Ultra-Low-Dose 18F-Florbetaben Amyloid PET Imaging Using Deep Learning with Multi-Contrast MRI Inputs.


:Purpose To reduce radiotracer requirements for amyloid PET/MRI without sacrificing diagnostic quality by using deep learning methods. Materials and Methods Forty data sets from 39 patients (mean age ± standard deviation [SD], 67 years ± 8), including 16 male patients and 23 female patients (mean age, 66 years ± 6 and 68 years ± 9, respectively), who underwent simultaneous amyloid (fluorine 18 [18F]-florbetaben) PET/MRI examinations were acquired from March 2016 through October 2017 and retrospectively analyzed. One hundredth of the raw list-mode PET data were randomly chosen to simulate a low-dose (1%) acquisition. Convolutional neural networks were implemented with low-dose PET and multiple MR images (PET-plus-MR model) or with low-dose PET alone (PET-only) as inputs to predict full-dose PET images. Quality of the synthesized images was evaluated while Bland-Altman plots assessed the agreement of regional standard uptake value ratios (SUVRs) between image types. Two readers scored image quality on a five-point scale (5 = excellent) and determined amyloid status (positive or negative). Statistical analyses were carried out to assess the difference of image quality metrics and reader agreement and to determine confidence intervals (CIs) for reading results. Results The synthesized images (especially from the PET-plus-MR model) showed marked improvement on all quality metrics compared with the low-dose image. All PET-plus-MR images scored 3 or higher, with proportions of images rated greater than 3 similar to those for the full-dose images (-10% difference [eight of 80 readings], 95% CI: -15%, -5%). Accuracy for amyloid status was high (71 of 80 readings [89%]) and similar to intrareader reproducibility of full-dose images (73 of 80 [91%]). The PET-plus-MR model also had the smallest mean and variance for SUVR difference to full-dose images. Conclusion Simultaneously acquired MRI and ultra-low-dose PET data can be used to synthesize full-dose-like amyloid PET images. © RSNA, 2018 Online supplemental material is available for this article. See also the editorial by Catana in this issue.






Chen KT,Gong E,de Carvalho Macruz FB,Xu J,Boumis A,Khalighi M,Poston KL,Sha SJ,Greicius MD,Mormino E,Pauly JM,Srinivas S,Zaharchuk G




Has Abstract


2019-03-01 00:00:00












  • Cervical radiculopathy: value of oblique MR imaging.

    abstract::Eighteen patients with cervical radiculopathy were entered into a prospective study to compare the accuracy of surface coil magnetic resonance (MR) imaging with that of metrizamide myelography and computed tomography (CT) with metrizamide. All MR studies included tailored axial and oblique images as well as routine sa...


    pub_type: 杂志文章


    authors: Modic MT,Masaryk TJ,Ross JS,Mulopulos GP,Bundschuh CV,Bohlman H

    更新日期:1987-04-01 00:00:00

  • The year 2000 threat: preparing radiology for nine realms of risk.

    abstract::The year 2000 computer problem arises from a long-standing and often-duplicated computer programming error. Affected programs use only two digits to represent years, which may lead to a variety of computer malfunctions and data errors related to crossing from 1999 (99) to 2000 (00), at which point computers may interp...


    pub_type: 杂志文章


    authors: Berland LL

    更新日期:1999-01-01 00:00:00

  • Hydatid cyst of the skull: report of four cases.

    abstract::Four new cases of cranial echinococcosis are presented and the literature is reviewed. Young males are most commonly affected. Early cases present as an expansile osteolytic lesion in the diploe. The more advanced forms manifest as multilocular or unilocular destructive lesions with adjacent soft-tissue masses. Two pa...


    pub_type: 杂志文章


    authors: Teymoorian GA,Bagheri F

    更新日期:1976-01-01 00:00:00

  • Dutch iliac stent trial: long-term results in patients randomized for primary or selective stent placement.

    abstract:PURPOSE:To determine long-term results of the prospective Dutch Iliac Stent Trial. MATERIALS AND METHODS:The study protocol was approved by local institutional review boards. All patients gave written informed consent. Two hundred seventy-nine patients (201 men, 78 women; mean age, 58 years) with iliac artery disease ...


    pub_type: 杂志文章,随机对照试验


    authors: Klein WM,van der Graaf Y,Seegers J,Spithoven JH,Buskens E,van Baal JG,Buth J,Moll FL,Overtoom TT,van Sambeek MR,Mali WP

    更新日期:2006-02-01 00:00:00

  • T1 hyperintense renal lesions: characterization with diffusion-weighted MR imaging versus contrast-enhanced MR imaging.

    abstract:PURPOSE:To compare the performance of apparent diffusion coefficient (ADC) measurement obtained with diffusion-weighted (DW) magnetic resonance (MR) imaging in the characterization of non-fat-containing T1 hyperintense renal lesions with that of contrast material-enhanced MR imaging, with histopathologic analysis and f...


    pub_type: 杂志文章


    authors: Kim S,Jain M,Harris AB,Lee VS,Babb JS,Sigmund EE,Rueff LE,Taouli B

    更新日期:2009-06-01 00:00:00

  • Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy.

    abstract:PURPOSE:To investigate the clinical parameters that are associated with the development of brain edema of hypertensive encephalopathy in patients with preeclampsia-eclampsia. MATERIALS AND METHODS:Twenty-eight patients with preeclampsia-eclampsia and neurologic symptoms underwent magnetic resonance (MR) imaging. Clini...


    pub_type: 杂志文章


    authors: Schwartz RB,Feske SK,Polak JF,DeGirolami U,Iaia A,Beckner KM,Bravo SM,Klufas RA,Chai RY,Repke JT

    更新日期:2000-11-01 00:00:00

  • Stent placement for renal arterial stenosis: where do we stand? A meta-analysis.

    abstract:PURPOSE:To perform a meta-analysis of renal arterial stent placement in comparison with renal percutaneous transluminal angioplasty (PTA) in patients with renal arterial stenosis. MATERIALS AND METHODS:Studies dealing with renal arterial stent placement (14 articles; 678 patients) and renal PTA (10 articles; 644 patie...


    pub_type: 杂志文章,meta分析


    authors: Leertouwer TC,Gussenhoven EJ,Bosch JL,van Jaarsveld BC,van Dijk LC,Deinum J,Man In 't Veld AJ

    更新日期:2000-07-01 00:00:00

  • Kidney function: glomerular filtration rate measurement with MR renography in patients with cirrhosis.

    abstract:PURPOSE:To assess the accuracy of glomerular filtration rate (GFR) measurements obtained with low-contrast agent dose dynamic contrast material-enhanced magnetic resonance (MR) renography in patients with liver cirrhosis who underwent routine liver MR imaging, with urinary clearance of technetium 99m ((99m)Tc) pentetic...


    pub_type: 杂志文章


    authors: Vivier PH,Storey P,Rusinek H,Zhang JL,Yamamoto A,Tantillo K,Khan U,Lim RP,Babb JS,John D,Teperman LW,Chandarana H,Friedman K,Benstein JA,Skolnik EY,Lee VS

    更新日期:2011-05-01 00:00:00

  • US of the painful hip in childhood: diagnostic value of cartilage thickening and muscle atrophy in the detection of Perthes disease.

    abstract:PURPOSE:To evaluate the combined use of several ultrasonographic (US) criteria in the detection of Perthes disease. MATERIALS AND METHODS:In a prospective study, 144 consecutive children with a painful hip underwent US. The thicknesses of the (a) anterior recess of the joint capsule, (b) cartilage of the femoral head,...


    pub_type: 杂志文章


    authors: Robben SG,Meradji M,Diepstraten AF,Hop WC

    更新日期:1998-07-01 00:00:00

  • Stereotactic core biopsy breast and blood cell by-products: a source of material for molecular genetics research--initial experience.

    abstract::Stereotactic core biopsy washings and blood drop samples, routinely discarded by-products, provide satisfactory fresh cellular material for flow cytometry and molecular genetics microsatellite polymerase chain reaction (PCR) analysis for detection of loss of DNA alleles (loss of heterozygosity). Cytokeratin-positive (...


    pub_type: 杂志文章


    authors: Stomper PC,Stewart CC,Stoler DL

    更新日期:2001-03-01 00:00:00

  • Breast cancer screening: first round in the population-based program in Valencia, Spain. Collaborative Group of Readers of the Breast Cancer Screening Program of the Valencia Community.

    abstract:PURPOSE:To analyze the results of round 1 of the population-based Valencia Breast Cancer Screening Program. MATERIALS AND METHODS:In this program, 78,224 (72.98%) of the 107,178 women invited (aged 45-65 years) underwent screening. Complementary views were obtained in 5,771 women (7.38%). Among the total population st...


    pub_type: 杂志文章


    authors: Vizcaíno I,Salas D,Vilar JS,Ruiz-Perales F,Herranz C,Ibáñez J

    更新日期:1998-01-01 00:00:00

  • Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: technique and prospective results.

    abstract:PURPOSE:To evaluate magnetic resonance (MR) imaging-guided laser-induced thermotherapy (LITT) of liver metastases. MATERIALS AND METHODS:In a phase II study, 20 patients with 33 metastases from colorectal carcinoma (75%) or other primary tumors (25%) underwent LITT. MR thermometry performed with fast low-angle shot se...


    pub_type: 临床试验,杂志文章


    authors: Vogl TJ,Müller PK,Hammerstingl R,Weinhold N,Mack MG,Philipp C,Deimling M,Beuthan J,Pegios W,Riess H

    更新日期:1995-07-01 00:00:00

  • Imaging of Brown Adipose Tissue: State of the Art.

    abstract::The rates of diabetes, obesity, and metabolic disease have reached epidemic proportions worldwide. In recent years there has been renewed interest in combating these diseases not only by modifying energy intake and lifestyle factors, but also by inducing endogenous energy expenditure. This approach has largely been st...


    pub_type: 杂志文章,评审


    authors: Sampath SC,Sampath SC,Bredella MA,Cypess AM,Torriani M

    更新日期:2016-07-01 00:00:00

  • Cytotoxic and radiosensitizing effects of 5-thio-D-glucose on hypoxic cells.

    abstract::The effect of 5-thio-D-glucose on the viability and radiosensitivity of P815-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells; moreover, it sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These featur...


    pub_type: 杂志文章


    authors: Song CW,Clement JJ,Levitt SH

    更新日期:1977-04-01 00:00:00

  • Measurement of the velocity of ultrasound in human cortical bone in vivo. Estimation of its potential value in the diagnosis of osteoporosis and metabolic bone disease.

    abstract::Using a method combining the velocity of ultrasound and photon absorptiometry in the human radius in vivo, the authors measured the speed of sound in bone (U) and bone mineral content (BMC). From these measurements and a "simple" bone model, they then computed the bone mineral density, compact bone density, and modulu...


    pub_type: 杂志文章


    authors: Greenfield MA,Craven JD,Huddleston A,Kehrer ML,Wishko D,Stern R

    更新日期:1981-03-01 00:00:00

  • Hepatic perfusion disorder associated with focal liver lesions: contrast-enhanced US patterns--correlation study with contrast-enhanced CT.

    abstract:PURPOSE:To retrospectively compare the detection and characterization of hepatic perfusion disorder (HPD) associated with focal liver lesions (FLLs) at contrast material-enhanced ultrasonography (US) by using contrast-enhanced computed tomography (CT) as the reference standard. MATERIALS AND METHODS:The study was appr...


    pub_type: 杂志文章


    authors: Zhou X,Luo Y,Peng YL,Cai W,Lu Q,Lin L,Sha XX,Li YZ,Zhu M

    更新日期:2011-07-01 00:00:00

  • CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke.

    abstract:PURPOSE:To measure mean cerebral blood flow (CBF) in ischemic and nonischemic territories and in low-attenuation regions in patients with acute stroke by using deconvolution-derived hemodynamic imaging. MATERIALS AND METHODS:Twelve patients with acute middle cerebral artery stroke and 12 control patients were examined...


    pub_type: 杂志文章


    authors: Eastwood JD,Lev MH,Azhari T,Lee TY,Barboriak DP,Delong DM,Fitzek C,Herzau M,Wintermark M,Meuli R,Brazier D,Provenzale JM

    更新日期:2002-01-01 00:00:00

  • Right atrial MR imaging studies of cadaveric atrial casts and comparison with right and left atrial volumes and function in healthy subjects.

    abstract:PURPOSE:To assess magnetic resonance (MR) imaging of the right atrium by measuring volumes of right atrial casts and determining right atrial volume cycles in healthy subjects. MATERIALS AND METHODS:Fourteen human cadaveric atrial casts were imaged and right atrial volumes of eight subjects were measured with cardiac-...


    pub_type: 杂志文章


    authors: Järvinen VM,Kupari MM,Hekali PE,Poutanen VP

    更新日期:1994-04-01 00:00:00

  • Hemorrhage in intracerebral arteriovenous malformations: angiographic determinants.

    abstract::The most serious and frequent complication of intracranial arteriovenous malformations (AVMs) is intracranial hemorrhage. Identification of patients at greatest risk for intracranial bleeding would be beneficial. Detailed analysis of vascular architecture was performed in 65 patients with intracranial AVMs to identify...


    pub_type: 杂志文章


    authors: Marks MP,Lane B,Steinberg GK,Chang PJ

    更新日期:1990-09-01 00:00:00

  • Paratracheal lymphadenopathy: radiographic findings and correlation with CT.

    abstract::Possible signs of paratracheal lymphadenopathy on the posteroanterior (PA) chest radiograph were assessed in 98 patients and correlated with computed tomography (CT). The nodes were normal in size in 62 patients and enlarged (greater than 15 mm) in 36. Among the latter group, widening of the right paratracheal stripe ...


    pub_type: 杂志文章


    authors: Müller NL,Webb WR,Gamsu G

    更新日期:1985-09-01 00:00:00

  • Brodie abscess: reappraisal.

    abstract::Upon review, 25 cases of Brodie abscess demonstrated a radiological spectrum not previously appreciated. One third of the lesions were diaphyseal in location, and 50% had associated cortical thickening, while 40% showed a stimulated periosteal reaction, and 20% contained sequestra. The variable radiological appearance...


    pub_type: 杂志文章


    authors: Miller WB Jr,Murphy WA,Gilula LA

    更新日期:1979-07-01 00:00:00

  • MR colonography: development of optimized method with ex vivo and in vivo systems.

    abstract::An ex vivo magnetic resonance (MR) colonographic system with a bovine colon with polyps of predetermined dimensions was developed for evaluation and optimization of different combinations of imaging sequences and intraluminal contrast agents. Findings were then applied during in vivo testing in human subjects. The res...


    pub_type: 杂志文章


    authors: Martin DR,Yang M,Thomasson D,Acheson C

    更新日期:2002-11-01 00:00:00

  • Intracranial hemorrhage: gradient-echo MR imaging at 1.5 T. Comparison with spin-echo imaging and clinical applications.

    abstract::Fifty-seven patients with hemorrhagic intracranial lesions were examined with magnetic resonance (MR) imaging at 1.5 T with use of both spin-echo (SE) and gradient-echo-acquisition (GEA) techniques to assess the clinical applications and limitations of GEA in evaluation of intracranial hemorrhage at high field strengt...


    pub_type: 杂志文章


    authors: Atlas SW,Mark AS,Grossman RI,Gomori JM

    更新日期:1988-09-01 00:00:00

  • Carcinoma of the prostate gland: MR imaging with pelvic phased-array coils versus integrated endorectal--pelvic phased-array coils.

    abstract:PURPOSE:To compare the performance of pelvic phased-array (PPA) coils and integrated endorectal PPA coils in evaluation of local extent of prostate cancer. MATERIALS AND METHODS:Seventy-one men underwent magnetic resonance (MR) imaging within 3 weeks of radical prostatectomy. MR findings of tumor, extracapsular extens...


    pub_type: 临床试验,杂志文章


    authors: Hricak H,White S,Vigneron D,Kurhanewicz J,Kosco A,Levin D,Weiss J,Narayan P,Carroll PR

    更新日期:1994-12-01 00:00:00

  • Emergency room radiography of asthma: an efficacy study.

    abstract::The chest radiographs of asthmatic patients in an emergency room setting over a four-year period were reviewed. A total of 997 radiographs was reviewed; radiographic findings were compared with history and clinical data. In adults 2.2% of the radiographs were abnormal; in children 13%. It is concluded that a chest rad...


    pub_type: 杂志文章


    authors: Zieverink SE,Harper AP,Holden RW,Klatte EC,Brittain H

    更新日期:1982-10-01 00:00:00

  • Periportal tuberculous adenitis: CT features.

    abstract::The computed tomographic (CT) findings in six patients with periportal tuberculous adenitis were reviewed retrospectively to analyze the main morphologic features of the disease. In all patients, hypodense lymph nodes were observed close to the porta hepatis, with peripheral enhancement seen after administration of co...


    pub_type: 杂志文章


    authors: Mathieu D,Ladeb MF,Guigui B,Rousseau M,Vasile N

    更新日期:1986-12-01 00:00:00

  • Persistent bile leak after liver transplantation: biloma drainage and endoscopic retrograde cholangiopancreatographic sphincterotomy.

    abstract::Persistent bile leaks after liver transplantation were successfully treated in three patients with percutaneous or surgical drainage of bilomas and endoscopic retrograde ampullary sphincterotomy. In all three patients, biliary anastomoses were achieved by means of choledochocholedochostomies, with a T-tube stent in th...


    pub_type: 杂志文章


    authors: Ward EM,Wiesner RH,Hughes RW,Krom RA

    更新日期:1991-06-01 00:00:00

  • Calcifications in breast biopsy specimens: discrepancies in radiologic-pathologic identification.

    abstract::To analyze the effectiveness and accuracy of the diagnostic process from screening mammography to final diagnosis at pathologic examination, the authors conducted a prospective study of 277 consecutive patients who underwent 291 mammographically directed biopsies of nonpalpable lesions. Of the 170 lesions that demonst...


    pub_type: 杂志文章


    authors: Stein MA,Karlan MS

    更新日期:1991-04-01 00:00:00

  • Economic and cost-effectiveness investigations of radiologic practices.

    abstract::Economic evaluations provide scientific data regarding the cost implications of radiologic practices and, most important, which strategies for patient care yield the best outcomes for the least cost. Although this article is meant to enrich understanding of cost-effectiveness studies, it cannot be regarded as a comple...


    pub_type: 杂志文章,评审


    authors: Powe NR

    更新日期:1994-07-01 00:00:00

  • Double-lumen central venous catheter for percutaneous ureteral perfusion studies.

    abstract::A commercially available double-lumen central venous catheter that can be inserted over a 0.018-inch guide wire was used for ureteral perfusion studies in three infants. Complications or difficulties were not encountered in any patients. This technique allows simultaneous monitoring of perfusion and intrarenal pressur...


    pub_type: 杂志文章


    authors: Diament MJ,Koenig JC Jr

    更新日期:1991-10-01 00:00:00