Deciphering the Role of a SLOG Superfamily Protein YpsA in Gram-Positive Bacteria.

Abstract:

:Bacteria adapt to different environments by regulating cell division and several conditions that modulate cell division have been documented. Understanding how bacteria transduce environmental signals to control cell division is critical in understanding the global network of cell division regulation. In this article we describe a role for Bacillus subtilis YpsA, an uncharacterized protein of the SLOG superfamily of nucleotide and ligand-binding proteins, in cell division. We observed that YpsA provides protection against oxidative stress as cells lacking ypsA show increased susceptibility to hydrogen peroxide treatment. We found that the increased expression of ypsA leads to filamentation and disruption of the assembly of FtsZ, the tubulin-like essential protein that marks the sites of cell division in B. subtilis. We also showed that YpsA-mediated filamentation is linked to the growth rate. Using site-directed mutagenesis, we targeted several conserved residues and generated YpsA variants that are no longer able to inhibit cell division. Finally, we show that the role of YpsA is possibly conserved in Firmicutes, as overproduction of YpsA in Staphylococcus aureus also impairs cell division.

journal_name

Front Microbiol

authors

Brzozowski RS,Huber M,Burroughs AM,Graham G,Walker M,Alva SS,Aravind L,Eswara PJ

doi

10.3389/fmicb.2019.00623

subject

Has Abstract

pub_date

2019-04-05 00:00:00

pages

623

issn

1664-302X

journal_volume

10

pub_type

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