Abstract:
:Thrombosis is an extremely critical clinical condition where a clot forms inside a blood vessel which blocks the blood flow through the cardiovascular system. Previous sonothrombolysis methods using ultrasound and microbubbles (MBs) often have a relatively low lysis rate due to the low microbubbles concentration at clot region caused by blood flow in the vessel. To solve this problem, the magnetic microbubbles (MMBs) that can be retained by an outer magnetic field against blood flow are used in this study. Here we report the development of a new method using the rotational magnetic field to trap and vibrate magnetic microbubbles at target clot region and then using an intravascular forward-looking ultrasound transducer to activate them acoustically. In this study, we investigated the influence of different blood flow conditions, vessel occlusion conditions (partial and fully occluded), clot ages (fresh, retracted), ultrasound parameters (input voltage, duty cycle) and rotational magnetic field parameters (amplitude, frequency) on the thrombolysis rate. The results showed that the additional use of magnetic microbubbles significantly enhances in vitro lysis of blood clot.
journal_name
Ultrasonicsjournal_title
Ultrasonicsauthors
Zhang B,Kim H,Wu H,Gao Y,Jiang Xdoi
10.1016/j.ultras.2019.06.004subject
Has Abstractpub_date
2019-09-01 00:00:00pages
62-71eissn
0041-624Xissn
1874-9968pii
S0041-624X(19)30007-1journal_volume
98pub_type
杂志文章相关文献
ULTRASONICS文献大全abstract::In the present work a general model of the vibrational behavior of the axle of a piezoelectric motor is proposed. In this motor, a cylinder-shaped permanent magnet, which act as a rotor, is pressed in contact with an end of a steel axle by means of the magnetic forces. The other end of the axle is fitted at the center...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2004.01.080
更新日期:2004-04-01 00:00:00
abstract::An ultrasonic technique for imaging nonlinear scatterers, such as partially-closed cracks, buried in a medium has been recently proposed. The method called fundamental wave amplitude difference (FAD) consists of a sequence of acquisitions with different subsets of elements for each line of the image. An image revealin...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2019.02.003
更新日期:2019-07-01 00:00:00
abstract::High-frequency calibration of hydrophones is becoming increasingly important, both for clinical and scientific applications of ultrasound, and user safety. At present, the calibrations available routinely to the user community extend to 60 MHz. However, hydrophones that can measure beyond this are available, and ultra...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2020.106218
更新日期:2020-12-01 00:00:00
abstract::The design and simulation of power transducers are difficult since piezoelectric, dielectric and elastic properties of ferroelectric materials differ from linear behavior when driven at large levels. This paper is devoted to modeling of a resonant power transducer at a high level of dynamic mechanical stress. The powe...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2011.05.017
更新日期:2011-12-01 00:00:00
abstract::The Total Focusing Method (TFM) yields a focused image in emission and in reception while Phased Array (PA) imaging provides Dynamic Depth Focusing (DDF) in reception only. Besides, most NDE applications have two propagation media, where refraction at the interface complicates time-of-flight (TOF) and focal law comput...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2019.105965
更新日期:2019-11-01 00:00:00
abstract::Single clouds of cavitation bubbles, driven by 254kHz focused ultrasound at pressure amplitudes in the range of 0.48-1.22MPa, have been observed via high-speed shadowgraphic imaging at 1×10(6) frames per second. Clouds underwent repetitive growth, oscillation and collapse (GOC) cycles, with shock-waves emitted periodi...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2014.06.011
更新日期:2014-12-01 00:00:00
abstract::We have developed an ultrasonic array sensor useable for locating air leaks in manned spacecraft and have found that this sensor locates leaks in a 1-m(2) plate to within 2 cm. The sensor consists of a 63-element multiplexed array plus a reference element, all constructed from a single PZT disc and a printed circuit b...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.07.020
更新日期:2006-12-01 00:00:00
abstract::Sonothrombolysis is one of the most feasible methods for enhancing clot lysis with a recombinant tissue plasminogen activator (rt-PA) in cases of acute ischemic strokes. For safe and efficient clinical practices of sonothrombolysis, accurate estimation of ultrasound transmittance through the human skull is critical. P...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2017.02.012
更新日期:2017-05-01 00:00:00
abstract::The aim of this work was to show the applicability of light diffraction tomography on airborne ultrasound in the frequency range 40 kHz-2 MHz. Seven different air-coupled transducers were measured to show the method's performance regarding linearity, absolute pressure measurements, phase measurements, frequency respon...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/s0041-624x(99)00168-7
更新日期:2000-01-01 00:00:00
abstract::Classically, rotary motors with gears and spindle mechanisms are used to achieve translatory motion. In means of miniaturization and weight reduction piezoelectric linear motors are of interest. Several ultrasonic linear motors found in literature base on the use of two different vibration modes. Most often flexural a...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.05.056
更新日期:2006-12-22 00:00:00
abstract::The second and third-order Brugger elastic constants are obtained for liquids and ideal gases having an initial hydrostatic pressure p1. For liquids the second-order elastic constants are C₁₁=A+p₁, C₁₂=A-p₁, and the third-order constants are C₁₁₁=-(B+5A+3p₁), C₁₁₂=-(B+A-p₁), and C₁₂₃=A-B-p₁, where A and B are the Beye...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2014.01.012
更新日期:2014-07-01 00:00:00
abstract::Guided waves propagating in cylindrical tubes are frequently applied for the characterization of material or geometrical properties of tubes. In a tube, guided waves can propagate in the axial direction and called axial guided waves, or in the circumferential direction called circumferential guided waves. Dispersion s...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2010.11.013
更新日期:2011-05-01 00:00:00
abstract::The aim of this paper is to investigate propagation characteristics and the generation mechanism of the nonlinear lowest-order symmetric Lamb mode (S0) which propagates downslope in free elastic plates with slowly linearly varying-thickness. From theoretical analyses, in a low frequency-thickness product (fd) range, t...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2018.11.013
更新日期:2019-04-01 00:00:00
abstract::Guided modes propagation in intact, fractured and healing long bone has drawn significant research interests. However, mode quantifications for the direct comparison are still necessary to address. The aim of the study is to analyze the mode interaction with a notch-fracture in the long bone and find quantitative ultr...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2013.09.015
更新日期:2014-07-01 00:00:00
abstract::Intraluminal (within the alimentary tract) thermal surgery has been shown to be a useful therapeutic option when extracorporeal focused ultrasound applicators cannot be used since their beam may not reach the target site. If plane transducers are used for the treatment of alimentary tract tumours, the applicator must ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2004.01.088
更新日期:2004-04-01 00:00:00
abstract::Traditional rotary corers and sample retrieval mechanisms for planetary drilling suffer from a variety of technical difficulties. A heavy and rigid drillstring must be assembled on-site and deployed with considerable applied preload and torque, and these mechanical loadings are difficult to react in a low gravity envi...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2011.06.001
更新日期:2011-12-01 00:00:00
abstract::The dispersion and attenuation features of the multi-physical fields coupled waves propagating in an infinite piezoelectric semiconductor and the reflection problem at a boundary which is mechanically free, electrically insulation and the dielectrically open circuit are studied in this paper. Different from the classi...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2018.09.009
更新日期:2019-02-01 00:00:00
abstract::During the last decade, the introduction of ultrasound techniques in arc welding with the intention of improving the operational performance and technical characteristics of the welding processes have been studied intensively. In this work is presented a broad review of the literature surrounding the utilization of th...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2014.10.007
更新日期:2015-02-01 00:00:00
abstract::Reflections of 4 MHz ultrasound pulses from 60 sites on 15 human aorta specimens were analysed using the plane-wave Born approximation (PWBA) inverse scattering method. The recovered high-resolution acoustic impedance profile for each site was correlated with an analysis (by microscope) of sections taken from that sit...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/0041-624x(95)00025-x
更新日期:1995-07-01 00:00:00
abstract::An improved method for ultrasonic location of multiple flaws using perpendicular ultrasonic arrays, working in near-field conditions, is presented. The method uses the pulse-echo technique and is based on the processing of the information acquired by both the elemental emitting transducers and their adjacent ones. Thi...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.05.107
更新日期:2006-12-22 00:00:00
abstract::The T-matrix approach is used to calculate the scattering of sound waves by an ellipsoidal void in a fluid. Results are presented for the total cross-section of a sphere as a function of frequency; this is related to the detection of the onset of bends in divers. Results are also presented for the angular variation in...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/0041-624x(83)90073-2
更新日期:1983-07-01 00:00:00
abstract::The frequency dependence of H2O2 generation from H2O by a sonochemical reaction was detected experimentally. The results are in good agreement with previous experimental results, which indicate that in sonochemical reactions, frequencies higher than 90 kHz are more effective than frequencies of several tens of kiloher...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/s0041-624x(99)00114-6
更新日期:2000-03-01 00:00:00
abstract::Our objective was to investigate whether hemorrhage control can be achieved faster when high-intensity focused ultrasound (HIFU) is applied in the presence of ultrasound contrast agents (UCA) as compared to HIFU only application. Incisions (3 cm long and 0.5 cm deep) were produced in the livers of anesthetized rabbits...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.07.018
更新日期:2006-12-01 00:00:00
abstract::Transducer is the necessary and most important part in the maxonics. New applications demand for new transducer, and the renovation of the transducer will open a new field for the application of the maxonics. The important method to develop new transducer is to find and develop new material. The rare earth giant magne...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.05.128
更新日期:2006-12-22 00:00:00
abstract::One of the important issues in the field of ultrasound medical imaging using contrast agents is the development of techniques able to separate the response of the contrast media from that of the biological tissues. In the literature, one can find various solutions involving the use of multiple transmitted signals and ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2008.05.008
更新日期:2009-01-01 00:00:00
abstract::In this paper, the resonance frequency equation and expression of displacement amplitude magnifications of a full-wave barber ultrasonic horn are obtained. By discussing the relationships between the displacement amplitude magnifications and the geometrical dimensions, the optimized design of the horn for the largest ...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2011.12.006
更新日期:2012-07-01 00:00:00
abstract::The ultrasound-induced harmonic microbubble response spectrum is known to shift to lower frequencies with increasing tissue attenuation. We hypothesized that this shift could be reproducibly detected in received broadband radiofrequency spectra. We used an automatic Gaussian curve-fitting technique to measure the mean...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/s0041-624x(02)00397-9
更新日期:2003-03-01 00:00:00
abstract::In this paper a high intensity focused ultrasound (FUS) phantom model was developed, in order to be used in experiments for Blood Brain Barrier (BBB) disruption. The target was to create a phantom model that represents the disruption of the BBB during ultrasound application. An appropriate experimental setup was creat...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2020.106244
更新日期:2021-02-01 00:00:00
abstract::The main component of every device used for investigating internal object structure by Ultrasound Transmission Tomography (UTT) is a special ultrasonic probe. This paper presents the structure of model multielement ring probe for examining objects using this method in divergent ray projection geometry. The probe is ma...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2006.05.126
更新日期:2006-12-22 00:00:00
abstract::The acoustic source localization technique for anisotropic plates proposed by the authors in an earlier publication ([1] Kundu et al., 2012) is improved in this paper by adopting some modifications. The improvements are experimentally verified on anisotropic flat and curved composite plates. Difficulties associated wi...
journal_title:Ultrasonics
pub_type: 杂志文章
doi:10.1016/j.ultras.2014.03.001
更新日期:2014-09-01 00:00:00