Abstract:
:Previous studies have revealed several genes involved in the carcinogenesis of oral cancer. However, the detailed mechanisms underlying this process are poorly understood. Previously, we established a database cataloging the transcriptional progression profile of oral carcinogenesis and identified several candidate genes with continuously increasing or decreasing expression, which specifically promote the transition of oral premalignant lesions to invasive carcinomas. In this study, using our microarray database, we attempted to determine significant genes that may contribute to metabolic alterations during oral carcinogenesis. After performing a literature survey, we focused on 15 candidate genes associated with glucose metabolism changes, particularly the tri-carboxylic acid cycle, and investigated the mRNA-expression status of these genes with our database. Only the solute carrier family 2 member 1 gene (also known as GLUT1), showed significantly increased mRNA expression during oral tumorigenesis. Immunohistochemical analysis confirmed that GLUT1 protein expression significantly increased during oral carcinogenesis. In addition, tumors with high expression of this protein significantly correlated with nodal status (P=0.002). Kaplan-Meier survival curves clearly demonstrated the adverse impact of high GLUT1 protein expression on disease-free survival (P=0.004). GLUT1 mRNA and protein expression increased in the order of normal mucosal tissues, epithelial dysplastic lesions and invasive carcinomas. Therefore, metabolic alterations, especially in glucose metabolism, occurred at the very early stage of development of oral malignancies. In addition, GLUT1 played a significant role in oral cancer, acquiring a malignant phenotype.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Nakazato K,Mogushi K,Kayamori K,Tsuchiya M,Takahashi KI,Sumino J,Michi Y,Yoda T,Uzawa Ndoi
10.3892/ol.2019.10420subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1372-1380issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-10420journal_volume
18pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::MicroRNAs are proposed to serve vital functions in the regulation of tumor progression and invasion. However, the expression levels of miR-203 in non-small cell lung cancer (NSCLC) and its clinical significance remain unknown. In the present study, the association between B-cell-specific moloney murine leukemia virus ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3080
更新日期:2015-06-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cause of cancer-associated mortality worldwide. Currently, 5-fluorouracil (5-FU) remains a widely used chemotherapeutic drug in the treatment of CRC; however, 5-FU resistance during treatment has become a common problem. Livin, a member of the inhibitor of apoptosis pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8282
更新日期:2018-05-01 00:00:00
abstract::Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, the suitability and optimal settings of ICG fluorescence imaging for SN biopsy in early gastric cancer were determined. Patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4492
更新日期:2016-06-01 00:00:00
abstract::High-fat diet induced obesity was associated with more aggressive prostate cancer. Recent research has demonstrated that integrin-linked kinase (ILK), β-parvin and downstream cofilin 1 jointly affected cancer progression. Meanwhile, these proteins were also involved in energy metabolism. Therefore, the present study w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9276
更新日期:2018-10-01 00:00:00
abstract::MicroRNAs (miRs) can function as tumor suppressors or oncogenes in different types of human malignancy, and may provide an effective therapy for cancer. The expression and functions of miR-592 have previously been studied in relation to cancer. However, the expression and potential functions of miR-592 in hepatocellul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5902
更新日期:2017-05-01 00:00:00
abstract::Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6050
更新日期:2017-06-01 00:00:00
abstract::The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12265
更新日期:2021-01-01 00:00:00
abstract::Endostar, a modified recombinant human endostatin, inhibits the growth of a variety of tumors by suppressing neovascularization. Vascular endothelial growth factor (VEGF) has an important role in malignant ascites formation. In order to determine whether Endostar can suppress the formation of ascites and prolong survi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3134
更新日期:2015-06-01 00:00:00
abstract::Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7928
更新日期:2018-04-01 00:00:00
abstract::Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11938
更新日期:2020-10-01 00:00:00
abstract::In the present study, the incidence of surgical wound complications in patients with large and deep high-grade soft tissue sarcoma (STS) was investigated. In addition, the disease-specific and event-free survival rates were examined in these patients. In total, 30 adult patients with primary high-grade deep STS with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3289
更新日期:2015-08-01 00:00:00
abstract::The present study investigated the effects of N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine, on the growth of gliomas. To analyze the effects of ketamine treatment, rat C6 glioma cells arising from astrocytes, and RNB cells representing non-malignant astrocytes, were examined. In ketamine-treated C6 cells,...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6806
更新日期:2017-10-01 00:00:00
abstract::Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8902
更新日期:2018-08-01 00:00:00
abstract::Solitary fibrous tumors (SFTs) are uncommon, with the pleura as a site of predilection. Central nervous system SFTs, particularly intracranial SFTs, are extremely rare. The lesions are generally benign and localized, and surgery is the main therapeutic solution. The current study reports the cases of a patient who pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3985
更新日期:2016-02-01 00:00:00
abstract::As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to inves...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11199
更新日期:2020-02-01 00:00:00
abstract::Expression of the transcription factor hypoxiainducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia, particularly in relation to tumour angiogenesis. Expression of the HIF-1α subunit is responsive to changes in oxygen levels. Overexpression of HIF-1α has been reported to be associated with a po...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1185
更新日期:2013-04-01 00:00:00
abstract::Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11293
更新日期:2020-03-01 00:00:00
abstract::The present study aimed to evaluate the effects of amentoflavone on sorafenib-induced apoptosis in sorafenib-resistant hepatocellular carcinoma (HCC) cells. The sorafenib-resistant SK-Hep1 (SK-Hep1R) cell line was established for the present study. Initially, the differences in sorafenib-induced cytotoxicity and apopt...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6540
更新日期:2017-09-01 00:00:00
abstract::Pancreatic cancer remains among the most lethal cancers, despite ongoing advances in treatment for all stages of the disease. Disease prevention represents another opportunity to improve patient outcome, with metabolic syndrome and its components, such as diabetes, obesity and dyslipidemia, having been recognized as m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5572
更新日期:2017-03-01 00:00:00
abstract::Propofol is an intravenous anesthetic, which is widely used in clinical anesthesia induction and maintenance and is critical in the sedation of patients. However, the functions and mechanisms of propofol on apoptosis of melanoma cells remain unclear. The present study investigated whether propofol promotes cell apopto...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7297
更新日期:2018-01-01 00:00:00
abstract::As an important chemotherapeutic agent for the treatment of osteosarcoma, the effectiveness of cisplatin is considered to be due to its unique properties, which allow it to penetrate the cell membrane and form various DNA-platinum adducts, resulting in genetic alterations or DNA damage. However, chemoresistance to cis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7432
更新日期:2018-01-01 00:00:00
abstract::Retroperitoneal primary mucinous adenocarcinoma (RPMA) is extremely rare and the histogenesis of this tumor remains unclear. There is no consensus on the appropriate treatment for RPMA. Surgical resection is standard for the treatment of RPMA, whereas the benefits of chemotherapy with regard to this tumor remain to be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.319
更新日期:2011-07-01 00:00:00
abstract::Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5669
更新日期:2017-03-01 00:00:00
abstract::Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of to...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2311
更新日期:2014-09-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common tumor in south China. Kinesin family member 2A (KIF2A) belongs to the kinesin-13 family and is associated with the growth and invasion of a number of different types of human cancer, including ovarian, breast and prostate cancer. The aim of the present study was to evaluate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10597
更新日期:2019-09-01 00:00:00
abstract::The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7940
更新日期:2018-04-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been reported to participate in multiple biological processes, including tumorigenesis. In the current study, the function of a novel lncRNA LINC00887 was investigated in lung carcinoma. For this purpose, LINC00887 expression was assessed by reverse-transcription quantitative PCR. C...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12348
更新日期:2021-02-01 00:00:00
abstract::The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8048
更新日期:2018-04-01 00:00:00
abstract::The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4894
更新日期:2016-09-01 00:00:00
abstract::Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10347
更新日期:2019-07-01 00:00:00