Abstract:
BACKGROUND:Throughout the world multi drug resistant nosocomial infections are one of the leading causes of death and morbidity among hospitalized patients. Antimicrobial resistance [AMR] has become a major problem in treatment of such infections. High consumption of antimicrobials particularly in ICUs is often described as the most important factor leading to AMR. OBJECTIVE:The aim of the study was to study the magnitude of antimicrobial resistance amongst nosocomial pathogens and the antimicrobial prescription patterns of patients admitted in intensive care unit. METHODS:The study was conducted in I.C.U of a tertiary care government hospital in Delhi over a period of 4 months, on 100 patients admitted in I.C.U. Depending on clinical suspicion laboratory samples were collected and subjected to antimicrobial sensitivity testing. Antimicrobial prescription of these patients were collected from I.C.U records and analyzed. OBSERVATIONS:Staphylococcus aureus and Klebsiella species were the most common organism [23%]. Among patients where causative organism was isolated, two or more organisms were isolated from 50% of the samples. Most of the Klebsiella species and Acinetobacter species were resistant to beta lactam group of antibiotics such as cephalosporins and piperacillin-tazobactam. 60% of isolates of S. aureus were found to be MRSA while none of the S. aureus were resistant to linezolid and vancomycin. All patients were prescribed two or more antimicrobials while 66% patients were prescribed 3-5 antimicrobials. Commonest combination was beta lactam with metronidazole followed by levofloxacin with metronidazole with addition of aminoglycosides or linezolid as third drug. Total 20 antimicrobial agents were used in the treatment of the patients. Among these consumption [in DDD/100bed days] of metronidazole was highest [100.9] followed by fluconazole [76.6] and levofloxacin [62.7]. CONCLUSION:High usage of antimicrobial consumption has been noted in this study, prompting institution of measures to formulate and adherence to antimicrobial policy strictly.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Saxena S,Priyadarshi M,Saxena A,Singh Rdoi
10.1016/j.jiph.2019.03.014subject
Has Abstractpub_date
2019-01-01 00:00:00pages
695-699issue
5eissn
1876-0341issn
1876-035Xpii
S1876-0341(19)30123-6journal_volume
12pub_type
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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doi:10.1016/j.jiph.2010.09.007
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journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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abstract:BACKGROUND:COVID-19 (Coronavirus Disease-2019) is a pandemic disease, infecting more than 26.5 million people. Since there is no specific and effective treatment; early diagnosis and optimal isolation of the patient are of vital importance. Real-time polymerase chain reaction-based (RT-PCR) analyses do not achieve suff...
journal_title:Journal of infection and public health
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abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has been highly epidemic in China since January 2020. Rapid detection of the causative agent, severe acute respiratory coronavirus-2 (SARS-CoV-2), is very important due to its high rate of infectivity. This study aimed to clarify the epidemiology and clinical characteristi...
journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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abstract::Leptospires are spirochetes of Leptospira genus. Infection in humans occurs by penetration into the mucous membranes, or into the skin (small wounds or abrasions). Humans are infected when they contact with urine of rodents, the main reservoirs. We aimed to evaluate the presence of anti-Leptospira spp antibodies and l...
journal_title:Journal of infection and public health
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