mSphere of Influence: a Systematic Approach To Dissect Virulence Traits in Candida albicans.

abstract：:Parasitic protozoans of the genus Theileria are intracellular pathogens that induce the cellular transformation of leukocytes, causing uncontrolled proliferation of the infected host cell. The transforming stage of the parasite has a strictly intracellular lifestyle and ensures its distribution to both daughter cells ...

journal_title：mSphere

authors： Huber S,Bär A,Epp S,Schmuckli-Maurer J,Eberhard N,Humbel BM,Hemphill A,Woods K

更新日期：2020-02-05 00:00:00

abstract：:The stability of the Escherichia coli populations in the human gastrointestinal tract is not fully appreciated, and represents a significant knowledge gap regarding gastrointestinal community structure, as well as resistance to incoming pathogenic bacterial species and antibiotic treatment. The current study examines ...

journal_title：mSphere

authors： Richter TKS,Hazen TH,Lam D,Coles CL,Seidman JC,You Y,Silbergeld EK,Fraser CM,Rasko DA

更新日期：2018-11-07 00:00:00

abstract：:The gut microbiota has a key role in determining susceptibility to Clostridioides difficile infections (CDIs). However, much of the mechanistic work examining CDIs in mouse models uses animals obtained from a single source. We treated mice from 6 sources (2 University of Michigan colonies and 4 commercial vendors) wit...

journal_title：mSphere

authors： Tomkovich S,Stough JMA,Bishop L,Schloss PD

更新日期：2020-10-21 00:00:00

abstract：:Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory infections, many of which are characterized by coughing of the infected hosts. The pathogenesis of the coughing remains to be analyzed, mainly because there were no convenient infection models of small animals that replicate coughing after...

journal_title：mSphere

authors： Nakamura K,Shinoda N,Hiramatsu Y,Ohnishi S,Kamitani S,Ogura Y,Hayashi T,Horiguchi Y

更新日期：2019-04-24 00:00:00

abstract：:Increasing evidence shows that exosomes are key regulators in cancer cell-to-cell communication. Several reports on Epstein-Barr virus (EBV)-related malignancies demonstrate that latent membrane protein 1 (LMP1) secreted by exosomes derived from EBV- or LMP1-positive cells can promote cancer progression and metastasis...

journal_title：mSphere

authors： Kobayashi E,Aga M,Kondo S,Whitehurst C,Yoshizaki T,Pagano JS,Shackelford J

更新日期：2018-02-07 00:00:00

abstract：:As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread around the world, there is an urgent need for new assay formats to characterize the humoral response to infection. Here, we present an efficient, competitive serological assay that can simultaneously determine an individual's seroreact...

journal_title：mSphere

authors： Byrnes JR,Zhou XX,Lui I,Elledge SK,Glasgow JE,Lim SA,Loudermilk RP,Chiu CY,Wang TT,Wilson MR,Leung KK,Wells JA

更新日期：2020-09-16 00:00:00

abstract：:Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitr...

journal_title：mSphere

authors： Bhatt K,Machado H,Osório NS,Sousa J,Cardoso F,Magalhães C,Chen B,Chen M,Kim J,Singh A,Ferreira CM,Castro AG,Torrado E,Jacobs WR Jr,Bhatt A,Saraiva M

更新日期：2018-10-31 00:00:00

abstract：:Immunity to Toxoplasma gondii at early stages of infection in C57BL/6 mice depends on gamma interferon (IFN-γ) production by NK cells, while at later stages it is primarily mediated by CD8 T cells. We decided to explore the requirement for CD4 T cells during T. gondii infection in Batf3-/- mice, which lack CD8α+ dendr...

journal_title：mSphere

authors： Tussiwand R,Behnke MS,Kretzer NM,Grajales-Reyes GE,Murphy TL,Schreiber RD,Murphy KM,Sibley LD

更新日期：2020-07-15 00:00:00

abstract：:The genomes of Leishmania and trypanosomes encode six paralogs of the eIF4E cap-binding protein, known in other eukaryotes to anchor the translation initiation complex. In line with the heteroxenous nature of these parasites, the different LeishIF4E paralogs vary in their biophysical features and their biological beha...

journal_title：mSphere

authors： Shrivastava R,Tupperwar N,Drory-Retwitzer M,Shapira M

更新日期：2019-09-04 00:00:00

abstract：:Periodontal disease induced by periodontopathic bacteria like Porphyromonas gingivalis is demonstrated to increase the risk of metabolic, inflammatory, and autoimmune disorders. Although precise mechanisms for this connection have not been elucidated, we have proposed mechanisms by which orally administered periodonto...

journal_title：mSphere

authors： Kato T,Yamazaki K,Nakajima M,Date Y,Kikuchi J,Hase K,Ohno H,Yamazaki K

更新日期：2018-10-17 00:00:00

abstract：:The Amazon River watershed and its associated plume comprise a vast continental and oceanic area. The microbial activities along this continuum contribute substantially to global carbon and nutrient cycling, and yet there is a dearth of information on the diversity, abundance, and possible roles of viruses in this glo...

journal_title：mSphere

authors： Silva BSO,Coutinho FH,Gregoracci GB,Leomil L,de Oliveira LS,Fróes A,Tschoeke D,Soares AC,Cabral AS,Ward ND,Richey JE,Krusche AV,Yager PL,de Rezende CE,Thompson CC,Thompson FL

更新日期：2017-10-04 00:00:00

abstract：:The major surface lipophosphoglycan (LPG) of Leishmania parasites is critical to vector competence in restrictive sand fly vectors in mediating Leishmania attachment to the midgut epithelium, considered essential to parasite survival and development. However, the relevance of LPG for sand flies that harbor multiple sp...

journal_title：mSphere

authors： Coutinho-Abreu IV,Oristian J,de Castro W,Wilson TR,Meneses C,Soares RP,Borges VM,Descoteaux A,Kamhawi S,Valenzuela JG

更新日期：2020-09-09 00:00:00

abstract：:Type I interferons (IFN) initiate an antiviral state through a signal transduction cascade that leads to the induction of hundreds of IFN-stimulated genes (ISGs) to restrict viral infection. Recently, RNA modifications on both host and viral RNAs have been described as regulators of infection. However, the impact of h...

journal_title：mSphere

authors： Williams GD,Gokhale NS,Snider DL,Horner SM

更新日期：2020-05-13 00:00:00

abstract：:We are exposed daily to many glycans from bacteria and food plants. Bacterial glycans are generally antigenic and elicit antibody responses. It is unclear if food glycans' sharing of antigens with bacterial glycans influences our immune responses to bacteria. We studied 14 different plant foods for cross-reactivity wi...

journal_title：mSphere

authors： Nahm MH,Yu J,Vlach J,Bar-Peled M

更新日期：2020-04-08 00:00:00

abstract：:Escherichia coli populations undergo repeated replacement of parental genotypes with fitter variants deep in stationary phase. We isolated one such variant, which emerged after 3 weeks of maintaining an E. coli K-12 population in stationary phase. This variant displayed a small colony phenotype and slow growth and was...

journal_title：mSphere

authors： Nandy P,Chib S,Seshasayee A

更新日期：2020-04-15 00:00:00

abstract：:The chikungunya virus (CHIKV) is transmitted by female Aedes aegypti and Aedes albopictus mosquitoes, mostly present in (sub)tropical regions. No antivirals are available to treat CHIKV infections. If antiviral drugs are proven efficient to treat CHIKV-infected patients, it will be pivotal to determine whether drug-re...

journal_title：mSphere

authors： Delang L,Yen PS,Vallet T,Vazeille M,Vignuzzi M,Failloux AB

更新日期：2018-08-22 00:00:00

abstract：:In densely populated urban environments, the distribution of microbes and the drivers of microbial community assemblages are not well understood. In sprawling metropolitan habitats, the "urban microbiome" may represent a mix of human-associated and environmental taxa. Here we carried out a baseline study of automated ...

journal_title：mSphere

authors： Bik HM,Maritz JM,Luong A,Shin H,Dominguez-Bello MG,Carlton JM

更新日期：2016-11-16 00:00:00

abstract：:Opsonophagocytic assays are used to measure functional antibodies important in protection against pneumococcal capsular antigens. There have been efforts to standardize these methods, as the assays are commonly used to measure vaccine immunogenicity. We report here the results from three international laboratories usi...

journal_title：mSphere

authors： Balloch A,Roalfe L,Ekstrom N,Nguyen CD,Spry L,Marimla RA,Licciardi PV,Goldblatt D,Mulholland EK

更新日期：2018-04-25 00:00:00

abstract：:The Enterobacterales order of Gram-negative bacteria includes the common nosocomial pathogens Klebsiella pneumoniae, Escherichia coli, Serratia marcescens, and Enterobacter species. Intestinal domination by some colonizing bacterial taxa is associated with subsequent infection, but 16S rRNA gene sequencing is too cost...

journal_title：mSphere

authors： Rao K,Seekatz A,Bassis C,Sun Y,Mantlo E,Bachman MA

更新日期：2020-07-22 00:00:00

abstract：:Commensal and generally harmless in healthy individuals, Enterococcus faecalis causes opportunistic infections in immunocompromised patients. Plasmid-cured E. faecalis strain VE14089, derived from sequenced reference strain V583, is widely used for functional studies due to its improved genetic amenability. Although s...

journal_title：mSphere

authors： Furlan S,Matos RC,Kennedy SP,Doublet B,Serror P,Rigottier-Gois L

更新日期：2019-07-10 00:00:00

abstract：:Most observation of human respiratory virus carriage is derived from medical surveillance; however, the infections documented by this surveillance represent only a symptomatic fraction of the total infected population. As the role of asymptomatic infection in respiratory virus transmission is still largely unknown and...

journal_title：mSphere

authors： Birger R,Morita H,Comito D,Filip I,Galanti M,Lane B,Ligon C,Rosenbloom D,Shittu A,Ud-Dean M,Desalle R,Planet P,Shaman J

更新日期：2018-07-11 00:00:00

abstract：:Competitive interactions between bacteria reveal physiological adaptations that benefit fitness. Bacillus subtilis is a Gram-positive species with several adaptive mechanisms for competition and environmental stress. Biofilm formation, sporulation, and motility are the outcomes of widespread changes in a population of...

journal_title：mSphere

authors： Liu Y,Kyle S,Straight PD

更新日期：2018-02-21 00:00:00

abstract：:Felipe Santiago-Tirado studies the cell biology of cryptococcal infections. In this mSphere of Influence article, he reflects on how the papers "Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans" (https://doi.org/10.1016/j.cell.2008.07.046) and "Unraveling the Biology of a F...

journal_title：mSphere

authors： Santiago-Tirado FH

更新日期：2019-10-02 00:00:00

abstract：:Zoonosis is the leading cause of emerging infectious diseases. In a recent article, R. S. Shabman et al. (mSphere 1[1]:e00070-15, 2016, http://dx.doi.org/10.1128/mSphere.00070-15) report the identification of a novel gammaherpesvirus in a cell line derived from the microbat Myotis velifer incautus. This is the first r...

journal_title：mSphere

authors： Host KM,Damania B

更新日期：2016-02-17 00:00:00

abstract：:Microsporidia are obligate intracellular parasites that infect a wide variety of host organisms, including humans. The sporoplasm is the initial stage of microsporidian infection and proliferation, but its morphological and molecular characteristics are poorly understood. In this study, the sporoplasm of Nosema bombyc...

journal_title：mSphere

authors： He Q,Luo J,Xu JZ,Wang CX,Meng XZ,Pan GQ,Li T,Zhou ZY

更新日期：2020-02-12 00:00:00

abstract：:Antibiotic resistance is a global crisis that threatens our ability to treat bacterial infections, such as tuberculosis, caused by Mycobacterium tuberculosis Of the 10 million cases of tuberculosis in 2017, approximately 19% of new cases and 43% of previously treated cases were caused by strains of M. tuberculosis res...

journal_title：mSphere

authors： Harrison GA,Mayer Bridwell AE,Singh M,Jayaraman K,Weiss LA,Kinsella RL,Aneke JS,Flentie K,Schene ME,Gaggioli M,Solomon SD,Wildman SA,Meyers MJ,Stallings CL

更新日期：2019-09-11 00:00:00

abstract：:Export of parasite proteins into the host erythrocyte is essential for survival of Plasmodium falciparum during its asexual life cycle. While several studies described key factors within the parasite that are involved in protein export, the mechanisms employed to traffic exported proteins within the host cell are curr...

journal_title：mSphere

authors： Cobb DW,Florentin A,Fierro MA,Krakowiak M,Moore JM,Muralidharan V

更新日期：2017-09-27 00:00:00

abstract：:Most of our knowledge relating to molecular mechanisms of human fungal pathogenesis in Candida albicans relies on reverse genetics approaches, requiring strain engineering. DNA-mediated transformation of C. albicans has been described as highly mutagenic, potentially accentuated by the organism's genome plasticity, in...

journal_title：mSphere

authors： Marton T,Maufrais C,d'Enfert C,Legrand M

更新日期：2020-09-02 00:00:00

abstract：:The wide distribution of colistin-resistant bacteria in developing countries has become a common phenomenon. To understand the mechanisms underlying their distribution, we studied the mcr genetic background of colistin-resistant Escherichia coli isolates from the fecal microbiota of healthy human residents from a comm...

journal_title：mSphere

authors： Yamaguchi T,Kawahara R,Hamamoto K,Hirai I,Khong DT,Nguyen TN,Tran HT,Motooka D,Nakamura S,Yamamoto Y

更新日期：2020-03-04 00:00:00

abstract：:Megan E. Spurgeon works in the field of viral oncology. In this mSphere of Influence article, she reflects on how the paper "Rescuing US biomedical research from its systemic flaws" by Bruce Alberts, Marc W. Kirschner, Shirley Tilghman, and Harold Varmus (Proc Natl Acad Sci U S A 111:5773-5777, 2014, https://doi.org/1...

journal_title：mSphere

authors： Spurgeon ME

更新日期：2019-07-03 00:00:00