WITHDRAWN: Proton pump inhibitor treatment for acute peptic ulcer bleeding.

Abstract:

BACKGROUND:Randomised controlled trials (RCTs) evaluating the clinical effect of proton pump inhibitors (PPIs) in peptic ulcer (PU) bleeding yield conflicting results. OBJECTIVES:To evaluate the efficacy of PPIs in acute bleeding from PU using evidence from RCTs. SEARCH STRATEGY:We searched CENTRAL, The Cochrane Library (Issue 4, 2004), MEDLINE (1966 to November 2004), EMBASE (1980 to November 2004), proceedings of major meetings to November 2004, and reference lists of articles. We contacted pharmaceutical companies and experts in the field. SELECTION CRITERIA:RCTs of PPI treatment (oral or intravenous) compared with placebo or H(2)-receptor antagonist (H(2)RA) in acute bleeding from PU. DATA COLLECTION AND ANALYSIS:Two reviewers extracted data independently, assessed study validity, summarised studies and undertook meta-analysis. The influence of study characteristics on the outcomes was examined by subgroup analyses and meta-regression. MAIN RESULTS:Twenty-four RCTs comprising 4373 participants in total were included. Statistical heterogeneity was found among trials for rebleeding (P = 0.04), but not for all-cause mortality (P = 0.24) or surgery (P = 0.45). There was no significant difference in all-cause mortality rates between PPI and control treatment; pooled rates were 3.9% on PPI versus 3.8% on control (odds ratio (OR) 1.01; 95% CI 0.74 to 1.40). PPIs significantly reduced rebleeding compared to control; pooled rates were 10.6% with PPI versus 17.3% with control treatment (OR 0.49; 95% CI 0.37 to 0.65). PPI treatment significantly reduced surgery compared with control; pooled rates were 6.1% on PPI versus 9.3% on control (OR 0.61; 95% CI 0.48 to 0.78). There was no evidence to suggest that results on mortality and rebleeding were dependent on study quality, route of PPI administration, type of control treatment or application of initial endoscopic haemostatic treatment. PPIs significantly reduced surgery compared with placebo but not when compared with H(2)RA. There was no evidence to suggest that study quality, route of PPI administration or application of initial endoscopic haemostatic treatment influenced results on surgery. PPI treatment appeared more efficacious in studies conducted in Asia compared to studies conducted elsewhere. All-cause mortality was reduced only in Asian studies; reductions in rebleeding and surgery were quantitatively greater in Asian studies. Among patients with active bleeding or non-bleeding visible vessel, PPI treatment reduced mortality (OR 0.53; 95% CI 0.31 to 0.91), rebleeding and surgery. AUTHORS' CONCLUSIONS:PPI treatment in PU bleeding reduces rebleeding and surgery compared with placebo or H(2)RA, but there is no evidence of an overall effect on all-cause mortality.

authors

Leontiadis GI,Sharma VK,Howden CW

doi

10.1002/14651858.CD002094.pub4

subject

Has Abstract

pub_date

2010-05-12 00:00:00

pages

CD002094

issue

5

issn

1469-493X

pub_type

杂志文章,评审
  • Prostaglandins versus oxytocin for prelabour rupture of membranes at or near term.

    abstract:BACKGROUND:The conventional method of induction of labour is with intravenous oxytocin. More recently, induction with prostaglandins, followed by an infusion of oxytocin if necessary, has been used. OBJECTIVES:The objective of this review was to assess the effects of induction of labour with prostaglandins compared wi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000158

    authors: Tan BP,Hannah ME

    更新日期:2000-01-01 00:00:00

  • Families and Schools Together (FAST) for improving outcomes for children and their families.

    abstract:BACKGROUND:Parents and carers have a major influence on children's learning and development from birth, through the school years, and into adulthood. Parental contributions to education include providing a secure environment in which to learn, providing intellectual stimulation, transmitting social norms and values, sh...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD012760.pub2

    authors: Valentine JC,Leach SM,Fowler AP,Stojda DK,Macdonald G

    更新日期:2019-07-31 00:00:00

  • Sensory stimulation for brain injured individuals in coma or vegetative state.

    abstract:BACKGROUND:Coma and vegetative state follow traumatic brain injury in about one out of eight patients, and in patients with non traumatic injury the prognosis is worse. The use of sensory stimulation for coma and vegetative state has gained popularity during the 1980's but beliefs and opinions about its effectiveness v...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001427

    authors: Lombardi F,Taricco M,De Tanti A,Telaro E,Liberati A

    更新日期:2002-01-01 00:00:00

  • Perioperative beta-blockers for preventing surgery-related mortality and morbidity.

    abstract:BACKGROUND:Randomized controlled trials have yielded conflicting results regarding the ability of beta-blockers to influence perioperative cardiovascular morbidity and mortality. Thus routine prescription of these drugs in unselected patients remains a controversial issue. OBJECTIVES:The objective of this review was t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004476.pub3

    authors: Blessberger H,Kammler J,Domanovits H,Schlager O,Wildner B,Azar D,Schillinger M,Wiesbauer F,Steinwender C

    更新日期:2018-03-13 00:00:00

  • Aerosolized prostacyclins for acute respiratory distress syndrome (ARDS).

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) is a critical condition that is associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far.This review was originally published in 2010 and updated in 2017. OBJECTIVES:To...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007733.pub3

    authors: Afshari A,Bastholm Bille A,Allingstrup M

    更新日期:2017-07-24 00:00:00

  • Palliative interventions for controlling vaginal bleeding in advanced cervical cancer.

    abstract:BACKGROUND:This is an updated version of the original Cochrane review published in Issue 5, 2015.Cervical cancer is the fourth most common cancer among women worldwide, with estimated 569,847 new diagnoses and 311,365 deaths per year. However, incidence and stage at diagnosis vary greatly between geographic areas and a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD011000.pub3

    authors: Eleje GU,Eke AC,Igberase GO,Igwegbe AO,Eleje LI

    更新日期:2019-03-19 00:00:00

  • Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation.

    abstract:BACKGROUND:Chronic pulmonary infection is one of the hallmarks of lung disease in cystic fibrosis. Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 17 closely-related species of gram-negative bacteria, are particularly difficult to treat. These infections may be associated with...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009529.pub2

    authors: Horsley A,Jones AM

    更新日期:2012-10-17 00:00:00

  • Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer.

    abstract:BACKGROUND:Epithelial ovarian cancer is diagnosed in 4500 women in the UK each year of whom 1700 will ultimately die of their disease. Ten to fifteen percent of all cases are diagnosed early when there is still a good possibility for cure. The treatment of early stage disease involves surgery to remove disease often fo...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004706.pub3

    authors: Winter-Roach BA,Kitchener HC,Dickinson HO

    更新日期:2009-07-08 00:00:00

  • Autoinflation for hearing loss associated with otitis media with effusion.

    abstract:BACKGROUND:This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2006.Otitis media with effusion (OME) or 'glue ear' is an accumulation of fluid in the middle ear, in the absence of acute inflammation or infection. It is the commonest cause of acquired hearing loss in childhood and ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006285.pub2

    authors: Perera R,Glasziou PP,Heneghan CJ,McLellan J,Williamson I

    更新日期:2013-05-31 00:00:00

  • Conservative management of pelvic organ prolapse in women.

    abstract:BACKGROUND:Pelvic organ prolapse is common, and some degree of prolapse is seen in 50% of parous women. Women with prolapse can experience a variety of pelvic floor symptoms. Treatments include surgery, mechanical devices and conservative management. Conservative management approaches, such as giving lifestyle advice a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003882.pub3

    authors: Hagen S,Stark D,Maher C,Adams E

    更新日期:2006-10-18 00:00:00

  • Routine intracranial pressure monitoring in acute coma.

    abstract:BACKGROUND:Studies in traumatic encephalopathy first led to the insight that the damage seen was not just due to direct consequences of the primary injury. A significant, and potentially preventable, contribution to the overall morbidity arose from secondary hypoxic-ischaemic damage. Brain swelling accompanied by raise...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002043

    authors: Forsyth R,Baxter P,Elliott T

    更新日期:2001-01-01 00:00:00

  • Screening for genital chlamydia infection.

    abstract:BACKGROUND:Genital infections caused by Chlamydia trachomatis are the most prevalent bacterial sexually transmitted infection worldwide. Screening of sexually active young adults to detect and treat asymptomatic infections might reduce chlamydia transmission and prevent reproductive tract morbidity, particularly pelvic...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD010866.pub2

    authors: Low N,Redmond S,Uusküla A,van Bergen J,Ward H,Andersen B,Götz H

    更新日期:2016-09-13 00:00:00

  • Fluphenazine (oral) versus placebo for schizophrenia.

    abstract:BACKGROUND:Fluphenazine is one of the first drugs to be classed as an 'antipsychotic' and has been widely available for five decades. OBJECTIVES:To compare the effects of oral fluphenazine with placebo for the treatment of schizophrenia. To evaluate any available economic studies and value outcome data. SEARCH METHOD...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006352.pub3

    authors: Matar HE,Almerie MQ,Sampson SJ

    更新日期:2018-06-12 00:00:00

  • Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.

    abstract:BACKGROUND:Lactoferrin, a normal component of human colostrum and milk, can enhance host defenses and may be effective for prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates. OBJECTIVES:Primary objective 1. To assess the safety and effectiveness of lactoferrin supplementation to enteral feeds...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007137.pub5

    authors: Pammi M,Suresh G

    更新日期:2017-06-28 00:00:00

  • Written action plans for asthma in children.

    abstract:BACKGROUND:While all asthma consensus statements recommend the use of written action plan (WAP) as a central part of asthma management, a recent systematic review of randomised trials highlighted the paucity of trials where the only difference between groups was the provision or not of a written action plan. OBJECTIVE...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005306.pub2

    authors: Bhogal S,Zemek R,Ducharme FM

    更新日期:2006-07-19 00:00:00

  • Magnesium sulphate versus diazepam for eclampsia.

    abstract:BACKGROUND:Eclampsia, the occurrence of a convulsion in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further fits. OBJECTIVES:The objective of this review was to assess the effects of magnes...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000127

    authors: Duley L,Henderson-Smart D

    更新日期:2003-01-01 00:00:00

  • Intercessory prayer for the alleviation of ill health.

    abstract:BACKGROUND:Prayer is an ancient and widely used intervention for alleviating illness and promoting good health. This review focuses specifically on intercessory prayer, which is organised, regular and committed, and those who practise it will almost inevitably hold some committed belief that they are praying to God. Wh...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000368

    authors: Roberts L,Ahmed I,Hall S

    更新日期:2000-01-01 00:00:00

  • Treatment of hypertension in peripheral arterial disease.

    abstract:BACKGROUND:Peripheral arterial disease (PAD) causes considerable morbidity and mortality. Hypertension is a risk factor for PAD. Treatment for hypertension must be compatible with the symptoms of PAD. Controversy regarding the effects of beta-blockade for hypertension in patients with PAD has led many physicians to sto...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003075.pub2

    authors: Lane DA,Lip GY

    更新日期:2009-10-07 00:00:00

  • Pharmacological interventions for obsessive-compulsive personality disorder.

    abstract::This is the protocol for a review and there is no abstract. The objectives are as follows: To evaluate the potential beneficial and adverse effects of pharmacological interventions for people with obsessive-compulsive personality disorder and to make recommendations for future areas of research. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD008517

    authors: Alex R,Ferriter M,Jones H,Huband N,Duggan C,Völlm BA,Stoffers J,Lieb K

    更新日期:2010-01-01 00:00:00

  • Topical treatments for scalp psoriasis.

    abstract:BACKGROUND:People with chronic plaque psoriasis often have lesions on the scalp. Hair makes the scalp difficult to treat and the adjacent facial skin is particularly sensitive to topical treatments. OBJECTIVES:To assess the efficacy and safety of topical treatments for scalp psoriasis. SEARCH METHODS:We searched the ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009687.pub2

    authors: Schlager JG,Rosumeck S,Werner RN,Jacobs A,Schmitt J,Schlager C,Nast A

    更新日期:2016-02-26 00:00:00

  • Booster dose vaccination for preventing hepatitis B.

    abstract:BACKGROUND:Antibodies against hepatitis B surface antigen (HBsAg) wane over time following hepatitis B immunisation; hence, it is unclear whether people vaccinated in three-dose or four-dose schedules of the hepatitis B vaccine are still immune when the hepatitis B surface antibody (anti-HBs) level in their body is und...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008256.pub3

    authors: Poorolajal J,Hooshmand E

    更新日期:2016-06-07 00:00:00

  • Oestrogens and progestogens for preventing and treating postnatal depression.

    abstract:BACKGROUND:Postnatal depression, with a prevalence of at least 10%, is probably the most common complication of the puerperium. A deficiency or imbalance of sex hormones has repeatedly been suggested as a cause. OBJECTIVES:The objective of this review was to evaluate the role of oestrogens and progestogens in the prev...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001690

    authors: Lawrie TA,Herxheimer A,Dalton K

    更新日期:2000-01-01 00:00:00

  • Single dose paracetamol (acetaminophen), with and without codeine, for postoperative pain.

    abstract:BACKGROUND:Patient surveys have shown that postoperative pain is often not managed well, and there is a need to assess the efficacy and safety of commonly used analgesics as newer treatments become available. Paracetamol (acetaminophen) is an important non-opiate analgesic, commonly prescribed, as well as being availab...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001547

    authors: Moore A,Collins S,Carroll D,McQuay H,Edwards J

    更新日期:2000-01-01 00:00:00

  • Spinal cord stimulation for cancer-related pain in adults.

    abstract:BACKGROUND:This is an update of a review first published in The Cochrane Library in Issue 3, 2013. Cancer-related pain places a heavy burden on public health with related high expenditure. Severe pain is associated with a decreased quality of life in patients with cancer. A significant proportion of patients with cance...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009389.pub3

    authors: Peng L,Min S,Zejun Z,Wei K,Bennett MI

    更新日期:2015-06-29 00:00:00

  • Lay-led and peer support interventions for adolescents with asthma.

    abstract:BACKGROUND:Adolescents with asthma are at high risk of poor adherence with treatment. This may be compounded by activities that worsen asthma, in particular smoking. Additional support above and beyond routine care has the potential to encourage good self-management. We wanted to find out whether sessions led by their ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012331.pub2

    authors: Kew KM,Carr R,Crossingham I

    更新日期:2017-04-19 00:00:00

  • Bisphosphonates in multiple myeloma.

    abstract:BACKGROUND:Bisphosphonates are specific inhibitors of osteoclastic activity and are currently used as supportive therapy for multiple myeloma (MM). However, the exact clinical role of bisphosphonates in MM remains unclear. OBJECTIVES:This update of the first review published in 2002. We have also analyzed observationa...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003188.pub2

    authors: Mhaskar R,Redzepovic J,Wheatley K,Clark OA,Miladinovic B,Glasmacher A,Kumar A,Djulbegovic B

    更新日期:2010-03-17 00:00:00

  • Environmental interventions to reduce the consumption of sugar-sweetened beverages and their effects on health.

    abstract:BACKGROUND:Frequent consumption of excess amounts of sugar-sweetened beverages (SSB) is a risk factor for obesity, type 2 diabetes, cardiovascular disease and dental caries. Environmental interventions, i.e. interventions that alter the physical or social environment in which individuals make beverage choices, have bee...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD012292.pub2

    authors: von Philipsborn P,Stratil JM,Burns J,Busert LK,Pfadenhauer LM,Polus S,Holzapfel C,Hauner H,Rehfuess E

    更新日期:2019-06-12 00:00:00

  • Prophylactic antibiotics for penetrating abdominal trauma.

    abstract:BACKGROUND:Penetrating abdominal trauma occurs when the peritoneal cavity is breached. Routine laparotomy for penetrating abdominal injuries began in the 1800s, with antibiotics first being used in World War II to combat septic complications associated with these injuries. This practice was marked with a reduction in s...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007370.pub2

    authors: Brand M,Goosen J,Grieve A

    更新日期:2009-10-07 00:00:00

  • Antimicrobial drugs for treating cholera.

    abstract:BACKGROUND:Cholera is an acute watery diarrhoea caused by infection with the bacterium Vibrio cholerae, which if severe can cause rapid dehydration and death. Effective management requires early diagnosis and rehydration using oral rehydration salts or intravenous fluids. In this review, we evaluate the additional bene...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008625.pub2

    authors: Leibovici-Weissman Y,Neuberger A,Bitterman R,Sinclair D,Salam MA,Paul M

    更新日期:2014-06-19 00:00:00

  • Haloperidol for the treatment of nausea and vomiting in palliative care patients.

    abstract:BACKGROUND:Nausea and vomiting are common symptoms of patients with terminal, incurable illnesses and can be distressing. OBJECTIVES:The primary objective of the review was to evaluate the efficacy and adverse events associated with the use of haloperidol for the treatment of nausea and vomiting in palliative care pat...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006271.pub2

    authors: Perkins P,Dorman S

    更新日期:2009-04-15 00:00:00