Racial disparities in treatment and survival from ovarian cancer.


BACKGROUND:Black women with ovarian cancer in the U.S. have lower survival than whites. We aimed to identify factors associated with racial differences in ovarian cancer treatment and overall survival (OS). METHODS:We examined data from 365 white and 95 black ovarian cancer patients from the Hollings Cancer Center Cancer Registry in Charleston, S.C. between 2000 and 2015. We used unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) between race and receipt of surgery and chemotherapy, and Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% CIs between race and OS. Model variables included diagnosis center, stage, histology, insurance status, smoking, age-adjusted Charlson comorbidity index (AACI) and residual disease. Interactions between race and AACI were assessed using -2 log likelihood tests. RESULTS:Blacks vs. whites were over two-fold less likely to receive a surgery-chemotherapy sequence (multivariable-adjusted OR 2.46, 95% CI 1.43-4.21), particularly if they had a higher AACI (interaction p = 0.008). In multivariable-adjusted Cox models, black women were at higher risk of death (HR 1.81, 95% CI 1.35-2.43) than whites, even when restricted to patients who received a surgery-chemotherapy sequence (HR 1.79, 95% CI 1.10-2.89) and particularly for those with higher AACI (HR 4.70, 95% CI 2.00 - 11.02, interaction p = 0.01). CONCLUSIONS:Among blacks, higher comorbidity associates with less chance of receiving guideline-based treatment and also modifies OS. Differences in receipt of guideline-based care do not completely explain survival differences between blacks and whites with ovarian cancer. These results highlight opportunities for further research.


Cancer Epidemiol


Cancer epidemiology


Hildebrand JS,Wallace K,Graybill WS,Kelemen LE




Has Abstract


2019-02-01 00:00:00












  • Temporal trends in incidence of childhood cancer in Switzerland, 1985-2014.

    abstract:BACKGROUND:Incidence of childhood cancer increased in most countries worldwide, but reasons are unclear. This study investigates trends of childhood cancer incidence in Switzerland from 1985 to 2014. METHODS:We extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Chil...

    journal_title:Cancer epidemiology

    pub_type: 历史文章,杂志文章


    authors: Sommer G,Schindler M,Redmond S,Pfeiffer V,Konstantinoudis G,Ammann RA,Ansari M,Hengartner H,Michel G,Kuehni CE,Swiss Paediatric Oncology Group (SPOG).

    更新日期:2019-08-01 00:00:00

  • Tobacco, alcohol and tea drinking as risk factors for esophageal cancer: A case-control study from Mumbai, India.

    abstract::Esophageal cancer is a relatively rare form of cancer, but some world areas have a markedly higher incidence than others: China, Iceland, India, Japan and United Kingdom, appear to have a higher incidence, as well as the region around the Caspian Sea. In India the incidence rates vary across the country. Despite highe...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Ganesh B,Talole SD,Dikshit R

    更新日期:2009-12-01 00:00:00

  • Patterns of metachronous metastases after curative treatment of colorectal cancer.

    abstract:BACKGROUND:This study aimed to provide information on timing, anatomical location, and predictors for metachronous metastases of colorectal cancer based on a large consecutive series of non-selected patients. METHODS:All patients operated on with curative intent for colorectal cancer (TanyNanyM0) between 2003 and 2008...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: van Gestel YR,de Hingh IH,van Herk-Sukel MP,van Erning FN,Beerepoot LV,Wijsman JH,Slooter GD,Rutten HJ,Creemers GJ,Lemmens VE

    更新日期:2014-08-01 00:00:00

  • Population-based incidence of lymphoid neoplasms: Twenty years of epidemiological data in the Girona province, Spain.

    abstract:BACKGROUND:The aim of this study was to describe incidence patterns of lymphoid neoplasms in the Girona province (Spain) (1996-2015), and to predict the number of cases in Spain during 2020. METHODS:Data were extracted from the Girona cancer registry. Incident cases were classified using the ICD-O-3, third revision, a...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Solans M,Fàbrega A,Morea D,Auñon-Sanz C,Granada I,Roncero JM,Blanco A,Kelleher N,Buch J,Saez M,Marcos-Gragera R

    更新日期:2019-02-01 00:00:00

  • Associations of coffee, tea and caffeine intake with risk of breast, endometrial and ovarian cancer among Canadian women.

    abstract:BACKGROUND:Although, biologically plausible evidence has implicated coffee, tea and caffeine with carcinogenesis, there is a paucity of data on their associations with risk of cancer among Canadian women. Hence, we assessed their associations with risk of breast, endometrial and ovarian cancers within this population. ...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Arthur R,Kirsh VA,Rohan TE

    更新日期:2018-10-01 00:00:00

  • The burden of squamous cell carcinoma of the conjunctiva in Africa.

    abstract::Squamous cell carcinoma of the conjunctiva (SCCC) is a relatively common cancer in Africa, although its precise incidence and geographic distribution have not been previously systematically studied. METHODS:Using the methods employed to produce national estimates of cancer incidence for the "Globocan" series of the I...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Hämmerl L,Ferlay J,Borok M,Carrilho C,Parkin DM

    更新日期:2019-08-01 00:00:00

  • Clinical value of 18F-FDG PET-CT in detecting primary tumor for patients with carcinoma of unknown primary.

    abstract:OBJECTIVE:To investigate the clinical value in detecting occult primary tumors with (18)F-FDG PET-CT whole body imaging. METHODS:120 patients with unknown primary origin were referred for (18)F-FDG PET-CT whole body imaging. All patients were performed (18)F-FDG PET-CT whole body scan. PET-CT images were interpreted b...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Han A,Xue J,Hu M,Zheng J,Wang X

    更新日期:2012-10-01 00:00:00

  • Regional trends in prostate cancer incidence, treatment with curative intent and mortality in Norway 1980-2007.

    abstract:OBJECTIVES:To compare the trends in prostate cancer incidence, treatment with curative intent and mortality across regions and counties in Norway, and to consider changes in incidence (an indicator for early diagnosis) and treatment with curative intent as explanatory factors for the decreasing prostate cancer mortalit...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Kvåle R,Møller B,Angelsen A,Dahl O,Fosså SD,Halvorsen OJ,Hoem L,Solberg A,Wahlqvist R,Bray F

    更新日期:2010-08-01 00:00:00

  • Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study.

    abstract:BACKGROUND:Little is known about the epidemiology and etiology of Waldenstrom macroglobulinemia (WM). Despite several studies of the relation between family history and B-cell disorders and WM, family history of non-hematologic cancers has not been systematically investigated. We thus examined associations of family hi...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Ojha RP,Hanzis CA,Hunter ZR,Greenland S,Offutt-Powell TN,Manning RJ,Lewicki M,Brodsky PS,Ioakimidis L,Tripsas CK,Patterson CJ,Sheehy P,Singh KP,Treon SP

    更新日期:2012-06-01 00:00:00

  • Is melanoma survival influenced by month of diagnosis?

    abstract:BACKGROUND:Despite being a well-documented phenomenon, seasonal variation in the incidence of cutaneous melanoma is poorly understood, and data on the seasonality of melanoma survival are scarce. We sought to explore the seasonal variation in melanoma incidence and survival in Belgium and to assess the characteristics ...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Savoye I,Jegou D,Kvaskoff M,Rommens K,Boutron-Ruault MC,Coppieters Y,Francart J

    更新日期:2015-10-01 00:00:00

  • Levothyroxine treatment is associated with an increased relative risk of overall and organ specific incident cancers - a cohort study of the Swedish population.

    abstract::High thyroid hormone values have been associated with an increased risk of incident cancers, especially breast cancer but also lung cancer and any solid cancers. We explored whether there is an increased risk of overall and cause-specific cancers in those receiving levothyroxine treatment. We included all individuals ...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Wändell P,Carlsson AC,Li X,Sundquist J,Sundquist K

    更新日期:2020-06-01 00:00:00

  • Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians.

    abstract:BACKGROUND/AIM:This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. METHODS:This test dataset comprised 950 Aboriginal cases and all other cases recor...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Banham D,Roder D,Keefe D,Farshid G,Eckert M,Cargo M,Brown A,CanDAD Aboriginal Community Reference Group and other CanDAD investigators.

    更新日期:2017-06-01 00:00:00

  • Cancer incidence trends using American Community Survey estimates are not consistent with SEER for small populations.

    abstract:BACKGROUND:American Community Survey (ACS) estimates are said to be uncertain for small areas and small population groups. The Surveillance, Epidemiology and End Results (SEER) database uses a decennial census extrapolation methodology to yield population estimates used by cancer researchers across the country. We comp...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Mantey J,Ruterbusch J,Meza R,Schwartz K

    更新日期:2016-08-01 00:00:00

  • Areca (betel) nut chewing practices of adults and health behaviors of their children in the Freely Associated States, Micronesia: Findings from the Children's Healthy Living (CHL) Program.

    abstract:BACKGROUND:Chewing areca (betel) nut has been deemed carcinogenic. The practice has become a public health concern in Micronesia. The Children's Healthy Living (CHL) Program included an areca (betel) nut questionnaire in a survey of household characteristics in the Freely Associated States (FAS). This paper describes a...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Paulino YC,Ettienne R,Novotny R,Wilkens LR,Shomour M,Sigrah C,Remengesau SD,Johnson EL,Alfred JM,Gilmatam DF

    更新日期:2017-10-01 00:00:00

  • Different androgen deprivation therapies might have a differential impact on cognition - An analysis from a population-based study using time-dependent exposure model.

    abstract:BACKGROUND:Androgen deprivation therapy (ADT) remains the mainstay treatment for locally advanced or metastatic prostate cancer (PC). However, potential effects of ADT treatment on neurocognitive dysfunction remain unclear. The present study was conducted to assess the relation between ADT treatment and risk of cogniti...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Hong JH,Huang CY,Chang CH,Muo CH,Jaw FS,Lu YC,Chung CJ

    更新日期:2020-02-01 00:00:00

  • Haplotype analysis of eight genes of the monoubiquitinated FANCD2-DNA damage-repair pathway in breast cancer patients.

    abstract:BACKGROUND:Ten genes are associated with increased susceptibility to inherited breast cancer have also been associated with population breast cancer risk, and all are involved directly or indirectly in the monoubiquitinated FANCD2-DNA damage repair pathway. We analyzed 13 haplotype blocks in eight of these genes to est...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Tang LL,Chen FY,Wang H,Hu XL,Dai X,Mao J,Shen ZT,Wu YH,Wang SM,Hai J,Yan GJ,Li H,Huang J

    更新日期:2013-06-01 00:00:00

  • Nrf2-ARE signaling pathway and natural products for cancer chemoprevention.

    abstract:BACKGROUND:One of the potential strategies for preventing cancers is using food-based natural products to induce cytoprotective enzymes including phase II and antioxidative enzymes that act in concert to detoxify and eliminate harmful reactive intermediates formed from carcinogens. The antioxidant response element (ARE...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章,评审


    authors: Zhao CR,Gao ZH,Qu XJ

    更新日期:2010-10-01 00:00:00

  • Methodological issues of assessing the risk of a second cancer occurring in the same site as a first cancer using registry data.

    abstract:OBJECTIVE:To present methodological issues that can arise with the assessment of the risk of a second primary cancer (SPC) occurring in the same site as a first cancer using registry data. MATERIAL AND METHODS:Data from ten French cancer registries were used, including data for patients with a first prostate cancer (i...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Jégu J,Moitry M,Bara S,Trétarre B,Guizard AV,Woronoff AS,Daubisse-Marliac L,Bouvier V,Troussard X,Colonna M,Klein D,Lapôtre-Ledoux B,Velten M

    更新日期:2017-12-01 00:00:00

  • Incidence, survival and mortality rates of stage-specific bladder cancer in United States: a trend analysis.

    abstract:PURPOSE:To examine the overall and stage-specific age-adjusted incidence, 5-year survival and mortality rates of bladder cancer (BCa) in the United States, between 1973 and 2009. MATERIALS AND METHODS:A total of 148,315 BCa patients were identified in the Surveillance, Epidemiology and End Results database, between ye...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Abdollah F,Gandaglia G,Thuret R,Schmitges J,Tian Z,Jeldres C,Passoni NM,Briganti A,Shariat SF,Perrotte P,Montorsi F,Karakiewicz PI,Sun M

    更新日期:2013-06-01 00:00:00

  • Temporal and geospatial trends of pediatric cancer incidence in Nebraska over a 24-year period.

    abstract:BACKGROUND:Data from the Surveillance, Epidemiology, and End Results (SEER) revealed that the incidence of pediatric cancer in Nebraska exceeded the national average during 2009-2013. Further investigation could help understand these patterns. METHODS:This retrospective cohort study investigated pediatric cancer (0-19...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Farazi PA,Watanabe-Galloway S,Westman L,Rettig B,Hunt P,Cammack R,Sparks JW,Coulter DW

    更新日期:2018-02-01 00:00:00

  • Trends in survival of multiple myeloma: a thirty-year population-based study in a single institution.

    abstract:BACKGROUND:Despite the progress made in recent years, multiple myeloma is still considered an incurable disease. Most survival data come from clinical trials. Little is known about the outcome in unselected real-life patients. METHODS:Overall survival was analyzed in a cohort of newly diagnosed symptomatic multiple my...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Ríos-Tamayo R,Sánchez MJ,Puerta JM,Sáinz J,Chang DY,Rodríguez T,López P,de Pablos JM,Navarro P,de Veas JL,Romero A,Garrido P,Moratalla L,Alarcón-Payer C,López-Fernández E,González PA,Jiménez-Moleón JJ,Calleja-Hernández

    更新日期:2015-10-01 00:00:00

  • The role of cancer stem cells in cancer metastasis: new perspective and progress.

    abstract::Recent studies have identified the important role of cancer stem cells (CSCs) in carcinogenesis and relapse. However, with respect to multistage cancer metastasis, the role of CSCs has not been well-defined. In several human cancers, data showed that some phenotypic subsets of CSCs were responsible for cancer metastas...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章,评审


    authors: Wang X,Zhu Y,Ma Y,Wang J,Zhang F,Xia Q,Fu D

    更新日期:2013-02-01 00:00:00

  • A 5-year evaluation of using stool-based test for opportunistic colorectal cancer screening in primary health institutions across Malaysia.

    abstract:INTRODUCTION:The immunochemical fecal occult blood test (iFOBT) has been widely used for opportunistic colorectal cancer (CRC) screening in average-risk individuals seeking care from public health clinics in Malaysia. This study provides a 5-year outcome evaluation of such a practice. METHODS:The findings for a few ou...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Tamin NSI,Razalli KA,Sallahuddin SN,Chan HK,Hassan MRA

    更新日期:2020-12-01 00:00:00

  • Fallout from the Chernobyl accident and overall cancer incidence in Finland.

    abstract:AIM:We studied whether incidence of all cancer sites combined was associated with the radiation exposure due to fallout from the Chernobyl accident in Finland. An emphasis was on the first decade after the accident to assess the suggested "promotion effect". METHODS:The segment of Finnish population with a stable resi...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Kurttio P,Seppä K,Pasanen K,Patama T,Auvinen A,Pukkala E,Heinävaara S,Arvela H,Hakulinen T

    更新日期:2013-10-01 00:00:00

  • A ten-year study of Retinoblastoma in Uganda: An approach to improving outcome with limited resources.

    abstract:BACKGROUND:Survival of children with cancer in resource-limited regions is very poor compared to better-resourced regions. Retinoblastoma (RB) is a childhood cancer that is commonly reported in many regions of Africa. RB may be safely and effectively treated by non-specialists, which could facilitate more widespread av...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Waddell K,Matua M,Bidwell C,Atwine R,Onyango J,Picton SV,Simmons I,Stahlschmidt J,Johnston WT,Newton R

    更新日期:2020-07-10 00:00:00

  • Colorectal cancer risk factors in the detection of advanced adenoma and colorectal cancer.

    abstract::Several risk factors for colorectal cancer (CRC) have been identified. If individuals with risk factors are more likely to harbor cancer or it precursors screening programs should be targeted toward this population. We evaluated the predictive value of colorectal cancer risk factors for the detection of advanced color...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Stegeman I,de Wijkerslooth TR,Stoop EM,van Leerdam ME,Dekker E,van Ballegooijen M,Kuipers EJ,Fockens P,Kraaijenhagen RA,Bossuyt PM

    更新日期:2013-06-01 00:00:00

  • Incidence of skeletal-related events in patients with breast or prostate cancer-induced bone metastasis or multiple myeloma: A 12-year longitudinal nationwide healthcare database study.

    abstract:BACKGROUND:This study examined the incidence of skeletal-related events (SRE) among patients with breast cancer (BC)- or prostate cancer (PC)-induced bone metastasis or multiple myeloma (MM) based on a population-based, 12-year healthcare database. METHODS:Patients aged ≥18 years with bone metastasis from BC or PC or ...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Baek YH,Jeon HL,Oh IS,Yang H,Park J,Shin JY

    更新日期:2019-08-01 00:00:00

  • Partial nephrectomy seems to confer a survival benefit relative to radical nephrectomy in metastatic renal cell carcinoma.

    abstract:OBJECTIVE:Partial nephrectomy (PN) is technically feasible in patients with metastatic renal cell carcinoma (mRCC). We tested the contemporary effect of PN on cancer-specific mortality (CSM), other-cause mortality (OCM) and early postoperative outcomes compared to radical nephrectomy (RN) in mRCC patients. MATERIALS A...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Mazzone E,Nazzani S,Preisser F,Tian Z,Marchioni M,Bandini M,Capitanio U,Kapoor A,Tilki D,Montorsi F,Shariat SF,Saad F,Briganti A,I Karakiewicz P

    更新日期:2018-10-01 00:00:00

  • Trends in use of contralateral prophylactic mastectomy by racial/ethnic group and ER/PR status among patients with breast cancer: A SEER population-based study.

    abstract:BACKGROUND:While differences in CPM use between White and Black patients are well known, it is not clear whether CPM use differs by estrogen/progesterone receptor (ER/PR) status of tumors and whether racial/ethnic differences in the use are affected by ER/PR status, which varies between racial groups. The purpose of th...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Brown D,Shao S,Jatoi I,Shriver CD,Zhu K

    更新日期:2016-06-01 00:00:00

  • Estimation of age-standardized net survival, even when age-specific data are sparse.

    abstract:BACKGROUND:Age-standardization is vital in international comparison studies of cancer patient survival, but standard approaches can fail to produce estimates in the case of sparsity. METHODS:The purpose of this paper is to demonstrate that using a standardization pre-weighting approach is a viable alternative approach...

    journal_title:Cancer epidemiology

    pub_type: 杂志文章


    authors: Rutherford MJ,Dickman PW,Coviello E,Lambert PC

    更新日期:2020-08-01 00:00:00