract:INTRODUCTION:Revision framework surgeries might be required for unilateral vocal fold paralyses. However, outcomes and indications of revision surgeries have not been adequately documented. For a better understanding of indications for the procedure and to help in achieving better vocal outcomes, we performed a retrosp...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2020.11.016

    authors: Kishimoto Y,Hiwatashi N,Kawai Y,Fujimura S,Sogami T,Hayashi Y,Omori K

    更新日期:2020-12-26 00:00:00

  • Communication disorders in subjects with normal hearing: a behavioral and electrophysiological study.

    abstract:UNLABELLED:Hearing thresholds are not always predictive of performance in environments with reduced extrinsic redundancy. OBJECTIVE:To investigate the communication disorders reported by adults with normal hearing, and to assess their underlying conditions through behavioral and electrophysiological testing. METHOD:T...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.5935/1808-8694.20130012

    authors: Prestes MR,Feitosa MA,Sampaio AL,Carvalho Mde F

    更新日期:2013-01-01 00:00:00

  • Endoscopic endonasal technique: treatment of paranasal and anterior skull base malignancies.

    abstract:UNLABELLED:Technical and technological innovations have spearheaded the expansion of the indications for the use of endoscopic endonasal approaches to extirpate malignancies of the sinonasal tract and adjacent skull base. OBJECTIVE:Critical review of the available literature regarding the use of endoscopic endonasal a...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.5935/1808-8694.20130138

    authors: Kasemsiri P,Prevedello DM,Otto BA,Old M,Ditzel Filho L,Kassam AB,Carrau RL

    更新日期:2013-11-01 00:00:00

  • Factors influencing the development of otitis media among Sicilian children affected by upper respiratory tract infections.

    abstract:INTRODUCTION:Upper respiratory tract infection is a nonspecific term used to describe an acute infection involving the nose, paranasal sinuses, pharynx and larynx. Upper respiratory tract infections in children are often associated with Eustachian tube dysfunction and complicated by otitis media, an inflammatory proces...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.04.002

    authors: Martines F,Salvago P,Ferrara S,Messina G,Mucia M,Plescia F,Sireci F

    更新日期:2016-03-01 00:00:00

  • The relationship of the medial roof and the posterior wall of the maxillary sinus to the sphenoid sinus: a radiologic study.

    abstract:INTRODUCTION:The medial maxillary sinus roof is a ridge formed by the superior margin of the maxillary sinus antrostomy. The posterior wall of the maxillary sinus is always included in operative fields. OBJECTIVE:To perform a radiologic study assessing the utility of the medial maxillary sinus roof and the posterior w...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2016.04.007

    authors: Lee SJ

    更新日期:2017-01-01 00:00:00

  • Otologic and audiologic characteristics of type 2 diabetics in a tertiary health institution in Nigeria.

    abstract:INTRODUCTION:This cross-sectional comparative study was carried out at the Diabetes outpatient clinic of LAUTECH Teaching Hospital (LTH) Ogbomoso, Nigeria. OBJECTIVE:This study assessed patterns of otologic diseases and auditory acuity among type 2 diabetics and determinants of these findings among diabetics. METHODS...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.10.016

    authors: Adebola SO,Olamoyegun MA,Sogebi OA,Iwuala SO,Babarinde JA,Oyelakin AO

    更新日期:2016-09-01 00:00:00

  • The basaloid variant of squamous cell carcinoma of the larynx.

    abstract:INTRODUCTION:Basaloid squamous cell carcinoma (BSCC) is a rare subtype of squamous cell carcinoma (SCC). Because of its rarity, both clinical and prognostic features of this variant are not well known. OBJECTIVE:In this study, we aimed to determine the frequency of BSCC and other SCC variants among all laryngeal SCC c...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2014.02.005

    authors: Tutar H,Aydil U,Ekinci O,Bakkal FK,Tutar VB,Kizil Y,Ugur MB

    更新日期:2014-05-01 00:00:00

  • Behavioral and histologic experimental model of facial nerve regeneration in rats.

    abstract:UNLABELLED:To setup an experimental model is the first step to study neural regeneration. AIM:Setting up an experimental model on facial nerve regeneration. MATERIAL AND METHODS:Wistar rats with complete sectioning and suturing of the extratemporal facial nerve trunk; with a behavioral and histological analysis for 9...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:

    authors: Borin A,Toledo RN,Faria SD,Testa JR,Cruz OL

    更新日期:2006-11-01 00:00:00

  • Treatment of tympanic membrane perforation using bacterial cellulose: a randomized controlled trial.

    abstract:INTRODUCTION:Promising treatments for tympanic membrane perforation closure have been studied. Therapies derived from tissue engineering probably eliminate the need for conventional surgery. Bacterial cellulose is presented as an alternative that is safe, biocompatible, and has low toxicity. OBJECTIVES:To investigate ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bjorl.2015.03.015

    authors: Silveira FC,Pinto FC,Caldas Neto Sda S,Leal Mde C,Cesário J,Aguiar JL

    更新日期:2016-03-01 00:00:00

  • Frontonasal dysplasia: clinical evaluation on audiological and brainstem electrophysiological profiles.

    abstract:UNLABELLED:Frontonasal dysplasia (FND) is a rare malformative complex affecting the frontal portion of the face, the eyes and the nose; it may occur singly or associated with other clinical signs. No systematic studies describing hearing in this condition were found. AIM:To evaluate hearing sensitivity and sound stimu...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1590/s1808-86942011000500013

    authors: Antoneli MZ,Giacheti CM,Genaro KF,Zorzetto NL,Richieri-Costa A

    更新日期:2011-09-01 00:00:00

  • Results of endoscopic transcanal tympanoplasty performed by a young surgeon in a secondary hospital.

    abstract:INTRODUCTION:Tympanoplasty is performed to close the tympanic membrane perforation and recover the hearing level of patients with non-suppurative chronic otitis media. Endoscopic tympanoplasty has recently been increasingly preferred by ear nose and throat surgeons to treat tympanic membrane perforations. OBJECTIVE:Th...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2018.12.012

    authors: Gokgoz MC,Tasli H,Helvacioglu B

    更新日期:2020-01-01 00:00:00

  • Comparison: real and simulated ear insertion gain.

    abstract:UNLABELLED:The development of hearing aid (HA) software programming does not replace the analysis of real ears with probe microphones. AIM:To compare simulated insertion gain in HA software programming and real ear insertion gain. METHOD:A prospective study of 62 patients (aged from 29 to 93 years; 30 male and 32 fem...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1590/s1808-86942011000500003

    authors: Campos PD,Mondelli MF,Ferrari DV

    更新日期:2011-09-01 00:00:00

  • Mastication and deglutition changes in children with tonsillar hypertrophy.

    abstract:UNLABELLED:The changes in mastication and deglutition in children with adenotonsillar hypertrophy need to be better characterized. OBJECTIVE:To evaluate the frequency of parent-reported myofunctional changes and to determine if there are differences in the alteration patterns of children with adenotonsillar hypertroph...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.5935/1808-8694.20130076

    authors: Souza JF,Grechi TH,Anselmo-Lima WT,Trawitzki LV,Valera FC

    更新日期:2013-08-01 00:00:00

  • The role of tumor necrosis factor-alpha (TNF-alpha) in bone resorption present in middle ear cholesteatoma.

    abstract:UNLABELLED:Cholesteatoma may cause bone erosion, with high morbidity and mortality rates. Tumor necrosis factor-alpha (TNF-a) is one of the main cytokines involved in this process. Our goal was to evaluate the role of TNF-a in Bone Resorption and its effect on cholesteatoma. MATERIAL AND METHODS:analysis and critical ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章,评审

    doi:10.1016/s1808-8694(15)31133-2

    authors: Vitale RF,Ribeiro Fde A

    更新日期:2007-01-01 00:00:00

  • Molecular approach of auditory neuropathy.

    abstract:INTRODUCTION:Mutations in the otoferlin gene are responsible for auditory neuropathy. OBJECTIVE:To investigate the prevalence of mutations in the mutations in the otoferlin gene in patients with and without auditory neuropathy. METHODS:This original cross-sectional case study evaluated 16 index cases with auditory ne...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.03.005

    authors: Silva MA,Piatto VB,Maniglia JV

    更新日期:2015-05-01 00:00:00

  • Auditory brainstem response in gas station attendants.

    abstract:UNLABELLED:Ototoxicity of organic solvents can affect the hearing system up to the cochlea level and the central structures of hearing. OBJECTIVE:To evaluate the neurophysiological integrity of the hearing system in subjects exposed to fuels using ABR. METHOD:Prospective study. We evaluated attendants from three gas ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.5935/1808-8694.20120035

    authors: Quevedo Lda S,Tochetto T,Siqueira MA,Machado MS

    更新日期:2012-12-01 00:00:00

  • Diagnostic validity of methods for assessment of swallowing sounds: a systematic review.

    abstract:INTRODUCTION:Oropharyngeal dysphagia is a highly prevalent comorbidity in neurological patients and presents a serious health threat, which may lead to outcomes of aspiration pneumonia, ranging from hospitalization to death. This assessment proposes a non-invasive, acoustic-based method to differentiate between individ...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2017.12.008

    authors: Taveira KVM,Santos RS,Leão BLC,Stechman Neto J,Pernambuco L,Silva LKD,De Luca Canto G,Porporatti AL

    更新日期:2018-01-01 00:00:00

  • Prevalence of depressive symptoms in patients with cleft lip and palate.

    abstract:INTRODUCTION:Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face. OBJECTIVE:To evaluate the prevalence of depressive symptoms in children and adolescents with nonsyndromic cleft lip and/or palate (nsCL/P). METHODS:We conducted an observational, case-control study, with a case stu...

    journal_title:Brazilian journal of otorhinolaryngology

    pub_type: 杂志文章

    doi:10.1016/j.bjorl.2015.01.004

    authors: Lima LS,Ribeiro GS,Aquino SN,Volpe FM,Martelli DR,Swerts MS,Paranaíba LM,Martelli Júnior H

    更新日期:2015-03-01 00:00:00