Hexamethylmelamine as first-line chemotherapy in the treatment of advanced or recurrent carcinoma of the endometrium: a phase II trial of the Gynecologic Oncology Group.

abstract：:By serendipity we have had the opportunity to evaluate cis-platin-based chemotherapy in ovarian tumors of low malignant potential (LMP). Optimal (less than 1 cm residual disease) FIGO stage III ovarian carcinomas were randomly assigned to treatment with cisplatin plus cyclophosphamide with or without doxorubicin on a ...

journal_title：Gynecologic oncology

authors： Sutton GP,Bundy BN,Omura GA,Yordan EL,Beecham JB,Bonfiglio T

更新日期：1991-06-01 00:00:00

abstract：STUDY OBJECTIVE:To describe our technique for excision of the pre-caval and laterocaval nodes using an extraperitoneal approach. This technique was developed to make the dissection and excision of the less accessible nodes in an easier and safer way by minimizing the risk of great vessels injury and bleeding. DESIGN:S...

journal_title：Gynecologic oncology

authors： Gorostidi M,Villalain C,Ruiz R,Jaunarena I,Lekuona A

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Endometrioid endometrial carcinoma is caused by a combination of mutational events and hormonal factors. We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated d...

journal_title：Gynecologic oncology

authors： Mutter GL,Baak JP,Fitzgerald JT,Gray R,Neuberg D,Kust GA,Gentleman R,Gullans SR,Wei LJ,Wilcox M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Different Human Papilloma Virus (HPV) tests are currently used. An integrated comparison of the Amplicor, Cobas4800, PreTect HPV-Proofer and APTIMA HPV tests has not been done. METHODS:We compared the high-risk HPV detection power of these HPV tests in 528 consecutive population-based follow-up Liquid-Based ...

journal_title：Gynecologic oncology

authors： Ovestad IT,Vennestrøm U,Andersen L,Gudlaugsson E,Munk AC,Malpica A,Feng W,Voorhorst F,Janssen EA,Baak JP

更新日期：2011-11-01 00:00:00

abstract：:Adenocarcinoma originating in the endocervix may remain occult for many years. This may result in an extension to the uterine isthmus and corpus, with subsequent dissemination along the pathways of spread of uterine carcinoma, including metastasis to the ovaries. The patient described in this report had a bulky stage ...

journal_title：Gynecologic oncology

authors： Parham G,Heppard MC,DiSaia PJ

更新日期：1994-12-01 00:00:00

abstract：:Ninety-three consecutive operative cases of myometrial invasive endometrioid adenocarcinoma of the uterus without evidence of extrauterine spread at surgery were reviewed to determine whether any histopathologic features other than those traditionally reported might predict recurrence. Recurrence was associated with t...

journal_title：Gynecologic oncology

authors： Lee KR,Vacek PM,Belinson JL

更新日期：1994-07-01 00:00:00

abstract：:A total of 246 endocervical samples were collected for Papanicolaou staining and one-parameter flow cytometric DNA analysis (FCDA) using 4',6-diamidino-2-phenylindole as a DNA stain. Typical histograms derived from FCDA analysis were designated class I, II, III, and V. Two groups of patients were studied: 135 women re...

journal_title：Gynecologic oncology

authors： Tsou KC,Pearson S,Atkinson BF,Giuntoli R,Mangan C

更新日期：1983-06-01 00:00:00

abstract：:Forty patients with locally advanced cervical carcinoma were entered into a protocol utilizing the bolus administration of both mitomycin C (10 or 15 mg) on Day 1 and 5-fluorouracil (400 mg) on Day 1-5 followed by sequential pelvic irradiation on Day 6 between September 1980 and October 1985. All patients had poor-pro...

journal_title：Gynecologic oncology

authors： Denehy TR,Eastman R,SanFilippo L,Gregori CA,Breen JL

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:In preparation for the launch of a gynecologic oncology survivorship program, this study looked at the informational needs of women with gynecologic cancers. Although studies have touched on some of these needs, no published literature has investigated the comprehensive informational needs of gynecologic onc...

journal_title：Gynecologic oncology

authors： Papadakos J,Bussière-Côté S,Abdelmutti N,Catton P,Friedman AJ,Massey C,Urowitz S,Ferguson SE

更新日期：2012-03-01 00:00:00

abstract：:Normal and neoplastic endometrial tissues were examined immunohistochemically for chromogranin which was shown to be a specific marker for neuroendocrine cells. All 20 normal endometriums and 20 endometrial carcinomas without argyrophilia were chromogranin negative. Endometrial carcinomas with argyrophilia tested were...

journal_title：Gynecologic oncology

authors： Ueda G,Nishino T,Saito J,Abe Y,Shimizu H,Tanizawa O

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:The objective was to determine the frequency with which regression or progression of disease without treatment occurred in women diagnosed with squamous cell cervical carcinoma in situ (CIS) during pregnancy. METHODS:. A retrospective chart review of all women evaluated at the University of Iowa Colposcopy C...

journal_title：Gynecologic oncology

authors： Coppola A,Sorosky J,Casper R,Anderson B,Buller RE

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:This study aims to identify favorable preoperative characteristics and examine the impact of secondary cytoreductive surgery on survival for patients with recurrent epithelial ovarian carcinoma. METHODS:Patients who underwent cytoreductive surgery for recurrent epithelial ovarian cancer were identified in ou...

journal_title：Gynecologic oncology

authors： Tebes SJ,Sayer RA,Palmer JM,Tebes CC,Martino MA,Hoffman MS

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Radiation treatment is one of the most standardized and effective modalities for contemporary cervical cancer therapy. In addition, the radiation-potentiating effects of retinoic acid have been recently described. In order to investigate whether enhanced immunogenicity might be responsible for such potentiat...

journal_title：Gynecologic oncology

authors： Santin AD,Hermonat PL,Ravaggi A,Chiriva-Internati M,Hiserodt JC,Pecorelli S,Parham GP

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:Ras gene mutations have been identified in squamous cell carcinomas of the cervix and are associated with advanced-stage tumors. The current study was designed to determine the prevalence of c-Ki-ras mutations in invasive endocervical adenocarcinomas and associations between mutations, HPV status, and known p...

journal_title：Gynecologic oncology

authors： Koulos JP,Wright TC,Mitchell MF,Silva E,Atkinson EN,Richart RM

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To develop a nomogram to predict overall survival (OS) in women with recurrent ovarian cancer treated with bevacizumab and chemotherapy. METHODS:A multicenter retrospective study was conducted. Potential prognostic variables included age; stage; grade; histology; performance status; residual disease; presenc...

journal_title：Gynecologic oncology

authors： Previs RA,Bevis KS,Huh W,Tillmanns T,Perry L,Moore K,Chapman J,McClung C,Kiet T,Java J,Chan J,Secord AA

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Australia's HPV vaccination and HPV-based cervical screening programs are changing the landscape in cervical cancer prevention. We aim to identify areas which can make the biggest further impact on cervical cancer burden. This protocol describes the first stage of a program of work called Pathways-Cervix that...

journal_title：Gynecologic oncology

authors： Velentzis LS,Smith MA,Simms KT,Lew JB,Hall M,Hughes S,Yuill S,Killen J,Keane A,Butler K,Darlington-Brown J,Hui H,Brotherton JML,Skinner R,Brand A,Roeske L,Heley S,Carter J,Bateson D,Frazer I,Garland SM,Guy R,H

更新日期：2019-03-01 00:00:00

abstract：:Malignant diseases have been shown to cause hypercoagulable states. Elevated prothrombin fragment F 1 + 2 plasma levels occur, when prothrombin is converted into thrombin by factor Xa. In order to evaluate the role of prothrombin fragment F 1 + 2 as an indicator for hemostatic disorders in patients with gynecologic ma...

journal_title：Gynecologic oncology

authors： Hanzal E,Tatra G

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Treatment with weekly cisplatin (CDDP) plus radiotherapy (RT) is the standard regimen for stage IB to stage IVA cervical carcinoma (CC). We performed a systematic review and meta-analysis of published studies to evaluate whether CDDP-based doublet therapy improves survival compared to weekly CDDP plus RT in ...

journal_title：Gynecologic oncology

authors： Petrelli F,De Stefani A,Raspagliesi F,Lorusso D,Barni S

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy between acupuncture and ondansetron in the prevention of delayed chemotherapy induced nausea and vomiting (CINV). METHODS:70 patients were randomized to receive either 1) acupuncture at P6 point before chemotherapy infusion or 2) ondansetron 8 mg intravenously 30 min before chemothera...

journal_title：Gynecologic oncology

authors： Rithirangsriroj K,Manchana T,Akkayagorn L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Pelvic exenteration (PE) is an extensive surgery associated with high rates of postoperative morbidity and mortality. The absence of well-defined preoperative selection criteria to identify patients eligible for PE prompted the assessment of pre-operative predictors of 30-day major surgical complications. ME...

journal_title：Gynecologic oncology

authors： Tortorella L,Casarin J,Mara KC,Weaver AL,Multinu F,Glaser GE,Cliby WA,Scambia G,Mariani A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether the number of lymph nodes obtained during lymphadenectomy affects the survival of patients with intermediate- or high-risk endometrioid-type endometrial cancer. METHODS:A total of 476 patients who were diagnosed with FIGO stage IB to IIIC2 endometrioid adenocarcinoma through surgical s...

journal_title：Gynecologic oncology

authors： Kim TH,Kim HS,Kim TJ,Chang SJ,Kim DY,Ryu SY,Kim BG,Kim YT,Bae DS,Ryu HS,Nam JH

更新日期：2016-06-01 00:00:00

abstract：:Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of CIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papi...

journal_title：Gynecologic oncology

authors： Romney SL,Ho GY,Palan PR,Basu J,Kadish AS,Klein S,Mikhail M,Hagan RJ,Chang CJ,Burk RD

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Chemoradiation based on cisplatin is the standard treatment for locally advanced cervical carcinoma; however, the optimal scheduling and dosing have still not been established. This study was conducted to determine the maximum-tolerated dose (MTD) of cisplatin for daily administration during pelvic radiothera...

journal_title：Gynecologic oncology

authors： Mitsuhashi A,Uno T,Tanaka N,Suzuka K,Tate S,Yamazawa K,Matsui H,Yamamoto S,Ito H,Sekiya S

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To determine if preoperative metabolic tumor volume (MTV) measured by integrated (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) imaging has prognostic value in patients with cervical cancer treated primarily with radical hysterectomy. METHODS:Patients with FIGO s...

journal_title：Gynecologic oncology

authors： Chung HH,Kim JW,Han KH,Eo JS,Kang KW,Park NH,Song YS,Chung JK,Kang SB

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the rate of occult metastasis, including isolated tumor cells, in para-aortic lymph nodes of patients with stage IIIC1 endometrial cancer who underwent pelvic and para-aortic lymphadenectomy. METHODS:A series of 15 patients who had undergone combined pelvic and para-aor...

journal_title：Gynecologic oncology

authors： Todo Y,Suzuki Y,Azuma M,Hatanaka Y,Konno Y,Watari H,Kato H,Matsuno Y,Yamashiro K,Sakuragi N

更新日期：2012-12-01 00:00:00

abstract：:Immunotherapy (IO) is an important new pillar in the treatment of solid tumors, and the integration of IO agents with chemotherapy, targeted therapy, surgery and radiation has yet to be defined. As preclinical and clinical studies have described synergistic activity with the combination of radiation and immunotherapy,...

journal_title：Gynecologic oncology

authors： Lee L,Matulonis U

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate the histological outcome of laser ring biopsies in patients with one or more smears showing cytological mild dyskaryosis where punch biopsies were not performed. The possibilities of predicting histological findings of CIN 2 and CIN 3 were analyzed. METHODS:The study com...

journal_title：Gynecologic oncology

authors： Risberg B,Andersson A,Lie KA,Nordin B,Zetterberg C

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Three founder alleles of the CHEK2 gene have been associated with predisposition to a range of cancer types in Poland. Two founder alleles (1100delC and IVS2 + 1G >A) result in a truncated CHEK2 protein and the other is a missense substitution, leading to the replacement of a threonine with an isoleucine (I15...

journal_title：Gynecologic oncology

authors： Szymanska-Pasternak J,Szymanska A,Medrek K,Imyanitov EN,Cybulski C,Gorski B,Magnowski P,Dziuba I,Gugala K,Debniak B,Gozdz S,Sokolenko AP,Krylova NY,Lobeiko OS,Narod SA,Lubinski J

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:To examine the impact of treatment- and disease-related factors on the quality of life of patients with ovarian cancers undergoing chemotherapy. PATIENTS AND METHODS:Over 18 months period, all patients with ovarian cancer receiving chemotherapy at the Saskatoon Cancer Center were recruited. The Functional A...

journal_title：Gynecologic oncology

authors： Le T,Leis A,Pahwa P,Wright K,Ali K,Reeder B,Hopkins L,Fung MF

更新日期：2004-03-01 00:00:00

abstract：:This study evaluated the effects of cisplatin on 18 nerve conduction parameters of median, ulnar, peroneal, and sural nerves in relation to age, magnesium nadir, average magnesium, and magnesium replacement in gynecologic oncology patients. The 37 patients in this study received cisplatin (70 mg/m2) at 4-week interval...

journal_title：Gynecologic oncology

authors： Ashraf M,Riggs JE,Wearden S,Scotchel P

更新日期：1990-04-01 00:00:00