Does Tranexamic Acid Increase the Incidence of Thromboembolism After Spinal Fusion Surgery?

Abstract:

STUDY DESIGN:This was a retrospective analysis of prospectively collected data. OBJECTIVE:To investigate the incidence of thromboembolism in patients who received tranexamic acid (TXA) after lumbar spine fusion and determine the diagnostic value of lower limb duplex sonography as a screening test. SUMMARY OF BACKGROUND DATA:TXA is effective in reducing blood drainage in spine fusion surgery but some studies have reported increased incidence of venous thromboembolism associated with TXA. MATERIALS AND METHODS:One hundred twenty-two patients who underwent lumbar fusion for degenerative spinal disease received intravenous TXA in doses equivalent to 10 mg/kg for 48 hours after surgery. As a control group, 85 patients received intravenous administration of the same amount of normal saline. D-dimer levels were checked on the day of admission and the seventh postoperative day (POD#7). All patients underwent duplex sonography on POD#7, and patients with abnormal results were further evaluated with computed tomography angiography and pulmonary arterial angiography. RESULTS:None of the patients showed symptoms of deep vein thrombosis (DVT). Suspicious signs of DVT were observed in 5 patients in the TXA group and 4 patients in the control group in lower limb duplex sonography. Finally, DVT was confirmed by computed tomography angiography in one of 122 patients (0.8%) in the TXA group and in one of 85 patients (1.2%) in the control group. D-dimer levels on POD#7 were higher in the patients with DVT than in patients without DVT. Average postoperative blood drain was 421.3±133.1 mL in the TXA group and 635.2±151.2 mL in the control group (P<0.001), which showed TXA was effective to reduce postoperative hemorrhage. CONCLUSIONS:The incidence of thromboembolism after using TXA in lumbar fusion surgery was 0.8%, as comparable as the incidence of thromboembolism in the control group. Lower limb duplex sonography is not recommended for screening test of DVT because of high false-positive rate. LEVEL OF EVIDENCE:Level III.

journal_name

Clin Spine Surg

journal_title

Clinical spine surgery

authors

Ko BS,Cho KJ,Kim YT,Park JW,Kim NC

doi

10.1097/BSD.0000000000000860

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

E71-E75

issue

2

eissn

2380-0186

issn

2380-0194

journal_volume

33

pub_type

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