Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia.

Abstract:

:Eight new glycosides, morindaparvins P-W, were isolated from the butanol extract of the aerial parts of Morinda parvifolia. These new structures were elucidated by comprehensive spectroscopic analysis and by comparing the experimental and calculated electronic circular dichroism spectra. The butanol extract was observed to significantly reduce the levels of alanine aminotransferase, aspartate transaminase, and lactate dehydrogenase in the sera of mice with concanavalin A-induced hepatitis. At a concentration of 10 μM, five compounds (1, and 4-7) isolated from the butanol extract possessed hepatoprotective activities against the damage induced by acetaminophen in human HepG2 liver cancer cells.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Su X,Li L,Sun H,Zhang F,Li C,Li F,Wang H,Li B,Chen R,Kang J

doi

10.1016/j.bioorg.2018.11.055

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

867-875

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(18)31043-5

journal_volume

87

pub_type

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