Abstract:
:Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process; proving to be a powerful technique in the screening of peptide with high affinity and selectivity. In this review, we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ, in vitro, in vivo, and ex vivo screening methods. We will then discuss prominent examples of solid tumor targeting-peptides; namely peptide targeting tumor vasculature, tumor microenvironment (TME) and over-expressed receptors on cancer cells identified through phage display screening. We will also discuss the current challenges and future outlook for targeting peptide-based therapeutics in the clinics.
journal_name
Protein Celljournal_title
Protein & cellauthors
Saw PE,Song EWdoi
10.1007/s13238-019-0639-7subject
Has Abstractpub_date
2019-11-01 00:00:00pages
787-807issue
11eissn
1674-800Xissn
1674-8018pii
10.1007/s13238-019-0639-7journal_volume
10pub_type
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