Treatment of pediatric pulmonary arterial hypertension: A focus on the NO-sGC-cGMP pathway.

abstract：:The consequences of poor quality and/or inadequate sleep in children and adolescents have become a major public health concern, and one in which pediatric health care professionals have become increasingly involved. In particular, insufficient and/or fragmented sleep resulting from primary sleep disorders such as obst...

journal_title：Pediatric pulmonology

authors： Owens JA

更新日期：2009-05-01 00:00:00

abstract：AIM:Children with respiratory conditions benefit from care provided by pediatric pulmonologists. As these physicians are a small portion of the overall pediatric workforce, it is necessary to understand the practices and career plans of these specialists. METHODS:An internet survey was developed by the American Academ...

journal_title：Pediatric pulmonology

authors： Harris C,Katkin J,Cataletto M,Dorkin H,Laskosz L,Ruch-Ross H

更新日期：2019-04-01 00:00:00

abstract：:A group of 153 children (51 with a history of bronchiolitis and 102 matched controls) were evaluated in a historical cohort study at a mean age of 8 years and again at 13 years to test the primary hypothesis that mild bronchiolitis, far more common than severe (hospitalized) bronchiolitis, predicts wheezing. A seconda...

journal_title：Pediatric pulmonology

authors： McConnochie KM,Roghmann KJ

更新日期：1989-01-01 00:00:00

abstract：:Exercise challenge tests are helpful in the diagnosis and management of childhood asthma, but methodology is complex and time-consuming. The aim of this study was to investigate whether exercise-induced bronchoconstriction (EIB) can be predicted by the results of different surrogate tests in a pediatric population. Ei...

journal_title：Pediatric pulmonology

authors： Lex C,Dymek S,Heying R,Kovacevic A,Kramm CM,Schuster A

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To determine the interpretative consequences of adopting the Global Lungs 2012 (GLI-2012) spirometric prediction equations in a pediatric hospital population. MATERIAL:Spirometric records from 2,192 white boys and 1,842 white girls, and 412 and 334 African-American boys and girls, respectively, aged 6.0-18.0...

journal_title：Pediatric pulmonology

authors： Quanjer PH,Weiner DJ

更新日期：2014-02-01 00:00:00

abstract：AIM:The aim of this study was to investigate the status and effects of vitamin D supplement as adjuvant therapy in the management of respiratory distress syndrome (RDS) in preterm infants. PATIENT AND METHODS:Vitamin D was prospectively studied in 196 preterm neonates, 96 of them developed RDS, which further subdivide...

journal_title：Pediatric pulmonology

authors： Al-Beltagi M,Rowiesha M,Elmashad A,Elrifaey SM,Elhorany H,Koura HG

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff. PATIENTS AND METHODS:Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed us...

journal_title：Pediatric pulmonology

authors： Balaguer M,Alejandre C,Vila D,Esteban E,Carrasco JL,Cambra FJ,Jordan I

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a common sleep problem. The aim of this study is to investigate the association between OSAHS and blood pressure (BP) in snoring children. METHODS:Snoring children were recruited from January 2009 to December 2010. Clinical history was taken accompanied by...

journal_title：Pediatric pulmonology

authors： Xu Z,Li B,Shen K

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Lung involvement in children with Niemann-Pick disease has rarely been studied systematically. OBJECTIVE:To assess the involvement of the lung and the value of bronchoalveolar lavage in children with Niemann-Pick diseases. DESIGN:Retrospective analysis of patient records. PATIENTS:Thirteen patients, with ...

journal_title：Pediatric pulmonology

authors： Guillemot N,Troadec C,de Villemeur TB,Clément A,Fauroux B

更新日期：2007-12-01 00:00:00

abstract：:Lung diseases caused by surfactant protein C (SFTPC) mutations are inherited as autosomal traits with variable penetrance and severity or as sporadic disease caused by a de novo mutation on one allele. Here, we report the case of a child surviving with a homozygous surfactant protein C mutation after aggressive clinic...

journal_title：Pediatric pulmonology

authors： Arıkan-Ayyıldız Z,Caglayan-Sozmen S,Isık S,Deterding R,Dishop MK,Couderc R,Epaud R,Louha M,Uzuner N

更新日期：2014-03-01 00:00:00

abstract：:Our purpose was to identify and further characterize physiologic mechanisms relevant to autoresuscitation from hypoxic apnea in infants dying suddenly and unexpectedly. We studied cardiorespiratory recordings of 24 infants (age range, 0.8-21 months) who died suddenly while being monitored at home. These recordings wer...

journal_title：Pediatric pulmonology

authors： Sridhar R,Thach BT,Kelly DH,Henslee JA

更新日期：2003-08-01 00:00:00

abstract：:Ten children with mild bronchial asthma underwent bronchial challenge with carbachol on three consecutive days; using a double-blind technique, they were given inhaled saline placebo on the first day and placebo or sodium cromoglycate (SCG) on the second and third days 15 min prior to the bronchial provocation test wi...

journal_title：Pediatric pulmonology

authors： Barbato A,Pisetta F,Mesirca P,Ragusa A,Zacchello F

更新日期：1987-05-01 00:00:00

abstract：RATIONALE:Increasing evidence suggests the forced oscillation technique (FOT) has the capacity to provide non-invasive monitoring and diagnosis of respiratory disease in young children. However, which FOT outcomes provide the most pertinent clinical information is currently unknown. The aim of this study was to determi...

journal_title：Pediatric pulmonology

authors： Evans DJ,Schultz A,Verheggen M,Hall GL,Simpson SJ

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Multiple breath washout (MBW) in infants presents a number of technical challenges. Conventional MBW is based on simultaneous measurement of flow and gas concentrations. These two signals are aligned and combined to derive expired gas volumes from which lung volumes and measures of ventilation inhomogeneity ...

journal_title：Pediatric pulmonology

authors： Shawcross A,Murray CS,Goddard N,Gupta R,Watson S,Horsley A

更新日期：2016-05-01 00:00:00

abstract：:During the final prenatal period of fetal lung development in humans, important maturational processes occur, including the production of surfactant necessary to decrease surface tension at the air-liquid interface of the alveoli. During early gestation, the glucocorticoid receptor is expressed in the fetal lung, and ...

journal_title：Pediatric pulmonology

authors： Bolt RJ,van Weissenbruch MM,Lafeber HN,Delemarre-van de Waal HA

更新日期：2001-07-01 00:00:00

abstract：:The long-term efficacy and safety of aminoglycoside aerosol therapy for Pseudomonas aeruginosa colonization/infection in cystic fibrosis has not been fully investigated. In the present study, 14 patients with cystic fibrosis, ages 8-19 years (mean: 13.3 years), received tobramycin aerosol therapy for a mean duration o...

journal_title：Pediatric pulmonology

authors： Steinkamp G,Tümmler B,Gappa M,Albus A,Potel J,Döring G,von der Hardt H

更新日期：1989-01-01 00:00:00

abstract：:Previous research has demonstrated a significant reciprocal relationship between psychosocial factors and asthma morbidity in children. The National Cooperative Inner-City Asthma Study investigated both asthma-specific and non-specific psychosocial variables, including asthma knowledge beliefs and management behavior,...

journal_title：Pediatric pulmonology

authors： Wade S,Weil C,Holden G,Mitchell H,Evans R 3rd,Kruszon-Moran D,Bauman L,Crain E,Eggleston P,Kattan M,Kercsmar C,Leickly F,Malveaux F,Wedner HJ

更新日期：1997-10-01 00:00:00

abstract：:Our aim was to determine whether antenatal corticosteroids improve perinatal adaptation of the pulmonary circulation in lambs with lung hypoplasia (LH). LH was induced in 12 ovine fetuses between 105 and 140 days gestation (term approximately 147 days); in 6 of these the ewe was given a single dose of betamethasone (1...

journal_title：Pediatric pulmonology

authors： Suzuki K,Hooper SB,Wallace MJ,Probyn ME,Harding R

更新日期：2006-09-01 00:00:00

abstract：INTRODUCTION:The prognosis of postinfectious bronchiolitis obliterans (PIBO) has many implications, ranging between reduced quality of life and life-threatening complications. We evaluated the prognostic factors for PIBO using the baseline clinical characteristics of patients and built a prediction model for determinin...

journal_title：Pediatric pulmonology

authors： Jung JH,Kim GE,Min IK,Jang H,Kim SY,Kim MJ,Kim YH,Shin HJ,Yoon H,Sohn MH,Lee MJ,Kim KW

更新日期：2020-12-11 00:00:00

abstract：OBJECTIVES:Sildenafil, tezosentan, and prostacyclin reduce pulmonary vascular pressures in pulmonary hypertension, but have potential to vasodilate the systemic circulation. Nebulized vasodilators allow targeted drug delivery, high local drug concentrations, less systemic hypotension, and better matching of the lung's ...

journal_title：Pediatric pulmonology

authors： Katz SL,Adatia I,Louca E,Leung K,Humpl T,Reyes JT,Coates AL

更新日期：2006-07-01 00:00:00

abstract：:Assessment of dynamic inspiratory function may provide valuable information about the degree and progression of pulmonary involvement in patients with Duchenne muscular dystrophy (DMD). The aims of this study were to characterize inspiratory function and to assess the efficacy of idebenone on this pulmonary function o...

journal_title：Pediatric pulmonology

authors： Buyse GM,Voit T,Schara U,Straathof CS,D'Angelo MG,Bernert G,Cuisset JM,Finkel RS,Goemans N,Rummey C,Leinonen M,Mayer OH,Spagnolo P,Meier T,McDonald CM,DELOS Study Group.

更新日期：2017-04-01 00:00:00

abstract：:Our objective was to compare the effectiveness of maximum forced expiratory flow measured at functional residual capacity (V'maxFRC) and the ratio of flow at 75% of the forced expiratory volume to peak forced expiratory flow (FEF(75)/FEF(peak)) for detecting bronchodilator-related changes in wheezy infants. In 55 infa...

journal_title：Pediatric pulmonology

authors： Sheikh S,Castile R,Hayes J,McCoy K,Eid N

更新日期：2003-09-01 00:00:00

abstract：:Mucus plugging constitutes a nutrient-rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infan...

journal_title：Pediatric pulmonology

authors： Balázs A,Mall MA

更新日期：2019-11-01 00:00:00

abstract：:A study was designed to determine the sensitivity and specificity of a cold air bronchial provocation test. A total of 18 children with asthma (mean age 12 years) and 18 normal children (mean age 14 years) were studied. The cold air challenge consisted of a 4 min period of isocapnic hyperventilation of subfreezing air...

journal_title：Pediatric pulmonology

authors： Reisman J,Mappa L,de Benedictis F,McLaughlin J,Levison H

更新日期：1987-07-01 00:00:00

abstract：:Neutrophil elastase is present at high levels in airway fluid of patients with cystic fibrosis (CF), and is responsible for considerable inflammatory damage. Human monocyte/neutrophil elastase inhibitor (MNEI), a 42-kDa serpin protein, is an effective inhibitor of neutrophil elastase, cathepsin G, and proteinase-3, re...

journal_title：Pediatric pulmonology

authors： Woods DE,Cantin A,Cooley J,Kenney DM,Remold-O'Donnell E

更新日期：2005-02-01 00:00:00

abstract：:Malacoplakia is an unusual inflammatory condition with distinctive histologic features. Involvement of the lung is quite uncommon and is rarely described in paediatrics. We report on a case of pulmonary malacoplakia in a teenage girl. ...

journal_title：Pediatric pulmonology

authors： Kumar P,Rassl DM,Hamilton JR,Spencer DA

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVES:The present pilot study was performed to evaluate the HPA axis and ANS activity by measuring salivary cortisol and α-amylase diurnal trajectory and production, respectively, in mild or moderate-to-severe (MS) OSA-affected, but otherwise healthy, children. Moreover, a correlative analysis was performed betwee...

journal_title：Pediatric pulmonology

authors： Patacchioli FR,Tabarrini A,Ghiciuc CM,Dima-Cozma LC,Prete A,Bianchini C,Nicoletti F,Gozal D,Villa MP

更新日期：2014-11-01 00:00:00

abstract：:Patients with cystic fibrosis (CF) can be discriminated from healthy subjects by measurement of the nasal potential difference, which has become a useful outcome measure for therapies directed toward correcting defective electrolyte transport in CF. A standard operating procedure was developed by a CF Foundation clini...

journal_title：Pediatric pulmonology

authors： Standaert TA,Boitano L,Emerson J,Milgram LJ,Konstan MW,Hunter J,Berclaz PY,Brass L,Zeitlin PL,Hammond K,Davies Z,Foy C,Noone PG,Knowles MR

更新日期：2004-05-01 00:00:00

abstract：:Between October, 1985 and May 1987, 29 children (mean age 22 +/- 22 months, range 2-54 months) with AIDS or ARC developed acute respiratory illness. The initial diagnostic procedure was flexible fiberoptic bronchoscopy, with bronchoalveolar lavage (BAL). BAL was positive for Pneumocystis carinii in 14 and for respirat...

journal_title：Pediatric pulmonology

authors： Bye MR,Bernstein L,Shah K,Ellaurie M,Rubinstein A

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:The pH of exhaled breath condensate (EBC) of adolescent athletes engaged in vigorous physical activity is low compared to healthy controls; however, the ionic determinants of EBC pH and the acute effects of exercise on those determinants have not been definitively established. OBJECTIVES:This study had two ...

journal_title：Pediatric pulmonology

authors： Greenwald R,Ferdinands JM,Teague WG

更新日期：2009-08-01 00:00:00