[Hypersensitivity pneumonitis in children].

Abstract:

:Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by an immune response to a variety of antigens to which patients have been previously sensitised. It can occur at any age. In children, it is a rare disease, probably under-diagnosed, with an estimated prevalence of 4 per million. The paediatric forms are not really different from those of adults but present some particularities. Avian exposure is by far the most frequent cause of HP, accounting for nearly two-thirds of cases. Although there is no current recommendation for the diagnosis of HP, it is commonly considered that the diagnosis can be made with confidence on the combination of (1) compatible respiratory symptoms, (2) exposure to a known offending antigen, (3) lymphocytic alveolitis, (4) decreased transfer factor for carbon monoxide or hypoxia on exertion and (5) compatible radiologic features. The treatment is based on antigen avoidance that must be complete and definitive. Corticosteroids can be necessary in severe forms. The prognosis of HP in children is better than in adults, with a full clinical and functional recovery in the majority of cases after complete antigenic withdrawal.

journal_name

Rev Mal Respir

authors

Soumagne T,Dalphin ML,Dalphin JC

doi

10.1016/j.rmr.2018.06.010

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

495-507

issue

4

eissn

0761-8425

issn

1776-2588

pii

S0761-8425(19)30053-1

journal_volume

36

pub_type

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