Abstract:
:Direct exposure to cadmium (Cd) may induce persistent impairment in learning and memory. However, the outcomes of maternal exposure on the neurological development of offspring are much less clear, and the underlying mechanism leading to toxicity remains undisclosed. Following chronic exposure of female rats during gestation and lactation, low level of Cd was detectable in the cerebral cortex but not in the hippocampus of F1 male offspring. The synapses and neurites in hippocampus were destroyed by high Cd exposure level as evidenced by abnormal morphology and cognitive behavior deficit lasting from childhood to adulthood. The membrane glycoprotein M6a (GPM6A) regulates the filopodium formation, neurite outgrowth and synaptogenesis, and is a possible target which Cd acts upon. The signaling pathway Coronin-1a (CORO1A), Ras-related C3 botulinum toxin substrate 1 (RAC1) and p21-activated kinase 1 (PAK1) promotes GPM6A-induced filopodium formation. Our results showed that maternal exposure dramatically down-regulated the level of CORO1A as well as the expression of downstream effectors RAC1, PAK1 and GPM6A. CORO1A-knockdown by siRNA caused decreases in the expression of RAC1, PAK1 and GPM6A; and siRNA targeting combined with Cd insult further decreased the expression of these proteins. Following CORO1A overexpression, the neurites were lengthened with increased expression of all the effector proteins in SH-SY5Y cells exposed to Cd, confirming the significance of CORO1A in mediating the Cd neurotoxicity. These findings may help to disclose how Cd impairs the learning and cognitive development in children, and facilitate finding of potential therapeutic targets for the treatment of Cd poisoning.
journal_name
Chemospherejournal_title
Chemosphereauthors
Feng J,Chen S,Wang Y,Liu Q,Yang M,Li X,Nie C,Qin J,Chen H,Yuan X,Huang Y,Zhang Qdoi
10.1016/j.chemosphere.2019.03.094subject
Has Abstractpub_date
2019-06-01 00:00:00pages
765-774eissn
0045-6535issn
1879-1298pii
S0045-6535(19)30536-3journal_volume
225pub_type
杂志文章相关文献
CHEMOSPHERE文献大全abstract::The dipyridyl herbicide paraquat induces oxidative stress in cells and is implicated in adult neurodegenerative diseases. However, less is known about paraquat toxicity in early stages of vertebrate development. To address this gap, zebrafish (Danio rerio) embryos were exposed to 1, 10 and 100 μM paraquat for 96 h. Pa...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.10.032
更新日期:2018-01-01 00:00:00
abstract::In this study, the bioactivity, acute toxicity and dissipation in vegetables of the individual enantiomers of the fungicide hexaconazole had been investigated. The optical pure single enantiomers were prepared and the bioactivity of (+)-, (-)- and rac-hexaconazole was tested using four target fungi including Colletotr...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2013.09.052
更新日期:2013-11-01 00:00:00
abstract::This study evaluated the impact of medium-term exposure to elevated pCO(2) levels (750-1200 ppm) on the physiological processes of juvenile Mytilus chilensis mussels over a period of 70 d in a mesocosm system. Three equilibration tanks filled with filtered seawater were adjusted to three pCO(2) levels: ~380 (control),...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2012.09.063
更新日期:2013-01-01 00:00:00
abstract::Gross alpha and gross beta activities were determined for 27 different tap water samples collected from Eastern Black Sea region of Turkey. The instrumentation used to count the gross alpha and gross beta activities was a alpha/beta counter of the low background multiple detector type with 10 sample detectors (Berthol...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.05.051
更新日期:2006-02-01 00:00:00
abstract::The interaction of nanoparticles with coexisting chemicals affects the fate and transport of nanoparticles, as well as their combined effects on aquatic organisms. Here, we evaluated the joint effect of ZnO nanoparticle (nano-ZnO) and cetyltrimethyl ammonium chloride (CTAC) on the growth of Chlorella vulgaris and expl...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.12.184
更新日期:2018-04-01 00:00:00
abstract::A growing body of evidence suggests that aquatic plants can mitigate the toxicity of insecticides to sensitive aquatic animals. The current paradigm is that this ability is driven primarily by insecticide sorption to plant tissues, especially for hydrophobic compounds. However, recent work shows that submerged plants ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2014.02.041
更新日期:2014-08-01 00:00:00
abstract::We investigated anaerobic degradation rates for three phthalate esters (PAEs), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), and di-(2-ethylhexyl) phthalate (DEHP), from river sediment in Taiwan. The respective anaerobic degradation rate constants for DEP, DBP, and DEHP were observed as 0.045, 0.074, and 0.027 ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.11.031
更新日期:2005-03-01 00:00:00
abstract::The activity of fish monooxygenases has been extensively used as a monitoring tool to detect contamination of water bodies by cytochrome P450-inducing agents. In this study we evaluated the activities of ethoxy- (EROD), methoxy- (MROD) and pentoxy- (PROD) resorufin-O-dealkylases in the liver of Nile tilapias (Oreochro...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2003.09.027
更新日期:2004-03-01 00:00:00
abstract::The extensive industrial use of brominated flame retardants has aroused rapidly growing public concerns about their ubiquity in the environment. The feasibility of uptake and translocation of decabromodiphenyl ether (BDE-209) by three rice cultivars, namely Fengmeizhan, Hefengzhan and Guangyinzhan, and the uptake mech...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2014.10.016
更新日期:2015-01-01 00:00:00
abstract::Prediction of adsorption equilibrium coefficients (K) of organic compounds onto single walled carbon nanotubes (SWNTs) from in silico molecular descriptors is of importance for probing potential applications of SWNTs as well as for evaluating environmental behavior and ecological risks of organic pollutants and SWNTs....
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.09.074
更新日期:2019-01-01 00:00:00
abstract::Ambient levels and variability of major atmospheric halocarbons, i.e. CFC-12, CFC-11, CFC-113, CCl4, CH3CCl3, C2HCl3, and C2Cl4 in a major metropolis (Taipei, Taiwan) were re-investigated after fourteen years by flask sampling in 2012. Our data indicates that the variability expressed as standard deviations (SD) of CF...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2015.06.070
更新日期:2015-11-01 00:00:00
abstract::Partitioning of dioxins, dibenzofurans and the dioxin-like coplanar PCBs was determined by congener-specific high resolution gc-ms analysis of compounds in 6 tissue samples each from 5 women. Samples were whole blood obtained prior to delivery; maternal adipose tissue, cord blood and placenta obtained during cesarean ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(98)00247-1
更新日期:1998-10-01 00:00:00
abstract::The experiments described provide insight into the feasibility of using compressible particulate packs to filter live plankton. The pore constriction sizes are controlled by subjecting the filter pack to isotropic confinement, thereby allowing for: (1) enhanced filtration upon confinement and (2) enhanced unclogging u...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2010.10.098
更新日期:2011-01-01 00:00:00
abstract::Atmospheric polychlorinated-dibenzo-dioxins/dibenzo-furans (PCDD/Fs) remains an important environmental health concern. Although the total emission inventories of PCDD/Fs in Taiwan decreased from 320 to 52.1 g-I-TEQ/year during 2002-2016, the resulting concentrations of atmospheric PCDD/F and distributions in Taiwan a...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.126979
更新日期:2020-09-01 00:00:00
abstract::Common wastewater treatment plants often do not eliminate endocrine disrupting chemicals (EDCs). Aqueous solutions of three EDCs were treated with an enhanced corona discharge technology. The three EDCs were clofibric acid, a blood lipid regulator, carbamazepine, an antiepileptic drug, and iopromide, a contrast media....
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.12.020
更新日期:2009-04-01 00:00:00
abstract::In addition to the biodegradation problems encountered in buildings, exposure of their occupants to mold is responsible for numerous diseases such as respiratory infections, immediate or delayed allergies and different types of irritations. However, current techniques are unable to detect mold at an early stage of dev...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2015.06.072
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to determine the tissue distribution of 17 PCDD/Fs following the chronic ingestion of contaminated milk in rats and to assess the "target tissue/milk" BioConcentration Factors (BCFs) of these molecules. Contaminated milk, collected in a polluted area, has been incorporated into the diet of ma...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.01.041
更新日期:2005-08-01 00:00:00
abstract::Quinestrol is synthetic estrogen used in contraceptive and hormone replacement therapy and occasionally for treating breast cancer and prostate cancer. It can make its way into the environment through sewage discharge and waste disposal produced by human excretions. In this study, the photodegradation kinetics of quin...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2012.06.011
更新日期:2012-11-01 00:00:00
abstract::A simple method to functionalize diatomite with hydrous iron oxide was attempted and its performance as a new active filtration material to remove and recover phosphate from water was investigated under varying solution conditions. The Langmuir phosphate adsorption capacity increased from 0.6 mgP/g for raw diatomite t...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2015.10.015
更新日期:2016-02-01 00:00:00
abstract::Heterogeneous formation of chlorinated dibenzo-p-dioxins (CDDs) and dibenzofurans (CDFs) on CuCl2 from three phenols without ortho chlorine and one phenol with two ortho chlorines was studied in a flow reactor over a temperature range of 325-450 degrees C. Heated nitrogen gas streams containing 8% oxygen, 1.5% benzene...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.08.084
更新日期:2005-02-01 00:00:00
abstract::Growing numbers of nanotoxicity research demonstrating that mechanical damage and oxidative stress are potential modes of nanoparticles (NPs) induced toxicity. However, the underlying mechanisms by which NPs interact with the eukaryotic cell and affect their physiological and metabolic functions are not fully known. W...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.09.028
更新日期:2018-12-01 00:00:00
abstract::The present study was conducted to determine the effect of waterborne copper (Cu) exposure on carnitine concentration, carnitine palmitoyltransferases I (CPT I) kinetics, and expression levels of four CPT I isoforms in the liver, muscle and heart of yellow catfish Pelteobagrus fulvidraco. Yellow catfish were exposed t...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2015.06.075
更新日期:2015-11-01 00:00:00
abstract::Mussels, such as the marine bivalve Mytilus galloprovincialis are sentinels for marine pollution but they are also excellent bioindicators under laboratory conditions. For that, in this study we tested the modulation of biochemical responses under realistic concentrations of the toxic metal Lead (Pb) in water for 28 d...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.05.221
更新日期:2019-11-01 00:00:00
abstract::Metal oxide nanomaterials have exhibited toxicity to a variety of aquatic organisms, especially microbes and invertebrates. To date, few studies have evaluated the toxicity of metal oxide nanomaterials on aquatic vertebrates. Therefore, this study examined effects of ZnO, TiO(2), Fe(2)O(3), and CuO nanomaterials (20-1...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.01.061
更新日期:2011-05-01 00:00:00
abstract::A survey undertaken in Northern Greece has shown that organochlorine pesticides are present in the surface waters. Surface water samples have been collected seasonally from four rivers and five lakes for a period of two years. Solid-phase extraction followed by gas chromatographic techniques with electron capture dete...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(02)00480-0
更新日期:2003-01-01 00:00:00
abstract::To evaluate the body burdens of heavy metals correlated with health impact on school-age children living around a waste incinerator. A total of 81 children from the exposure area and 95 from the control area were recruited in our study. We measured the blood levels of chromium (Cr), cadmium (Cd) and lead (Pb) by an in...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.05.016
更新日期:2019-08-01 00:00:00
abstract::Possible use of wine wastes containing ethanol as carbon and energy source for sulphate-reducing bacteria (SRB) growth and activity in the treatment of acid mine drainage (AMD) is studied for the first time. The experiments were performed using anaerobic down-flow packed bed reactors in semi-continuous systems. The pe...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.12.062
更新日期:2009-05-01 00:00:00
abstract::Spatial distributions of perfluoroalkyl substances (PFASs) were investigated in surface waters in Shanghai, Jiangsu and Zhejiang Provinces of eastern China during 2011. A total of 39 samples of surface waters, including 29 rivers, 6 lakes and 4 reservoirs were collected. High performance liquid chromatography/negative...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2014.08.045
更新日期:2015-01-01 00:00:00
abstract::Due to their widespread use, organophosphate flame retardants (OPFRs) are commonly detected in various environmental matrices and have been identified as emerging contaminants. Considering the adverse effects of OPFRs, many researchers have paid their attention on the absorption, bioaccumulation, metabolism and intern...
journal_title:Chemosphere
pub_type: 杂志文章,评审
doi:10.1016/j.chemosphere.2016.03.003
更新日期:2016-06-01 00:00:00
abstract::Carbon based solid waste materials have been intensively investigated for the preparation of solid acid catalysts through sulfonation, but the acidity varies significantly depending on the material. In this study, the role of aromatic hydrogen in sulfonation with concentrated H2SO4 was investigated using petroleum cok...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.125981
更新日期:2020-06-01 00:00:00