Phage display screening of therapeutic peptide for cancer targeting and therapy.

Abstract:

:Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process; proving to be a powerful technique in the screening of peptide with high affinity and selectivity. In this review, we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ, in vitro, in vivo, and ex vivo screening methods. We will then discuss prominent examples of solid tumor targeting-peptides; namely peptide targeting tumor vasculature, tumor microenvironment (TME) and over-expressed receptors on cancer cells identified through phage display screening. We will also discuss the current challenges and future outlook for targeting peptide-based therapeutics in the clinics.

journal_name

Protein Cell

journal_title

Protein & cell

authors

Saw PE,Song EW

doi

10.1007/s13238-019-0639-7

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

787-807

issue

11

eissn

1674-800X

issn

1674-8018

pii

10.1007/s13238-019-0639-7

journal_volume

10

pub_type

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