Abstract:
OBJECTIVE:We present the diagnostic and clinical course of the first multicenter case series of pediatric patients with autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies. METHODS:Data from 2 university hospitals were retrospectively reviewed and records of 3 patients with autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies were evaluated. RESULTS:The 3 pediatric patients (all female) had symptoms that spanned the clinical spectrum. All 3, however, had regression of expressive language and agitation. Neuroimaging in all 3 patients was normal; electroencephalographic (EEG) findings varied among the 3 patients. Positive titers against the N-type voltage-gated calcium channel antibody were found in their cerebrospinal fluid. Following administration of intravenous immunoglobulin, all 3 had improvement in their core presenting symptoms. CONCLUSION:Autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies in the pediatric population presents with a wide clinical spectrum, although expressive language delay and agitation seem to be common symptoms. Treatment with intravenous immunoglobulin improves core symptoms.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Kornitzer J,Taha F,Segal Edoi
10.1177/0883073819840448subject
Has Abstractpub_date
2019-08-01 00:00:00pages
499-505issue
9eissn
0883-0738issn
1708-8283journal_volume
34pub_type
杂志文章,多中心研究abstract::Tuberous sclerosis complex is a multisystem, chronic genetic condition characterized by systemic growth of benign tumors and often accompanied by epilepsy, autism spectrum disorders, and intellectual disability. Nonetheless, the neurodevelopmental phenotype of these patients is not often detailed. The authors describe...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073815600871
更新日期:2015-12-01 00:00:00
abstract::Lissencephaly is a brain malformation manifested by a smooth cerebral surface and caused by incomplete neuronal migration. Clinical sequellae include minor craniofacial changes (bitemporal hollowing, small jaw), severe mental retardation, and other neurological abnormalities. Patients with classical or type I lissence...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389000500113
更新日期:1990-01-01 00:00:00
abstract::Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal. For decades the diagnosis was confirmed only with pyridoxine treatment withdrawal trial. Recently described biochemical and molecular pathology improved the diagnosti...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808318543
更新日期:2008-12-01 00:00:00
abstract::Basilar artery occlusion in children is rare. The clinical diagnosis of basilar artery occlusion is often difficult because the initial neurologic findings, most frequently hemiparesis, involuntary movements, or headache, are often transient and can suggest complicated migraine, seizures, or both. We have reviewed 37 ...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738030180070601
更新日期:2003-07-01 00:00:00
abstract::Children and adolescents with the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) diagnosis of attention-deficit hyperactivity disorder (ADHD) can have comorbid conditions such as conduct disorder, oppositional defiant disorder, and obsessive-compulsive disorder (comorbid type). The purpose of our st...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738040190020201
更新日期:2004-02-01 00:00:00
abstract::The aim of this study was to investigate the clinical, demographic, and electromyographic (EMG) characteristics of 12 earthquake victims in the pediatric age group and to compare the findings with those of the adult group. Following the 1999 Marmara earthquake, 75 subjects with suspected peripheral nerve injury were r...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200030701
更新日期:2005-03-01 00:00:00
abstract::We present the results from the evaluations of three children ages of 2, 7, and 11 years with hemiparesis and multiple white-matter lesions on magnetic resonance images (MRIs). The initial symptoms were mainly acute/subacute hemiparesis in all and headache/vomiting in one of them. Before admission, one of them had a h...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380201700901
更新日期:2002-09-01 00:00:00
abstract::We present a case of a 1-year-old female child who was referred to the Early Intervention Clinic for evaluation of developmental delay and progressively enlarging head size. Developmental assessment revealed significant motor delay with borderline cognitive impairment. MRI of the brain revealed generalized ventriculom...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814533149
更新日期:2015-03-01 00:00:00
abstract::Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral pa...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738060210050201
更新日期:2006-05-01 00:00:00
abstract::We describe a case of pathologically confirmed Alexander's disease in which serial cranial ultrasound studies demonstrated unique findings of enlarging subependymal cysts with evolving periventricular hyperechogenicity. Computed tomographic scan of the head showed low attenuation of the periventricular white matter an...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389000500320
更新日期:1990-07-01 00:00:00
abstract::We sent questionnaires concerning the current therapy for West syndrome to 208 institutions at which pediatric care members of the Japan Epilepsy Society were working. Of these, 129 (62%) institutions responded. Vitamin B6 was the preferred first-line drug, followed by the combination of vitamin B6 and valproate or mo...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380001500615
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:The classic phenotype of CLN2 disease (neuronal ceroid lipofuscinosis type 2) typically manifests between ages 2 and 4 years with a predictable clinical course marked by epilepsy, language developmental delay, and rapid psychomotor decline. Atypical phenotypes exhibit variable time of onset, symptomatology, ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820977997
更新日期:2020-12-23 00:00:00
abstract::Intractable epilepsies pose a therapeutic challenge. Precise localization of the epileptic focus is imperative before planning surgical intervention. Functional imaging is an important component of presurgical work-up. Positron emission tomography is unavailable in developing countries; hence, the need to evaluate the...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101600405
更新日期:2001-04-01 00:00:00
abstract::Our current purpose is to evaluate the applicability of dynamic statistical parametric mapping, a novel method for localizing epileptiform activity recorded with magnetoencephalography in patients with epilepsy. We report four pediatric patients with focal epilepsies. Magnetoencephalographic data were collected with a...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200041601
更新日期:2005-04-01 00:00:00
abstract::The purpose of this study was to determine whether children with epilepsy undergoing valproate therapy and who are otherwise healthy have lower levels of serum and muscle carnitine. A total of 50 patients with epilepsy, 3 to 14 years of age, who were treated solely with valproate and free of abnormal neurologic findin...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
doi:10.1177/0883073808321060
更新日期:2009-01-01 00:00:00
abstract::The infantile form of neuronal ceroid lipofuscinosis (ie, infantile Batten disease) is the most rapidly progressing type and is caused by an inherited deficiency in the lysosomal enzyme palmitoyl protein thioesterase 1. The absence of enzyme activity leads to progressive accumulation of autofluorescent material in man...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813495960
更新日期:2013-09-01 00:00:00
abstract::Sandhoff's disease is a rare, genetic lysosomal storage disease leading to delayed myelination or demyelination. Although neuroimaging findings in this disease have been reported previously, magnetic resonance spectroscopy findings have not been reported. In this report, we present magnetic resonance imaging and magne...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738030180061201
更新日期:2003-06-01 00:00:00
abstract::Multiple sclerosis and acute disseminated encephalomyelitis are demyelinating disorders of the central nervous system that can present initially as an acute focal demyelinating syndrome. We report an 11-year-old girl who initially presented with intractable vomiting and hypertension and later developed a subacute onse...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389501000611
更新日期:1995-11-01 00:00:00
abstract::Using diffusion tensor imaging tractography and color-coded anisotropy map quantification, we investigated asymmetry of the arcuate fasciculus to determine language laterality in children and compared it with the Wada test. Arcuate fasciculus volume and fractional anisotropy were measured after tractography. We also q...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811409225
更新日期:2011-12-01 00:00:00
abstract::We investigated familial and environmental risk factors in a cohort of South African children diagnosed with attention-deficit hyperactivity disorder (ADHD). A prospective, hospital-based case control study was conducted comprising 50 children diagnosed with ADHD and 50 matched non-ADHD controls. The adjusted effect o...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814560630
更新日期:2015-09-01 00:00:00
abstract::Girls with Rett syndrome display signs of neuronal dysfunction including mental retardation, seizures, stereotyped movements, and abnormal breathing and autonomic control. Decelerating head growth during infancy might reflect a disorder in production or pruning of neuronal synapses or both. Recent immunocytochemical s...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738030180100501
更新日期:2003-10-01 00:00:00
abstract::Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. Epidemiologic data suggest that malnutrition is a common feature in amyotrophic lateral sclerosis and being overweight or obese confers a survival advantage in this patient population. In amyotrophic lateral sclerosis mouse models, a high-fat diet has...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813488669
更新日期:2013-08-01 00:00:00
abstract::There are conflicting reports regarding the efficacy of trihexyphenidyl, an anticholinergic drug, for treatment of dystonia in cerebral palsy. The author hypothesized that trihexyphenidyl may be more effective in specific subgroups and performed a retrospective analysis of 31 children (8.2 ± 5.8 years) with dystonia f...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073810392582
更新日期:2011-07-01 00:00:00
abstract::Maternal intrauterine inflammation has been implicated in the development of periventricular leukomalacia and white matter injury in the neonate. We hypothesized that intrauterine endotoxin administration would lead to microstructural changes in the neonatal rabbit white matter in vivo that could be detected at birth ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073809338213
更新日期:2009-09-01 00:00:00
abstract::High-functioning adolescents and young adults with mitochondrial disease are now attempting transitions to postsecondary environments. This pilot and case study explores factors that interfere with their successful transition through behavior-rating scales addressing academic skills and behavior. In the Behavior Asses...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812442589
更新日期:2012-12-01 00:00:00
abstract::We report a case of a neonate with sectional narrowing of the spinal cord on the level of T12 to L2 and a deformed vertebral body on a different level, L4. In previously described cases of sectional spinal dysgenesis, the vertebral and spinal cord malformations are usually found on the same level. Our case may represe...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101600819
更新日期:2001-08-01 00:00:00
abstract::Macrocephaly-capillary malformation syndrome is characterized by cutaneous vascular malformations with associated anomalies as macrocephaly, macrosomia, hemihypertrophy, hypotonia, developmental delay, lax joints, loose skin, polysyndactyly, and neuroimaging abnormalities. We present a newborn with a prenatal diagnosi...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812439346
更新日期:2013-01-01 00:00:00
abstract::We describe a case of pediatric Sjögren's syndrome with progressive neurologic involvement. At age 4 years, she had been diagnosed with Melkersson-Rosenthal syndrome. After being stable with facial diplegia and swelling for 5 years, she acutely presented with diplopia, vertigo, and ataxia. Cranial magnetic resonance i...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101600911
更新日期:2001-09-01 00:00:00
abstract::Epilepsy, together with mental retardation, represents a common manifestation of chromosomal aberrations. Specific electroencephalographic (EEG) and epileptic patterns have been described in several chromosomal disorders, such as Angelman's syndrome, Miller-Dieker syndrome, Wolf-Hirschhorn syndrome, and ring 20 syndro...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380401900807
更新日期:2004-08-01 00:00:00
abstract::Cerebral venous sinus compression can mimic idiopathic intracranial hypertension. The authors report the case of a 12-year-old girl who presented with diplopia and papilledema 3 weeks after a head injury. Lumbar puncture confirmed raised intracranial pressure, and neuroimaging subsequently identified a skull fracture ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807300532
更新日期:2007-03-01 00:00:00