Abstract:
:Eight new glycosides, morindaparvins P-W, were isolated from the butanol extract of the aerial parts of Morinda parvifolia. These new structures were elucidated by comprehensive spectroscopic analysis and by comparing the experimental and calculated electronic circular dichroism spectra. The butanol extract was observed to significantly reduce the levels of alanine aminotransferase, aspartate transaminase, and lactate dehydrogenase in the sera of mice with concanavalin A-induced hepatitis. At a concentration of 10 μM, five compounds (1, and 4-7) isolated from the butanol extract possessed hepatoprotective activities against the damage induced by acetaminophen in human HepG2 liver cancer cells.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Su X,Li L,Sun H,Zhang F,Li C,Li F,Wang H,Li B,Chen R,Kang Jdoi
10.1016/j.bioorg.2018.11.055subject
Has Abstractpub_date
2019-06-01 00:00:00pages
867-875eissn
0045-2068issn
1090-2120pii
S0045-2068(18)31043-5journal_volume
87pub_type
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