Abstract:
:Nerve regeneration after injury requires proper axon alignment to bridge the lesion site and myelination to achieve functional recovery. Transplanted scaffolds with aligned channels, have been shown to induce axon growth to some extent. However, the penetration of axons into the microchannels remain a challenge, influencing the functional recovery of regenerated nerves. We previously demonstrated that the size of microchannels exerts significant impact on Schwann cells (SCs) migration. Here we demonstrate that migration of SCs promotes, significantly, the dorsal root ganglion (DRG) neurons to extend axons into three-dimensional channels and form aligned fascicular-like axon tracts. Moreover, the migrating SCs attach and wrap around the aligned axons of DRG neurons in the microchannels and initiate myelination. The SCs release growth factors that provide chemotactic signals to the regenerating axons, similar to the response achieved with nerve growth factor (NGF), but with the additional capability of promoting myelination, thereby demonstrating the beneficial effects of including SCs over NGF alone in enhancing axon penetration and myelination in three-dimensional microchannels.
journal_name
Tissue Eng Regen Medjournal_title
Tissue engineering and regenerative medicineauthors
Liu C,Kray J,Chan Cdoi
10.1007/s13770-018-0115-0subject
Has Abstractpub_date
2018-02-28 00:00:00pages
351-361issue
3eissn
1738-2696issn
2212-5469pii
115journal_volume
15pub_type
杂志文章abstract::Tissue-resident stem cells are surrounded by a microenvironment known as 'stem cell niche' which is specific for each stem cell type. This niche comprises of cell-intrinsic and -extrinsic factors like biochemical and biophysical signals, which regulate stem cell characteristics and differentiation. Biochemical signals...
journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,评审
doi:10.1007/s13770-020-00301-4
更新日期:2020-11-24 00:00:00
abstract::In almost all human tissues and organs, adult stem cells or tissue stem cells are present in a unique location, the so-called stem cell niche or its equivalent, continuously replenishing functional differentiated cells. Those endogenous stem cells can be expanded for cell therapeutics using ex vivo cell culture or rec...
journal_title:Tissue engineering and regenerative medicine
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journal_title:Tissue engineering and regenerative medicine
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doi:10.1007/s13770-020-00288-y
更新日期:2020-12-01 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,评审
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更新日期:2017-03-14 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,评审
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-019-00237-4
更新日期:2020-04-01 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-016-0021-2
更新日期:2017-01-17 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
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更新日期:2016-04-05 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-020-00312-1
更新日期:2021-01-07 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
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journal_title:Tissue engineering and regenerative medicine
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doi:10.1007/s13770-016-9092-3
更新日期:2016-10-20 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-017-0048-z
更新日期:2017-05-23 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-017-0106-6
更新日期:2018-01-19 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,评审
doi:10.1007/s13770-018-0159-1
更新日期:2018-09-14 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-015-0029-z
更新日期:2016-02-02 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,评审
doi:10.1007/s13770-019-00208-9
更新日期:2019-08-19 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,评审
doi:10.1007/s13770-020-00245-9
更新日期:2020-12-01 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-017-0030-9
更新日期:2017-03-02 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
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更新日期:2016-12-17 00:00:00
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journal_title:Tissue engineering and regenerative medicine
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更新日期:2016-02-06 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-018-0156-4
更新日期:2018-08-28 00:00:00
abstract::The author would like to correct the names for the below co-authors in the online published article. ...
journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,已发布勘误
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更新日期:2020-06-01 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,评审
doi:10.1007/s13770-020-00300-5
更新日期:2020-11-04 00:00:00
abstract::[This corrects the article DOI: 10.1007/s13770-016-0016-z.]. ...
journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章,已发布勘误
doi:10.1007/s13770-017-0072-z
更新日期:2017-07-26 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-019-00224-9
更新日期:2020-02-01 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-018-0160-8
更新日期:2018-10-19 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-016-9051-z
更新日期:2016-06-09 00:00:00
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journal_title:Tissue engineering and regenerative medicine
pub_type: 杂志文章
doi:10.1007/s13770-017-0039-0
更新日期:2017-03-08 00:00:00