Treatment of pediatric pulmonary arterial hypertension: A focus on the NO-sGC-cGMP pathway.

abstract：BACKGROUND:In young children with cystic fibrosis (CF) the forced expiratory volume in 1 second (FEV1 ) is often normal and a more sensitive measure to detect early obstructive lung disease is needed. AIM:To evaluate the progression of selected spirometry parameters with age in a cohort of CF patients and healthy chil...

journal_title：Pediatric pulmonology

authors： Bakker EM,Borsboom GJ,van der Wiel-Kooij EC,Caudri D,Rosenfeld M,Tiddens HA

更新日期：2013-11-01 00:00:00

abstract：:Impaired respiratory function has been found frequently in ex-premature children, but it is unclear which specific factors influence this impairment the most. The aim of this study was to determine the importance of the contributions of birth weight, gestational age, neonatal respiratory disease, and its treatment on ...

journal_title：Pediatric pulmonology

authors： Kennedy JD,Edward LJ,Bates DJ,Martin AJ,Dip SN,Haslam RR,McPhee AJ,Staugas RE,Baghurst P

更新日期：2000-07-01 00:00:00

abstract：:Diffuse panbronchiolitis is a progressive fatal respiratory disease of unknown cause seen predominantly in Southeast Asian adults. We report this condition in a 10-year-old child of Korean birth because of the uncommon presentation at this age and the favorable outcome associated with early diagnosis. Our objective wa...

journal_title：Pediatric pulmonology

authors： Weinberger M,Fischer A,Kao S

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess pulmonary function and its predictors in very low birth weight (birth weight ≤1,500 g) children (VLBWc) with or without bronchopulmonary dysplasia (BPD), born at gestational age ≤32 weeks at a single tertiary center during 1996-1999, after the introduction of surfactant the...

journal_title：Pediatric pulmonology

authors： Cazzato S,Ridolfi L,Bernardi F,Faldella G,Bertelli L

更新日期：2013-08-01 00:00:00

abstract：:The airway occlusion techniques for assessing passive respiratory mechanics have become well established methods in fullterm neonates and older infants. The single breath technique (SBT) is frequently used for assessing lung function in intubated infants on neonatal intensive care units. However, less is known about t...

journal_title：Pediatric pulmonology

authors： Gappa M,Rabbette PS,Costeloe KL,Stocks J

更新日期：1993-05-01 00:00:00

abstract：:SUMMARY. Patients with idiopathic scoliosis are reported to have a restrictive pattern on pulmonary function tests. A case is presented of a teenage girl with juvenile idiopathic scoliosis who had evidence of airways obstruction in addition to restriction on pulmonary function tests (PFT). Examination of flow-volume l...

journal_title：Pediatric pulmonology

authors： Borowitz D,Armstrong D,Cerny F

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Disease burden in cystic fibrosis (CF) impacts quality of life, distress, and treatment adherence. The promoting resilience in stress management (PRISM), is a brief patient-focused intervention to promote resilience in adolescents and young adults (AYAs), which may mitigate the negative outcomes, and is prov...

journal_title：Pediatric pulmonology

authors： Toprak D,Nay L,McNamara S,Rosenberg AR,Rosenfeld M,Yi-Frazier JP

更新日期：2020-03-01 00:00:00

abstract：:Bronchial responsiveness to isocapnic hyperventilation with cold air (CAH) and to inhaled methacholine (MCH) was compared in 17 children with bronchial asthma. The response to cold air was expressed as the percent drop in FEV1 from baseline at 4 min. after the challenge (delta % FEV1 CAH), and the response to methacho...

journal_title：Pediatric pulmonology

authors： de Benedictis FM,Canny GJ,MacLusky IB,Levison H

更新日期：1995-06-01 00:00:00

abstract：:To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days. Animals rece...

journal_title：Pediatric pulmonology

authors： Fabris VE,Pato MD,Belik J

更新日期：2001-05-01 00:00:00

abstract：:We describe a method for measuring carbon monoxide diffusing capacity (DL(CO)) and alveolar volume (V(A)) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with ro...

journal_title：Pediatric pulmonology

authors： Castillo A,Llapur CJ,Martinez T,Kisling J,Williams-Nkomo T,Coates C,Tepper RS

更新日期：2006-06-01 00:00:00

abstract：:The gene that encodes for the cystic fibrosis transmembrane regulator protein (CFTR) was identified in 1989, yet major pathophysiologic questions remain unanswered. There is emerging evidence that CFTR is a bicarbonate channel, a driver of chloride-bicarbonate exchange and through its action on local pH, a regulator o...

journal_title：Pediatric pulmonology

authors： Borowitz D

更新日期：2015-10-01 00:00:00

abstract：:Patients with cystic fibrosis (CF) often experience acute pulmonary exacerbations (APE) and may be treated with a wide variety of intravenous antibiotics. The aim of this review is to provide an evidence-based summary of pharmacokinetic/pharmacodynamic (PK/PD), tolerability, and efficacy studies utilizing the intraven...

journal_title：Pediatric pulmonology

authors： Young DC,Zobell JT,Waters CD,Ampofo K,Stockmann C,Sherwin CM,Spigarelli MG

更新日期：2013-01-01 00:00:00

abstract：:We compared proliferation (growth) and differentiation (development) related proteins in normal and hypoplastic fetal murine lungs. The hypoplastic lungs were created in CD-1 fetal mice by nitrofen exposure (25 mg per pregnant mouse given intragastrically on gestational day 8 [Gd8]), as published earlier. The lungs we...

journal_title：Pediatric pulmonology

authors： Chinoy MR,Chi X,Cilley RE

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVES:To determine B-type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome. DESIGN:Prospective observational study. SUBJECTS:After informed consent, plasma was collected from 48 pediatric patients on day...

journal_title：Pediatric pulmonology

authors： Reel B,Oishi PE,Hsu JH,Gildengorin G,Matthay MA,Fineman JR,Flori H

更新日期：2009-11-01 00:00:00

abstract：:The efficacy and tolerability of high-dose salmeterol (100 mcg, BID) and albuterol (2.5 mg, BID) were compared with those of albuterol (2.5 mg, BID) in outpatients with cystic fibrosis in a randomized, double-blind, double-dummy, placebo-controlled, crossover study with both short- (4 weeks of each) and long-term (24 ...

journal_title：Pediatric pulmonology

authors： Hordvik NL,Sammut PH,Judy CG,Colombo JL

更新日期：2002-10-01 00:00:00

abstract：:Eight patients with cystic fibrosis [CF] colonized with Pseudomonas aeruginosa (P. aeruginosa) had serial lung function, peripheral blood inflammatory markers, and serum IgG antibodies to Burkholderia cepacia (B. cepacia) lipopolysaccharide measured in the months preceding and following colonisation with B. cepacia. O...

journal_title：Pediatric pulmonology

authors： Hendry J,Nixon L,Dodd M,Elborn JS,Govan J,Shale DJ,Webb AK

更新日期：2000-01-01 00:00:00

abstract：:Although airway obstruction and chronic endobronchial infection have long been recognized as major factors in the pathogenesis of lung disease in cystic fibrosis (CF), only recently has it been recognized that the inflammatory process itself may be responsible in a major way for destroying the lungs. The most characte...

journal_title：Pediatric pulmonology

authors： Konstan MW,Berger M

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Among older children, sleep-disordered breathing (SDB) is associated with measurable neurocognitive consequences. However, diagnostic SDB thresholds are lacking for infants < 12 months. We sought to evaluate the relationship between SDB indices, gestational age (GA), and postmenstrual age (PMA) for infants wh...

journal_title：Pediatric pulmonology

authors： Matlen LB,Hassan F,Shellhaas RA

更新日期：2019-08-01 00:00:00

abstract：:Neurally adjusted ventilatory assistance (NAVA) can overcome technical difficulties with synchronizing noninvasive ventilation breaths with the patient, a modality often used in very low birthweight infants (VLBW) with apnea of prematurity (AOP). This study is a retrospective single-center investigation into whether N...

journal_title：Pediatric pulmonology

authors： Tabacaru CR,Moores RR Jr,Khoury J,Rozycki HJ

更新日期：2019-11-01 00:00:00

abstract：:In past decades, several chest radiograph scoring systems for cystic fibrosis were developed. This study was performed to compare interobserver variability of six different radiograph scores and to correlate them with clinical parameters. Thirty chest radiographs of 30 patients with cystic fibrosis were scored accordi...

journal_title：Pediatric pulmonology

authors： Terheggen-Lagro S,Truijens N,van Poppel N,Gulmans V,van der Laag J,van der Ent C

更新日期：2003-06-01 00:00:00

abstract：:A study was designed to determine the sensitivity and specificity of a cold air bronchial provocation test. A total of 18 children with asthma (mean age 12 years) and 18 normal children (mean age 14 years) were studied. The cold air challenge consisted of a 4 min period of isocapnic hyperventilation of subfreezing air...

journal_title：Pediatric pulmonology

authors： Reisman J,Mappa L,de Benedictis F,McLaughlin J,Levison H

更新日期：1987-07-01 00:00:00

abstract：:End-tidal PCO2 (PETCO2) measurements from two commercially available neonatal infrared capnometers with different sampling systems and a mass spectrometer were compared with arterial PCO2 (PaCO2) to determine whether the former could predict the latter in mechanically ventilated rabbits with and without lung injury. T...

journal_title：Pediatric pulmonology

authors： Hopper AO,Nystrom GA,Deming DD,Brown WR,Peabody JL

更新日期：1994-03-01 00:00:00

abstract：INTRODUCTION:Advance care planning (ACP), though recommended, has not been studied in adolescents with cystic fibrosis (CF). This quality improvement project engaged adolescents with advanced CF disease in ACP and assessed patient and CF provider attitudes and preferences regarding ACP discussions and tools. MATERIALS...

journal_title：Pediatric pulmonology

authors： Kazmerski TM,Weiner DJ,Matisko J,Schachner D,Lerch W,May C,Maurer SH

更新日期：2016-12-01 00:00:00

abstract：:The purpose of this study was to determine if the interrupter technique, a noninvasive method for measuring airflow resistance, could be used to assess airway obstruction in children. In 107 children (74 with asthma, 12 with cystic fibrosis, and 21 without lung disease) conductance (mostly of airways) measured with th...

journal_title：Pediatric pulmonology

authors： Carter ER,Stecenko AA,Pollock BH,Jaeger MJ

更新日期：1994-04-01 00:00:00

abstract：:The aim of this study was to examine a possible association between birth season (date of birth) and future development of asthma in children. A case-control study was designed to include asthmatic children aged 2-7 years, living in the city of Beer-Sheva, in southern Israel, registered in one pediatric center. Contro...

journal_title：Pediatric pulmonology

authors： Gazala E,Ron-Feldman V,Alterman M,Kama S,Novack L

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:The present pilot study was performed to evaluate the HPA axis and ANS activity by measuring salivary cortisol and α-amylase diurnal trajectory and production, respectively, in mild or moderate-to-severe (MS) OSA-affected, but otherwise healthy, children. Moreover, a correlative analysis was performed betwee...

journal_title：Pediatric pulmonology

authors： Patacchioli FR,Tabarrini A,Ghiciuc CM,Dima-Cozma LC,Prete A,Bianchini C,Nicoletti F,Gozal D,Villa MP

更新日期：2014-11-01 00:00:00

abstract：:Previously, there was insufficient evidence to confirm that pneumonia in infants and children might lead to the development of pulmonary hypertension. Recently, it has been shown that acceleration time corrected for heart rate (ATc) and the ratios of right ventricular preejection period to right ventricular ejection t...

journal_title：Pediatric pulmonology

authors： Du JB,Li SZ,Wang BL,Li YA

更新日期：1991-01-01 00:00:00

abstract：:Allergic bronchopulmonary aspergillosis (ABPA) is a well-known complication of cystic fibrosis (CF), with an estimated incidence of up to 11%. In patients with CF, the diagnosis of ABPA must be based on significant elevation of Aspergillus fumigatus (Af) antibody and total serum IgE, since it is common to already have...

journal_title：Pediatric pulmonology

authors： Chung Y,Kraut JR,Stone AM,Valaitis J

更新日期：1994-02-01 00:00:00

abstract：:While the use of the raised volume rapid thoraco-abdominal compression (RVRTC) technique has been shown to provide new insights into airway and pulmonary pathophysiology in infants, and appears to resemble the spirometric techniques used in older subjects, there is as yet no consensus regarding measurement procedures,...

journal_title：Pediatric pulmonology

authors： Lum S,Hoo AF,Stocks J

更新日期：2002-11-01 00:00:00

abstract：:Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...

journal_title：Pediatric pulmonology

authors： Koumbourlis AC,Belessis Y,Cataletto M,Cutrera R,DeBoer E,Kazachkov M,Laberge S,Popler J,Porcaro F,Kovesi T

更新日期：2020-10-01 00:00:00