A Novel Model for Cutaneous Wound Healing and Scarring in the Rat.


BACKGROUND:Current rodent models of wound healing and scarring are flawed because of rapid wound contraction and inconspicuous scarring after healing, which is not closely parallel to the physiologic process in humans. This study aimed to establish a novel model of wound healing and scarring in rats. METHODS:Excisional wounds were generated in rat tail or dorsal skin and histologic changes and wound contraction were assessed 2, 10, and 16 days after injury. After healing, rat tail scar was investigated for 24 consecutive weeks by histologic and immunohistochemical staining. Finally, a stretched scar model was generated in rat tail with high or low strain after reepithelialization to mimic human hypertrophic scars. The tail hypertrophic scars were analyzed by histology, immunohistochemical staining, and mRNA quantification 0, 2, 6, 12, and 24 weeks after stretching. RESULTS:Compared with the dorsal wounds, a larger dermal gap percentage (p < 0.05) and more pronounced granulation were found in rat tail wounds. Tail scars remained conspicuous and underwent maturation over 24 weeks after wound healing. In addition, high mechanical strain induced significantly increased scar area (p < 0.01), scar height (p < 0.05), vessel density (p < 0.01) and hypertrophic scar-related molecule expression, and distorted collagen arrangement in rat tail scars. CONCLUSIONS:The rat tail model exhibits minor wound contraction and biological features analogous to both normotrophic and hypertrophic scar in humans when generated with or without stretching, respectively. It is a promising new model for studies of both cutaneous wound healing and scarring.


Plast Reconstr Surg


Zhou S,Wang W,Zhou S,Zhang G,He J,Li Q




Has Abstract


2019-02-01 00:00:00














  • Predictors of readmission after outpatient plastic surgery.

    abstract:BACKGROUND:Hospital readmissions have become a topic of focus for quality care measures and cost-reduction efforts. However, no comparative multi-institutional data on plastic surgery outpatient readmission rates currently exist. The authors endeavored to investigate hospital readmission rates and predictors of readmis...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Mioton LM,Buck DW 2nd,Rambachan A,Ver Halen J,Dumanian GA,Kim JYS

    更新日期:2014-01-01 00:00:00

  • Functional return of tendon graft protected entirely by pseudosheath--experimental study.

    abstract::Sixty-three white Leghorn chickens were used in a two-stage tendon grafting into the deep flexor of the third toe. In the first stage, a 4- or 8-week-old pseudosheath was created around the Silastic rod. In the second stage, the grafting was carried out: in 33 birds the new sheath covered the entire tendon graft and i...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Farkas LG,Lindsay WK

    更新日期:1980-02-01 00:00:00

  • Forehead flap for reconstruction after ablative surgery for oral and oropharyngeal malignancy.

    abstract::The forehead flap is a reliable means of bringing viable lining to the oral and oropharyngeal cavities after composite resections for cancer in locally radiated areas. We discuss the complications and results of such reconstructions. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Lewis MB,Remensnyder JP

    更新日期:1978-07-01 00:00:00

  • The evolution of techniques for reconstruction of full-thickness cheek defects.

    abstract::Our experience with 20 full-thickness cheek reconstruction in 17 patients over the past 27 years is presented. The evolution of techniques for management of full-thickness cheek defects reflects our gradual appreciation of the longitudinal artery concept within axial and musculocutaneous flap units. During the 1950s, ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bunkis J,Mulliken JB,Upton J,Murray JE

    更新日期:1982-09-01 00:00:00

  • Morphologic study of mandibular outer cortex osteotomy.

    abstract:BACKGROUND:The purpose of this study was to illustrate the morphologic changes of the mandible after outer cortex osteotomy. METHODS:Ten patients had undergone mandibular outer cortex osteotomy. By using the true-up and dissection techniques based on three-dimensional spiral computed tomography, variables of effect an...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Zhao YF,Liu XJ,Hao YF,Lu P,Gui L

    更新日期:2008-10-01 00:00:00

  • One-stage reconstruction of an infected skin and Achilles tendon defect with a composite distally planned lateral arm flap.

    abstract::In this paper, the treatment of a complicated Achilles tendon defect with a composite lateral arm flap with distal design of the skin paddle has been presented. The extended portion of the flap was sufficient to restore adequate contour to the posterior aspect of the ankle, and reinervation showed good protective sens...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Berthe JV,Toussaint D,Coessens BC

    更新日期:1998-10-01 00:00:00

  • The influence of procedure delay on resource use: a national study of patients with open tibial fracture.

    abstract:BACKGROUND:The purpose of this study was to (1) understand national variation in delay of emergency procedures in patients with open tibial fracture at the hospital level and (2) compare length of stay and cost in patients cared for at the best- and worst-performing hospitals for delay. METHODS:The authors retrospecti...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Sears ED,Burke JF,Davis MM,Chung KC

    更新日期:2013-03-01 00:00:00

  • Electrolyte and plasma enzyme analyses during large-volume liposuction.

    abstract::Substantial fluid shifts occur during liposuction as wetting solution is infiltrated subcutaneously and fat is evacuated, causing potential electrolyte imbalances. In the porcine model for large-volume liposuction, plasma aspartate aminotransferase and alanine transaminase levels were elevated following liposuction. T...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Lipschitz AH,Kenkel JM,Luby M,Sorokin E,Rohrich RJ,Brown SA

    更新日期:2004-09-01 00:00:00

  • Heterotopic Procedures in Mutilating Hand Injuries: A Synopsis of Essential Reconstructive Tools.

    abstract:BACKGROUND:In the complex and challenging treatment of a mutilating hand injury, any available resources need to be primarily recruited. Besides direct digital replantation, the tissue of the nonreplantable "spare parts" could often be "recycled," and also some replantable or injured structures could be "redistributed"...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kokkoli E,Spyropoulou GA,Shih HS,Feng GM,Jeng SF

    更新日期:2015-11-01 00:00:00

  • Role of Early Application of Pressure Garments following Burn Injury and Autografting.

    abstract:BACKGROUND:Pressure garment therapy, used for reduction of postburn scarring, is commonly initiated after complete healing of the wound or autograft. Although some clinicians have suggested that earlier treatment may improve outcomes, the effect of early initiation of therapy has not been studied in a controlled enviro...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: DeBruler DM,Baumann ME,Blackstone BN,Zbinden JC,McFarland KL,Bailey JK,Supp DM,Powell HM

    更新日期:2019-02-01 00:00:00

  • Evaluation of plastic surgery training programs: integrated/combined versus independent.

    abstract:BACKGROUND:The authors aimed to differentiate between combined/integrated and independent (traditional) methods of plastic surgery training with regard to quality of trainees, caliber of graduates, and practice or career outcomes once graduated. METHODS:To compare combined/integrated with independent residency program...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Roostaeian J,Fan KL,Sorice S,Tabit CJ,Liao E,Rahgozar P,Tanna N,Bradley JP

    更新日期:2012-07-01 00:00:00

  • The Importance of Reproducibility in Plastic Surgery Research.

    abstract::With the advent of big data and database-driven research, the need for reproducible methods has become especially relevant. Given the rise of evidence-based practice, it is crucial to ensure that findings making use of big data can be consistently replicated by other physician-scientists. A call for transparency and r...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Ascha M,Ascha MS,Gatherwright J

    更新日期:2019-07-01 00:00:00

  • Reconstructive surgery training: increased operative volume in plastic surgery residency programs.

    abstract:BACKGROUND:Practitioners in other surgical specialties have increasingly advanced their volume of reconstructive procedures traditionally served by plastic surgeons. Because there has not been a previous specialty training comparison, the average operative reconstructive volume of graduating plastic surgery residents w...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,收录出版


    authors: Tanna N,Boyd JB,Kawamoto HK,Miller TA,Da Lio AL,Azhar H,Bradley JP

    更新日期:2012-03-01 00:00:00

  • Complex Open Abdominal Wall Reconstruction: Management of the Skin and Subcutaneous Tissue.

    abstract::Optimal skin and soft tissue management in complex open abdominal wall reconstruction is an integral element of the operation to achieve optimal outcomes. Failure to provide stable, well-vascularized soft tissue coverage over the hernia repair can jeopardize the reconstruction through association with nonhealing wound...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Khansa I,Janis JE

    更新日期:2018-09-01 00:00:00

  • Computerized tomography and B-scan ultrasonography in the diagnosis of fractures of the medial orbital wall.

    abstract::Ultrasound and CT scans have been used to examine 12 patients with suspected medial orbital wall fractures. A good correlation between ultrasound and CT scanning was demonstrated, and the authors believe that either investigation is a suitable alternative to conventional radiology when this type of injury is suspected...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Ord RA,Le May M,Duncan JG,Moos KF

    更新日期:1981-03-01 00:00:00

  • Pharmacologic manipulation of postoperative labial wound contraction and midfacial growth in rabbits.

    abstract::Recent experimental work has suggested that increased lip pressure and scar contraction following lip repair with wide soft-tissue undermining may, in part, contribute to midfacial growth inhibition. The present study was designed to test this hypothesis through the application of pharmacologic agents reported to mini...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Mooney MP,Siegel MI,Hurwitz DJ,Edington H

    更新日期:1991-07-01 00:00:00

  • Introducing Knowledge Translation to Plastic Surgery: Turning Evidence into Practice.

    abstract::Best evidence has no bearing on quality of life if it is not implemented in clinical practice. The authors introduce knowledge translation as a theoretical framework for closing the gap between evidence and practice in plastic surgery. The current state of published evidence in plastic surgery is reviewed and evaluate...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Moltaji S,Alkhatib AH,Liu H,Murphy J,Gallo L,Karpinski M,Mowakket S,Thoma A

    更新日期:2018-11-01 00:00:00

  • Reconstruction of ablated rat rectus abdominis by muscle regeneration.

    abstract::Skeletal muscle regeneration is a powerful, naturally occurring process of tissue reconstruction that follows myofiber damage secondary to myotoxic injury that does not normally affect the tissue circulation and scaffold. The ablated tissue, in traumatology and free muscle grafts, is frequently replaced by scars. The ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Vindigni V,Mazzoleni F,Rossini K,Fabbian M,Zanin ME,Bassetto F,Carraro U

    更新日期:2004-11-01 00:00:00

  • Does steroid medication reduce facial edema following face lift surgery? A prospective, randomized study of 30 consecutive patients.

    abstract::A prospective, double-blinded study of 30 consecutive face lift patients was conducted to determine if the administration of corticosteroid medication would reduce postoperative facial edema. Half the patients received steroid medications in a random fashion. Three independent plastic surgeons who were blinded to the ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Owsley JQ,Weibel TJ,Adams WA

    更新日期:1996-07-01 00:00:00

  • Early Results Using Sterilized Acellular Human Dermis (Neoform) in Post-Mastectomy Tissue Expander Breast Reconstruction.

    abstract::Acellular dermal products play a beneficial role in immediate tissue expander breast reconstruction. They provide improved coverage and support in the lower pole, allowing the pectoralis muscle to drape over most of the expander and maximize lower pole expansion. Tissue incorporation is desired without any adverse aff...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Losken A

    更新日期:2009-06-01 00:00:00

  • Pedicled latissimus dorsi transfer for immediate soft-tissue coverage and elbow flexion.

    abstract::This case report describes a new method of unipolar transfer of the latissimus dorsi for restoration of elbow flexion. The advantages of the technique are that it has superior resting tension compared to other unipolar transfers and provides more extensive soft-tissue coverage at the elbow than other unipolar or bipol...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Mordick TG 2nd,Britton EN,Brantigan C

    更新日期:1997-05-01 00:00:00

  • Unpredictable growth pattern of costochondral graft.

    abstract::Costochondral grafts have gained increasing popularity in reconstruction of the temporomandibular joint and condyle in children. This is a report on the long-term follow-up of eight adolescent patients who underwent reconstruction of the temporomandibular joint and ramus for correction of hemifacial microsomia or trau...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Guyuron B,Lasa CI Jr

    更新日期:1992-11-01 00:00:00

  • A comparison of factors affecting aesthetic outcomes of TRAM flap breast reconstructions.

    abstract::The aesthetic results of TRAM flap breast reconstructions were assessed in 237 consecutive breast cancer patients. Nine independent judges, none of whom were plastic surgeons or members of the reconstructive team, assigned an aesthetic score to each patient after viewing postoperative photographs. We found that bilate...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kroll SS,Coffey JA Jr,Winn RJ,Schusterman MA

    更新日期:1995-09-01 00:00:00

  • Impact of hypertonic and hyperoncotic saline solutions on ischemia-reperfusion injury in free flaps.

    abstract:BACKGROUND:The purpose of this study was to evaluate the influence of hypertonic and hyperoncotic saline solutions on ischemia-reperfusion injury after free tissue transfer. METHODS:Twenty-eight Sprague-Dawley rats were used to design an inferior epigastric flap. After skin incision, microcirculation was investigated ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Scholz T,Evans GRD

    更新日期:2008-07-01 00:00:00

  • Venous Thromboembolism: A Comparison of Chronic Spinal Cord Injury and General Surgery Patients in a Metropolitan Veterans Affairs Hospital.

    abstract:BACKGROUND:Venous thromboembolic events result in significant morbidity, mortality, and costly therapeutic interventions. As medical resource allocation strategies are becoming more pervasive, appropriate risk stratification and prophylactic regimens are essential. Previous studies have shown a decreased incidence of p...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Moore RM,Rimler J,Smith BR,Wirth GA,Paydar KZ

    更新日期:2016-11-01 00:00:00

  • Long-Term Outcomes of Total Knee Arthroplasty following Soft-Tissue Defect Reconstruction with Muscle and Fasciocutaneous Flaps.

    abstract:BACKGROUND:Insufficient soft-tissue coverage following total knee arthroplasty jeopardizes prosthesis retention and may lead to significant complications. The aim of this study was to evaluate the natural history of total knee arthroplasty following flap reconstruction of soft-tissue defects. METHODS:A retrospective r...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kwiecien GJ,Lamaris G,Gharb BB,Murray T,Hendrickson MF,Zins JE,Isakov R

    更新日期:2016-01-01 00:00:00

  • Global Adverse Event Reports of Breast Implant-Associated ALCL: An International Review of 40 Government Authority Databases.

    abstract:BACKGROUND:Tracking world cases of breast implant-associated anaplastic large cell lymphoma (ALCL) is currently limited to patient registries at a few academic centers, dependent upon patient referral and case reports in the literature. The purpose of this study was to review and compare federal database adverse event ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Srinivasa DR,Miranda RN,Kaura A,Francis AM,Campanale A,Boldrini R,Alexander J,Deva AK,Gravina PR,Medeiros LJ,Nast K,Butler CE,Clemens MW

    更新日期:2017-05-01 00:00:00

  • The Efficacy of Breast Implant Irrigant Solutions: A Comparative Analysis Using an In Vitro Model.

    abstract:BACKGROUND:Infections are challenging complications of implant-based breast reconstruction and augmentation. They pose a clinical challenge, with significant economic implications. One proposed solution is implant irrigation at the time of placement. There is no consensus on the optimal irrigant solution. METHODS:The ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Ngaage LM,Elegbede A,Brao K,Chopra K,Gowda AU,Nam AJ,Ernst RK,Shirtliff ME,Harro J,Rasko YM

    更新日期:2020-08-01 00:00:00

  • Phenotypically unusual combined craniosynostoses: presentation and management.

    abstract:BACKGROUND:Although most craniosynostoses can be determined by pattern recognition, some patients defy phenotypic diagnosis and require computed tomography to determine sutural fusions. METHODS:The authors' craniofacial database was reviewed for patients treated for craniosynostosis between 1989 and 2007. Children wit...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Greene AK,Mulliken JB,Proctor MR,Meara JG,Rogers GF

    更新日期:2008-09-01 00:00:00

  • From birth to maturity: a group of patients who have completed their protocol management. Part I. Unilateral cleft lip and palate.

    abstract::The optimal management of the cleft lip and palate patient from birth to completion of treatment presents a formidable challenge to the plastic surgeon and the associated health care system. The multidisciplinary team approach for the management of these patients is widely accepted. However, a paucity of literature ex...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Schnitt DE,Agir H,David DJ

    更新日期:2004-03-01 00:00:00