An Update on the Evolution of Glucosyltransferase (Gtf) Genes in Streptococcus.


:In many caries-promoting Streptococcus species, glucosyltransferases (Gtfs) are recognized as key enzymes contributing to the modification of biofilm structures, disruption of homeostasis of healthy microbiota community and induction of caries development. It is therefore of great interest to investigate how Gtf genes have evolved in Streptococcus. In this study, we conducted a comprehensive survey of Gtf genes among 872 streptococci genomes of 37 species and identified Gtf genes from 364 genomes of 18 species. To clarify the relationships of these Gtf genes, 45 representative sequences were used for phylogenic analysis, which revealed two clear clades. Clade I included 12 Gtf genes from nine caries-promoting species of the Mutans and Downei groups, which produce enzymes known to synthesize sticky, water-insoluble glucans (WIG) that are critical for modifying biofilm structures. Clade II primarily contained Gtf genes responsible for synthesizing water-soluble glucans (WSG) from all 18 species, and this clade further diverged into three subclades (IIA, IIB, and IIC). An analysis of 16 pairs of duplicated Gtf genes revealed high divergence levels at the C-terminal repeat regions, with ratios of the non-synonymous substitution rate (dN) to synonymous substitution rate (dS) ranging from 0.60 to 1.03, indicating an overall relaxed constraint in this region. However, among the clade I Gtf genes, some individual repeat units possessed strong functional constraints by the same criterion. Structural variations in the repeat regions were also observed, with detection of deletions or recent duplications of individual repeat units. Overall, by establishing an updated phylogeny and further elucidating their evolutionary patterns, this work enabled us to gain a greater understanding of the origination and divergence of Gtf genes in Streptococcus.


Front Microbiol


Xu RR,Yang WD,Niu KX,Wang B,Wang WM




Has Abstract


2018-12-04 00:00:00








  • Bacterial Catabolism of Dimethylsulfoniopropionate (DMSP).

    abstract::Dimethylsulfoniopropionate (DMSP) is a metabolite produced primarily by marine phytoplankton and is the main precursor to the climatically important gas dimethylsulfide (DMS). DMS is released upon bacterial catabolism of DMSP, but it is not the only possible fate of DMSP sulfur. An alternative demethylation/demethiola...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Reisch CR,Moran MA,Whitman WB

    更新日期:2011-08-12 00:00:00

  • Fecal Microbiota Characterization of Seychelles Giant Tortoises (Aldabrachelys gigantea) Living in Both Wild and Controlled Environments.

    abstract::A microbiome is defined as a complex collection of microorganisms and their genetic material. Studies regarding gut microbiomes of different animals have provided ecological and evolutionary information showing a strong link between health and disease. Very few studies have compared the gut microbiota of animals house...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Sandri C,Correa F,Spiezio C,Trevisi P,Luise D,Modesto M,Remy S,Muzungaile MM,Checcucci A,Zaborra CA,Mattarelli P

    更新日期:2020-10-20 00:00:00

  • New Approaches on Quantification of Campylobacter jejuni in Poultry Samples: The Use of Digital PCR and Real-time PCR against the ISO Standard Plate Count Method.

    abstract::Campylobacteriosis is the most frequently reported bacterial food-borne illness in the European Union and contaminated broiler meat is considered the most important source of infection in humans. The aim of the present study was to evaluate real-time PCR (qPCR) and digital PCR (dPCR) for quantification of Campylobacte...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Papić B,Pate M,Henigman U,Zajc U,Gruntar I,Biasizzo M,Ocepek M,Kušar D

    更新日期:2017-03-02 00:00:00

  • Functional Characterization of PknI-Rv2159c Interaction in Redox Homeostasis of Mycobacterium tuberculosis.

    abstract::Mycobacterium tuberculosis adapts to stress conditions by responding to the signals from its external environment. M. tuberculosis genome encodes 11 eukaryotic like serine/threonine protein kinases (STPK) and their importance in regulating the physiology and virulence of the bacteria are being explored. Previous study...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Venkatesan A,Palaniyandi K,Sharma D,Bisht D,Narayanan S

    更新日期:2016-10-21 00:00:00

  • To Construct an Engineered (S)-Equol Resistant E. coli for in Vitro (S)-Equol Production.

    abstract::(S)-equol is one of the major metabolites of daidzein that is produced by human and animal gut bacteria. Most of the physiological functions of soybean isoflavones, such as anti-oxidative activity, anti-cancer activity, and cardiovascular protection have been ascribed to (S)-equol. However, only 30-50% people contain ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Li H,Mao S,Chen H,Zhu L,Liu W,Wang X,Yin Y

    更新日期:2018-06-04 00:00:00

  • High Diversity of Myocyanophage in Various Aquatic Environments Revealed by High-Throughput Sequencing of Major Capsid Protein Gene With a New Set of Primers.

    abstract::Myocyanophages, a group of viruses infecting cyanobacteria, are abundant and play important roles in elemental cycling. Here we investigated the particle-associated viral communities retained on 0.2 μm filters and in sediment samples (representing ancient cyanophage communities) from four ocean and three lake location...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Hou W,Wang S,Briggs BR,Li G,Xie W,Dong H

    更新日期:2018-05-03 00:00:00

  • Strong Seasonality in Arctic Estuarine Microbial Food Webs.

    abstract::Microbial communities in the coastal Arctic Ocean experience extreme variability in organic matter and inorganic nutrients driven by seasonal shifts in sea ice extent and freshwater inputs. Lagoons border more than half of the Beaufort Sea coast and provide important habitats for migratory fish and seabirds; yet, litt...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审


    authors: Kellogg CTE,McClelland JW,Dunton KH,Crump BC

    更新日期:2019-11-29 00:00:00

  • Morphologically Different Pectobacterium brasiliense Bacteriophages PP99 and PP101: Deacetylation of O-Polysaccharide by the Tail Spike Protein of Phage PP99 Accompanies the Infection.

    abstract::Soft rot caused by numerous species of Pectobacterium and Dickeya is a serious threat to the world production of potatoes. The application of bacteriophages to combat bacterial infections in medicine, agriculture, and the food industry requires the selection of comprehensively studied lytic phages and the knowledge of...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Lukianova AA,Shneider MM,Evseev PV,Shpirt AM,Bugaeva EN,Kabanova AP,Obraztsova EA,Miroshnikov KK,Senchenkova SN,Shashkov AS,Toschakov SV,Knirel YA,Ignatov AN,Miroshnikov KA

    更新日期:2020-01-23 00:00:00

  • Antimicrobial and Antibiofilm Potential of Acyclic Amines and Diamines against Multi-Drug Resistant Staphylococcus aureus.

    abstract::Multi-drug resistant Staphylococcus aureus (MDRSA) remains a great challenge despite a decade of research on antimicrobial compounds against their infections. In the present study, various acyclic amines and diamines were chemically synthesized and tested for their antimicrobial as well as antibiofilm activity against...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Kaur G,Balamurugan P,Vasudevan S,Jadav S,Princy SA

    更新日期:2017-09-15 00:00:00

  • Naturally Fermented Milk From Northern Senegal: Bacterial Community Composition and Probiotic Enrichment With Lactobacillus rhamnosus.

    abstract::A variety of foods fermented with lactic acid bacteria serve as dietary staples in many African communities; yet, their bacterial profiles are poorly characterized. The integration of health-promoting probiotics into naturally fermented milk products could make a profound impact on human health. Here, we characterize ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Parker M,Zobrist S,Donahue C,Edick C,Mansen K,Hassan Zade Nadjari M,Heerikhuisen M,Sybesma W,Molenaar D,Diallo AM,Milani P,Kort R

    更新日期:2018-09-21 00:00:00

  • Stormwater runoff drives viral community composition changes in inland freshwaters.

    abstract::Storm events impact freshwater microbial communities by transporting terrestrial viruses and other microbes to freshwater systems, and by potentially resuspending microbes from bottom sediments. The magnitude of these impacts on freshwater ecosystems is unknown and largely unexplored. Field studies carried out at two ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Williamson KE,Harris JV,Green JC,Rahman F,Chambers RM

    更新日期:2014-03-14 00:00:00

  • A Bivalent Human Adenovirus Type 5 Vaccine Expressing the Rabies Virus Glycoprotein and Canine Distemper Virus Hemagglutinin Protein Confers Protective Immunity in Mice and Foxes.

    abstract::The development of a safe and efficient multivalent vaccine has great prospects for application. Both rabies virus (RABV) and canine distemper virus (CDV) are highly infectious antigens, causing lethal diseases in domestic dogs and other carnivores worldwide. In this study, a replication-deficient human adenovirus 5 (...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Yan L,Zhao Z,Xue X,Zheng W,Xu T,Liu L,Tian L,Wang X,He H,Zheng X

    更新日期:2020-06-16 00:00:00

  • PdtaS Deficiency Affects Resistance of Mycobacteria to Ribosome Targeting Antibiotics.

    abstract::Two-component regulatory systems (TCSSs) are key regulatory elements responsible for the adaptation of bacteria to environmental stresses. A classical TCSS is typically comprised of a sensory histidine kinase and a corresponding response regulator. Here, we used homologous recombination to construct a Mycobacterium sm...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Dadura K,Płocińska R,Rumijowska-Galewicz A,Płociński P,Żaczek A,Dziadek B,Zaborowski A,Dziadek J

    更新日期:2017-11-03 00:00:00

  • Basis of Virulence in Enterotoxin-Mediated Staphylococcal Food Poisoning.

    abstract::The Staphylococcus aureus enterotoxins are a superfamily of secreted virulence factors that share structural and functional similarities and possess potent superantigenic activity causing disruptions in adaptive immunity. The enterotoxins can be separated into two groups; the classical (SEA-SEE) and the newer (SEG-SEl...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审


    authors: Fisher EL,Otto M,Cheung GYC

    更新日期:2018-03-13 00:00:00

  • cpubi4 Is Essential for Development and Virulence in Chestnut Blight Fungus.

    abstract::Ubiquitination plays key roles in eukaryotic growth, stress adaptation, and metabolic regulation. In our previous work, ubiquitin was found to be secreted in the hypovirus-infected strain of Cryphonectria parasitica, a phytopathogenic filamentous fungus responsible for the chestnut blight. Here we report the functiona...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Chen Q,Li Y,Wang J,Li R,Chen B

    更新日期:2018-06-15 00:00:00

  • Perspectives on Functional Red Mold Rice: Functional Ingredients, Production, and Application.

    abstract::Monacolin K (MK) is a secondary metabolite of the Monascus species that can inhibit cholesterol synthesis. Functional red mold rice (FRMR) is the fermentation product of Monascus spp., which is rich in MK. FRMR is usually employed to regulate serum cholesterol, especially for hypercholesterolemic patients who refuse s...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Yanli F,Xiang Y

    更新日期:2020-11-25 00:00:00

  • Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor.

    abstract::Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia. We recently reported that BRSV infection significantly increased PM adherence to bovine lower respiratory tract epithelial cells. However, the molecular mechanis...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Sudaryatma PE,Saito A,Mekata H,Kubo M,Fahkrajang W,Mazimpaka E,Okabayashi T

    更新日期:2020-07-31 00:00:00

  • Differences between the rhizosphere microbiome of Beta vulgaris ssp. maritima-ancestor of all beet crops-and modern sugar beets.

    abstract::The structure and function of the plant microbiome is driven by plant species and prevailing environmental conditions. Effectuated by breeding efforts, modern crops diverge genetically and phenotypically from their wild relatives but little is known about consequences for the associated microbiota. Therefore, we studi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Zachow C,Müller H,Tilcher R,Berg G

    更新日期:2014-08-26 00:00:00

  • Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity.

    abstract::Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of new active antibiotic agents. Among effective mechanisms that contribute to the spread of MDR Gram-negative bacteria are drug efflux pumps that expel clinically important antibiotic classes out of the cell. Drug pumps are attracti...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Otręebska-Machaj E,Chevalier J,Handzlik J,Szymańska E,Schabikowski J,Boyer G,Bolla JM,Kieć-Kononowicz K,Pagès JM,Alibert S

    更新日期:2016-05-03 00:00:00

  • Colonization and Internalization of Salmonella enterica and Its Prevalence in Cucumber Plants.

    abstract::Consumption of cucumbers (Cucumis sativus var. sativus) has been linked to several foodborne outbreaks involving Salmonella enterica. The purpose of this work was to investigate the efficiency of colonization and internalization of S. enterica into cucumber plants by various routes of contamination. Produce-associated...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Burris KP,Simmons OD,Webb HM,Deese LM,Moore RG,Jaykus LA,Zheng J,Reed E,Ferreira CM,Brown EW,Bell RL

    更新日期:2020-05-29 00:00:00

  • A Cross-Protective Vaccine Against 4b and 1/2b Listeria monocytogenes.

    abstract::Listeria monocytogenes (Lm) is a foodborne zoonotic pathogen that causes listeriosis with a mortality rate of 20-30%. Serovar 4b and 1/2b isolates account for most of listeriosis outbreaks, however, no listeriosis vaccine is available for either prophylactic or therapeutic use. Here, we developed a triple-virulence-ge...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Meng F,Zhu T,Yao H,Ling Z,Feng Y,Li G,Li J,Sun X,Chen J,Meng C,Jiao X,Yin Y

    更新日期:2020-12-11 00:00:00

  • Explication of the Potential of 2-Hydroxy-4-Methoxybenzaldehyde in Hampering Uropathogenic Proteus mirabilis Crystalline Biofilm and Virulence.

    abstract::Proteus mirabilis is an important etiological agent of catheter-associated urinary tract infections (CAUTIs) owing to its efficient crystalline biofilm formation and virulence enzyme production. Hence, the present study explicated the antibiofilm and antivirulence efficacies of 2-hydroxy-4-methoxybenzaldehyde (HMB) ag...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Durgadevi R,Abirami G,Alexpandi R,Nandhini K,Kumar P,Prakash S,Veera Ravi A

    更新日期:2019-12-10 00:00:00

  • Distinctive Nuclear Localization Signals in the Oomycete Phytophthora sojae.

    abstract::To date, nuclear localization signals (NLSs) that target proteins to nuclei in oomycetes have not been defined, but have been assumed to be the same as in higher eukaryotes. Here, we use the soybean pathogen Phytophthora sojae as a model to investigate these sequences in oomycetes. By establishing a reliable in vivo N...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Fang Y,Jang HS,Watson GW,Wellappili DP,Tyler BM

    更新日期:2017-02-02 00:00:00

  • Therapeutic Efficacy of a Trichinella Spiralis Paramyosin-Derived Peptide Modified With a Membrane-Targeting Signal in Mice With Antigen-Induced Arthritis.

    abstract::Helminth-derived molecules have the ability to modulate the host immune system. Our previous study identified a tetradecapeptide derived from Trichinella spiralis paramyosin (Ts-pmy) that could bind to human complement component C9 to inhibit its polymerization, making the peptide a candidate therapeutic agent for com...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Chen Y,Shao S,Huang J,Gu Y,Cheng Y,Zhu X

    更新日期:2020-12-23 00:00:00

  • Biosynthesis and Bioactivity of Prodiginine Analogs in Marine Bacteria, Pseudoalteromonas: A Mini Review.

    abstract::The Prodiginine family consists of primarily red-pigmented tripyrrole secondary metabolites that were first characterized in the Gram-negative bacterial species Serratia marcescens and demonstrates a wide array of biological activities and applications. Derivatives of prodiginine have since been characterized in the m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审


    authors: Sakai-Kawada FE,Ip CG,Hagiwara KA,Awaya JD

    更新日期:2019-07-24 00:00:00

  • Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.

    abstract::[This corrects the article DOI: 10.3389/fmicb.2019.00159.]. ...

    journal_title:Frontiers in microbiology

    pub_type: 已发布勘误


    authors: Tian X,Hellman J,Horswill AR,Crosby HA,Francis KP,Prakash A

    更新日期:2019-03-26 00:00:00

  • Plasmodium attenuation: connecting the dots between early immune responses and malaria disease severity.

    abstract::Sterile attenuation of Plasmodium parasites at the liver-stage either by irradiation or genetic modification, or at the blood-stage by chemoprophylaxis, has been shown to induce immune responses that can protect against subsequent wild-type infection. However, following certain interventions, parasite attenuation can ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Fernandes P,Frank R,Lewis MD,Mueller AK

    更新日期:2014-12-02 00:00:00

  • Protein Composition of Mycobacterium smegmatis Differs Significantly Between Active Cells and Dormant Cells With Ovoid Morphology.

    abstract::Mycobacteria are able to form dormant cells, which survive for a long time without multiplication. The molecular mechanisms behind prolonged survival of dormant cells are not fully described. In particular, little information is known on biochemical processes which might take place in cells under dormancy. To gain ins...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Trutneva K,Shleeva M,Nikitushkin V,Demina G,Kaprelyants A

    更新日期:2018-09-04 00:00:00

  • Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.

    abstract::Expression of non-native transcriptional activators may be a powerful general method to activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose archetype is PimM, activate the biosynthesis of polyene macrolide antifungals and other antibiotics, and have been shown to be functionally preserved ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Martínez-Burgo Y,Santos-Aberturas J,Rodríguez-García A,Barreales EG,Tormo JR,Truman AW,Reyes F,Aparicio JF,Liras P

    更新日期:2019-03-26 00:00:00

  • Effect of Bifidobacterium breve in Combination With Different Antibiotics on Clostridium difficile.

    abstract::While combinations of probiotics with antibiotics have exhibited beneficial and adverse effects in the treatment of Clostridium difficile infection (CDI), no substantive explanation has been provided for these effects. In this study, C. difficile ATCC 9689 (CD) was treated with Bifidobacterium breve (YH68) in combinat...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章


    authors: Yang J,Yang H

    更新日期:2018-12-04 00:00:00