Platelet-derived growth factor-D expression mediates the effect of differentiated degree on prognosis in epithelial ovarian cancer.

Abstract:

:Platelet-derived growth factor-D (PDGF-D) can enhance invasion and metastasis in several human malignancies. Although several studies have been performed to investigate the association between clinicopathological characteristics and prognosis in epithelial ovarian cancer (EOC), the mediation effect of PDGF-D on above-mentioned association have been seldom assessed. In this study, we detected the PDGF-D expression from the tissues of patients with EOC and further collected clinicopathological characteristics and prognostic information to identify whether PDGF-D mediated the effect of differentiated degree on prognosis in patients with EOC. A total of 190 paraffin-embedded tissue samples from patients with EOC between July 2005 and December 2010 were collected. We performed a Kaplan-Meier analysis for the association between differentiated degree and prognosis followed by a causal mediation analysis. The analysis results indicated that differentiated degree was associated with prognosis and PDGF-D mediated the effect of differentiated degree on prognosis in patients with EOC, which might be a potential target for ovarian cancer treatment.

journal_name

J Cell Biochem

authors

Yang C,Zhang M,Cai Y,Rong Z,Wang C,Xu Z,Xu H,Song W,Hou Y,Lou G

doi

10.1002/jcb.27432

subject

Has Abstract

pub_date

2019-01-16 00:00:00

eissn

0730-2312

issn

1097-4644

pub_type

杂志文章
  • Effect of simvastatin in different concentrations on free radicals in A-2058 human melanoma malignum cells-EPR studies.

    abstract::The influence of concentration of simvastatin (SIM) on free radicals in A-2058 human melanoma malignum cells was studied. The proliferation assay for melanoma A-2058 cells with SIM in concentration range from 0.1 to 20 µM was performed. SIM in the concentrations of 0.1, 0.3, and 1 μM only slightly changed the growth o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27540

    authors: Zdybel M,Chodurek E,Pilawa B

    更新日期:2018-09-11 00:00:00

  • miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease.

    abstract::As the most common neurodegenerative disease, Alzheimer's disease (AD) is characterized by memory, perception, and behavioral damage, which may ultimately lead to emotional fluctuation and even lethal delirium. Increasing studies indicate that microRNAs (miRNAs) are associated with pathological features of AD. However...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28276

    authors: Li J,Chen W,Yi Y,Tong Q

    更新日期:2019-06-01 00:00:00

  • Regulation of rat haptoglobin gene expression is coordinated by the nuclear matrix.

    abstract::Using computer stress-induced duplex destabilization (SIDD) analysis and binding experiments, we identified a S/MAR element (-599/-200 bp) (Hp-S/MAR) adjacent to the cis-element (-165/-56 bp) in the rat haptoglobin gene. We examined its functional interactions with the lamins and lamin-associated proteins in the basal...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22225

    authors: Vidaković M,Dinić S,Grdović N,Mihailović M,Uskoković A,Quesada P,Poznanović G

    更新日期:2009-08-15 00:00:00

  • lncRNA MIR503HG functioned as a tumor suppressor and inhibited cell proliferation, metastasis and epithelial-mesenchymal transition in bladder cancer.

    abstract::Bladder cancer is the most common malignancy with high recurrence. Currently, the long noncoding RNAs (lncRNAs) have been suggested to play vital roles in the pathogenesis of bladder cancer. The present study investigated the role of lncRNA MIR503 host gene (MIR503HG) in the pathogenesis of bladder cancer by using bot...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28373

    authors: Qiu F,Zhang MR,Zhou Z,Pu JX,Zhao XJ

    更新日期:2019-06-01 00:00:00

  • Evidence for the functional association of enzyme I and HPr of the phosphoenolpyruvate-sugar phosphotransferase system with the membrane in sealed vesicles of Escherichia coli.

    abstract::Several independent assay procedures were used to estimate the activities of the enzyme constituents of the phosphoenolpyruvate-sugar phosphotransferase system (PTS) in osmotically shocked bacterial membrane vesicles. The soluble enzymes of the system were found to be in association with the membrane by several criter...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.1982.240180210

    authors: Saier MH Jr,Cox DF,Feucht BU,Novotny MJ

    更新日期:1982-01-01 00:00:00

  • miR-125a-3p suppresses the growth and progression of papillary thyroid carcinoma cell by targeting MMP11.

    abstract::The dysregulation of miR-125a-3p has been observed in multiple tumor types. Nevertheless, the function of miR-125a-3p in papillary thyroid carcinoma (PTC) is yet to be explored. Herein, we find that miR-125a-3p is markedly downregulated in PTC tissues, and its level is inversely related to the histological grade of PT...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.29333

    authors: Song M,Wang N,Li Z,Zhang Y,Zheng Y,Yi P,Chen J

    更新日期:2020-02-01 00:00:00

  • Vitamin A as an enzyme that catalyzes the reduction of MTT to formazan by vitamin C.

    abstract::The tetrazolium salt 3(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) is reduced to formazan by the succinate dehydrogenase system of active mitochondria, and hence, specifically used to assay for the viable cells, such as measurement of cell proliferation, cytotoxicity, and cell number. However, in ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/1097-4644(20010101)80:1<133::aid-jcb120>3.

    authors: Chakrabarti R,Kundu S,Kumar S,Chakrabarti R

    更新日期:2000-09-18 00:00:00

  • Strategies for In Vivo Imaging Using Fluorescent Proteins.

    abstract::Fluorescent proteins have enabled the color-coding of cells growing in vivo. Noninvasive imaging of cells expressing fluorescent proteins has allowed the real-time determination of the behavior of cancer cells, the progression of infection, the differentiation of stem cells, and interaction of stromal and cancer cells...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.25677

    authors: Hoffman RM

    更新日期:2017-09-01 00:00:00

  • The mammalian iris-ciliary complex affects organization and synthesis of cytoskeletal proteins of organ and tissue cultured lens epithelial cells.

    abstract::A water soluble growth inhibitor was isolated from the mammalian ocular iris-ciliary complex. The molecular weight of this protein is 10 kD or lower as determined by ultrafiltration fractionation. The iris-ciliary (IC) complex water soluble protein(s) significantly inhibits synthesis of lower molecular weight proteins...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240500205

    authors: Banerjee A,Emanuel K,Parafina J,Bagchi M

    更新日期:1992-10-01 00:00:00

  • Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells.

    abstract::Colorectal cancer (CRC) is one of the most common cancers worldwide. Epidemiological and experimental studies suggest that bile acids may play a role in CRC etiology. Our aim was to characterize the effect of the primary bile acid chenodeoxycholic acid (CDCA) upon(14) C-BT uptake in tumoral (Caco-2) and non-tumoral (I...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24172

    authors: Gonçalves P,Catarino T,Gregório I,Martel F

    更新日期:2012-09-01 00:00:00

  • Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.

    abstract::Heparan sulfate proteoglycans (HSPGs), via their interactions with numerous effector molecules such as FGF-2, IL-8, and VEGF, regulate the biological activity of cells by acting as co-receptors that promote signaling. The extent and nature of their role as co-receptors is often misregulated in cancer as manifested by ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.20602

    authors: Sanderson RD,Yang Y,Kelly T,MacLeod V,Dai Y,Theus A

    更新日期:2005-12-01 00:00:00

  • miR-627/HMGB1/NF-κB regulatory loop modulates TGF-β1-induced pulmonary fibrosis.

    abstract::Pulmonary fibrosis (PF) is a fibroproliferative disease that can eventually lead to fatal lung failure. It is characterized by abnormal proliferation of fibroblasts, dysregulated fibroblast differentiation to myofibroblast, and disorganized collagen and extracellular matrix production, deposition and degradation. Ther...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27038

    authors: Li J,Kong X,Jiang S,Liao W,Zhang Z,Song J,Liang Y,Zhang W

    更新日期:2019-03-01 00:00:00

  • Identification of NPAC as a novel biomarker and regulator for hepatocellular carcinoma.

    abstract:OBJECTIVE:Hepatocellular carcinoma (HCC) has a high morbidity and mortality around the world, yet the effective therapeutic option for HCC is still limited. NPAC, also known as glyoxylate reductase 1 homolog, is a new nuclear protein recently implicated in tumor biology. However, the role of NPAC in HCC remains unclear...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28106

    authors: Zhang J,Sun N,Guo W,Wu X,Yang X,Jin H,Zhang Y,Wu X,Zhang F,Hu L,Hu H,Gao Y

    更新日期:2018-11-26 00:00:00

  • Tangeretin protects human brain microvascular endothelial cells against oxygen-glucose deprivation-induced injury.

    abstract::Tangeretin, a citrus flavonoid extracted from the peel of citrus fruits, was reported to possess antiasthmatic, antioxidant, anti-inflammatory, and neuroprotective properties. However, the effect of tangeretin on human brain microvascular endothelial cells (HBMECs) has not been examined. This study was designed to inv...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27762

    authors: Wu C,Zhao J,Chen Y,Li T,Zhu R,Zhu B,Zhang Y

    更新日期:2019-04-01 00:00:00

  • 17β-Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl-2, and FoxO Families.

    abstract::17β-Estradiol (E2 ) protects several nonreproductive tissues from apoptosis, including skeletal muscle. Previously, we showed that E2 at physiological concentrations prevented apoptosis induced by H2 O2 in skeletal myoblasts, reverting PKCδ, JNK, and p66Shc activation and exerting a beneficial action over mitochondria...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25616

    authors: La Colla A,Vasconsuelo A,Milanesi L,Pronsato L

    更新日期:2017-01-01 00:00:00

  • Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade.

    abstract::4-hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by elucidating the signaling cascad...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.21110

    authors: Vaillancourt F,Morquette B,Shi Q,Fahmi H,Lavigne P,Di Battista JA,Fernandes JC,Benderdour M

    更新日期:2007-04-01 00:00:00

  • High-mobility group box 2 promoted proliferation of cervical cancer cells by activating AKT signaling pathway.

    abstract::Cervical cancer is one of the leading killers for female worldwide. Nevertheless, the less knowledge of molecular mechanism for cervical cancer limited the improvement of treatment effects. High-mobility group box 2 (HMGB2) belongs to the HMGB family, which could play diverse roles in cell proliferation. This work mai...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28998

    authors: Zhang P,Lu Y,Gao S

    更新日期:2019-10-01 00:00:00

  • DNA methylation in breast cancers: Differences based on estrogen receptor status and recurrence.

    abstract::DNA methylation plays a role in the etiology of primary breast cancers. We analyzed paired primary and second breast tumors to elucidate the role of methylation in recurrence. Methylation profiles from paired primary and second breast tumors of 23 women were assessed using the HumanMethylation450 BeadChip. Twelve wome...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27431

    authors: Williams KE,Jawale RM,Schneider SS,Otis CN,Pentecost BT,Arcaro KF

    更新日期:2019-01-01 00:00:00

  • Passage-dependent expression of STRO-1 in human gingival mesenchymal stem cells.

    abstract::The expression of STRO-1, the essential mesenchymal stem cell marker, was found to decrease with advancing passages in few tissues. Because STRO-1 was identified and isolated from human gingiva, we were interested to know its status after a few passages. Human gingival mesenchymal stem cells (HGMSCs) were isolated fro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27674

    authors: Ranga Rao S,Subbarayan R

    更新日期:2019-03-01 00:00:00

  • Comprehensive analysis of novel three-long noncoding RNA signatures as a diagnostic and prognostic biomarkers of human triple-negative breast cancer.

    abstract::Currently, traditional predictors of prognosis (tumor size, nodal status, progesterone receptor [PR], estrogen receptor [ER], or human epidermal growth factor receptor-2 [HER2]) are insufficient for precise survival prediction for triple-negative breast cancer (TNBC). Long noncoding RNAs (lncRNAs) have been observed t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27584

    authors: Fan CN,Ma L,Liu N

    更新日期:2019-03-01 00:00:00

  • The beta3 chain short arm of laminin-332 (laminin-5) induces matrix assembly and cell adhesion activity of laminin-511 (laminin-10).

    abstract::The basement membrane (BM) protein laminin-332 (Lm332) (laminin-5) has unique activity and structure as compared with other laminins: it strongly promotes cellular adhesion and migration, and its alpha3, beta3, and gamma2 chains are all truncated in their N-terminal regions (short arms). In the present study, we inves...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.21032

    authors: Nakashima Y,Kariya Y,Miyazaki K

    更新日期:2007-02-15 00:00:00

  • microRNA-542-5p protects against acute lung injury in mice with severe acute pancreatitis by suppressing the mitogen-activated protein kinase signaling pathway through the negative regulation of P21-activated kinase 1.

    abstract::Severe acute pancreatitis (SAP) is a condition associated with high rates of mortality and lengthy hospital stays. In the current study, SAP mouse models were established in BALB/c wild-type and P21-activated kinase 1 (PAK1) knockdown mice with the objective of determining the expression of microRNA-542-5p (miR-542-5p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27356

    authors: Wu XM,Ji KQ,Wang HY,Zhao Y,Jia J,Gao XP,Zang B

    更新日期:2019-01-01 00:00:00

  • Butyrate stimulates ApoA-IV-containing lipoprotein secretion in differentiated Caco-2 cells: role in cholesterol efflux.

    abstract::The aim of this study was to determine: (1) whether the Short Chain Fatty Acids (SCFA) Acetate, Propionate, and Butyrate enhance the synthesis and secretion of intestinal apolipoprotein A-IV-containing lipoproteins and (2) if so, whether these particles are able to promote cholesterol efflux in vitro. For this purpose...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.1221

    authors: Nazih H,Nazih-Sanderson F,Krempf M,Michel Huvelin J,Mercier S,Marie Bard J

    更新日期:2001-08-01 00:00:00

  • Pancreatic stellate cell-potentiated insulin secretion from Min6 cells is independent of interleukin 6-mediated pathway.

    abstract::Pancreatic stellate cells (PSCs) secrete various factors, which can influence the β-cell function. The identification of stellate cell infiltration into the islets in pancreatic diseases suggests possible existence of cross-talk between these cells. To elucidate the influence of PSCs on β-cell function, mouse PSCs wer...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.29329

    authors: Bynigeri RR,Mitnala S,Talukdar R,Singh SS,Duvvuru NR

    更新日期:2020-01-01 00:00:00

  • Rationale for active vitamin D and analogs in the treatment of osteoporosis.

    abstract::In 1981, Chugai Pharmaceutical succeeded in marketing alfacalcidol, a prodrug of calcitriol, as a therapeutic agent for renal osteodystrophy. In 1983, Chugai succeeded in extending the application of alfacalcidol to the treatment of osteoporosis as well. Clinicians in Japan have accepted alfacalcidol as a remedy for o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.10328

    authors: Nishii Y

    更新日期:2003-02-01 00:00:00

  • Retraction.

    abstract::"microRNA-383 suppresses the PI3K-AKT-MTOR signaling pathway to inhibit development of cervical cancer via downregulating PARP2," by Peng Teng, Yan Jiao, Min Hao, Xin Tang, J Cell Biochem. 2018; 5243-5252: The above article, published online on 13 December 2017 in Wiley Online Library (https://onlinelibrary.wiley.com/...

    journal_title:Journal of cellular biochemistry

    pub_type: 撤回出版物

    doi:10.1002/jcb.29854

    authors:

    更新日期:2021-01-01 00:00:00

  • Concepts of epithelial-mesenchymal interactions during development: tooth and lung organogenesis.

    abstract::One of the major problems in developmental biology concerns how differential gene activity is regionally controlled. One approach to this problem is the use of mesenchyme specification of epithelial-specific gene expression, such as, during tooth morphogenesis or lung morphogenesis. In the example of tooth morphogenes...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.240260207

    authors: Slavkin HC,Snead ML,Zeichner-David M,Jaskoll TF,Smith BT

    更新日期:1984-01-01 00:00:00

  • Expression of osteoprotegerin and receptor activator for the nuclear factor-κB ligand in XACB/LV-bFGF/MSCs transplantation for repair of rabbit femoral head defect necrosis.

    abstract::The aim of this study is to observe the changes in osteoprotegerin (OPG) and receptor activator for the nuclear factor-κB ligand (RANKL) in a rabbit model, and to explore the therapeutic effect of tissue engineering bone on femoral head necrosis. A total of 60 rabbits were randomly divided into 5 groups. The necrosis ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27201

    authors: Peng W,Zhang J,Zhang F,Zhao Y,Dong W

    更新日期:2018-10-18 00:00:00

  • ChIP-based methods for the identification of long-range chromatin interactions.

    abstract::Chromatin immunoprecipitation (ChIP) is an important technique for studying protein-DNA interactions. Whole genome ChIP methods have enjoyed much success, but are limited in that they cannot uncover important long-range chromatin interactions. Chromosome conformation capture (3C) and related methods are capable of det...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.22116

    authors: Fullwood MJ,Ruan Y

    更新日期:2009-05-01 00:00:00

  • Identification and characterisation of transcript and protein of a new short N-terminal utrophin isoform.

    abstract::Dystrophin and utrophin are known to link the intracellular cytoskeleton to the extracellular matrix via a transmembraneous glycoprotein complex. Four short C-terminal isoforms (Dp71, Dp116, Dp140, and Dp260) are described for dystrophin and three for utrophin (Up71, Up113, and Up140). We describe here for the first t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(20000601)77:3<418::aid-jcb

    authors: Zuellig RA,Bornhauser BC,Knuesel I,Heller F,Fritschy JM,Schaub MC

    更新日期:2000-04-01 00:00:00