Abstract:
OBJECTIVE:In this study, expression of cancer stem cells (CSCs)-related factor-Sex-determining region of Y chromosome-related high-mobility-group box 2 (SOX2) and anti-apoptotic specific factor- Survivin in salivary adenoid cystic carcinoma (SACC) was detected to provide important clues for effective SACC prevention and treatment by combining clinical pathological parameters analysis. METHODS:Paraffin and fresh specimens were collected from SACC patients who underwent surgery at the Oral and Maxillofacial Surgery Department of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital. The experimental group was designed as SACC tissue, and the control group normal paracancerous normal gland tissue. (1) SOX2 and Survivin expression were detected using immunohistochemistry and analyzed by comnining clinical pathological parameter analysis. (2) mRNA and protein expression levels of SOX2 and Survivin were detected using RT-PCR, Western Blot. RESULTS:1. Immunohistochemistry: (1) SOX2 was mainly expressed on the nucleus. The SOX2 positive rate was 28.57% in clinical stage I-II, and 76.92% in stage III-IV. (2) Survivin was mainly expressed in the cytoplasm. The Survivin positive rate was 61.90% in clinical stage I-II, and 76.92% in stage III-IV. (3) There was a clear correlation between SOX2 and Survivin. 2. RT-PCR and Western Blot: The mRNA and protein expression levels of SOX2 and Survivin were significantly higher in the experimental group than in the control group (P < 0.01). CONCLUSION:(1) The mRNA and protein expression level of SOX2 and Survivin was significantly higher in SACC tissues than in paracancerous normal salivary gland tissues, indicating that both of the two are tissue-specific and may become SACC oncogenes. (2) SOX2 and Survivin are significantly correlated in expression, which may coorinatively participate in SACC incidence and development.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Luo Y,Liu T,Fei W,Yue XGdoi
10.1016/j.jiph.2019.03.015subject
Has Abstractpub_date
2019-01-01 00:00:00pages
847-853issue
6eissn
1876-0341issn
1876-035Xpii
S1876-0341(19)30124-8journal_volume
12pub_type
杂志文章abstract:OBJECTIVE:Secondary bacteraemia infections (SBI) are poorly studied. We analyse the epidemiology of nosocomial SBI, potential risk factors and mortality of affected patients. METHODS:Prospective study of patients with bacteraemia from 2009 to 2014 in a tertiary hospital. For each SBI was recorded: primary source of in...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.08.011
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Natural products derived from marine microbes have more potential toward to treatment of various diseases. Among the microbes, the secondary metabolites recovered from the marine actinomycetes were more added values. OBJECTIVE:A promising antimicrobial metabolite producing filamentous actinomycete SCA-7 rec...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.07.002
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Healthcare-associated infections (HCAIs) are an important public health problem. It is estimated that approximately 1 out of every 20 hospitalized patients will contract an HCAI. The risk is substantial not only to patients but also to healthcare workers, who may contract deadly blood-borne infectious diseas...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2013.02.006
更新日期:2013-08-01 00:00:00
abstract::A self-administered network-based questionnaire survey was conducted on 91 HIV-positive Chinese men having sex with men (MSM). Affiliation matrices were created to assess their networking pattern. The individuals' preferential use of venues for sex partnership before HIV infection has changed over three time periods o...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2009.09.002
更新日期:2009-01-01 00:00:00
abstract::Zika virus (ZIKV), an Aedes mosquito-borne flavivirus, has captured public health attention worldwide. Initially, the virus was reported in Africa and Asia. However, the outbreak of ZIKV in Brazil and the United States of America demonstrated the global health risk. Symptoms of ZIKV infection vary from mild fever, ras...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2019.05.004
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Panton-Valentine Leukocidin (PVL), is one of the virulence gene expressed by Methicillin Resistant Staphylococcus aureus (MRSA) and is known to be associated with severe form of community acquired MRSA infection. The aim of this study is to investigate its prevalence in our setting and patient's clinical out...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2020.06.018
更新日期:2020-10-01 00:00:00
abstract::The World Alliance for Patient Safety is an evolving programme of the WHO, established to raise the profile of patient safety within the global health care agenda. The decision taken in 2004 to focus the effort and attention of the First Global Patient Safety Challenge on the problem of health care-associated infectio...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2008.08.006
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to explore the effects of Psidium guajava L. extracts on mice diarrhea model and changes in their intestinal microflora diversity. METHODS:Mice diarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose s...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.04.015
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To assess compliance with the American Society of Health-System Pharmacists (ASHP) guidelines of prophylactic antibiotic use in private hospitals in Shiraz, Iran. METHODS:This cross-sectional study was performed using prospective data gathered from April to September 2010 in the surgical wards of all privat...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2011.08.004
更新日期:2011-11-01 00:00:00
abstract::Neurocysticercosis is a common parasitic infection in children in developing countries and neurological symptoms such as seizures are the most common manifestations. However, symptoms of encephalopathy are an unusual presentation in children. A 4-year-old boy presented with recurrent episodes of febrile encephalopathy...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.02.006
更新日期:2018-01-01 00:00:00
abstract::Rapid tests to diagnose tuberculosis relies on molecular detection of the M. tuberculosis. GeneXpert MTB/RIF test identifies M. tuberculosis and rifampicin resistance. We present a case of simultaneous coinfection with M. tuberculosis and M. avium. M. tuberculosis was detected in the sputum by PCR GeneXpert method. Un...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2020.01.006
更新日期:2020-05-01 00:00:00
abstract::Brucellosis is an ancient disease that still remains a significant threat to humans and is typically linked to exposure to infected animals and/or consumption of unpasteurized animal products. Despite this history, we have a relatively limited understanding of the host characteristics of this disease; consequently, fu...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2012.03.006
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Despite the advancement in diagnostic modalities of sepsis, it is still a leading cause of morbidity and mortality. Differentiation between sepsis and non-infectious disease states remains a diagnostic challenge. Procalcitonin (PCT) is useful for the diagnosis of sepsis but it varies in cut-off ranges at d...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.11.004
更新日期:2019-01-01 00:00:00
abstract::Trauma-related infections remain a concerning and potentially avoidable complication of conflict-related injuries. During the Israeli conflict in South Lebanon, more than four million sub-munitions were dropped over South Lebanese soil. In this study, we will explore the different types of infection caused by sub-muni...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2013.05.006
更新日期:2013-12-01 00:00:00
abstract::Repeat HAIs among frequently hospitalized patients may be contributing to the high rates of antibiotic resistance seen in gram-negative bacteria (GNB) in hospital settings. This systematic review examines the state of the literature assessing the association between repeat GNB HAIs and changes in antibiotic susceptibi...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2017.09.024
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Patient-professional interactions and adherence to infection control measures are central to the quality of care and patient safety in healthcare. Persons colonized with methicillin-resistant Staphylococcus aureus (MRSA) describe insufficient support and unprofessional behavior among healthcare personnel. M...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2014.02.004
更新日期:2014-09-01 00:00:00
abstract::Nearly four months have passed since the emergence of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which caused the rapidly spreading Coronavirus Disease 2019 (COVID-19) pandemic. To date, there have been more than 2.3 million confirmed cases and more than 160,000 deaths globally caused by COVID-1...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2020.04.016
更新日期:2020-06-01 00:00:00
abstract::Leprosy is a chronic disease caused by Mycobacterium leprae. Although the occurrence of leprosy has declined in Saudi Arabia, it has not yet been eradicated. To our knowledge, this descriptive retrospective study is the first to assess the clinical presentation of leprosy at the time of diagnosis in Saudi Arabia. All ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2015.12.015
更新日期:2016-09-01 00:00:00
abstract::This study was designed to explore baseline data about the prevalence and distribution of human papillomavirus (HPV) genotypes among Chinese women who had cervical intraepithelial lesions and cervical cancer. A total of 511 patients were recruited, and biopsy samples were collected from these patients. Polymerase chai...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.06.012
更新日期:2018-01-01 00:00:00
abstract::In the last few years, Cryptococcus laurentii infections have increased, particularly in immunocompromised patients. Here we report the first case of C. laurentii fungemia in low birth weight preterm infant from India. A preterm neonate was admitted for feeding intolerance and respiratory distress. Blood culture ascer...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.04.012
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:Incidence of tuberculosis (TB) is greatest among patients with impaired immunity. India is experiencing a double epidemic of HIV and diabetes mellitus (DM), both of which are strongly associated with immuno-suppression. This study aimed to discover the prevalence of HIV and DM in both the pulmonary and extra...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2011.03.005
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:This study aimed to explore the demographic and distributive features of acute hemorrhagic conjunctivitis (AHC). We constructed seasonal autoregressive integrated moving average (SARIMA) and exponential smoothing (ETS) models to predict its trend in incidence in mainland China and provided evidence for the g...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.12.008
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Environmental and climatic risk factors of dengue outbreak has been studied in detail. However, the socio-epidemiological association with the disease is least explored. The study aims to identify the social and ecological factors associated with emerging dengue in Odisha, India. METHODS:A population-based ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.08.015
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Acute respiratory tract infections (RTIs) are an important cause of morbidity in the military setting. Respiratory viruses are the most frequently implicated pathogens, especially adenovirus and respiratory syncytial virus. We performed this study to investigate the role of factors such as obesity, cigarette...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2008.09.002
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Throughout the world multi drug resistant nosocomial infections are one of the leading causes of death and morbidity among hospitalized patients. Antimicrobial resistance [AMR] has become a major problem in treatment of such infections. High consumption of antimicrobials particularly in ICUs is often describ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.03.014
更新日期:2019-01-01 00:00:00
abstract::Idiopathic granulomatous mastitis (IGM) is a benign chronic inflammatory disorder of the breast tissue, with unknown etiology. IGM is extremely rare among male gender. In this case report, we present a male patient with superficial high grade bladder cancer, who was complaining of a palpable mass in his right breast f...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.09.006
更新日期:2020-05-01 00:00:00
abstract::This study focused on 77 isolates of Salmonella enterica serotype Enteritidis collected during 2009 to 2013 from healthy and sick chickens and environmental farm samples in Tunisia. Resistance to 14 antimicrobials and the encoding genes were analyzed. 66, 26, 6.5, 3.9 and 1.3% were pan-susceptible or showed resistance...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.01.012
更新日期:2017-01-01 00:00:00
abstract::Hand washing is widely accepted as the cornerstone of infection control in the intensive care unit (ICU). Nosocomial infections are frequently viewed as indicating poor compliance with hand washing guidelines. To determine the hand hygiene (HH) compliance rate among healthcare workers (HCWs) and its effect on the noso...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2012.09.014
更新日期:2013-02-01 00:00:00
abstract::Dengue fever (DF) is the most serious mosquito-borne viral disease worldwide. DF is an acute febrile illness caused by Aedes aegypti and Aedes albopictus, which are endemic in certain cities of Saudi Arabia, such as Jeddah and Makkah (Mecca). An online literature search was conducted using relevant keywords to retriev...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2015.05.006
更新日期:2016-03-01 00:00:00
abstract::Morocco is a country known for its vulnerability of water resources because of its arid and semi-arid climate. Thus, recycled wastewater has been suggested for agricultural activities, but contamination of these wastewaters is a major concern. The current study aims to determine the occurrence of helminth eggs in urba...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.07.026
更新日期:2018-01-01 00:00:00