Clinical significance of detecting serum melatonin and SBDPs in brain injury in preterm infants.

Abstract:

BACKGROUND:To investigate the clinical values of serum melatonin and αII spectrin cleavage products (SBDPs) in assessing the severity of brain injury in preterm infants. METHODS:Sixty-four premature infants in total were selected and classified into the brain injury group (BI, n = 30) and the non-brain injury group (CON, n = 34) according to cranial imaging examination. The serum melatonin and SBDPs were detected by ELISA. All the preterm infants were received NBNA testing at 40 weeks of corrected gestational age. RESULTS:The levels of melatonin and SBDPs in the BI group were significantly higher than the CON group (p < 0.05) and the levels in the infants with severe brain injury were significantly higher than those with mild brain injury (p < 0.05), as well as exhibiting a negative correlation with the NBNA score at 40 weeks of corrected gestational age (p < 0.05). CONCLUSIONS:Detecting melatonin and SBDPs has clinical value in diagnosing and assessing the severity of brain injury in preterm infants.

journal_name

Pediatr Neonatol

authors

Yan C,Zhang B

doi

10.1016/j.pedneo.2018.11.005

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

435-440

issue

4

eissn

1875-9572

issn

2212-1692

pii

S1875-9572(18)30387-5

journal_volume

60

pub_type

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