Abstract:
Objective:Acute organophosphorus(OP) pesticide poisoning is associated with dysfunctions in multiple organs, especially skeletal muscles, the nervous system and the heart. However, little is known about the specific microRNA (miRNA) changes that control the pathophysiological processes of acute OP poisoning damage. We aimed to explore miRNA expression profiles and gain insight into molecular mechanisms of OP toxic effects. Methods:MicroRNA expression was analyzed by TaqMan Human MicroRNA Array analysis and subsequent validated with quantitive PCR. The targets of the significantly different miRNAs were predicted with miRNA prediction databases, and pathway analysis of the predicted target genes was performed using bioinformatics resources. Results:37 miRNAs were significantly different in the sera of poisoned patients compared to the healthy controls, including 29 miRNAs that were up-regulated and 8 miRNAs that were down-regulated. Functional analysis indicated that many pathways potentially regulated by these miRNAs are involved in skeletal muscle, nervous system and heart disorders. Conclusion:This study mapped changes in the serum miRNA expression profiles of poisoning patients and predicted functional links between miRNAs and their target genes in the regulation of acute OP poisoning. Our findings are an important resource for further understanding the role of these miRNAs in the regulation of OP-induced injury.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Yuan H,Yuan M,Tang Y,Wang B,Zhan Xdoi
10.4314/ahs.v18i2.18subject
Has Abstractpub_date
2018-06-01 00:00:00pages
333-342issue
2eissn
1680-6905issn
1729-0503pii
jAFHS.v18.i2.pg333journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Thrombocytopenia has been shown to predict mortality. We hypothesize that platelet indices may be more useful prognostic indicators. Our study subjects were children one month to 14 years old admitted to our hospital. AIM:To determine whether platelet count, plateletcrit (PCT), mean platelet volume (MPV) an...
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-12-01 00:00:00
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更新日期:2013-09-01 00:00:00
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更新日期:2011-03-01 00:00:00
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更新日期:2020-09-01 00:00:00
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更新日期:2018-06-01 00:00:00