Effect of nimodipine on the outcome of patients after aneurysmal subarachnoid hemorrhage and surgery.


:The effect of intravenous nimodipine on the incidence of mortality and delayed ischemic neurological deficits of patients after aneurysmal subarachnoid hemorrhage (SAH) and surgery was studied in a prospective double-blind placebo-controlled trial. Upon admission, all of the patients were in Grades I to III according to the classification of Hunt and Hess. Of the 213 patients enrolled in the study, 58 underwent early surgery (within 72 hours after the bleed: Days 0 to 3), 69 were operated on subacutely (between Days 4 and 7), and 74 had late surgery (on Day 8 or later). Eleven patients died before surgery was undertaken and one was not scheduled for operation. Administration of the drug was started immediately after the radiological diagnosis of a ruptured aneurysm had been made. The dose of nimodipine or matching placebo was 0.5 micrograms/kg/min via continuous intravenous infusion for 7 to 10 days after the SAH and, if the patient was operated on late, for 2 to 3 days after the operation as well. After intravenous treatment, oral administration of nimodipine or placebo was continued for up to 21 days after SAH in a dose of 60 mg every 4 hours. Nimodipine treatment was associated with a significant decrease in mortality rate (p = 0.03) in the early and subacute surgery groups. In the total series the number of deaths due to delayed ischemic deterioration was significantly lower in the nimodipine group than in the placebo group (p = 0.01).


J Neurosurg


Journal of neurosurgery


Ohman J,Heiskanen O




Has Abstract


1988-11-01 00:00:00












  • Endoscopic transorbital surgery for Meckel's cave and middle cranial fossa tumors: surgical technique and early results.

    abstract::OBJECTIVETumors involving Meckel's cave remain extremely challenging because of the surrounding complex neurovascular structures and deep-seated location. The authors investigated a new minimal-access technique using the endoscopic transorbital approach (eTOA) through the superior eyelid crease to Meckel's cave and mi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Jeon C,Hong CK,Woo KI,Hong SD,Nam DH,Lee JI,Choi JW,Seol HJ,Kong DS

    更新日期:2018-11-01 00:00:00

  • Outpatient brain tumor craniotomy under general anesthesia.

    abstract::OBJECTIVE Outpatient craniotomy has many advantages to the psychological and physical well-being of patients, as well as benefits to the health care system. Its efficacy and safety have been well demonstrated, but barriers to its widespread adoption remain. Among the challenges is a perception that its application is ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Au K,Bharadwaj S,Venkatraghavan L,Bernstein M

    更新日期:2016-11-01 00:00:00

  • Arteriovenous malformations of the medial temporal lobe. Surgical approach and neuroradiological characterization.

    abstract::Arteriovenous malformations (AVM's) of the medial temporal lobe frequently involve the basal ganglia and the thalamus and, for this reason, are commonly judged to be inoperable. However, when the medial involvement is limited to the posterolateral part of the thalamus and to the inferior portion of the basal ganglia l...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Heros RC

    更新日期:1982-01-01 00:00:00

  • Meningiomas causing spontaneous intracranial hematomas.

    abstract::Four cases of spontaneous intracranial hematomas caused by unsuspected meningiomas are reported. Nine previous cases were found in the literature and the entire series of 13 cases is reviewed. Because of their unusual clinical presentation, these cases were not diagnosed correctly prior to radiological studies. Hypert...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Modesti LM,Binet EF,Collins GH

    更新日期:1976-10-01 00:00:00

  • Arteriovenous malformations in the posterior fossa.

    abstract::We have operated on 12 of 14 cases of arteriovenous malformation (AVM) in the posterior fossa since 1968, with one death. The lesions were in the cerebellum in 10 cases (three anteromedial, one central, three lateral, and three posteromedial), and in the cerebellopontine angle in two; in two cases the lesions were dir...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Matsumura H,Makita Y,Someda K,Kondo A

    更新日期:1977-07-01 00:00:00

  • Accurate placement of the atrial catheter in ventriculoatrial shunts. Technical note.

    abstract::A combined radiological and surgical technique that permits identification of appropriate recipient vessels and accurate placement of the atrial catheter in ventriculoatrial shunts is described. The procedure uses readily available radiological skills and reduces operation time and morbidity related to malpositioning ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Thompson DN,Casey AT,Hayward RD,Harkness WF

    更新日期:1995-01-01 00:00:00

  • Quantification of thermal asymmetry. Part 2: Application in low-back pain and sciatica.

    abstract::Temperature differences between the lower extremities were measured using a computerized thermometric scanning system in order to compare the degree of thermal asymmetry in 144 patients with low-back pain. The patients displayed highly significant thermal asymmetries, with the involved limb being cooler (p less than 0...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Uematsu S,Jankel WR,Edwin DH,Kim W,Kozikowski J,Rosenbaum A,Long DM

    更新日期:1988-10-01 00:00:00

  • Neurosurgery and consciousness: historical sketch and future possibilities.

    abstract::Neurosurgery has played an important role in the development of neuroscience and the science of consciousness. In this paper, the authors reflect on some of the historical contributions of neurosurgeons to the science of consciousness and discuss the ways in which clinical neurosurgery can contribute to the science of...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章


    authors: Hasegawa H,Jamieson GA,Ashkan K

    更新日期:2012-09-01 00:00:00

  • Neurovascular compression findings in hemifacial spasm.

    abstract:OBJECT:It is generally accepted that hemifacial spasm (HFS) is caused by pulsatile vascular compression upon the facial nerve root exit zone. This 2-3 mm area, considered synonymous with the Obersteiner-Redlich zone, is a transition zone (TZ) between central and peripheral axonal myelination that is situated at the ner...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Campos-Benitez M,Kaufmann AM

    更新日期:2008-09-01 00:00:00

  • Lymphomatoid granulomatosis apparently confined to one temporal lobe. Case report.

    abstract::Lymphomatoid granulomatosis is of uncertain etiology and poses problems with diagnosis and treatment. A case with involvement of the right temporal lobe, but associated with cystoid macular edema of the retina, is described. The unusual mode of presentation, the radiographic, operative, and pathological findings, the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kerr RS,Hughes JT,Blamires T,Teddy PJ

    更新日期:1987-10-01 00:00:00

  • Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury.

    abstract:OBJECT:Recent observations indicate that traumatic brain injury (TBI) may be associated with mitochondrial dysfunction. This, along with growing use of brain tissue PO2 monitors, has led to considerable interest in the potential use of ventilation with 100% oxygen to treat patients who have suffered a TBI. To date, the...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Diringer MN,Aiyagari V,Zazulia AR,Videen TO,Powers WJ

    更新日期:2007-04-01 00:00:00

  • Management of symptomatic deep venous thrombosis and pulmonary embolism on a neurosurgical service.

    abstract::The authors present a retrospective analysis of the management of deep vein thrombosis (DVT) and pulmonary embolism (PE) in neurosurgical patients at the Massachusetts General Hospital from January, 1978, through June, 1982. There were 44 cases of DVT and 13 cases of PE. Management modalities included observation only...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Swann KW,Black PM,Baker MF

    更新日期:1986-04-01 00:00:00

  • Combined treatment of advanced stages of recurrent skin cancer of the head.

    abstract:OBJECT:The authors investigated whether skull base resection and primary free-flap reconstruction in a single-stage surgery is oncologically effective for treating advanced stages of recurrent skin cancer (RSC) of the head. METHODS:Eighteen consecutive patients were surgically treated. Twelve of them underwent an ante...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Pompucci A,Rea G,Farallo E,Salgarello M,Campanella A,Fernandez E

    更新日期:2004-04-01 00:00:00

  • Effects of ventricular entry on patient outcome during glioblastoma resection.

    abstract:OBJECTIVE:Tumor proximity to the ventricle and ventricular entry (VE) during surgery have both been associated with worse prognoses; however, the interaction between these two factors is poorly understood. Given the benefit of maximal tumor resection, it is imperative for surgical planning and technique to know if VE h...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Young JS,Gogos AJ,Pereira MP,Morshed RA,Li J,Barkovich MJ,Hervey-Jumper SL,Berger MS

    更新日期:2021-01-08 00:00:00

  • Window anatomy for neurosurgical approaches. Laboratory investigation.

    abstract:OBJECT:Knowledge of the cranium projections of the gyral structures is essential to reduce the surgical complications and to perform minimally invasive interventions in daily neurosurgical practice. Thus, in this study the authors aimed to provide detailed information on cranial projections of the eloquent cortical are...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kendir S,Acar HI,Comert A,Ozdemir M,Kahilogullari G,Elhan A,Ugur HC

    更新日期:2009-08-01 00:00:00

  • Prediction of tolerance to carotid artery occlusion using transcranial Doppler ultrasound.

    abstract::Surgical sacrifice of the carotid artery is a frequently anticipated event during the treatment of certain aneurysms and tumors. The ability to predict tolerance to carotid artery occlusion is therefore of benefit when planning procedures in which the carotid artery is at risk. A trial of carotid artery occlusion usin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Giller CA,Mathews D,Walker B,Purdy P,Roseland AM

    更新日期:1994-07-01 00:00:00

  • Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats.

    abstract:OBJECT:Mitoxantrone is a drug with potent in vitro activity against malignant brain tumor cell lines; however, its effectiveness as a systemic agent has been hampered by poor central nervous system penetration and dose-limiting myelosuppression. To avoid these problems, we incorporated mitoxantrone into biodegradable p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: DiMeco F,Li KW,Tyler BM,Wolf AS,Brem H,Olivi A

    更新日期:2002-11-01 00:00:00

  • Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model.

    abstract:OBJECTIVE:Direct brain compression and secondary injury due to increased intracranial pressure are believed to be the pathognomic causes of a grave outcome in acute subdural hemorrhage (aSDH). However, ischemic damage from aSDH has received limited attention. The authors hypothesized that cerebral microcirculation is a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Wang HC,Tsai JC,Lee JE,Huang SJ,Po-Hao Huang A,Lin WC,Hsieh ST,Wang KC

    更新日期:2018-10-01 00:00:00

  • Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus.

    abstract:OBJECTIVE:The objective of this open-label, nonrandomized trial was to evaluate the efficacy and safety of bilateral caudate nucleus deep brain stimulation (DBS) for treatment-resistant tinnitus. METHODS:Six participants underwent DBS electrode implantation. One participant was removed from the study for suicidality u...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Cheung SW,Racine CA,Henderson-Sabes J,Demopoulos C,Molinaro AM,Heath S,Nagarajan SS,Bourne AL,Rietcheck JE,Wang SS,Larson PS

    更新日期:2019-09-24 00:00:00

  • Presence of immunosuppressive factors in brain-tumor cyst fluid.

    abstract::The present investigation was conducted to examine the effects upon normal lymphocyte activation of the addition of brain-tumor cyst fluid or cerebrospinal fluid (CSF) to an in vitro culture system. It was believed that factors present in these fluids may play a role in local and systemic immunosuppression in brain-tu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kikuchi K,Neuwelt EA

    更新日期:1983-11-01 00:00:00

  • Occlusion of cerebral artery due to metastasis of chorioepithelioma. Case report.

    abstract::A case of cerebral metastasis of chorioepithelioma with an occlusion of the angular artery is presented. The occlusion was verified angiographically, surgically, and microscopically. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Nakagawa Y,Tashiro K,Isu T,Tsuru M

    更新日期:1979-08-01 00:00:00

  • Evolution of the graded repair of CSF leaks and skull base defects in endonasal endoscopic tumor surgery: trends in repair failure and meningitis rates in 509 patients.

    abstract:Objective:The authors previously described a graded approach to skull base repair following endonasal microscopic or endoscope-assisted tumor surgery. In this paper they review their experience with skull base reconstruction in the endoscopic era. Methods:A retrospective review of a single-institution endonasal endosc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Conger A,Zhao F,Wang X,Eisenberg A,Griffiths C,Esposito F,Carrau RL,Barkhoudarian G,Kelly DF

    更新日期:2018-05-11 00:00:00

  • Endoscopic endonasal skull base surgery: analysis of complications in the authors' initial 800 patients.

    abstract:OBJECT:The development of endoscopic endonasal approaches, albeit in the early stages, represents part of the continuous evolution of skull base surgery. During this early period, it is important to determine the safety of these approaches by analyzing surgical complications to identify and eliminate their causes. MET...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kassam AB,Prevedello DM,Carrau RL,Snyderman CH,Thomas A,Gardner P,Zanation A,Duz B,Stefko ST,Byers K,Horowitz MB

    更新日期:2011-06-01 00:00:00

  • Spontaneous intracerebral hematoma in carotid-cavernous fistula. Report of three cases.

    abstract::Spontaneous intracerebral hematoma associated with carotid-cavernous fistula is rare. Three new cases are presented. In each, the hemorrhage originated in the vicinity of localized intracranial venous engorgement, as demonstrated by cerebral angiography. Rupture of one or several of the distended venous channels from ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Turner DM,Vangilder JC,Mojtahedi S,Pierson EW

    更新日期:1983-10-01 00:00:00

  • A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor.

    abstract::In order to assess the clinical and biological effects of glucocorticoids in the therapy of epidural spinal cord compression, the T8-10 epidural space of 50 rats was implanted with Walker 256 tumor. The rats were studied 10 to 20 days later when they became paraparetic. The regional blood-spinal cord transport constan...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Delattre JY,Arbit E,Thaler HT,Rosenblum MK,Posner JB

    更新日期:1989-06-01 00:00:00

  • Conventional neurocritical care and cerebral oxygenation after traumatic brain injury.

    abstract:OBJECT:Control of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) is the foundation of traumatic brain injury (TBI) management. In this study, the authors examined whether conventional ICP- and CPP-guided neurocritical care ensures adequate brain tissue O2 in the first 6 hours after resuscitation. ME...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Stiefel MF,Udoetuk JD,Spiotta AM,Gracias VH,Goldberg A,Maloney-Wilensky E,Bloom S,Le Roux PD

    更新日期:2006-10-01 00:00:00

  • Evidence for a conditioning effect of inhalational anesthetics on angiographic vasospasm after aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is characterized by large-artery vasospasm, distal autoregulatory dysfunction, cortical spreading depression, and microvessel thrombi. Large-artery vasospasm has been identified as an independent predictor of poor outcome in numero...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Athiraman U,Aum D,Vellimana AK,Osbun JW,Dhar R,Tempelhoff R,Zipfel GJ

    更新日期:2019-06-14 00:00:00

  • Trigeminal neuralgia resulting from auditory brainstem implant cable compression.

    abstract::The authors report a case of neurofibromatosis Type 2 presenting with symptoms of trigeminal neuralgia refractory to medical management following placement of an auditory brainstem implant (ABI). Physical examination and history revealed trigeminal neuralgia. A 3D FIESTA (fast imaging employing steady-state acquisitio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Schwartz MS,Brackmann DE,Wilkinson EP,Go JL,Santos F

    更新日期:2011-01-01 00:00:00

  • Radiosurgery and radiotherapy: observations and clarifications.

    abstract:OBJECT:Radiosurgery and radiation therapy represent important but unique treatment paradigms for patients with certain neoplasms, vascular lesions, or functional disorders. The authors discuss their differences. METHODS:Reviewing the authors' experiences shows how the roles of these approaches vary just as their techn...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Kondziolka D,Lunsford LD,Loeffler JS,Friedman WA

    更新日期:2004-10-01 00:00:00

  • Computerized tomography of peripheral nerve lesions.

    abstract::Nine patients with a peripheral nerve lesion (six intrinsic and three extrinsic) were evaluated with computerized tomography (CT). In all but one instance, the CT scans gave useful information regarding the anatomical location, size, and relationship of the lesion to surrounding structures. These cases illustrate the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Powers SK,Norman D,Edwards MS

    更新日期:1983-07-01 00:00:00