Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults.


:The gut microbiota contributes to host energy metabolism, and altered gut microbiota has been associated with obesity-related metabolic disorders. We previously reported that a probiotic alone or together with a prebiotic controls body fat mass in healthy overweight or obese individuals in a randomised, double-blind, placebo controlled clinical study ( NCT01978691). We now aimed to investigate whether changes in the gut microbiota may be associated with the observed clinical benefits. Faecal and plasma samples were obtained from a protocol compliant subset (n=134) of participants from a larger clinical study where participants were randomised (1:1:1:1) into four groups: (1) placebo, 12 g/d microcrystalline cellulose; (2) Litesse® Ultra™ polydextrose (LU), 12 g/day; (3) Bifidobacterium animalis subsp. lactis 420™ (B420), 1010 cfu/d in 12 g microcrystalline cellulose; (4) LU+B420, 1010 cfu/d of B420 in 12 g/d LU for 6 months of intervention. The faecal microbiota composition and metabolites were assessed as exploratory outcomes at baseline, 2, 4, 6 months, and +1 month post-intervention and correlated to obesity-related clinical outcomes. Lactobacillus and Akkermansia were more abundant with B420 at the end of the intervention. LU+B420 increased Akkermansia, Christensenellaceae and Methanobrevibacter, while Paraprevotella was reduced. Christensenellaceae was consistently increased in the LU and LU+B420 groups across the intervention time points, and correlated negatively to waist-hip ratio and energy intake at baseline, and waist-area body fat mass after 6 months treatment with LU+B420. Functional metagenome predictions indicated alterations in pathways related to cellular processes and metabolism. Plasma bile acids glycocholic acid, glycoursodeoxycholic acid, and taurohyodeoxycholic acid and tauroursodeoxycholic acid were reduced in LU+B420 compared to Placebo. Consumption of B420 and its combination with LU resulted in alterations of the gut microbiota and its metabolism, and may support improved gut barrier function and obesity-related markers.


Benef Microbes


Beneficial microbes


Hibberd AA,Yde CC,Ziegler ML,Honoré AH,Saarinen MT,Lahtinen S,Stahl B,Jensen HM,Stenman LK




Has Abstract


2019-03-13 00:00:00












  • Are probiotic treatments useful on fibromyalgia syndrome or chronic fatigue syndrome patients? A systematic review.

    abstract::Evidence suggests that the gut microbiota might play an important role in fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). Our goal is to systematically review the reported effect of probiotic treatments in patients diagnosed with FMS or CFS. A systematic review was carried out using 14 databases (PubMe...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Roman P,Carrillo-Trabalón F,Sánchez-Labraca N,Cañadas F,Estévez AF,Cardona D

    更新日期:2018-06-15 00:00:00

  • Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 assimilate cholesterol and modulate ABCA1, CD36, NPC1L1 and SCARB1 in vitro.

    abstract::There is growing interest in the use of probiotic lactic acid bacteria (LAB) for prevention of hypercholesterolaemia. This study assessed the cholesterol lowering ability of Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in growth media. Both LAB yielded >98% (39.2 μg/ml) cholesterol lowering in growt...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Lim FT,Lim SM,Ramasamy K

    更新日期:2017-02-07 00:00:00

  • Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis.

    abstract::Gut microbiota and gut-associated lymphoid tissue have been increasingly appreciated as important players in pathogenesis of various autoimmune diseases, including multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that can be induced with an injection of spina...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Stanisavljević S,Lukić J,Momčilović M,Miljković M,Jevtić B,Kojić M,Golić N,Mostarica Stojković M,Miljković D

    更新日期:2016-06-01 00:00:00

  • Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics.

    abstract::The metabolic end products of the large bowel microbiota contribute significantly to human health. After weaning to solid foods, some of the most important of these are the short chain fatty acids (SCFA) produced by the fermentation of undigested dietary components and endogenous secretions. The main SCFA are acetate,...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审


    authors: Bird AR,Conlon MA,Christophersen CT,Topping DL

    更新日期:2010-11-01 00:00:00

  • Lactobacillus acidophilus and Clostridium butyricum ameliorate colitis in murine by strengthening the gut barrier function and decreasing inflammatory factors.

    abstract::Ulcerative colitis is a type of chronic inflammation present in the intestines for which the aetiology is not yet clear. The current therapies for ulcerative colitis cannot be considered to be long-term management strategies due to their significant side effects. Therefore, it is essential to identify an alternative t...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Wang Y,Gu Y,Fang K,Mao K,Dou J,Fan H,Zhou C,Wang H

    更新日期:2018-09-18 00:00:00

  • Propionic acid and its esterified derivative suppress the growth of methicillin-resistant Staphylococcus aureus USA300.

    abstract::Previously, we demonstrated that Propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. Propionic acid suppressed the growth of Staphylococcus aureus USA300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. In this...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Wang Y,Dai A,Huang S,Kuo S,Shu M,Tapia CP,Yu J,Two A,Zhang H,Gallo RL,Huang CM

    更新日期:2014-06-01 00:00:00

  • Probiotic properties of native Lactobacillus spp. strains for dairy calves.

    abstract::The use of native microorganisms with probiotic capacity is an alternative tool for the treatment and prevention of several diseases that affect animals, such as neonatal calf diarrhoea. The selection of probiotic strains within a collection is based on different in vitro and in vivo assays, which predict their potent...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Fernández S,Fraga M,Silveyra E,Trombert AN,Rabaza A,Pla M,Zunino P

    更新日期:2018-06-15 00:00:00

  • Consumer perception of beneficial effects of probiotics for human health.

    abstract::The purpose of this study was to evaluate the knowledge, perception and buying behaviour of probiotics. 72 participants in Middelburg, the Netherlands, filled out a detailed questionnaire regarding probiotics and their customer and consumer behaviour. It can be concluded from this study that the concept of probiotics ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Rijkers GT,Bimmel D,Grevers D,den Haan N,Hristova Y

    更新日期:2013-03-01 00:00:00

  • Persistent infection by Salmonella enterica servovar Typhimurium: are synbiotics a therapeutic option? - a case report.

    abstract::Little is known about the prevalence of persistent human infections by nontyphoidal Salmonella (NTS). Recently published study results indicate that a small fraction (at least 2.2%) of NTS-infected patients continue to shed Salmonella for an extended period of time (up to years). Despite the recommendation not to use ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Piatek J,Sommermeyer H,Bernatek M,Ciechelska-Rybarczyk A,Oleskow B,Mikkelsen LS,Barken KB

    更新日期:2019-03-13 00:00:00

  • The administration of probiotics and synbiotics in immune compromised adults: is it safe?

    abstract::This study aimed to systematically evaluate safety of probiotics and synbiotics in immune compromised adults (≥18 years). Safety was analysed using the Common Terminology Clinical Adverse Events (CTCAE version 4.0) classification, thereby providing an update on previous reports using the most recent available clinical...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Van den Nieuwboer M,Brummer RJ,Guarner F,Morelli L,Cabana M,Claasen E

    更新日期:2015-03-01 00:00:00

  • Identification and characterisation of lactobacilli isolated from Kimere, a spontaneously fermented pearl millet dough from Mbeere, Kenya (East Africa).

    abstract::The objective of the study was to isolate potential probiotic lactobacilli from Kimere, a pearl millet dough prepared in the Mbeere community of Kenya, East Africa, by fermentation for 18-24 hours. Kimere samples, collected from 11 different homesteads in Mbeere, showed average pH values of 3.63±0.29. Counts of presum...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Njeru PN,Rösch N,Ghadimi D,Geis A,Bockelmann W,de Vrese M,Schrezenmeir J,Heller KJ

    更新日期:2010-09-01 00:00:00

  • The use of konjac glucomannan hydrolysates to recover healthy microbiota in infected vaginas treated with an antifungal agent.

    abstract::The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assi...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,随机对照试验


    authors: Tester R,Al-Ghazzewi F,Shen N,Chen Z,Chen F,Yang J,Zhang D,Tang M

    更新日期:2012-03-01 00:00:00

  • Regulation of TLR4, p38 MAPkinase, IκB and miRNAs by inactivated strains of lactobacilli in human dendritic cells.

    abstract::Strain specific properties of probiotics in providing supportive health effects in the immune system and the gastrointestinal tract have been widely investigated in vivo and in vitro. However, the underlying responsible mechanism is poorly described. By unravelling the probiotic-induced responses in a complex network ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Giahi L,Aumueller E,Elmadfa I,Haslberger AG

    更新日期:2012-06-01 00:00:00

  • Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome.

    abstract::Faecal microbiota transfer (FMT) consists of the infusion of donor faecal material into the intestine of a patient with the aim to restore a disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on faecal microbial composition, its functional capacity, faecal metabolite profiles and th...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Holster S,Repsilber D,Geng D,Hyötyläinen T,Salonen A,Lindqvist CM,Rajan SK,de Vos WM,Brummer RJ,König J

    更新日期:2020-12-22 00:00:00

  • Effect of Saccharomyces cerevisiae strain UFMG A-905 in experimental model of inflammatory bowel disease.

    abstract::In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used: not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-9...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Tiago FC,Porto BA,Ribeiro NS,Moreira LM,Arantes RM,Vieira AT,Teixeira MM,Generoso SV,Nascimento VN,Martins FS,Nicoli JR

    更新日期:2015-01-01 00:00:00

  • Increased bacterial putrescine has no impact on gut morphology and physiology in gnotobiotic adolescent mice.

    abstract::Gut bacteria influence host anatomy and physiology. It has been proposed that bacterial metabolites including polyamines are responsible for intestinal maturation and mucosal growth. We have hypothesised that bacterially produced polyamines act as trophic factors and thereby influence large intestinal crypt depth and ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Slezak K,Hanske L,Loh G,Blaut M

    更新日期:2013-09-01 00:00:00

  • Isolation and structural identification of glycopolymers of Bifidobacterium bifidum BIM B-733D as putative players in pathogenesis of autoimmune thyroid diseases.

    abstract::Bifidobacterium bifidum 791 (commercially available as B. bifidum BIM B-733D) cell-surface biopolymers (BPs) interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti TPO and anti Tg, respectively). BPanti-TPO and BPanti-Tg were isolated from the soluble fraction of B. ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Kiseleva EP,Mikhailopulo KI,Novik GI,Szwajcer Dey E,Zdorovenko EL,Shashkov AS,Knirel YA

    更新日期:2013-12-01 00:00:00

  • On the importance of intraindividual variation in nutritional research.

    abstract::Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be in...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Larsen OFA,Claassen E,Brummer RJ

    更新日期:2020-10-12 00:00:00

  • Probiotic modulation of dendritic cells and T cell responses in the intestine.

    abstract::Over the past decade it has become clear that probiotic and commensal interactions with mucosal dendritic cells in the lamina propria or epithelial cells lining the mucosa can modulate specific functions of the mucosal immune system. Innate pattern-recognition receptors such as TLRs, NLRs and CLRs play a crucial role ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审


    authors: Meijerink M,Wells JM

    更新日期:2010-11-01 00:00:00

  • Treatment with Bifidobacterium longum 51A attenuates intestinal damage and inflammatory response in experimental colitis.

    abstract::This study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received Bi...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Abrantes FA,Nascimento BB,Andrade MER,de Barros PAV,Cartelle CT,Martins FS,Nicoli JR,Arantes RME,Generoso SV,Fernandes SOA,Cardoso VN

    更新日期:2020-02-19 00:00:00

  • Prebiotics to manage the microbial control of energy homeostasis.

    abstract::The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审


    authors: Grootaert C,Marzorati M,Van den Abbeele P,Van de Wiele T,Possemiers S

    更新日期:2011-12-01 00:00:00

  • Foreword: all things considered about probiotics, prebiotics and ıntestinal microbiota in children - from bench to bedside.

    abstract::There are numerorus published and ongoing experimental/clinical studies about probiotics and prebiotics, intestinal microbiota and nutrition. Three years ago, at the first International Symposium of Probiotics Prebiotics in Paediatrics in Istanbul (2012) we highlighted the 'paediatric perspective' on these issues and ...

    journal_title:Beneficial microbes



    authors: Ozen M,Dinleyici EC

    更新日期:2015-01-01 00:00:00

  • Saccharomyces boulardii CNCM I-745 changes lipidemic profile and gut microbiota in a hamster hypercholesterolemic model.

    abstract::Hypercholesterolemia is a main risk factor of cardiovascular disease. Probiotics are a safe approach to reduce elevated cholesterol without any deleterious effect to human health. Saccharomyces boulardii CNCM I-745 probiotic properties are well documented in a context of intestinal dysbiosis. Recent in vitro and precl...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Briand F,Sulpice T,Giammarinaro P,Roux X

    更新日期:2019-05-28 00:00:00

  • Mechanisms and immunomodulatory properties of pre- and probiotics.

    abstract::The human body is exposed to many xenobiotic, potentially harmful compounds. The intestinal immune system is crucial in protecting the human body from these substances. Moreover, many microorganisms, residing in the gastrointestinal tract, play an important role in modulating immune responses. Pre- and probiotics may ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审


    authors: Peters VBM,van de Steeg E,van Bilsen J,Meijerink M

    更新日期:2019-04-19 00:00:00

  • In vitro evaluation of Bifidobacterium strains of human origin for potential use in probiotic functional foods.

    abstract::The present study investigated some in vitro properties for probiotic use of four strains of bifidobacteria isolated from faeces of healthy children (Bifidobacterium longum 51A, Bifidobacterium breve 1101A, Bifidobacterium pseudolongum 1191A and Bifidobacterium bifidum 1622A). In vitro tests were carried out to compar...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Souza TC,Silva AM,Drews JR,Gomes DA,Vinderola CG,Nicoli JR

    更新日期:2013-06-01 00:00:00

  • The effects of the Lactobacillus casei strain on obesity in children: a pilot study.

    abstract::There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and orga...

    journal_title:Beneficial microbes

    pub_type: 临床试验,杂志文章


    authors: Nagata S,Chiba Y,Wang C,Yamashiro Y

    更新日期:2017-08-24 00:00:00

  • Association of life habits and fermented milk intake with stool frequency, defecatory symptoms and intestinal microbiota in healthy Japanese adults.

    abstract::Few studies have examined the effects of smoking habit, the frequency of alcohol drinking, exercise, and fermented milk consumption on defecatory symptoms and gut microbiota composition, and particularly their interactive effects. We examined the effect of these lifestyle factors on bowel movements and gut microbiota ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Shima T,Amamoto R,Kaga C,Kado Y,Sasai T,Watanabe O,Shiinoki J,Iwazaki K,Shigemura H,Tsuji H

    更新日期:2019-12-09 00:00:00

  • The serotonin receptor mediates changes in autonomic neurotransmission and gastrointestinal transit induced by heat-killed Lactobacillus brevis SBC8803.

    abstract::Lactobacilli exhibit several health benefits in mammals, including humans. Our previous reports established that heat-killed Lactobacillus brevis SBC8803 (SBC8803) increased both efferent gastric vagal nerve activity and afferent intestinal vagal nerve activity in rats. We speculated that this strain could be useful f...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Horii Y,Nakakita Y,Misonou Y,Nakamura T,Nagai K

    更新日期:2015-01-01 00:00:00

  • Screening for lactic acid bacteria capable of inhibiting Campylobacter jejuni in in vitro simulations of the broiler chicken caecal environment.

    abstract::Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim o...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Robyn J,Rasschaert G,Messens W,Pasmans F,Heyndrickx M

    更新日期:2012-12-01 00:00:00

  • Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions.

    abstract::Obesity is highly correlated with the dysbiosis of intestinal microbiota, and bifidobacteria are one of the soft targets of this metabolic syndrome. The aim of this study is to evaluate the efficacy of Bifidobacterium sp. MKK4 and rice-based fermented foods on physical, haematological, gut microbiota and lypogenic-lyp...

    journal_title:Beneficial microbes

    pub_type: 杂志文章


    authors: Ray M,Hor PK,Ojha D,Soren JP,Singh SN,Mondal KC

    更新日期:2018-04-25 00:00:00