Quinine inhibits ovulation and produces oxidative stress in the ovary of cyclic Sprague-Dawley rats.

Abstract:

Background:Quinine has been reported to possess anti-spermatogenic activities. Objectives:This study was carried out to determine the effect of quinine on ovarian function in Sprague-Dawley rats. Methods:Twenty rats with regular 4-days oestrous cycle divided into 4 groups (N=5) were used. Group I received quinine at 30 mg/kg body weight by gavage for 28 days after which they were sacrificed. The ovaries were excised for biochemical oxidation of glutathione peroxidase (GSH), superoxide dismutase (SOD), catalase and malondialdehyde (MDA). Group II received single dose quinine at 30 mg/kg body weight at 0900 hrs on day of proestrus. Blood was obtained at 1800 hrs for hormonal assay of FSH and LH. The animals were sacrificed the next morning on estrus: oviducts were examined for ova count. Groups III and IV served as controls. Results:Quinine treated rats recorded zero number of ova compared to control. Serum concentration of LH reduced significantly in the quinine treated group compared to the control. Furthermore, quinine significantly decreased the oxidant status of GSH, SOD and catalase and significantly increased MDA levels in the ovary compared to the control group. Conclusion:Quinine completely blocks ovulation, suppresses LH surge, and produces oxidative stress in the ovary.

journal_name

Afr Health Sci

journal_title

African health sciences

authors

Gbotolorun SC,Inikori O,Bamisi OD,Osinubi AAA,Okanlawon AO

doi

10.4314/ahs.v18i2.8

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

253-259

issue

2

eissn

1680-6905

issn

1729-0503

pii

jAFHS.v18.i2.pg253

journal_volume

18

pub_type

杂志文章
  • Effect of mother support groups on nutritional status in children under two years of age in Laisamis village, Kenya.

    abstract:BACKGROUND:In tackling the ongoing malnutrition problem in many parts of Kenya, the government has initialized preventive actions such as mother support groups in order to improve health and nutrition among children. Few studies have evaluated the effectiveness of such intervention. OBJECTIVE:This study aimed at deter...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v16i4.4

    authors: Undlien M,Viervoll HA,Rostad B

    更新日期:2016-12-01 00:00:00

  • Effect of removal of AuraOnce™ laryngeal mask in awake or deep anaesthesia: a randomized controlled trial.

    abstract:Background:The manufacturer Ambu® recommends that the AuraOnce™ laryngeal mask be removed once the patient is fully awake. Studies have shown benefit in removal of the laryngeal mask airway while a patient is deeply anaesthetized. Current evidence is inconclusive, as to which approach is preferable and safer in adults....

    journal_title:African health sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.4314/ahs.v19i4.16

    authors: Ombaka R,Mung'ayi V,Nekyon D,Mir S

    更新日期:2019-12-01 00:00:00

  • Echocardiographic pattern and severity of valve dysfunction in children with rheumatic heart disease seen at Uganda Heart Institute, Mulago hospital.

    abstract:BACKGROUND:Rheumatic heart disease (RHD) is the commonest acquired heart disease in children worldwide but in Uganda, data is scarce regarding its morbidity and mortality. The disease has a progressive course and patients usually require valve repair/replacement in the future. OBJECTIVES:To describe the frequency of e...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v14i3.17

    authors: Lubega S,Aliku T,Lwabi P

    更新日期:2014-09-01 00:00:00

  • Socio-economic status and hunger among orphans and vulnerable children households in Lagos State, Nigeria.

    abstract:Background:HIV/AIDS has contributed to increasing orphans and vulnerable children in Nigeria. A measure of vulnerability is household hunger. Objective:To assess level of household hunger and associated factors among OVC households in Lagos State. Methods:A cross-sectional survey of 1300 OVC households in 5 selected ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i2.47

    authors: Bamgboye E,Odusote T,Olusanmi I,Akinyemi J,Bidemi Y,Adebowale A,Gbenga A,Ladipo O

    更新日期:2020-06-01 00:00:00

  • Community participation in primary health care (PHC) programmes: lessons from tuberculosis treatment delivery in South Africa.

    abstract:BACKGROUND:Currently, there is renewed interest in the role community participation can play in Primary Health Care (PHC) programmes such as the delivery of effective anti-TB treatment to patients in high-burden settings. OBJECTIVES:To explore the feasibility of community participation in a high-burden Tuberculosis Co...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Kironde S,Kahirimbanyi M

    更新日期:2002-04-01 00:00:00

  • Synergistic effect of aqueous extract of Telfaria occidentalis on the biological activities of artesunate in Plasmodium berghei infected mice.

    abstract:BACKGROUND:Resistance to most antimalarial drugs has encouraged the use of herbal preparations along with prescribed orthodox drugs. OBJECTIVE:To investigate effect of co-administration of aqueous extract of T. occidentalis leaves; commonly used as antimalarial and haematinic agent in Nigeria and artesunate using P. b...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i4.16

    authors: Adegbolagun OM,Emikpe BO,Woranola IO,Ogunremi Y

    更新日期:2013-12-01 00:00:00

  • Molecular characterization of Hymenolepis nana based on nuclear rDNA ITS2 gene marker.

    abstract:Introduction:Hymenolepis nana is a zoonotic tapeworm with widespread distribution. The goal of the present study was to identify the parasite in the specimens collected from NorthWestern regions of Iran using PCR-sequencing method. Methods:A total of 1521 stool samples were collected from the study individuals. Initia...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i1.6

    authors: Shahnazi M,Mehrizi MZ,Alizadeh SA,Heydarian P,Saraei M,Alipour M,Hajialilo E

    更新日期:2019-03-01 00:00:00

  • Effects of meteorological factors on the incidence of meningococcal meningitis.

    abstract:BACKGROUND AND OBJECTIVES:Substantial climate changes have led to the emergence and re-emergence of various infectious diseases worldwide, presenting an imperative need to explore the effects of meteorological factors on serious contagious disease incidences such as that of meningococcal meningitis (MCM). METHODS:The ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i3.25

    authors: Bai X,Hu B,Yan Q,Luo T,Qu B,Jiang N,Liu J,Zhu Y

    更新日期:2017-09-01 00:00:00

  • The diagnostic accuracy of routine clinical findings for detection of esophageal varices in rural sub-Saharan Africa where schistosomiasis is endemic.

    abstract:Background:Variceal upper gastrointestinal bleeding (UGIB) is common in sub-Saharan Africa (SSA). However, poor access to endoscopy services precludes the diagnosis of varices. Objectives:We determined the diagnostic accuracy of routine clinical findings for detection of esophageal varices among patients with UGIB in ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i4.46

    authors: Opio CK,Rejani L,Kazibwe F,Ocama P

    更新日期:2019-12-01 00:00:00

  • Effect of tramadol addiction alone and its co-abuse with cannabis on urinary excretion of Copper, Zinc, and Calcium among Egyptian addicts.

    abstract:Background:The use of illicit drugs has become a worldwide health problem. Substances with the potential to be abused may have direct or indirect effects on physiologic mechanisms that lead to organ system dysfunction and diseases. Objective:The present study aims to investigate the structural and reabsorption integri...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v18i3.35

    authors: El-Safty I,Eltamany E,Shouman A,El-Gamel O,Nada A,Ali W

    更新日期:2018-09-01 00:00:00

  • Attitude of Lesotho health care workers towards HIV/AIDS and impact of HIV/AIDS on the population structure.

    abstract:BACKGROUND:The impact and management of HIV/AIDS in Lesotho in the context of disaster management was investigated. OBJECTIVES:Lesotho health care workers' perception on HIV/AIDS progression, whether HIV/AIDS was managed as a disaster, and the impact on the demographic profile was investigated. METHODS:The empirical ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i4.36

    authors: Belle JA,Ferriera SB,Jordaan A

    更新日期:2013-12-01 00:00:00

  • Empty sella syndrome: incidental findings at computerised tomography.

    abstract::A case is presented of a 43-year-old female patient who presented with severe dizziness, neck pain and headache. Clinical examination revealed diplopia with a horizontal gaze. Plain skull radiographs showed an enlarged sella turcica with no abnormal intracraial calcifications. Pre and post contrast axial and post cont...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Luutu I

    更新日期:2001-08-01 00:00:00

  • Relationship between plasma homocysteine and blood pressure in hypertensive Northern-Nigerians.

    abstract:Aim:The study sought to determine whether there is any relationship between plasma homocysteine and blood pressure levels in Nigerians with essential hypertension. Method:It was a cross-sectional analytical study done on 120 randomly selected hypertensive patients and 120 normal healthy controls seen at the large Conf...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i1.38

    authors: Onyemelukwe OU,Maiha BB

    更新日期:2020-03-01 00:00:00

  • Recombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1.

    abstract:BACKGROUND:Recombinant human endostatin (Endostar) has been widely used to suppress angiogenesis in carcinoma patients. Hypertrophic scar (HS) tissue, much like a carcinoma, is often associated with angiogenesis. However, there have been few studies conducted on the effects of Endostar on HS or its mechanism. OBJECTIV...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v16i2.23

    authors: Wang P,Jiang LZ,Xue B

    更新日期:2016-06-01 00:00:00

  • The hazards of conducting induction of labour in high-risk pregnancies at district hospitals in low- and middle-income countries: lessons to learn from a case report.

    abstract:Background:Induction of labour (IOL) is an obstetric procedure that should be conducted in a healthcare facility with the capacity to provide optimal care based on the patient risk status. Inadequate monitoring, untimely procedure and lack of readily available and experienced medical staff to participate in the care of...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i3.27

    authors: Ngene NC,Moodley J

    更新日期:2020-09-01 00:00:00

  • Barriers to oral health care utilization in Ibadan, South West Nigeria.

    abstract:BACKGROUND:Barriers to oral health utilization are many, but those that are significant for our environment are not yet clear. The current study was designed to identify and graduate the barriers to receipt of oral health care among a cross-section of patients attending our centre. We also investigated the influence of...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v12i4.17

    authors: Ajayi DM,Arigbede AO

    更新日期:2012-12-01 00:00:00

  • Sonographic assessment of the portal vein diameter in apparently healthy adults in a Northern Nigerian population.

    abstract:BACKGROUND:Sonography is a valuable tool in the assessment of porto-systemic pathologies. This study aimed at determining the mean portal vein diameter based on age, gender and anthropometric variables. METHODS:A cross sectional study conducted among 201 apparently healthy adults in Bauchi Metropolis. Participants wer...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v16i4.35

    authors: Luntsi G,Sani M,Zira JD,Ivor NC,Garba SH

    更新日期:2016-12-01 00:00:00

  • Exotic and indigenous problem plants species used, by the Bapedi, to treat sexually transmitted infections in Limpopo Province, South Africa.

    abstract:BACKGROUND:The ethnic usage of exotics and indigenous problem plants is a highly debated topic, as legislative requirements over-shadow their potential medicinal value, particularly to treat sexually transmitted infections (STIs). Limited information exists regarding their medicinal value among the Bapedi. OBJECTIVES:...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i2.17

    authors: Semenya SS,Potgieter MJ,Erasmus LJ

    更新日期:2013-06-01 00:00:00

  • Assessment of drug therapy problem and associated factors among adult hypertensive patients at Ayder comprehensive specialized hospital, Northern Ethiopia.

    abstract:Background:Drug-therapy problems(DTPs) among hypertensive patients can result in patient's morbidity and mortality. The main aim of this study was to assess drug therapy problem and associated factors among hypertensive patients. Methods:A hospital based cross sectional study was conducted. The data was collected from...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i3.33

    authors: Weldegebreal AS,Tezeta F,Mehari AT,Gashaw W,Dessale KT,Legesse NY

    更新日期:2019-09-01 00:00:00

  • Experiences of pregnant adolescents--voices from Wakiso district, Uganda.

    abstract:BACKGROUND:In Uganda, morbidity and mortality among adolescent mothers and their children are high. Social factors behind this problem need to be better understood. OBJECTIVE:To explore problems that pregnant adolescents face in order to design appropriate policies and interventions. METHODS:This was a descriptive st...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.5555/afhs.2005.5.4.304

    authors: Atuyambe L,Mirembe F,Johansson A,Kirumira EK,Faxelid E

    更新日期:2005-12-01 00:00:00

  • Colistin resistance in Acinetobacter baumannii isolated from critically ill patients: clinical characteristics, antimicrobial susceptibility and outcome.

    abstract:Background:Acinetobacter baumannii (AB) is increasingly becoming a clinically relevant organism due to the rising number of associated nosocomial infections. The therapeutic options are extremely minimal because of its ability to develop resistance to all available antimicrobials, including colistin (CST). Data on the ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i3.13

    authors: Elham B,Fawzia A

    更新日期:2019-09-01 00:00:00

  • Hemorrhagic fever in Saudi Arabia: challenge to public health, effective management and future considerations.

    abstract:Background:Viral hemorrhagic fevers (VHF) refers to a group of febrile illnesses caused by different viruses that result in high mortality in animals and humans. Many risk factors like increased human-animal interactions, climate change, increased mobility of people and limited diagnostic facility have contributed to t...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i3.17

    authors: Kumosani TA,Al-Malki AL,Razvi SS,Balgoon MJ,Kaleem M,Huwait EA,Alghamdi MA,Yaghmoor SS,Abualnaja KO,Barbour EK,Al-Madani KA,AlToukhi MH,Kumosani AT,Moselhy SS

    更新日期:2020-09-01 00:00:00

  • Renal histoarchitectural changes in nevirapine therapy: possible role of kolaviron and vitamin C in an experimental animal model.

    abstract:BACKGROUND:There is paucity of literature regarding the nephrotoxicity of antiretroviral drugs and its interaction with plant-based adjuvants. This study investigates the attenuating effect of kolaviron in nevirapine-therapy on the histological structure of the kidneys of adult male Sprague-Dawley rats. OBJECTIVE:To d...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i1.21

    authors: Offor U,Ajayi SA,Jegede IA,Kharwa S,Naidu EC,Azu OO

    更新日期:2017-03-01 00:00:00

  • HIV counseling and testing practices among clients presenting at a market HIV clinic in Kampala, Uganda: a cross-sectional study.

    abstract:BACKGROUND:Uptake of HIV counseling and testing (HCT) among informal sector workers is not well documented. OBJECTIVE:To assess HCT practices among clients presenting for HIV services at a market HIV clinic in Kampala, Uganda. METHODS:Between August 1 and September 15, 2009, clients presenting for HIV services at a m...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i3.15

    authors: Matovu JK,Bukuluki PW,Mafigiri DK,Mudondo H

    更新日期:2017-09-01 00:00:00

  • Endometriosis of the appendix.

    abstract::Endometriosis is a well known cause of infertility. Endometriosis of the appendix is a very rare condition. To highlight this rare entity, we are reporting a case of a young lady who was admitted with recurrent attacks of lower abdominal pain associated with primary infertility. Preoperative diagnosis was acute append...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Al Oulaqi NS,Hefny AF,Joshi S,Salim K,Abu-Zidan FM

    更新日期:2008-09-01 00:00:00

  • Normative ultrasound values of renal parenchymal thickness among adults in Enugu, South-East Nigeria.

    abstract:BACKGROUND:Reduction in renal length was found to be an insufficient independent indicator of chronic renal disease. OBJECTIVE:To determine the ultrasound normative values of renal parenchymal thickness (RPT) among adults and correlate them with age and somatometric parameters. METHODS:This was a prospective clinic b...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v14i3.27

    authors: Eze C,Okoye J,Agwu K

    更新日期:2014-09-01 00:00:00

  • Integrated approach to malaria prevention at household level in rural communities in Wakiso district, Uganda: impact evaluation of a pilot project.

    abstract:Background:The integrated approach to malaria prevention, which advocates for the use of several malaria prevention methods at households, is being explored to complement other existing strategies. We implemented a pilot project that promoted the integrated approach to malaria prevention in two rural communities in Wak...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v18i4.35

    authors: Musoke D,Karani G,Morris K,Ndejjo R,Atusingwize E,Guwatudde D,Musoke MB

    更新日期:2018-12-01 00:00:00

  • Alpha thalassemia among sickle cell anaemia patients in Kampala, Uganda.

    abstract:BACKGROUND:Sickle cell anaemia is prevalent in sub Saharan Africa. While α+-thalassaemia is known to modulate sickle cell anaemia, its magnitude and significance in Uganda have hitherto not been described. OBJECTIVES:To determine the prevalence of α+thalassaemia among sickle cell anaemia patients in Mulago Hospital an...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v15i2.48

    authors: Lubega I,Ndugwa CM,Mworozi EA,Tumwine JK

    更新日期:2015-06-01 00:00:00

  • Structural findings at hysterosalpingography in patients with infertility at two private clinics in Kampala, Uganda.

    abstract:INTRODUCTION:Hysterosalpingography (HSG) is still a commonly used investigation in the evaluation of the female genital tract and the main indication for HSG is infertility. OBJECTIVE:The purpose of this study was to find the pathology detected at HSG in patients with infertility in our setting. MATERIALS AND METHODS...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Kiguli-Malwadde E,Byanyima RK

    更新日期:2004-12-01 00:00:00

  • Breast cancer resistance protein (BCRP) gene expression in a cohort of adult Egyptian patients with acute myeloid leukemia.

    abstract:Background:Acute myeloid leukemia (AML), an aggressive clonal disease, is genetically heterozygous. The prognostic role of expression of Breast Cancer Resistance Protein (BCRP) gene, which behaves as a multidrug transporter, in adult AML is ambiguous. Objective:The objective is to assess the level of mRNA expression o...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v18i4.15

    authors: El-Masry MW,Gouda HM,Shaheen IA,Edesa W,Hassan NM,Ramzy R

    更新日期:2018-12-01 00:00:00