Abstract：
BACKGROUND:To investigate the clinical values of serum melatonin and αII spectrin cleavage products (SBDPs) in assessing the severity of brain injury in preterm infants. METHODS:Sixty-four premature infants in total were selected and classified into the brain injury group (BI, n = 30) and the non-brain injury group (CON, n = 34) according to cranial imaging examination. The serum melatonin and SBDPs were detected by ELISA. All the preterm infants were received NBNA testing at 40 weeks of corrected gestational age. RESULTS:The levels of melatonin and SBDPs in the BI group were significantly higher than the CON group (p < 0.05) and the levels in the infants with severe brain injury were significantly higher than those with mild brain injury (p < 0.05), as well as exhibiting a negative correlation with the NBNA score at 40 weeks of corrected gestational age (p < 0.05). CONCLUSIONS:Detecting melatonin and SBDPs has clinical value in diagnosing and assessing the severity of brain injury in preterm infants.
journal_name
Pediatr Neonatoljournal_title
Pediatrics and neonatologyauthors
Yan C,Zhang Bdoi
10.1016/j.pedneo.2018.11.005subject
Has Abstractpub_date
2019-08-01 00:00:00pages
435-440issue
4eissn
1875-9572issn
2212-1692pii
S1875-9572(18)30387-5journal_volume
60pub_type
杂志文章abstract：BACKGROUND:Community-acquired Gram-Negative (GN) bacteremia caused more morbidity and mortality recently in children. The increasing drug resistance was also an important issue. However, published reference was few about children. METHODS:We conducted a retrospective study to collect febrile patients with blood cultur...
journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
pub_type： 杂志文章,评审
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
pub_type： 杂志文章
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
pub_type： 杂志文章,评审
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
pub_type： 杂志文章
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
pub_type： 杂志文章,评审
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journal_title：Pediatrics and neonatology
pub_type： 杂志文章
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journal_title：Pediatrics and neonatology
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journal_title：Pediatrics and neonatology
pub_type： 杂志文章
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journal_title：Pediatrics and neonatology
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