Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment.

Abstract:

:The K+/Cl- cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.

journal_name

Sci Signal

journal_title

Science signaling

authors

Zamponi GW

doi

10.1126/scisignal.aay8960

subject

Has Abstract

pub_date

2019-10-15 00:00:00

issue

603

eissn

1945-0877

issn

1937-9145

pii

12/603/eaay8960

journal_volume

12

pub_type

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