Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke.

Abstract:

:Cigarette smoking has been identified as a major risk factor for osteoporosis decades ago. Several studies have shown a direct relationship between cigarette smoking, decreased bone mineral density, and impaired fracture healing. However, the mechanisms behind impaired fracture healing and cigarette smoking are yet to be elucidated. Migration and osteogenesis of mesenchymal stem/stromal cells (MSCs) into the fracture site play a vital role in the process of fracture healing. In human nicotine, the most pharmacologically active and major addictive component present in tobacco gets rapidly metabolized to the more stable cotinine. This study demonstrates that physiological concentrations of both nicotine and cotinine do not affect the osteogenic differentiation of MSCs. However, cigarette smoke exposure induces oxidative stress by increasing superoxide radicals and reducing intracellular glutathione in MSCs, negatively affecting osteogenic differentiation. Although, not actively producing reactive oxygen species (ROS) nicotine and cotinine inhibit catalase and glutathione reductase activity, contributing to an accumulation of ROS by cigarette smoke exposure. Coincubation with N-acetylcysteine or L-ascorbate improves impaired osteogenesis caused by cigarette smoke exposure by both activation of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling and scavenging of ROS, which thus might represent therapeutic targets to support fracture healing in smokers.

journal_name

Oxid Med Cell Longev

authors

Aspera-Werz RH,Ehnert S,Heid D,Zhu S,Chen T,Braun B,Sreekumar V,Arnscheidt C,Nussler AK

doi

10.1155/2018/3172480

subject

Has Abstract

pub_date

2018-11-06 00:00:00

pages

3172480

eissn

1942-0900

issn

1942-0994

journal_volume

2018

pub_type

杂志文章
  • Inhibitory Effect of Ursolic Acid on Ultraviolet B Radiation-Induced Oxidative Stress and Proinflammatory Response-Mediated Senescence in Human Skin Dermal Fibroblasts.

    abstract::Ultraviolet radiation is an environmental carcinogenic agent that enhances inflammation and immunological reactions in the exposed human skin cells leading to oxidative photoaging of the epidermal and dermal segment. In the present study, we investigated the protective role of ursolic acid (UA) against ultraviolet B (...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/1246510

    authors: Samivel R,Nagarajan RP,Subramanian U,Khan AA,Masmali A,Almubrad T,Akhtar S

    更新日期:2020-06-15 00:00:00

  • Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries.

    abstract::Oxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medicinal plant Rhododendron dauricum L., has been reported to show protective effects against oxidative stress-induced endothelial injuries i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/5967434

    authors: Yan C,Zhang X,Miao J,Yuan H,Liu E,Liang T,Li Q

    更新日期:2020-01-28 00:00:00

  • Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study.

    abstract::There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity. In addition, antioxidants have been suggested as adjuncts to standard therapy. However, there is no substantial evidence for t...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2015/329306

    authors: Nurulain SM,Ojha S,Tekes K,Shafiullah M,Kalasz H,Adem A

    更新日期:2015-01-01 00:00:00

  • Glutathione as a Biomarker in Parkinson's Disease: Associations with Aging and Disease Severity.

    abstract::Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity. Methods. 58 otherwise healthy individuals ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/9409363

    authors: Mischley LK,Standish LJ,Weiss NS,Padowski JM,Kavanagh TJ,White CC,Rosenfeld ME

    更新日期:2016-01-01 00:00:00

  • Increased Mitochondrial Protein Levels and Bioenergetics in the Musculus Rectus Femoris of Wfs1-Deficient Mice.

    abstract::Wfs1 deficiency leads to a progressive loss of plasma insulin concentration, which should reduce the consumption of glucose in insulin-dependent tissues, causing a variety of changes in intracellular energy metabolism. Our objective here was to assess the changes in the amount and function of mitochondrial proteins in...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/3175313

    authors: Eimre M,Paju K,Peet N,Kadaja L,Tarrend M,Kasvandik S,Seppet J,Ivask M,Orlova E,Kõks S

    更新日期:2018-11-21 00:00:00

  • Malondialdehyde and Uric Acid as Predictors of Adverse Outcome in Patients with Chronic Heart Failure.

    abstract::In chronic heart failure (HF), some parameters of oxidative stress are correlated with disease severity. The aim of this study was to evaluate the importance of oxidative stress biomarkers in prognostic risk stratification (death and combined endpoint: heart transplantation or death). In 774 patients, aged 48-59 years...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/9246138

    authors: Romuk E,Wojciechowska C,Jacheć W,Zemła-Woszek A,Momot A,Buczkowska M,Rozentryt P

    更新日期:2019-10-09 00:00:00

  • Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats.

    abstract::Curcumin is a bifunctional antioxidant derived from Curcuma longa. This study identifies curcumin as a neuroprotectant against hemin-induced damage in primary cultures of cerebellar granule neurons (CGNs) of rats. Hemin, the oxidized form of heme, is a highly reactive compound that induces cellular injury. Pretreatmen...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2013/801418

    authors: González-Reyes S,Guzmán-Beltrán S,Medina-Campos ON,Pedraza-Chaverri J

    更新日期:2013-01-01 00:00:00

  • The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats.

    abstract::N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/2745352

    authors: Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

    更新日期:2019-03-26 00:00:00

  • Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study.

    abstract:Purpose:Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Meth...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/1821969

    authors: Hsueh CY,Shao M,Cao W,Li S,Zhou L

    更新日期:2019-04-16 00:00:00

  • Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties.

    abstract::Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigat...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/9842908

    authors: de Oliveira TS,Thomaz DV,da Silva Neri HF,Cerqueira LB,Garcia LF,Gil HPV,Pontarolo R,Campos FR,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

    更新日期:2018-10-21 00:00:00

  • Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage.

    abstract:Background/Aims:Obesity, which is related to increased oxidative stress in various tissues, is a risk factor for male infertility. Metformin is reported to have an antioxidant effect; however, the precise role of metformin in obesity-induced male infertility remains unknown. The current study is aimed at exploring the ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/9151067

    authors: Ye J,Luo D,Xu X,Sun M,Su X,Tian Z,Zhang M,Yu C,Guan Q

    更新日期:2019-09-10 00:00:00

  • Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats.

    abstract::Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone gro...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/8235069

    authors: You Z,Sun J,Xie F,Chen Z,Zhang S,Chen H,Liu F,Li L,Chen G,Song Y,Xuan Y,Zheng G,Xin Y

    更新日期:2017-01-01 00:00:00

  • Phytochemical and Antioxidant Studies on a Rare Rheum cordatum Losinsk. Species from Kazakhstan.

    abstract::An optimisation of extraction towards an increased antioxidant capacity and the study on the extracts' composition by HPLC-ESI-Q-TOF-MS were performed on different organs of a rarely studied plant: Rheum cordatum Losinsk (Polygonaceae) growing in Kazakhstan. More than 20 compounds from anthraquinones and phenolics wer...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/5465463

    authors: Zhumashova G,Kukula-Koch W,Koch W,Baj T,Sayakova G,Shukirbekova A,Głowniak K,Sakipova Z

    更新日期:2019-11-16 00:00:00

  • Corrigendum to "Dexmedetomidine Postconditioning Alleviates Hypoxia/Reoxygenation Injury in Senescent Myocardial Cells by Regulating lncRNA H19 and m6A Modification".

    abstract::[This corrects the article DOI: 10.1155/2020/9250512.]. ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 已发布勘误

    doi:10.1155/2020/7059751

    authors: Zhang X,Fu Q,Xu L,Yang Y,Zhao W,Zhang Y,Mi W,Li H

    更新日期:2020-08-24 00:00:00

  • Corrigendum to "Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal-Induced Injuries in Rat Pheochromocytoma Cells".

    abstract::[This corrects the article DOI: 10.1155/2017/4824371.]. ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 已发布勘误

    doi:10.1155/2019/2029096

    authors: Song TY,Yang NC,Chen CL,Thi TLV

    更新日期:2019-08-06 00:00:00

  • Antioxidant Properties of Amazonian Fruits: A Mini Review of In Vivo and In Vitro Studies.

    abstract::Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living specie...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2019/8204129

    authors: Avila-Sosa R,Montero-Rodríguez AF,Aguilar-Alonso P,Vera-López O,Lazcano-Hernández M,Morales-Medina JC,Navarro-Cruz AR

    更新日期:2019-02-17 00:00:00

  • Role of tyrosine phosphorylation in the antioxidant effects of the p75 neurotrophin receptor.

    abstract::The p75 neurotrophin receptor (p75NTR) is an alpha- and gamma-secretase substrate expressed preferentially in the cholinergic neurons of the nucleus basalis of Meynert, the hippocampus, and the cerebellum of the adult brain. Mutations of the gamma-secretase, presenilin, have been implicated in familial Alzheimer's dis...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.4161/oxim.2.4.9745

    authors: Zhang T,Mi Z,Schor NF

    更新日期:2009-09-01 00:00:00

  • Sulfur Dioxide Enhances Endogenous Hydrogen Sulfide Accumulation and Alleviates Oxidative Stress Induced by Aluminum Stress in Germinating Wheat Seeds.

    abstract::Aluminum ions are especially toxic to plants in acidic soils. Here we present evidences that SO2 protects germinating wheat grains against aluminum stress. SO2 donor (NaHSO3/Na2SO3) pretreatment at 1.2 mM reduced the accumulation of superoxide anion, hydrogen peroxide, and malondialdehyde, enhanced the activities of g...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2015/612363

    authors: Zhu DB,Hu KD,Guo XK,Liu Y,Hu LY,Li YH,Wang SH,Zhang H

    更新日期:2015-01-01 00:00:00

  • Circadian Rhythms of Oxidative Stress Markers and Melatonin Metabolite in Patients with Xeroderma Pigmentosum Group A.

    abstract::Xeroderma pigmentosum group A (XPA) is a genetic disorder in DNA nucleotide excision repair (NER) with severe neurological disorders, in which oxidative stress and disturbed melatonin metabolism may be involved. Herein we confirmed the diurnal variation of melatonin metabolites, oxidative stress markers, and antioxida...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/5741517

    authors: Miyata R,Tanuma N,Sakuma H,Hayashi M

    更新日期:2016-01-01 00:00:00

  • Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway.

    abstract::Approximately 90% of male diabetes mellitus patients have varying degrees of testicular dysfunction. The molecular mechanism underlying diabetes-induced testicular damage has not been thoroughly elucidated. In this research, we sought to determine the influence of metformin (Met) on diabetes-induced testicular injury ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/5681701

    authors: Liu Y,Yang Z,Kong D,Zhang Y,Yu W,Zha W

    更新日期:2019-11-28 00:00:00

  • Neuroprotective effect of tea polyphenols on oxyhemoglobin induced subarachnoid hemorrhage in mice.

    abstract::Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases. In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2013/743938

    authors: Mo H,Chen Y,Huang L,Zhang H,Li J,Zhou W

    更新日期:2013-01-01 00:00:00

  • Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent.

    abstract::The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tes...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/2069250

    authors: Dimić DS,Marković ZS,Saso L,Avdović EH,Đorović JR,Petrović IP,Stanisavljević DD,Stevanović MJ,Potočňák I,Samoľová E,Trifunović SR,Dimitrić Marković JM

    更新日期:2019-02-13 00:00:00

  • Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels.

    abstract::Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI), synergistically induced cell death in breast cancer cells media...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/9561281

    authors: Villalpando-Rodriguez GE,Blankstein AR,Konzelman C,Gibson SB

    更新日期:2019-09-17 00:00:00

  • Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System.

    abstract::Hydrogen sulfide (H2S), a toxic gaseous molecule, plays a physiological role in regulating homeostasis and cell signaling. H2S is produced from cysteine by enzymes, such as cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST). The...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/1873962

    authors: Shefa U,Kim MS,Jeong NY,Jung J

    更新日期:2018-02-04 00:00:00

  • Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

    abstract::A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/3074769

    authors: Mohammad K,Dakik P,Medkour Y,McAuley M,Mitrofanova D,Titorenko VI

    更新日期:2018-01-31 00:00:00

  • Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells.

    abstract::Benzene is a chemical contaminant widespread in industrial and living environments. The oxidative metabolites of benzene induce toxicity involving oxidative damage. Protecting cells and cell membranes from oxidative damage, glucose-6-phosphate dehydrogenase (G6PD) maintains the reduced state of glutathione (GSH). This...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/3912515

    authors: Zhang J,Cao M,Yang W,Sun F,Xu C,Yin L,Pu Y

    更新日期:2016-01-01 00:00:00

  • MitoTEMPO Prevents Oxalate Induced Injury in NRK-52E Cells via Inhibiting Mitochondrial Dysfunction and Modulating Oxidative Stress.

    abstract::As one of the major risks for urolithiasis, hyperoxaluria can be caused by genetic defect or dietary intake. And high oxalate induced renal epithelial cells injury is related to oxidative stress and mitochondrial dysfunction. Here, we investigated whether MitoTEMPO, a mitochondria-targeted antioxidant, could protect a...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/7528090

    authors: Zhang J,Wang Q,Xu C,Lu Y,Hu H,Qin B,Wang Y,He D,Li C,Yu X,Wang S,Liu J

    更新日期:2017-01-01 00:00:00

  • It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease.

    abstract::Free radical-mediated damage to macromolecules and the resulting oxidative modification of different cellular components are a common feature of aging, and this process becomes much more pronounced in age-associated pathologies, including Alzheimer disease (AD). In particular, proteins are particularly sensitive to ox...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2756068

    authors: Tramutola A,Di Domenico F,Barone E,Perluigi M,Butterfield DA

    更新日期:2016-01-01 00:00:00

  • Cyclosporine A Promotes Bone Remodeling in LPS-Related Inflammation via Inhibiting ROS/ERK Signaling: Studies In Vivo and In Vitro.

    abstract::In some inflammatory diseases of bone, osteogenesis and osteoclasis are uncoupled and the balance is usually tipped resulting in bone destruction. The underlying mechanism of osteogenic dysfunction in inflammation still needs further study. This study is aimed at investigating the effects of cyclosporine A (CsA) on bo...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2021/8836599

    authors: Zhao Y,Gao J,Zhang Y,Gan X,Yu H

    更新日期:2021-01-07 00:00:00

  • Resveratrol inhibits phenotype modulation by platelet derived growth factor-bb in rat aortic smooth muscle cells.

    abstract::Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of pl...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2014/572430

    authors: Lee MH,Kwon BJ,Seo HJ,Yoo KE,Kim MS,Koo MA,Park JC

    更新日期:2014-01-01 00:00:00