Fenestrated endovascular aneurysm repair is associated with lower perioperative morbidity and mortality compared with open repair for complex abdominal aortic aneurysms.


OBJECTIVE:The Zenith Fenestrated Endovascular Graft (ZFEN; Cook Medical, Bloomington, Ind) has expanded the anatomic eligibility of endovascular aneurysm repair (EVAR) for complex abdominal aortic aneurysms (AAAs). Current data on ZFEN mainly consist of single-institution experiences and show conflicting results. Therefore, we compared perioperative outcomes after repair using ZFEN with open complex AAA repair and infrarenal EVAR in a nationwide multicenter registry. METHODS:We identified all patients undergoing elective AAA repair using ZFEN, open complex AAA repair, and standard infrarenal EVAR between 2012 and 2016 within the American College of Surgeons National Surgical Quality Improvement Program targeted vascular module. Open complex AAA repairs were defined as those with a juxtarenal or suprarenal proximal AAA extent in combination with an aortic cross-clamping position that was above at least one renal artery. The primary outcome was perioperative mortality, defined as death within 30 days or within the index hospitalization. Secondary outcomes included postoperative renal dysfunction (creatinine concentration increase of >2 mg/dL from preoperative value or new dialysis), occurrence of any complication, procedure times, blood transfusion rates, and length of stay. To account for baseline differences, we calculated propensity scores and employed inverse probability-weighted logistic regression. RESULTS:We identified 6825 AAA repairs-220 ZFENs, 181 open complex AAA repairs, and 6424 infrarenal EVARs. Univariate analysis of ZFEN compared with open complex AAA repair demonstrated lower rates of perioperative mortality (1.8% vs 8.8%; P = .001), postoperative renal dysfunction (1.4% vs 7.7%; P = .002), and overall complications (11% vs 33%; P < .001). In addition, fewer patients undergoing ZFEN received blood transfusions (22% vs 73%; P < .001), and median length of stay was shorter (2 vs 7 days; P < .001). After adjustment, open complex AAA repair was associated with higher odds of perioperative mortality (odds ratio [OR], 4.9; 95% confidence interval [CI], 1.4-18), postoperative renal dysfunction (OR, 13; 95% CI, 3.6-49), and overall complication rates (OR, 4.2; 95% CI, 2.3-7.5) compared with ZFEN. Compared with infrarenal EVAR, ZFEN presented comparable rates of perioperative mortality (1.8% vs 0.8%; P = .084), renal dysfunction (1.4% vs 0.7%; P = .19), and any complication (11% vs 7.7%; P = .09). Furthermore, after adjustment, there was no significant difference between the odds of perioperative mortality, postoperative renal dysfunction, or any complication between infrarenal EVAR and ZFEN. CONCLUSIONS:ZFEN is associated with lower perioperative morbidity and mortality compared with open complex AAA repair, and outcomes are comparable to those of infrarenal EVAR. Long-term durability of ZFEN compared with open complex AAA repair warrants future research.


J Vasc Surg


Varkevisser RRB,O'Donnell TFX,Swerdlow NJ,Liang P,Li C,Ultee KHJ,Pothof AB,De Guerre LEVM,Verhagen HJM,Schermerhorn ML




Has Abstract


2019-06-01 00:00:00














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    authors: Joyeux F,Canaud L,Hireche K,Berthet JP,Marty-Ane C,Alric P

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    pub_type: 杂志文章,评审


    authors: Muto A,Fitzgerald TN,Pimiento JM,Maloney SP,Teso D,Paszkowiak JJ,Westvik TS,Kudo FA,Nishibe T,Dardik A

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    更新日期:2020-09-01 00:00:00

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    authors: Lee CJ,Rodriguez HE,Kibbe MR,Malaisrie SC,Eskandari MK

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    更新日期:1992-03-01 00:00:00

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    journal_title:Journal of vascular surgery

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    authors: Nora JD,Hollier LH

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    authors: Markose G,Miller FN,Bolia A

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    authors: Cieri E,De Rango P,Isernia G,Simonte G,Ciucci A,Parlani G,Verzini F,Cao P

    更新日期:2014-04-01 00:00:00

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    authors: Kouvelos G,Koutsoumpelis A,Lazaris A,Matsagkas M

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    authors: Katada Y,Ouchi K,Wakita T,Nozaki M

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    authors: Ouriel K,Green RM

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    authors: Isaka M,Kumagai H,Sugawara Y,Okada K,Orihashi K,Ohtaki M,Sueda T

    更新日期:2006-06-01 00:00:00

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    authors: Colvard BD,Anaya-Ayala JE,Smolock CJ,Lumsden AB,Reardon MJ,Davies MG

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    pub_type: 历史文章,杂志文章


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    更新日期:2014-07-01 00:00:00