Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE.

abstract：:Thirty-eight boys, referred for psychiatric treatment because of serious problems of behaviour, underwent a double-blind, placebo-controlled, crossover trial of methylphenidate and placebo. Methylphenidate was an effective treatment over a 3-week period. A good response to methylphenidate was predicted by higher level...

journal_title：Psychological medicine

authors： Taylor E,Schachar R,Thorley G,Wieselberg HM,Everitt B,Rutter M

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Schizophrenia patients have a higher prevalence of type 2 diabetes mellitus with impaired glucose tolerance (IGT) than normals. We examined the relationship between IGT and clinical phenotypes or cognitive deficits in first-episode, drug-naïve (FEDN) Han Chinese patients with schizophrenia. METHOD:A total o...

journal_title：Psychological medicine

authors： Chen DC,Du XD,Yin GZ,Yang KB,Nie Y,Wang N,Li YL,Xiu MH,He SC,Yang FD,Cho RY,Kosten TR,Soares JC,Zhao JP,Zhang XY

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Women's vulnerability for a first lifetime-onset of major depressive disorder (MDD) during midlife is substantial. It is unclear whether risk factors differ for first lifetime-onset and recurrent MDD. Identifying these risk factors can provide more focused depression screening and earlier intervention. This ...

journal_title：Psychological medicine

authors： Bromberger JT,Schott L,Kravitz HM,Joffe H

更新日期：2015-06-01 00:00:00

abstract：:The increase in plasma prolactin which follows intravenous administration of L-tryptophan (LTP) was used to assess changes in brain 5-hydroxytryptamine (5-HT) function in normal male and female subjects, following a three week period of dieting. In women, but not men, there was a marked increase in the prolactin respo...

journal_title：Psychological medicine

authors： Goodwin GM,Fairburn CG,Cowen PJ

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:There is still a relative paucity of information about the long-term course of depression. METHODS:Consecutive patients admitted to a teaching hospital psychiatry unit with symptoms of depression, previously assessed at 6 months and 2, 5 and 15 years after index admission, were reviewed at 25 years (N = 49,...

journal_title：Psychological medicine

authors： Brodaty H,Luscombe G,Peisah C,Anstey K,Andrews G

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:The potential effects of antipsychotic drugs on brain structure represent a key factor in understanding neuroanatomical changes in psychosis. This review addresses two issues: (1) do antipsychotic medications induce changes in total or regional human brain volumes and (2) do such effects depend on antipsycho...

journal_title：Psychological medicine

authors： Navari S,Dazzan P

更新日期：2009-11-01 00:00:00

abstract：:We report the results of a survey of the burdens and needs for items of care of 45 supporters of long-term users of psychiatric day care facilities in Camberwell. The supporters reported high levels of disturbed behaviour and low levels of self-care skills in the attenders. They were also subject to high levels of soc...

journal_title：Psychological medicine

authors： MacCarthy B,Lesage A,Brewin CR,Brugha TS,Mangen S,Wing JK

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:High expressed emotion (EE) in families reliably predicts relapse in schizophrenia leading to the assumption that high EE stresses patients and is the cause of relapse. Attempts at validating the stressful properties of high EE using autonomic skin conductance measures have been inconclusive. Since memory lo...

journal_title：Psychological medicine

authors： Dixon MJ,King S,Stip E,Cormier H

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Sleep disruption is a common precursor to deterioration and relapse in people living with psychotic disorders. Understanding the temporal relationship between sleep and psychopathology is important for identifying and developing interventions which target key variables that contribute to relapse. METHODS:We...

journal_title：Psychological medicine

authors： Meyer N,Joyce DW,Karr C,de Vos M,Dijk DJ,Jacobson NC,MacCabe JH

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Excessive worry is required by DSM-IV, but not ICD-10, for a diagnosis of generalized anxiety disorder (GAD). No large-scale epidemiological study has ever examined the implications of this requirement for estimates of prevalence, severity, or correlates of GAD. METHOD:Data were analyzed from the US Nationa...

journal_title：Psychological medicine

authors： Ruscio AM,Lane M,Roy-Byrne P,Stang PE,Stein DJ,Wittchen HU,Kessler RC

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Causal attributions about bodily sensations may determine help-seeking and influence patients' demands for medical treatment. The present study aimed to differentiate the causal attributions associated with health-related and non-health-related anxiety. METHODS:Anxious hypochondriacal, generally anxious, an...

journal_title：Psychological medicine

authors： MacLeod AK,Haynes C,Sensky T

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Psychiatric history, familial history of suicide attempts, and certain traumatic life events are important predictors of suicidal thoughts and behaviour. We examined the epidemiology and genetics of suicidality (i.e. reporting persistent suicidal thoughts or a plan or suicide attempt) in a large community-ba...

journal_title：Psychological medicine

authors： Statham DJ,Heath AC,Madden PA,Bucholz KK,Bierut L,Dinwiddie SH,Slutske WS,Dunne MP,Martin NG

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Spontaneous movement disorders (SMDs), such as spontaneous dyskinesia and parkinsonism, have been described in patients with schizophrenia who have never been treated with antipsychotic medication. Their presence has been documented extensively in chronic schizophrenia but not at the time of illness onset. ...

journal_title：Psychological medicine

authors： Pappa S,Dazzan P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Most research on the prevalence, distribution, and psychiatric comorbidity of intellectual disability (ID) relies on clinical samples, limiting the generalizability and utility of ID assessment in a legal context. This study assessed ID prevalence in a population-representative sample of US adolescents and e...

journal_title：Psychological medicine

authors： Platt JM,Keyes KM,McLaughlin KA,Kaufman AS

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:To date, there has been no large-scale survey of geriatric depression (GD) involving both rural and urban areas in China using standardized assessment tools and diagnostic criteria. This study aimed to determine the 12-month and lifetime prevalence rates of GD and sociodemographic correlates in urban and rur...

journal_title：Psychological medicine

authors： Ma X,Xiang YT,Li SR,Xiang YQ,Guo HL,Hou YZ,Cai ZJ,Li ZB,Li ZJ,Tao YF,Dang WM,Wu XM,Deng J,Ungvari GS,Chiu HF

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Results of previous research examining long-term residual effects of marijuana use on cognition are conflicting. A major methodological limitation of prior studies is the inability to determine whether differences between users and non-users are due to differences in genetic vulnerability preceding drug use ...

journal_title：Psychological medicine

authors： Lyons MJ,Bar JL,Panizzon MS,Toomey R,Eisen S,Xian H,Tsuang MT

更新日期：2004-10-01 00:00:00

abstract：:The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...

journal_title：Psychological medicine

authors： Shioiri T,Oshitani Y,Kato T,Murashita J,Hamakawa H,Inubushi T,Nagata T,Takahashi S

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:There are no evidence-based treatments for severe and enduring anorexia nervosa (SE-AN). This study evaluated the relative efficacy of cognitive behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM) for adults with SE-AN. METHOD:Sixty-three participants with a diagnosis of AN, who...

journal_title：Psychological medicine

authors： Touyz S,Le Grange D,Lacey H,Hay P,Smith R,Maguire S,Bamford B,Pike KM,Crosby RD

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Generalized anxiety disorder (GAD) is highly co-morbid with depression. Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP), cross-sectionally and over time. To date, no studies have looked at the association between CRP and GAD. METHOD:A total of nine waves of ...

journal_title：Psychological medicine

authors： Copeland WE,Shanahan L,Worthman C,Angold A,Costello EJ

更新日期：2012-12-01 00:00:00

abstract：:In the face of shifting demographics and an increase in human longevity, it is important to examine carefully what is known about cognitive ageing, and to identify and promote possibly malleable lifestyle and health-related factors that might mitigate age-associated cognitive decline. The Lothian Birth Cohorts of 1921...

journal_title：Psychological medicine

authors： Corley J,Cox SR,Deary IJ

更新日期：2018-01-01 00:00:00

abstract：:Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are post-synaptic receptors that are located in striatal and limbic areas known to be involved in cognition and mood. Consistent with this, 5-HT4 ...

journal_title：Psychological medicine

authors： Murphy SE,de Cates AN,Gillespie AL,Godlewska BR,Scaife JC,Wright LC,Cowen PJ,Harmer CJ

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:Despite methodological differences between studies, it has been suggested that psychopathy may be associated with a ventromedial prefrontal cortex (VMPFC) deficit and antisocial personality disorder (ASPD), as classified in the DSM-IV, with a broader range of deficits in dorsolateral prefrontal cortex (DLPFC...

journal_title：Psychological medicine

authors： Dolan M

更新日期：2012-08-01 00:00:00

abstract：:Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving c...

journal_title：Psychological medicine

authors： Kaser M,Zaman R,Sahakian BJ

更新日期：2017-04-01 00:00:00

abstract：:A sample of over 6000 women was recruited in the last trimester of pregnancy and administered a 40-item self-report questionnaire designed to detect the presence of factors that were likely to increase the risk of postpartum depression. The mental state of almost 5000 of these women was determined at around 6 to 8 wee...

journal_title：Psychological medicine

authors： Cooper PJ,Murray L,Hooper R,West A

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Although accurate differentiation between bipolar disorder (BD) and unipolar major depressive disorder (MDD) has important prognostic and therapeutic implications, the distinction is often challenging based on clinical grounds alone. In this study, we tested whether psychiatric polygenic risk scores (PRSs) i...

journal_title：Psychological medicine

authors： Liebers DT,Pirooznia M,Ganna A,Bipolar Genome Study (BiGS).,Goes FS

更新日期：2020-02-17 00:00:00

abstract：BACKGROUND:Post-traumatic symptomatology is one of the signature effects of the pernicious exposures endured by responders to the World Trade Center (WTC) disaster of 11 September 2001 (9/11), but the long-term extent of diagnosed Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) post-traumati...

journal_title：Psychological medicine

authors： Bromet EJ,Hobbs MJ,Clouston SA,Gonzalez A,Kotov R,Luft BJ

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Risk factors that are associated with depression in the mother also negatively affect the child. This research sought to extend current knowledge by examining the duration and timing of maternal depression as a moderator of: (1) the impact of dependent interpersonal stress (DIS), such as partner conflict or ...

journal_title：Psychological medicine

authors： Barker ED

更新日期：2013-08-01 00:00:00

abstract：:Seventy-six women, with a mean age of 35.7 years, who reported premenstrual craving for sweet foods in a retrospective questionnaire, were assessed prospectively with a pre- and post-menstrual eating questionnaire and daily ratings of craving, mood, irritability and breast tenderness over two menstrual cycles. In 72% ...

journal_title：Psychological medicine

authors： Bancroft J,Cook A,Williamson L

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Little is known about the mental health of partners of survivors of high levels of trauma in post-conflict countries. METHOD:We studied 677 spouse dyads (n = 1354) drawn from a community survey (response 82.4%) in post-conflict Timor-Leste. We used culturally adapted measures of post-traumatic stress disord...

journal_title：Psychological medicine

authors： Silove DM,Tay AK,Steel Z,Tam N,Soares Z,Soares C,Dos Reis N,Alves A,Rees S

更新日期：2017-01-01 00:00:00

abstract：:Messenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly l...

journal_title：Psychological medicine

authors： Harrison PJ,Barton AJ,Najlerahim A,McDonald B,Pearson RC

更新日期：1991-11-01 00:00:00