Abstract：
BACKGROUND:Fragile X syndrome (FXS) is a genetic disorder that is highly comorbid with anxiety and autism spectrum disorder (ASD). Elevated negative affect in young children has been associated with increased risk for both anxiety and ASD; however, these relations remain poorly understood in FXS. METHODS:The present prospective longitudinal study examined the trajectory of negative affect from infancy through preschool in males and females with FXS and typical development and its relation to anxiety and ASD. RESULTS:Results indicate a complex association reflecting group, developmental, and sex effects. Specifically, the group with FXS displayed a trajectory of increasing negative affect across age that was distinct from the typical controls. This atypical trajectory of negative affect in FXS was driven by sex effects in that males showed lower negative affect during infancy followed by steep increases across the toddler and preschool years whereas the females displayed a flatter trajectory. Finally, elevated negative affect predicted anxiety symptoms in males, but not females, with no relationship to ASD in males or females with FXS. CONCLUSIONS:The current work addresses the importance of studying the development of psychopathology in a specific neurogenetic population. Temperamental negative affect was shown to be an important early marker for anxiety in young children with FXS, with subtle differences observed between males and females.
journal_name
J Neurodev Disordjournal_title
Journal of neurodevelopmental disordersauthors
Wall CA,Hogan AL,Will EA,McQuillin S,Kelleher BL,Roberts JEdoi
10.1186/s11689-019-9284-ysubject
Has Abstractpub_date
2019-09-13 00:00:00pages
22issue
1eissn
1866-1947issn
1866-1955pii
10.1186/s11689-019-9284-yjournal_volume
11pub_type
杂志文章abstract：:Prader-Willi syndrome (PWS) is a genetic imprinting disease that causes developmental and behavioral disturbances resulting from loss of expression of genes from the paternal chromosome 15q11-q13 region. In about 70% of subjects, this portion of the paternal chromosome is deleted, while 25% have two copies of the mate...
journal_title：Journal of neurodevelopmental disorders
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更新日期：2010-09-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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更新日期：2016-05-06 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/1866-1955-4-26
更新日期：2012-11-13 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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更新日期：2016-04-15 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/s11689-019-9280-2
更新日期：2019-08-19 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1007/s11689-011-9097-0
更新日期：2011-12-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/1866-1955-4-11
更新日期：2012-05-17 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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更新日期：2019-07-31 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/s11689-016-9136-y
更新日期：2016-01-27 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章,已发布勘误
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更新日期：2020-04-02 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/s11689-015-9121-x
更新日期：2015-01-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1007/s11689-009-9021-z
更新日期：2009-06-01 00:00:00
abstract：:Fragile X syndrome (FXS) is the most common identifiable genetic cause of intellectual disability and autistic spectrum disorders (ASD), with up to 50% of males and some females with FXS meeting criteria for ASD. Autistic features are present in a very high percent of individuals with FXS, even those who do not meet f...
journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1007/s11689-011-9074-7
更新日期：2011-09-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章,评审
doi：10.1186/1866-1955-6-39
更新日期：2014-01-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/s11689-017-9194-9
更新日期：2017-04-05 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/1866-1955-4-12
更新日期：2012-05-18 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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更新日期：2019-08-08 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/1866-1955-4-27
更新日期：2012-11-24 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1007/s11689-010-9067-y
更新日期：2011-03-01 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/s11689-019-9285-x
更新日期：2019-10-16 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章,评审
doi：10.1186/s11689-020-09347-w
更新日期：2020-12-13 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/s11689-020-09343-0
更新日期：2020-12-16 00:00:00
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journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/1866-1955-6-35
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Children with autism spectrum disorder (ASD) show marked impairment in social functioning and poor adaptation to new and changing contexts, which may be influenced by underlying regulatory processes. Oxytocin (OT) and cortisol are key neuromodulators of biological and behavioral responses, show a synergistic...
journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1186/s11689-016-9165-6
更新日期：2016-08-18 00:00:00
abstract：:To examine brain volumes in substructures associated with the behavioral features of children with FXS compared to children with idiopathic autism and controls. A cross-sectional study of brain substructures was conducted at the first time-point as part of an ongoing longitudinal MRI study of brain development in FXS....
journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章
doi：10.1007/s11689-009-9009-8
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:The mitochondrial aminoacyl-tRNA synthetase proteins (mt-aaRSs) are a group of nuclear-encoded enzymes that facilitate conjugation of each of the 20 amino acids to its cognate tRNA molecule. Mitochondrial diseases are a large, clinically heterogeneous group of disorders with diverse etiologies, ages of onset...
journal_title：Journal of neurodevelopmental disorders
pub_type： 杂志文章,评审
doi：10.1186/s11689-019-9292-y
更新日期：2019-12-16 00:00:00
