Abstract:
Background:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe life-threatening mucocutaneous reactions. There is an ongoing controversy regarding the use of systemic corticosteroids and intravenous immunoglobulin (IVIG) in SJS/TEN and their utility in HIV-infected patients. Objectives:The objective was to assess the outcome of a combination of intensive supportive care with oral corticosteroids in SJS and a combination of systemic steroids and IVIG for 3 consecutive days in HIV-infected patients with TEN. In addition, we assessed management in a general dermatology ward without implementing wound debridement. Methods:This was a retrospective cohort study of 36 HIV-infected adults with SJS/TEN admitted to a tertiary dermatology unit between 1st January 2010 and 31st July 2011. Standard-of-care protocols included identification and elimination of the possible causative drug, meticulous wound care without debridement, initiation of oral prednisone (1 mg/kg/day) on admission for 3 consecutive days, and the addition of IVIG (1 g/kg/day) for 3 consecutive days to those with TEN. Results:Of the 36 patients in the study, 32 were female. Nevirapine was the commonest drug implicated. A diagnosis of tuberculosis did not increase the case fatality rate. Complications included infections, anaemia, drug-induced hepatitis, ocular involvement, renal impairment, deep vein thrombosis, respiratory distress, Leucopenia, gastritis and hypernatremia. The overall survival rate was 97%. Conclusion:HIV-infected SJS and TEN patients were treated in a tertiary dermatology ward with a treatment plan of skin care, and a combination of systemic corticosteroids and IVIG respectively had a survival rate of 97%.
journal_name
South Afr J HIV Medjournal_title
Southern African journal of HIV medicineauthors
Chateau AV,Dlova NC,Dawood H,Aldous Cdoi
10.4102/sajhivmed.v20i1.944subject
Has Abstractpub_date
2019-07-04 00:00:00pages
944issue
1eissn
1608-9693issn
2078-6751pii
HIVMED-20-944journal_volume
20pub_type
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journal_title:Southern African journal of HIV medicine
pub_type: 杂志文章
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journal_title:Southern African journal of HIV medicine
pub_type: 杂志文章
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journal_title:Southern African journal of HIV medicine
pub_type: 杂志文章
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journal_title:Southern African journal of HIV medicine
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journal_title:Southern African journal of HIV medicine
pub_type: 杂志文章,评审
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journal_title:Southern African journal of HIV medicine
pub_type: 杂志文章
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journal_title:Southern African journal of HIV medicine
pub_type: 杂志文章
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journal_title:Southern African journal of HIV medicine
pub_type:
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