Clinical Outcomes after Revision of Autologous Chondrocyte Implantation to Osteochondral Allograft Transplantation for Large Chondral Defects: A Comparative Matched-Group Analysis.

abstract：OBJECTIVE:Both selenium (Se) deficiency and mycotoxin T2 lead to epiphyseal plate lesions, similar to Kashin-Beck disease (KBD). However, regulation of selenoproteins synthesis mediated by SECISBP2, in response to these 2 environmental factors, remained unclear. The present study proposed to explore the mechanism behin...

journal_title：Cartilage

authors： Sun J,Min Z,Zhao W,Hussain S,Zhao Y,Guo D,Zhang F,Guo Y,Sun M,Huang H,Han Y,Zhong N,Xu P,Lu S

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this systematic review and meta-analysis was to evaluate the effect of electromagnetic field treatment on the symptoms of knee osteoarthritis (OA). In addition, the influence of the type of control group and other covariates have been investigated to identify the sources of heterogeneity in the...

journal_title：Cartilage

authors： Viganò M,Perucca Orfei C,Ragni E,Colombini A,de Girolamo L

更新日期：2020-06-08 00:00:00

abstract：OBJECTIVE:Hyaluronic acid-transglutaminase (HA-TG) is an enzymatically crosslinkable adhesive hydrogel with chondrogenic properties demonstrated in vitro and in an ectopic mouse model. In this study, we investigated the feasibility of using HA-TG in a collagen scaffold to treat chondral lesions in an ovine model, to ev...

journal_title：Cartilage

authors： Levinson C,Cavalli E,von Rechenberg B,Zenobi-Wong M,Darwiche SE

更新日期：2021-01-29 00:00:00

abstract：OBJECTIVE:Articular cartilage is incapable of effective repair following injury or during osteoarthritis. While there have been developments in cartilage repair technologies, there is a need to advance biologically relevant models for preclinical testing of biomaterial and regenerative therapies. This study describes c...

journal_title：Cartilage

authors： Styczynska-Soczka K,Amin AK,Simpson AHW,Hall AC

更新日期：2020-06-21 00:00:00

abstract：BACKGROUND:Full-depth cartilage lesions do not heal and the long-term clinical outcome is uncertain. In the symptomatic middle-aged (35-60 years) patient, treatment with metal implants has been proposed. However, the cartilage health surrounding these implants has not been thoroughly studied. Our objective was to evalu...

journal_title：Cartilage

authors： Martinez-Carranza N,Hultenby K,Lagerstedt AS,Schupbach P,Berg HE

更新日期：2019-01-01 00:00:00

abstract：:Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure. These programs are based on knowledge of...

journal_title：Cartilage

authors： Wilk KE,Macrina LC,Reinold MM

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of intra-articular injection of autologous micronized adipose tissue (MAT) with ankle arthroscopic debridement in patients with advanced-stage posttraumatic osteoarthritis (PTOA) of ankle. DESIGN:A retrospective cohort study investigating patients treated with arthroscopic debridement ...

journal_title：Cartilage

authors： Shimozono Y,Dankert JF,Kennedy JG

更新日期：2020-08-06 00:00:00

abstract：:Introduction Autologous osteochondral transplantation (AOT) is a treatment for osteochondral lesions with known concerns, including histological degradation of the graft and poor cartilage integration. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have been described has having the potential to improve results. ...

journal_title：Cartilage

authors： Smyth NA,Ross KA,Haleem AM,Hannon CP,Murawski CD,Do HT,Kennedy JG

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:TNIIIA2 is a peptide of the extracellular matrix glycoprotein tenascin-C. We evaluated whether intra-articular injection of TNIIIA2 could prevent articular cartilage degeneration without inducing synovitis in an osteoarthritis mice model. DESIGN:Ten micrograms per milliliter of TNIIIA2 were injected into the...

journal_title：Cartilage

authors： Hattori T,Hasegawa M,Unno H,Iino T,Fukai F,Yoshida T,Sudo A

更新日期：2020-03-23 00:00:00

abstract：OBJECTIVE:Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype ...

journal_title：Cartilage

authors： Wilson B,Novakofski KD,Donocoff RS,Liang YX,Fortier LA

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To assess the continued effectiveness and safety of Gel-200 following observation and open-label retreatment in an extension protocol following a randomized, double-blind, phosphate buffered saline (PBS)-controlled trial (initial treatment trial). DESIGN:Patients who completed initial blinded treatment were ...

journal_title：Cartilage

authors： Strand V,Baraf HS,Lavin PT,Lim S,Hosokawa H

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Our aim was to compare T2 with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the hip and assess the reproducibility and effect of joint unloading on T2 mapping. DESIGN:Ten individuals at high risk of developing hip osteoarthritis (SibKids) underwent contemporaneous T2 mappi...

journal_title：Cartilage

authors： Fernquest S,Palmer A,Gammer B,Hirons E,Kendrick B,Taylor A,De Berker H,Bangerter N,Carr A,Glyn-Jones S

更新日期：2019-04-11 00:00:00

abstract：OBJECTIVE:There are limited data on bone dimension and cartilage thickness of the distal humeral articular surface. This study aimed to evaluate sex- and age-related bone dimension and cartilage thickness differences and assess the effect of cartilage thickness on distal humeral shape. DESIGN:Elbow magnetic resonance ...

journal_title：Cartilage

authors： Misir A,Gunay AE,Oguzkaya S,Uzun E,Kizkapan TB,Yildiz KI,Ozcamdalli M

更新日期：2020-02-10 00:00:00

abstract：OBJECTIVE:Traumatic impacts on the articular joint surface in vitro are known to lead to degeneration of the cartilage. The main objective of this study was to develop a spring-loaded impact device that can be used to deliver traumatic impacts of consistent magnitude and rate and to find whether impacts cause catabolic...

journal_title：Cartilage

authors： Alexander PG,Song Y,Taboas JM,Chen FH,Melvin GM,Manner PA,Tuan RS

更新日期：2013-01-01 00:00:00

abstract：:The objective of this study was to characterize magnetic resonance imaging (MRI) findings and correlate with clinical results in patients who underwent autologous chondrocyte implantation (ACI) of osteochondral lesions of the talus (OLT). METHODS:Twenty-four grafts were evaluated at a mean 65.8 months after ACI for O...

journal_title：Cartilage

authors： Chan KW,Ferkel RD,Kern B,Chan SS,Applegate GR

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To assess the clinical outcome of patients treated with autologous chondrocyte implantation using ChondroCelect in daily practice. METHODS:The study is a cross-sectional analysis of an open-label, noninterventional cohort. The setting was a compassionate use program, involving 43 orthopaedic centers in 7 Eur...

journal_title：Cartilage

authors： Vanlauwe J,Huylebroek J,Van Der Bauwhede J,Saris D,Veeckman G,Bobic V,Victor J,Almqvist KF,Verdonk P,Fortems Y,Van Lommel N,Haazen L

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Describe the local morphological response of the articular-epiphyseal cartilage complex to surgical stab incision in the distal femur of foals, with emphasis on the relationship between growth cartilage injury, enchondral ossification, and repair. DESIGN:Nine foals were induced into general anesthesia at the...

journal_title：Cartilage

authors： Olstad K,Hendrickson EH,Ekman S,Carlson CS,Dolvik NI

更新日期：2013-07-01 00:00:00

abstract：:Nucleofection of chondrocytes has been shown to be an adequate method of transfection. Using Amaxa's nucleofection system, transfection efficiencies up to 89% were achievable for vector (pmaxGFP) and 98% for siRNA (siGLO) into passaged chondrocytes. However, such methods rely on costly commercial kits with proprietary...

journal_title：Cartilage

authors： Parreno J,Delve E,Andrejevic K,Paez-Parent S,Wu PH,Kandel R

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To evaluate clinical, functional, and radiographic outcomes of patients who underwent bipolar osteochondral allograft transplantation (OCAT) of the patellofemoral joint (PFJ). DESIGN:Prospectively collected data on 18 knees who underwent fresh osteochondral allograft transplantation of the patella and trochl...

journal_title：Cartilage

authors： Mirzayan R,Charles MD,Batech M,Suh BD,DeWitt D

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Ankle arthropathy is a frequent and invalidating manifestation of hemophilia. Arthrodesis is the gold standard surgical procedure in end-stage disease, with many drawbacks in young patients. Recent literature has shown increase interest in regenerative procedures in hemophilic arthropathy, which may be desira...

journal_title：Cartilage

authors： Buda R,Cavallo M,Castagnini F,Cenacchi A,Natali S,Vannini F,Giannini S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Our aim is to explore the candidate pathogenesis genes and pathways of developmental dysplasia of hip (DDH). DESIGN:Proliferating primary chondrocytes from hip cartilage were used for total RNA extraction including 5 DDH patients and 5 neck of femur fracture (NOF) subjects. Genome-wide mRNA and microRNA (miR...

journal_title：Cartilage

authors： Cheng B,Jia Y,Wen Y,Hou W,Xu K,Liang C,Cheng S,Liu L,Chu X,Ye J,Yao Y,Zhang F,Xu P

更新日期：2021-02-01 00:00:00

abstract：:Joint injuries are very common in the athletic population, especially professional soccer players, with an incidence of 10 to 35.5 injuries per 1000 hours. Most soccer-related joint injuries occur in the lower extremities, with 16% to 46% occurring in the knee and 17% to 40% occurring in the ankle. Because of the limi...

journal_title：Cartilage

authors： Lee HH,Chu CR

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis is a painful, chronic joint disease affecting man and animals with no known curative therapies. Palliative nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but they cause adverse side effects prompting the search for safer alternatives. To address this need, we evaluated the anti...

journal_title：Cartilage

authors： Grzanna MW,Secor EJ,Fortuno LV,Au AY,Frondoza CG

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Cartilage health is thought to be dependent on the relationship between mechanics, structure, and metabolism, rather than these individual components in isolation. Due to sex differences in cartilage health, there is need to determine if the relationships between these cartilage components separately for male...

journal_title：Cartilage

authors： Harkey MS,Blackburn JT,Hackney AC,Lewek MD,Schmitz RJ,Pietrosimone B

更新日期：2020-09-19 00:00:00

abstract：OBJECTIVE:Bone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the in vivo loss of BMP2 in cells expressing aggrecan of the mandibular condyle and knee. DE...

journal_title：Cartilage

authors： O'Brien MH,Dutra EH,Mehta S,Chen PJ,Yadav S

更新日期：2020-12-14 00:00:00

abstract：:Objective To test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared ...

journal_title：Cartilage

authors： Friedman JM,Sennett ML,Bonadio MB,Orji KO,Neuwirth AL,Keah N,Carey JL,Moutos FT,Estes BT,Guilak F,Madry H,Mauck RL,Dodge GR

更新日期：2018-10-01 00:00:00

abstract：:Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication qual...

journal_title：Cartilage

authors： Frehner F,Benthien JP

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery. METHODS:This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Re...

journal_title：Cartilage

authors： Andrade R,Nunes J,Hinckel BB,Gruskay J,Vasta S,Bastos R,Oliveira JM,Reis RL,Gomoll AH,Espregueira-Mendes J

更新日期：2019-12-17 00:00:00

abstract：:Objective To evaluate the outcome of patients who have undergone simultaneous osteotomy and osteochondral allograft (OCA) transplantation. Our hypothesis is that use of high tibial osteotomy and fresh OCA in a combined procedure is safe and effective without increasing morbidity in comparison to OCA alone. Design A ca...

journal_title：Cartilage

authors： Hsu AC,Tirico LEP,Lin AG,Pulido PA,Bugbee WD

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor-β3 [TGF-β3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same factors could be combined immediatel...

journal_title：Cartilage

authors： Fisher MB,Belkin NS,Milby AH,Henning EA,Söegaard N,Kim M,Pfeifer C,Saxena V,Dodge GR,Burdick JA,Schaer TP,Steinberg DR,Mauck RL

更新日期：2016-04-01 00:00:00