Bone mineral density and its influencing factors in children with idiopathic nephrotic syndrome: a prospective observational study.

Abstract:

:Glucocorticoids are first-line therapy for children with idiopathic nephrotic syndrome (INS). These children are at risk of deranged bone metabolism and low bone mineral density (BMD). We studied 60 children with INS and divided them into two groups. Group 1 included 21 children (initial and infrequent relapsing) and group 2 included 39 children (frequent relapsing, steroid dependent and steroid resistant). Dual-energy X-ray absorptiometry of the lumbar spine was performed to assess BMD. Mean BMD Z-score was compared in both groups; this correlated significantly on univariate analysis with cumulative steroid dose, serum vitamin D levels and calcium supplementation. However, on multivariate analysis, serum vitamin D level was the only factor significantly predictive of low z-score.

journal_name

Trop Doct

journal_title

Tropical doctor

authors

Sharawat IK,Dawman L,Kumkhaniya MV,Devpura K,Mehta A

doi

10.1177/0049475519868055

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

292-298

issue

4

eissn

0049-4755

issn

1758-1133

journal_volume

49

pub_type

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