Abstract:
:The Prodiginine family consists of primarily red-pigmented tripyrrole secondary metabolites that were first characterized in the Gram-negative bacterial species Serratia marcescens and demonstrates a wide array of biological activities and applications. Derivatives of prodiginine have since been characterized in the marine γ-proteobacterium, Pseudoalteromonas. Although biosynthetic gene clusters involved in prodiginine synthesis display homology among genera, there is an evident structural difference in the resulting metabolites. This review will summarize prodiginine biosynthesis, bioactivity, and gene regulation in Pseudoalteromonas in comparison to the previously characterized species of Serratia, discuss the ecological contributions of Pseudoalteromonas in the marine microbiome and their eukaryotic hosts, and consider the importance of modern functional genomics and classic DNA manipulation to understand the overall prodiginine biosynthesis pathway.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Sakai-Kawada FE,Ip CG,Hagiwara KA,Awaya JDdoi
10.3389/fmicb.2019.01715subject
Has Abstractpub_date
2019-07-24 00:00:00pages
1715issn
1664-302Xjournal_volume
10pub_type
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