Abstract:
:Cancer clinical trials represent an important option for patients with a diagnosis of cancer and the clinician-investigators involved in their care who seek options for their disease. For all who are impacted by cancer, these studies offer opportunities for greater learning. Conducting these important studies involves several challenges, including recruiting eligible participants. To address barriers that arise over the course of these activities, the Department of Veterans Affairs (VA) and National Cancer Institute (NCI) have partnered to increase Veteran participation in oncology clinical trials. This initiative, the NCI And VA Interagency Group to Accelerate Trials Enrollment, or NAVIGATE, is focused on addressing recruitment across the VA healthcare system and finding systematic solutions related to activating, recruiting for and conducting oncology clinical trials at VA Medical Centers. Additional goals include (1) establishing a sustainable network that can serve as a model for other VA sites interested in doing cancer clinical trials, (2) recruitment of minority patients, and (3) developing best practices and policies that can be deployed across the VA healthcare system. In this manuscript, we describe the scope, organization, activities, and future directions of NAVIGATE while also highlighting key needs for successfully conducting cancer clinical trials within the VA system. This partnership between 2 large federal agencies with a shared commitment to improving cancer care may provide lessons to others who are also dedicated to helping those affected by the disease.
journal_name
Semin Oncoljournal_title
Seminars in oncologyauthors
Schiller SJ,Shannon C,Brophy MT,Denicoff AM,Good MJ,Prindiville SA,Huang GDdoi
10.1053/j.seminoncol.2019.09.005subject
Has Abstractpub_date
2019-01-01 00:00:00pages
308-313issue
4-5eissn
0093-7754issn
1532-8708pii
S0093-7754(19)30113-7journal_volume
46pub_type
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journal_title:Seminars in oncology
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abstract::Studies in vitro and in animal models have helped define the mechanism of action of antiestrogens and the differences in the physical properties of the various antiestrogens. Tamoxifen is the most widely studied antiestrogen. A review of 45 separate studies has shown a response rate to tamoxifen in advanced breast can...
journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章
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journal_title:Seminars in oncology
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abstract::Preclinical studies have indicated that hydroxyurea leads to enhancement of 5-fluorouracil (5-FU) activity when given after 5-FU. This is presumably due to hydroxyurea's actions resulting in maintaining low levels of deoxyuridine monophosphate pools. The combination of hydroxyurea and 5-FU has been tested in several i...
journal_title:Seminars in oncology
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Seminars in oncology
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doi:10.1053/j.seminoncol.2019.01.004
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1996-12-01 00:00:00
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journal_title:Seminars in oncology
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doi:
更新日期:1998-10-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:10.1053/j.seminoncol.2008.08.004
更新日期:2008-12-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1998-06-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:10.1053/sonc.2002.31680
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:10.1053/j.seminoncol.2004.11.013
更新日期:2005-04-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in oncology
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