Abstract：
:Thrombosis development in either arterial or venous system remains a major cause of death and disability worldwide. This poorly controlled in vivo clotting could result in many severe complications including myocardial infarction, venous thromboembolism, stroke, and cerebral venous thrombosis, to name a few. These conditions are collectively known as thromboembolic disorders (TEDs). Appropriate understanding of TEDs is challenging, as they are multifactorial and involve several and often different risk factors. Hence, it requires a collective effort and data from numerous research studies to fully comprehend molecular mechanisms for prediction, prevention, treatment, and overall management of these conditions. To accomplish this arduous feat, a comprehensive approach is required that can compile thousands of available experimental data and transform these into more applicable and purposeful findings. Thus, large datasets could be utilized to generate models that could be predictive of how an individual would respond when subjected to any kind of additional risk factors or surgery, hospitalization, etc., or in the presence of some susceptible genetic variations. Artificial intelligence-based methods harness the capabilities of computer software to imitate human behaviors such as language translation, visual perception, and, most importantly, decision making. These emerging tools, if appropriately explored, might assist in processing of large data and tackle the complexities of identifying novel or interesting pathways that could otherwise be hidden due to their enormity. This narrative review attempts to compile the applications of various subfields of artificial intelligence and machine learning in the context of thrombosis research to date. It further reflects on the potential of artificial intelligence in transforming enormous research data into translational application in the form of predictive computational models.
journal_name
Semin Thromb Hemostjournal_title
Seminars in thrombosis and hemostasisauthors
Mishra A,Ashraf MZdoi
10.1055/s-0039-1697949subject
Has Abstractpub_date
2020-06-01 00:00:00pages
410-418issue
4eissn
0094-6176issn
1098-9064journal_volume
46pub_type
杂志文章abstract：:Point-of-care (POC) testing in hemostasis has experienced a significant increase in the spectrum of available tests and the number of tests performed. Short turn-around time and observation of rapid changes in test results are facilitated. The quality control process in POC testing must encompass a preanalytic (collec...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0035-1544184
更新日期：2015-02-01 00:00:00
abstract：:Schizophrenia, a disabling mental disorder, is characterized by brain atrophy, especially in the superior temporal gyrus and the medial temporal lobe, which includes the hippocampus and the amygdala. The model that better explains brain atrophy includes a trigger and a predisposing condition. The trigger is exemplifie...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0033-1357505
更新日期：2013-11-01 00:00:00
abstract：:Analogues of L-arginine that are chemically modified at the terminal guanidino nitrogen group, such as Nomega-monomethy-L-arginine (L-NMMA), have been used for nitric oxide synthase inhibition. However, L-NMMA and other methylated L-arginine analogues are also endogenously formed. Among these, asymmetric dimethylargin...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2000-13210
更新日期：2000-01-01 00:00:00
abstract：:External Quality Control of Diagnostic Assays and Tests (ECAT) surveys on thrombin generation rests (TGTs) have identified that various tests show a more than 30-fold difference in time to peak (TTP). The survey included pooled normal plasmas, microparticle (MP)-depleted plasmas, and factor (F)XII-deficient patient pl...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0030-1265296
更新日期：2010-10-01 00:00:00
abstract：:The quiescent vascular system in the adult body represents the imbalanced net outcome of overproduction of endogenous angiogenesis inhibitors and reduced levels of angiogenic factors. While some endogenous inhibitors are expressed under physiological conditions, they can also be generated in association with tumor gro...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2004-822973
更新日期：2004-02-01 00:00:00
abstract：:Congenital thrombotic thrombocytopenic purpura (TTP) or Upshaw-Schulman syndrome is caused by homozygous or compound heterozygous mutations in the ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) gene. We investigated 30 patients with congenital TTP and analyzed clinical da...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0034-1376152
更新日期：2014-06-01 00:00:00
abstract：:From injury through healing, thrombin has several important functions in blood clotting, subsequent clot lysis, and tissue repair. These include edema, inflammation, cell recruitment, cellular releases, transformations, mitogenesis, and angiogenesis. Thrombin also participates in disease states, such as venous thrombo...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-995828
更新日期：1998-01-01 00:00:00
abstract：:The management of childhood acute idiopathic thrombocytopenic purpura is controversial, with recent guidelines highlighting the lack of suitable evidence upon which to base management decisions. Three European centers have used an expectant policy and results over the past decade demonstrate that this is safe and conv...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2001-15256
更新日期：2001-06-01 00:00:00
abstract：:The number of hip fractures in anticoagulated patients is predicted to increase, due to people living longer. However, evidence regarding urgent perioperative management of elderly patients with hip fracture who take oral anticoagulants (vitamin K antagonists or direct oral anticoagulants) is scarce. In this article, ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0039-1678718
更新日期：2019-03-01 00:00:00
abstract：:With the advent of highly active antiretroviral therapy (HAART), dramatic improvements have been made in the quality and length of life in people living with HIV/AIDS (PLWA). Complications that are seen with increasing frequency in this group include venous thromboembolism events (VTE) and cardiovascular disease. Rece...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0032-1328887
更新日期：2012-11-01 00:00:00
abstract：:The two components of biological variability are interindividual variability, which is the variability due to the heterogeneity of physiologic influences among subjects, and intraindividual variability, which is due to the variability in the same individual over time. Analysis of biological variation is crucial for es...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0029-1214155
更新日期：2009-02-01 00:00:00
abstract：:This epilogue represents a final summary of the issues discussed and highlighted at the International Summit on Differentiation of Low Molecular Weight Heparins (LMWHs). International scientists and physicians presented and discussed the physicochemical differences between LMWHs, and concluded that different productio...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Most plasma proteins are present in both normal and atherosclerotic intima, and their concentrations in intimal interstitial fluid are directly related to plasma concentration and molecular size. All intimal samples also contain soluble fibrin-fibrinogen-related antigens, consisting of variable mixtures of fibrinogen ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2007-999030
更新日期：1996-01-01 00:00:00
abstract：:Clinical and laboratory data of children with von Willebrand disease (VWD) types have been derived from retrospective studies and small case series. This article reports on the clinical and laboratory data of a large pediatric cohort in one single Argentinian center. The biological and clinical responses to desmopress...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0031-1281043
更新日期：2011-07-01 00:00:00
abstract：:von Willebrand disease (vWD) is the commonest bleeding disorder in women. More than 70% of women with vWD suffer from menorrhagia and half of them suffer from dysmenorrhea. There is also the risk of hemorrhage with ovulation and mid-cycle pain. These have a significant effect on all aspects of quality of life. vWD als...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2006-949665
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:The normalized dilute Russell viper venom time (DRVVT) ratio provides a robust assay methodology for lupus anticoagulant (LA) detection. OBJECTIVES:We evaluated six normalized DRVVT LA screen and confirm systems for inter-method consistency. Reagents were purchased from Diagnostica Stago, Inc. (Parsippany, ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0033-1334865
更新日期：2013-04-01 00:00:00
abstract：:Mixing patient and normal plasma has been used for many years to assist with making decisions on which direction to proceed for further investigation of abnormally prolonged coagulation tests, namely, either individual coagulation factor measurement or the search for circulating anticoagulants. Mixing tests, however, ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0032-1304717
更新日期：2012-06-01 00:00:00
abstract：:Atherosclerosis is the major underlying cause of cardiovascular diseases, the prevalence of which is continuously increasing, thus currently standing as the leading global cause of death. This pathology gradually develops over the course of 50 or more years throughout the life of an individual under the influence of a...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-0039-1701019
更新日期：2020-07-01 00:00:00
abstract：:Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility. The biological function of PCI is un...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0031-1276583
更新日期：2011-06-01 00:00:00
abstract：:In the past two decades, major improvements in antibiotics and other elements of supportive care have decreased the number and severity of complications of hematopoietic stem cell transplantation (HSCT). Despite these improvements, many subpopulations of transplant patients still have a significant morbidity and morta...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-994924
更新日期：1999-01-01 00:00:00
abstract：:Thromboembolic complications are leading causes of both maternal and fetal morbidity and mortality. To reduce the incidence of venous thromboembolism (VTE) in pregnancy and improve outcomes, a wider understanding of the risk factors involved and better identification of women at risk of thrombosis are required. Optima...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2002-34072
更新日期：2002-08-01 00:00:00
abstract：:Thrombotic events are very frequent and represent the main cause of morbidity and mortality in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), mainly polycythemia vera and essential thrombocythemia. Pathogenesis of blood clotting activation in these diseases is multifactorial, and i...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0034-1370794
更新日期：2014-04-01 00:00:00
abstract：:Thrombotic microangiopathy (TMA) after hematopoietic stem-cell transplantation (HSCT) or solid-organ transplantation is a serious complication that may be associated with diverse clinical conditions. The reported incidence varies widely, in part due to different diagnostic criteria. Currently, the diagnosis is based m...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2005-925475
更新日期：2005-12-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) are thrombotic microangiopathies (TMAs) that can present in pregnancy. The presentation can be with typical microangiopathic features and thrombocytopenia, but there is also a significant risk of in-utero fetal loss. TTP presents m...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0036-1587683
更新日期：2016-10-01 00:00:00
abstract：:To elucidate the mechanisms by which hematopoietic progenitor cells selectively lodge in bone marrow, we established endothelial cell lines derived from bone marrow and lung and then examined the transendothelial migration of hematopoietic progenitor cells by using cells was examined by a Transwell migration assay. He...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章
doi：10.1055/s-2007-995854
更新日期：1998-01-01 00:00:00
abstract：:Quiescent pulmonary endothelium establishes an antithrombotic, anti-inflammatory surface that promotes blood flow. However, the endothelium rapidly responds to injury and inflammation by promoting thrombosis and enabling the directed transmigration of inflammatory cells, such as neutrophils, into the alveolar airspace...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-0030-1253452
更新日期：2010-04-01 00:00:00
abstract：:It has been well known for many years that the ABO blood group has a major influence on hemostasis, through its influence on von Willebrand factor and, consequently, factor VIII plasma levels. Although the relationship between non-O blood type and the risk of venous thromboembolism is nowadays also well established, t...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,meta分析,评审
doi：10.1055/s-0033-1363460
更新日期：2014-02-01 00:00:00
abstract：:Protein C replacement therapy with a monoclonal antibody purified, virus inactivated protein C concentrate was carried out in nine infants (three male, six female) with severe congenital protein C deficiency and life-threatening purpura fulminans and/or thrombosis associated with disseminated intravascular coagulation...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2007-1000658
更新日期：1995-01-01 00:00:00
abstract：:Patients undergoing surgery for malignancy are at increased risk of initial and recurrent venous thromboembolism (VTE). Several factors have been found to increase the risk of deep vein thrombosis (DVT) in cancer patients both during the first days after the operation and after discharge from hospital. Although, in ge...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2002-36701
更新日期：2002-12-01 00:00:00
abstract：:Of all the coagulation factor deficiencies, only deficiency of factor XIII (FXIII) and fibrinogen are associated with pregnancy loss. FXIII deficiency and a complete or partial deficiency of fibrinogen are associated with bleeding since childhood, impaired wound repair, and recurrent spontaneous abortions. Both FXIII ...
journal_title：Seminars in thrombosis and hemostasis
pub_type： 杂志文章,评审
doi：10.1055/s-2003-38832
更新日期：2003-04-01 00:00:00
